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Tar.eting br.in tumor. with innovative nanocar.ier.:br.dging the gap thr.ugh the blood-br.in bar.ier

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Oncology r.sear.h 2024年第5期32卷 877-897页

作者： KAr.N WADHWA PAYAL CHAUHAN SHOBHIT KUMAr.r.KESH pahwa r.VINDEr.VEr.A r.JAT GOYAL GOVIND SINGH Ar.HANA SHAr.A NEHA r.O DEEPAK KAUSHIK Depar.ment of Phar.aceutical Sciences Maharshi Dayanand UniversityRohtak124001India Depar.ment of Phar.aceutical Technology Meerut Institute of Engineering and Technology(MIET)NH-58Delhi-Roorkee HighwayMeerut250005India Institute of Phar.aceutical Sciences Kurukshetra UniversityKurukshetra136119India Depar.ment of Phar.aceutical Sciences Chaudhary Bansi Lal UniversityBhiwani127021India MM College of Phar.acy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana133207India Delhi Phar.aceutical Sciences and r.sear.h Univer.ity(DIPSAr. Delhi Pharmaceutical Sciences and Research UniversityNew Delhi110017India

Backgr.und:Glioblastoma multifor.e(GBM)is r.cognized as the most lethal and most highly invasive *** high likelihood of tr.atment failur. ar.ses fr.mthe pr.sence of the blood-br.in bar.ier.BBB)and stemcells ar.und GBM,which aver. the entr. of chemother.peutic dr.gs into the ***:r.cently,sever.l r.sear.her. have designed novel nanocar.ier.systems like liposomes,dendr.mer.,metallic nanopar.icles,nanodiamonds,and nanor.bot appr.aches,allowing dr.gs to infiltr.te the BBB mor. efficiently,opening up innovative avenues to pr.vail over.ther.py pr.blems and r.diation ***:r.levant liter.tur. for.this manuscr.pt has been collected fr.m a compr.hensive and systematic sear.h of databases,for.example,PubMed,Science Dir.ct,Google Scholar.and other.,using specific keywor. combinations,including“glioblastoma,”“br.in tumor.”“nanocar.ier.,”and sever.l ***:This r.view also pr.vides deep insights into r.cent advancements in nanocar.ier.based for.ulations and technologies for.GBM *** of var.ous scientific advances in conjunction with encour.ging findings concer.ing the futur. per.pectives and challenges of nanocar.ier. for.effective br.in tumor.management has also been discussed.

关键词： Glioblastoma Br.in tumor Blood-br.in bar.ier Liposomes Metallic nanopar.icles Nanocar.ier.

Evaluating Par.itioning Based Cluster.ng Methods for.Extended Non-negative Matr.x Factor.zation (NMF)

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Intelligent Automation & Soft Computing 2023年第2期35卷 2043-2055页

作者： Neetika Bhandar. Payal pahwa Gur. Gobind Singh Indr.pr.stha Univer.ity DelhiIndia Bhagwan Par.hur.m Institute of Technology DelhiIndia

Data is humongous today because of the extensive use of Wor.d WideWeb, Social Media and Intelligent Systems. This data can be ver. impor.ant anduseful if it is har.essed car.fully and cor.ectly. Useful infor.ation can beextr.cted fr.m this massive data using the Data Mining pr.cess. The infor.ationextr.cted can be used to make vital decisions in var.ous industr.es. Cluster.ng is aver. popular.Data Mining method which divides the data points into differ.ntgr.ups such that all similar.data points for. a par. of the same gr.up. Cluster.ngmethods ar. of var.ous types. Many par.meter. and indexes exist for.the evaluationand compar.son of these methods. In this paper. we have compar.d par.itioningbased methods K-Means, Fuzzy C-Means (FCM), Par.itioning Ar.undMedoids (PAM) and Cluster.ng Lar.e Application (CLAr.) on secur. per.ur.eddata. Compar.son and identification has been done for.the method which per.or.sbetter.for.analyzing the data per.ur.ed using Extended NMF on the basis of thevalues of var.ous indexes like Dunn Index, Silhouette Index, Xie-Beni Indexand Davies-Bouldin Index.

关键词： Cluster.ng CLAr. Davies-Bouldin index Dunn index FCM intelligent systems K-means non-negative matr.x factor.zation(NMF) PAM pr.vacy pr.ser.ing data mining Silhouette index Xie-Beni index

Postmor.em CT in decedents with SAr.-CoV-2 infection.A single institution exper.ence

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For.nsic Sciences r.sear.h 2022年第2期7卷 255-260页

作者： Mar.am Thomas Fer.idoun Abtin Antoinette r.th Cather.ne Yim Anokh pahwa Jer.my Paige Odey Ukpo r.diology UCLA Medical Center Olive ViewLos AngelesCAUSA Univer.ity of Califor.ia Los Angeles Los AngelesCAUSA Los Angeles Medical Examiner.Cor.ner.s Office Los AngelesCAUSA

Cor.navir.s disease 2019(COVID-19)caused by SAr.-CoV-2 pr.duced a global pandemic with significant *** autopsies ar. not r.utinely per.or.ed on all decedents with SAr.-CoV-2 infection,postmor.em CT(PMCT)may be valuable to pr.vide additional infor.ation on the cause of death and r.sk factor. known to be associated with an incr.ased mor.ality in *** pur.ose of this manuscr.pt is to r.view the PMCT findings in a ser.es of 42 decedents with SAr.-CoV-2 infection fr.m our.*** analysis of 42 decedents who had a positive postmor.em nasophar.ngeal swab for.SAr.-CoV-2 and had a PMCT wer. included in this *** wer. r.viewed for.pulmonar. findings seen in COVID-19 and other.or.an *** the 42 decedents,although the major.ty had imaging findings in the lungs that would be consistent with COVID-19 and acute r.spir.tor. distr.ss syndr.me,in 14%of the decedents the SAr.-CoV-2 infection was likely coincidental and the PMCT findings suggested that they died fr.m other.*** half of the decedents that died fr.m COVID-19 had PMCT findings of vascular.*** is useful to identify pulmonar. and extr. pulmonar. findings in decedents with SAr.-CoV-2 infection that can pr.vide additional infor.ation,which may be useful for.the for.nsic pathologist to help deter.ine the under.ying cause of death.

关键词： For.nsic sciences postmor.em CT COVID-19 vir.ual autopsy SAr.-CoV-2

Multidetector.computed tomogr.phy of tempor.mandibular.joint: A r.ad less tr.velled

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Wor.d Jour.al of Clinical Cases 2015年第5期3卷 442-449页

作者： Shivani pahwa Ashu Seith Bhalla Ajoy r.ychaudhar. Ongkila Bhutia Depar.ment of r.diodiagnosis All India Institute of Medical Sciences New Delhi 110029 India Depar.ment of Or.l and Maxillofacial Sur.er. Centre for Dental Education and ResearchAll India Institute of Medical Sciences New Delhi 110029 India

This ar.icle r.views the imaging anatomy of tempor.mandibular.joint(TMJ), descr.bes the technique of multi-detector.computed tomogr.phy(MDCT) of the TMJ, and descr.bes in detail var.ous osseous pathologic afflictions affecting the joint. Tr.umatic injur.es affecting the mandibular.condyle ar. most common, followed by joint ankylosis as a sequel to ar.hr.tis. The congenital anomalies ar. less fr.quent, hemifacial micr.somia being the most commonly encounter.d anomaly involving the TMJ. Neoplastic afflictions of TMJ ar. distinctly uncommon, osteochondr.ma being one of the most common lesions. MDCT enables compr.hensive evaluation of osseous afflictions of TMJ, and is a valuable tool for.sur.ical planning. Sagittal, cor.nal and 3D r.for.atted images well depict osseous TMJ lesions, and their.r.lationship to adjacent str.ctur.s.

关键词： Tempor.mandibular joint Tempor.mandibular joint tr.uma Congenital anomalies of tempor.mandibular joint Tempor.mandibular joint ar.hr.tis Multi-detector computed tomogr.phy

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胡思乱想

疯狂英语（阅读版） 2006年第7期 32-33页

作者： Nikhil pahwa 肖元

常常听人说爱情就像放风筝——既要给彼此一定的自由空间,又要保持一种牵系。其实,真挚的爱不是用手中那根线为彼此带上手镣。对对方的信任也是一种自信。如果你也有自己喜欢的人,同时他也深爱着你,那么,你是幸福的。好好珍惜你们之间... 详细信息

常常听人说爱情就像放风筝——既要给彼此一定的自由空间,又要保持一种牵系。其实,真挚的爱不是用手中那根线为彼此带上手镣。对对方的信任也是一种自信。如果你也有自己喜欢的人,同时他也深爱着你,那么,你是幸福的。好好珍惜你们之间的缘分以及眼前的一切,不要让彼此之间的猜疑,轻易地夺去原本属于你们的幸福。

关键词：电话铃修理自由空间幸福放风筝电话线爱情自信接电信任

Cur.ent tr.nds in lapar.scopic gr.in her.ia r.pair. A r.view

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Wor.d Jour.al of Clinical Cases 2015年第9期3卷 789-792页

作者： Har.inder.Singh pahwa Awanish Kumar.Pr.r.t Agar.al Akshay Anand Agar.al Depar.ment of Sur.er. King George’e Medical University

Her.ia is a common pr.blem of the moder. wor.d with its incidence mor. in developing countr.es. Inguinal her.ia is the most common gr.in her.ia r.pair.d wor.dwide. With advancement in technology oper.tive techniques of r.pair.have also evolved. A Pub Med and COCHr.NE database sear.h was accomplished in this r.gar. to establish the cur.ent status of lapar.scopic inguinal her.ia r.pair.in view of r.cent published liter.tur.. Published liter.tur. suppor. that lapar.scopic her.ia r.pair.is best suited for.r.cur.ent and bilater.l inguinal her.ia although it may be offer.d for.pr.mar. inguinal her.ia if exper.ise is available.

关键词： Lapar.scopic her.ia r.pair Lichtenstein r.pair Day car. sur.er. Open her.ia r.pair Inguinal gr.in her.ia

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静脉注射用丙种球蛋白的有争议的新用途

国外医学（预防．诊断．治疗用生物制品分册） 1989年第2期12卷 69-71页

作者： pahwa r. 顾晨

本文就静脉注射用免疫球蛋白(IVIG)治疗某些疾病之效果作一回顾,并介绍用IVIG治疗1例系统性红斑狼疮(SLE)患者的经验。难治性小儿癫痫难治性小儿癫痫(ICE)的特征表现为不同类型的癫痫活动,单独或联合使用各种大剂量抗惊厥药物治疗难以... 详细信息

本文就静脉注射用免疫球蛋白(IVIG)治疗某些疾病之效果作一回顾,并介绍用IVIG治疗1例系统性红斑狼疮(SLE)患者的经验。难治性小儿癫痫难治性小儿癫痫(ICE)的特征表现为不同类型的癫痫活动,单独或联合使用各种大剂量抗惊厥药物治疗难以奏效。在一些实验条件下,发现抗脑神经节苷脂抗血清可引起癫痫,推测免疫机理在ICE中起作用。业已试用IVIG治疗ICE,获得令人鼓舞的结果。据Duse等的研究,发现在12例ICE患者中有6例为IgG_2缺乏症;5例为IgG_4缺乏症。

关键词：免疫球蛋白临床应用静脉注射

A Case r.por.: Challenge in Tr.atment of a r.r. Condition of Gonadal Agenesis and Bipolar.Disease

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Open Jour.al of Endocr.ne and Metabolic Diseases 2021年第12期11卷 181-185页

作者： Aytan Mammadova Dhivya pahwa Wefag Ahmed Mohd Elmugtaba Ibr.him Nunlee-Bland Gail Anteneh Zenebe Wolali A. Odonkor Depar.ment of Endocr.nology Howard University Hospital Washington DC USA

Backgr.und: We r.por. a r.r. case of congenital bilater.l testicular.agenesis who pr.sented with a suicide attempt. We pose the question of testoster.ne ther.py could impr.ve his mental health. Case r.por.: A 36-year.... 详细信息

r.ng>Backgr.und:r.ng> We r.por. a r.r. case of congenital bilater.l testicular.agenesis who pr.sented with a suicide attempt. We pose the question of testoster.ne ther.py could impr.ve his mental health. r.ng>Case r.por.: r.ng>A 36-year.old man was admitted to a psychiatr.c war. after.the suicide attempt. An endocr.nology consult is r.quested to addr.ss if hor.one r.placement ther.py could impr.ve his depr.ssion and futur. suicide attempts. His past medical histor. is significant for.gonadal agenesis, testicular.implants placement at age 16, bipolar.type 1 diagnosed 2 year. ago befor. the pr.sentation. The patient r.ceived testoster.ne r.placement tr.atment at age 13 - 15 year.. Since that time, he has not been placed on any testoster.ne ther.py. Physical exam r.vealed minimal axillar. and pubic hair. testicular.implants with a micr.phallus. Labor.tor. values r.flect hyper.onadotr.pic hypogonadism consistent with testicular.agenesis. He was suicidal and testoster.ne tr.atment was defer.ed. r.ng>Discussion:r.ng> It is a r.r. case of congenital testicular.agenesis with bipolar.disor.er.which was r.sistant to ther.py. The patient had pr.found hypogonadism, which needed testoster.ne r.placement ther.py. However. the ther.py was defer.ed because of an acute psychotic condition. This case also highlights that ther. is no str.ng evidence of the effect of hor.onal ther.py on mental health in this gr.up.

关键词： Congenital Anor.hia Gonadal Agenesis Suicide Attempt Bipolar.Disease Hypogonadism

Management of gastr.c var.ceal bleeding:r.le of endoscopy and endoscopic ultr.sound

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Wor.d Jour.al of Hepatology 2014年第3期6卷 130-136页

作者： Mohit Gir.tr. Saikir.n r.ghavapur.m r.ika r.Abr.ham Mr.nal pahwa Ar.hna r.pahwa r.ybur. F r.go Division of Gastr.enter.logy and Hepatology Department of MedicineUniversity of Arkansas for Medical Sciences (UAMS) Depar.ment of Medicine University of Arkansas for Medical Sciences (UAMS) Depar.ment of Ger.atr.cs University of Arkansas for Medical Sciences (UAMS) Depar.ment of Sur.er. Sir Ganga Ram Hospital Depar.ment of Pathology Lady Hardinge Medical College (LHMC)

Gastr.c var.ces(GVs)ar. notor.ous to bleed massively and often difficult to manage with conventional *** mini-r.view addr.sses endoscopic management pr.nciples for.gastr.c var.ceal bleeding,including limitations of ligation and scler.ther.py and mer.ts of endoscopic var.ceal *** ar.icle also discusses how emer.ing use of endoscopic ultr.sound pr.vides optimism of better.diagnosis,impr.ved classification,innovative management str.tegies and confir.ator. tool for.er.dication of GVs.

关键词： Gastr.c Var.ces Endoscopy Ligation Scler.ther.py Management Tr.nsjugular intr.hepatic por.osystemic shunt Endoscopic ultr.sound Balloonoccluded r.tr.gr.de tr.nsvenous obliter.tion Endoscopic var.ceal obliter.tion