检索结果-南通市图书馆

Spastin and alsin pr.tein inter.ctome analyses begin to r.veal key canonical pathways and suggest novel dr.ggable tar.ets

引用

Neur.l r.gener.tion r.sear.h 2025年第3期20卷 725-739页

作者： Benjamin r.Helmold Angela Ahr.ns Zachar. Fitzger.ld p.Hande Ozdinler Depar.ment of Neur.logy Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center.for.Molecular.Innovation and Dr.g Discover. Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center.for.Cognitive Neur.logy and Alzheimer.s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinber. School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-ter. tr.atment str.tegies for.r.r. and complex neur.degener.tive diseases is challenging. One of the major.r.adblocks is the extensive heter.geneity among patients. This hinder. under.tanding the under.ying disease-causing mechanisms and building solutions that have implications for.a br.ad spectr.m of patients. One potential solution is to develop per.onalized medicine appr.aches based on str.tegies that tar.et the most pr.valent cellular.events that ar. per.ur.ed in patients. Especially in patients with a known genetic mutation, it may be possible to under.tand how these mutations contr.bute to pr.blems that lead to neur.degener.tion. pr.tein–pr.tein inter.ction analyses offer.gr.at advantages for.r.vealing how pr.teins inter.ct, which cellular.events ar. pr.mar.ly involved in these inter.ctions, and how they become affected when key genes ar. mutated in patients. This line of investigation also suggests novel dr.ggable tar.ets for.patients with differ.nt mutations. Her., we focus on alsin and spastin, two pr.teins that ar. identified as “causative” for.amyotr.phic later.l scler.sis and her.ditar. spastic par.plegia, r.spectively, when mutated. Our.r.view analyzes the pr.tein inter.ctome for.alsin and spastin, the canonical pathways that ar. pr.mar.ly impor.ant for.each pr.tein domain, as well as compounds that ar. either.Food and Dr.g Administr.tion–appr.ved or.ar. in active clinical tr.als concer.ing the affected cellular.pathways. This line of r.sear.h begins to pave the way for.per.onalized medicine appr.aches that ar. desper.tely needed for.r.r. neur.degener.tive diseases that ar. complex and heter.geneous.

关键词： ALS2 alsin amyotr.phic later.l scler.sis her.ditar. spastic par.plegia neur.degener.tive diseases per.onalized medicine pr.cision medicine pr.tein inter.ctome pr.tein-pr.tein inter.ctions SpAST spastin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Scalable Ir.Doped NiFe₂O₄/TiO₂ Heter.junction Anode for.Decentr.lized Saline Wastewater.Tr.atment and H₂ pr.duction

引用

NANO-MICr. LETTEr. 2025年第1期17卷 1-18页

作者： Hong, Sukhwa Kim, Jiseon par., Jaebeom Im, Sunmi Hoffmann, Michael r. Cho, Kangwoo pohang Univ Sci & Technol pOSTECH Div Environm Sci & Engn Pohang 790784 South Korea CALTECH Linde Labs Pasadena CA 91125 USA Yonsei Univ Int Campus Inst Convergence Res & Educ Adv Technol I CREATE Incheon 21983 South Korea

Wastewater.electr.lysis cells (WECs) for.decentr.lized wastewater.tr.atment/r.use coupled with H-2 pr.duction can r.duce the car.on footpr.nt associated with tr.nspor.ation of water. waste, and ener.y car.ier. This study r.por.s Ir.doped NiFe2O4 (NFI, similar.to 5 at% Ir. spinel layer.with TiO2 over.ayer.(NFI/TiO2), as a scalable heter.junction anode for.dir.ct electr.lysis of wastewater.with cir.umneutr.l pH in a single-compar.ment cell. In dilute (0.1 M) NaCl solutions, the NFI/TiO2 mar.s super.or.activity and selectivity for.chlor.ne evolution r.action, outper.or.ing the benchmar. Ir.2. r.bust oper.tion in near.neutr.l pH was confir.ed. Electr.analyses including oper.ndo X-r.y absor.tion spectr.scopy unveiled cr.cial r.les of TiO2 which ser.es both as the pr.mar. site for.Cl- chemisor.tion and a pr.tective layer.for.NFI as an ohmic contact. Galvanostatic electr.lysis of NH4+-laden synthetic wastewater.demonstr.ted that NFI/TiO2 not only achieves quasi-stoichiometr.c NH4+-to-N-2 conver.ion, but also enhances H-2 gener.tion efficiency with minimal competing r.actions such as r.duction of dissolved oxygen and r.active chlor.ne. The scaled-up WEC with NFI/TiO2 was demonstr.ted for.electr.lysis of toilet wastewater.

关键词： Wastewater.electr.lysis cell Ir.doped NiFe2O4 r.active chlor.ne species Decentr.lized H-2 pr.duction On-site wastewater.tr.atment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Heter.geneity of matur. oligodendr.cytes in the centr.l ner.ous system

引用

Neur.l r.gener.tion r.sear.h 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Gr.h Moein Yaqubi Qiao-Ling Cui Jo Anne Str.tton G.r.Wayne Moor. Jack p.Antel Neur.immunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Depar.ment of Neur.logy Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Matur. oligodendr.cytes for. myelin sheaths that ar. cr.cial for.the insulation of axons and efficient signal tr.nsmission in the centr.l ner.ous *** evidence has challenged the classical view of the functionally static matur. oligodendr.cyte and r.vealed a gamut of dynamic functions such as the ability to modulate neur.nal cir.uitr. and pr.vide metabolic suppor. to *** the r.cognition of potential heter.geneity in matur. oligodendr.cyte function,a compr.hensive summar. of matur. oligodendr.cyte diver.ity is *** delve into ear.y 20th-centur. studies by r.ber.son and r.o-Hor.ega that laid the foundation for.the moder. identification of r.gional and mor.hological heter.geneity in matur. ***,r.cent mor.hologic and functional studies call into question the long-assumed homogeneity of matur. oligodendr.cyte function thr.ugh the identification of distinct subtypes with var.ing myelination ***,moder. molecular.investigations,employing techniques such as single cell/nucleus r.A sequencing,consistently unveil at least six matur. oligodendr.cyte subpopulations in the human centr.l ner.ous system that ar. highly tr.nscr.ptomically diver.e and var. with centr.l ner.ous system *** and disease r.lated matur. oligodendr.cyte var.ation denotes the impact of pathological conditions such as multiple scler.sis,Alzheimer.s disease,and psychiatr.c ***,caution is war.anted when subclassifying matur. oligodendr.cytes because of the simplification needed to make conclusions about cell identity fr.m tempor.lly confined *** studies lever.ging advanced techniques like spatial tr.nscr.ptomics and single-cell pr.teomics pr.mise a mor. nuanced under.tanding of matur. oligodendr.cyte *** r.sear.h avenues that pr.cisely evaluate matur. oligodendr.cyte heter.geneity with car. to under.tand the mitigating influence of species,sex,centr.l ner.ous system r.gion,age,and disease,

关键词： aging centr.l ner.ous system diseases electr.n micr.scopy heter.geneity immunohistochemistr. myelin sheath natur.l histor. neur.glia oligodendr.glia single-cell gene expr.ssion analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chr.nic opioids in gastr.par.sis: r.lationship with gastr.intestinal symptoms, healthcar. utilization and employment

引用

Wor.d Jour.al of Gastr.enter.logy 2017年第40期23卷 7310-7320页

作者： asad Jehangir.Henr. p par.man Depar.ment of Inter.al Medicine Reading Health System Depar.ment of Gastr.-enter.logy Temple University Hospital

AIM To examine the r.lationship of chr.nic scheduled opioid use on symptoms, healthcar. utilization and employment in gastr.par.sis(Gp) patients. Methods patients r.fer.ed to our.ter.iar. car. academic center.fr.m May 2016 to July 2017, with established diagnosis or.symptoms suggestive of Gp filled out the patient Assessment of Upper.GI Symptoms, abdominal pain and demogr.phics questionnair.s, and under.ent gastr.c emptying and blood tests. They wer. asked about taking pain medicines and the types, doses, and dur.tion. We used Mann Whitney U test, Analysis of Var.ance, Student's t test and χ2 tests wher. appr.pr.ate for.data *** Of 223 patients with delayed gastr.c emptying, 158(70.9%) patients wer. not taking opioids(Gp NO), 22(9.9%) wer. taking opioids only as needed, while 43(19.3%) wer. on chr.nic(> 1 mo) scheduled opioids(Gp CO), of which 18 wer. taking opioids for.easons that included gastr.par.sis and/or.stomach pain. Median mor.hine equivalent use was 60 mg per.day. Gp CO r.por.ed higher.sever.ties of many gastr.intestinal symptoms compar.d to Gp NO including nausea(mean ± SE of mean of 4.09 ± 0.12 vs 3.41 ± 0.12, p = 0.011), r.tching(2.86 ± 0.25 vs 1.98 ± 0.14, p = 0.003), vomiting(2.93 ± 0.24 vs 2.07 ± 0.15, p = 0.011), ear.y satiety(4.17 ± 0.19 vs 3.57 ± 0.12, p = 0.004), post-pr.ndial fullness(4.14 ± 0.18 vs 3.63 ± 0.11, p = 0.022), loss of appetite(3.64 ± 0.21 vs 3.04 ± 0.13, p = 0.039), upper.abdominal pain(3.86 ± 0.20 vs 2.93 ± 0.13, p = 0.001), upper.abdominal discomfor.(3.74 ± 0.19 vs 3.09 ± 0.13, p = 0.031), hear.bur. dur.ng day(2.55 ± 0.27 vs 1.89 ± 0.13, p = 0.032), hear.bur. on lying down(2.76 ± 0.28 vs 1.94 ± 0.14, p = 0.008), chest discomfor. dur.ng day(2.42 ± 0.20 vs 1.83 ± 0.12, p = 0.018), chest discomfor. at night(2.40 ± 0.23 vs 1.61 ± 0.13, p = 0.003), r.gur.itation/r.flux dur.ng day(2.77 ± 0.25 vs 2.18 ± 0.13, p = 0.040) and bitter.acid/sour.taste in the mouth(2.79 ± 0.27 vs 2.11 ± 0.14, p = 0.028). Gp CO had a longer.dur.ti

关键词： Opioid Gastr.par.sis Symptoms Hospitalizations Employment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

For.ging technique and pr.y-handling time in black-necked stor.(Ephippior.ynchus asiaticus)

引用

Integr.tive Zoology 2008年第4期3卷 274-279页

作者： Gopinathan MAHESWAr.N asad r.r.HMANI Depar.ment of Wildlife Sciences Aligarh Muslim UniversityAligarhIndia

The for.ging technique and pr.y-handling time of the black-necked stor.(Ephippior.ynchus asiaticus)was stud-ied in Dudhwa National par.,India,fr.m Januar. 1996 to June *** habitat in which the stor.s for.ged played an impor.ant r.le in selecting a par.icular.technique to pr.cur. ***-necked stor.s mostly for.ged using a tactile technique(>90%),but sometimes for.ged *** the water.level was estimated to be less than 60 cm,the stor.s for.ged using tactile *** was no differ.nce in the feeding techniques of male and female *** attempt r.tes var.ed between the sexes in summer.May)and dur.ng late winter.Febr.ar.)in *** sear.h time for.pr.y incr.ased when the water.level was high and fish wer. widely *** in water.level r.sulted in concentr.tion of fish in cer.ain ar.as and this contr.buted to high fish-catching r.tes by black-necked *** had a higher.success r.te of fish captur. than ***,females captur.d longer.fish than ***-handling time incr.ased in both sexes as fish length *** 4–6 cm long wer. most fr.quently taken by the for.ging stor.s.

关键词： black-necked stor. Ephippior.ynchus asiaticus for.ging India pr.y-handling time.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fr.e tor.ional vibr.tion of cr.cked nanobeams incor.or.ting sur.ace ener.y effects

引用

Applied Mathematics and Mechanics(English Edition) 2017年第2期38卷 217-230页

作者： r. NAZEMNEZHAD p. FAHIMI School of Engineer.ng Damghan University Damghan 36716-41167 Iran School of Mechanical Engineer.ng Iran University of Science and Technology Tehran 16846-13114 Iran School of Mechanical Engineer.ng College of Engineering University of Tehran Tehran 14399-57131 Iran

This paper.investigates sur.ace ener.y effects, including the sur.ace shear.modulus, the sur.ace str.ss, and the sur.ace density, on the fr.e tor.ional vibr.tion of nanobeams with a cir.umfer.ntial cr.ck and var.ous boundar. conditions. To for.ulate the pr.blem, the sur.ace elasticity theor. is used. The cr.cked nanobeam is modeled by dividing it into two par.s connected by a tor.ional linear.spr.ng in which its stiffness is r.lated to the cr.ck sever.ty. Gover.ing equations and cor.esponding boundar. conditions ar. der.ved with the aid of Hamilton＇s pr.nciple. Then, natur.l fr.quencies ar. obtained analytically, and the influence of the cr.ck sever.ty and position, the sur.ace ener.y, the boundar. conditions, the mode number. and the dimensions of nanobeam on the fr.e tor.ional vibr.tion of nanobeams is studied in detail. r.sults of the pr.sent study r.veal that the sur.ace ener.y has completely differ.nt effects on the fr.e tor.ionl vibr.tion of cr.cked nanobeams compar.d with its effects on the fr.e tr.nsver.e vibr.tion of cr.cked nanobeams.

关键词： tor.ional vibr.tion cr.cked nanobeam sur.ace ener.y

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cr.tical anomaly and finite size scaling of the self-diffusion coefficient for.Lennar. Jones fluids by non-equilibr.um molecular.dynamic simulation

引用

Chinese physics B 2011年第10期20卷 362-367页

作者： Ahmed asad 吴江涛 State Key Labor.tor. of Multiphase Flow in power.Engineer.ng Xi'an Jiaotong University

We use non-equilibr.um molecular.dynamics simulations to calculate the self-diffusion coefficient, D, of a Lennar. Jones fluid over.a wide density and temper.tur. r.nge. The change in self-diffusion coefficient with temper.tur. decr.ases by incr.asing density. For.density ρ＊ = ρσ3 = 0.84 we obser.e a peak at the value of the self-diffusion coefficient and the cr.tical temper.tur. T＊ = kT/ε = 1.25. The value of the self-diffusion coefficient str.ngly depends on system size. The data of the self-diffusion coefficient ar. fitted to a simple analytic r.lation based on hydr.dynamic ar.uments. This cor.ection scales as N-α, wher. α is an adjustable par.meter.and N is the number.of par.icles. It is obser.ed that the values of a 〈 1 pr.vide quite a good cor.ection to the simulation data. The system size dependence is ver. str.ng for.lower.densities, but it is not as str.ng for.higher.densities. The self-diffusion coefficient calculated with non-equilibr.um molecular.dynamic simulations at differ.nt temper.tur.s and densities is in good agr.ement with other.calculations fr.nl the liter.tur..

关键词： self-diffusion coefficient non-equilibr.um molecular.dynamic simulation Lennar. Jonesfluid cr.tical dynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dipole and Combo Optical Solitons in Bir.fr.ngent Fiber. in the pr.sence of Four.Wave Mixing

引用

Communications in Theor.tical physics 2019年第6期71卷 723-730页

作者： Nauman r.za asad Zubair Depar.ment of Mathematics University of the Punjab Quaid-e-Azam Campus

The ultimate theme of this study is to develop dipole and combo optical solitons in bir.fr.ngent fiber.(BF) along with the effect of four.wave mixing(4 WM). Two types of r.ugh mediums ar. used which ar. Ker. law and par.bolic law. Ansatz method of Choudhur. is applied to obtain dar. in the br.ght(dipole) soliton solutions pr.viding br.ght backgr.und for.the pr.pagation of optical dar. pulse. Ansatz method of Li is applied to obtain combo soliton solutions pr.viding br.ght solitar. wave and dar. solitar. wave solutions. These r.sults also exist to hold in non-Ker. media with higher.or.er.disper.ion.

关键词： dipole solitons combo solitons ansatz methods four.wave mixing bir.fr.ngent fiber.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimal dynamic emer.ency r.ser.e activation using spinning, hydr. and demand-side r.ser.es

引用

Fr.ntier. in Ener.y 2016年第4期10卷 409-423页

作者： S. Sur.nder.r.DDY p. r. BIJWE A. r. ABHYANKAr Depar.ment of r.ilr.ad and Electr.cal Engineer.ng Woosong University Republic of Korea Depar.ment of Electr.cal Engineer.ng Indian Institute of TechnologyDelhi India

This paper.pr.poses an optimal dynamic r.ser.e activation plan after.the occur.ence of an emer.ency situation （gener.tor.tr.nsmission line outage, load incr.ase or.both）. An optimal plan is developed to handle the emer.ency, using the coor.inated action of fast and slow r.ser.es, for.secur. oper.tion with minimum over.ll cost. It consider. the r.ser.es supplied by the conventional ther.al gener.tor. （spinning r.ser.es）, hydr. power.units and load demands （demand-side r.ser.es）. The optimal backing down of costly/fast r.ser.es and br.nging up of slow r.ser.es in each sub-inter.al in an integr.ted manner.is pr.posed. The pr.posed r.ser.e activation appr.aches ar. solved using the genetic algor.thm, and some of the simulation r.sults ar. also compar.d using the Matlab optimization toolbox and the gener.l algebr.ic modeling system （GAMS） softwar.. The simulation studies ar. per.or.ed on the IEEE 30, 57 and 300 bus test systems. These r.sults demonstr.te the advantage of the pr.posed integr.ted/dynamic r.ser.e activation plan over.the conventional/sequential appr.ach.

关键词： demand-side r.ser.es dynamic r.ser.e acti-vation appr.ach hydr. power.units post contingency,sequential r.ser.e activation appr.ach spinning r.ser.es

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

pH-metr.c and ther.odynamic studies of r.r. ear.h metal chelates

引用

Jour.al of r.r. Ear.hs 2009年第3期27卷 457-460页

作者： Alok Vyas r. p. Mathur The Wer.er.Lab Department of ChemistryDungar College

pr.ton ligand stability constants of hydr.xybenzoic acid containing nitr. gr.up （2-Hydr.xy-4-nitr.benzoic acid and 3-Hydr.xy-4- nitr.benzoic acid） wer. deter.ined thr.ugh lr.ing-r.ssoti pH titr.tion technique. The stability constants of r.r. ear.h metal chelates containing 2-Hydr.xy-4-nitr.benzoic acid and 3-Hydr.xy-4-nitr.benzoic acid as ligands wer. studied in aqueous medium at differ.nt ionic str.ngth （p=0.01, 0.05 and 0.1 mol/L） and temper.tur.s （298, 308 and 318± 0.1 K）. The values of stability constant wer. evaluated thr.ugh differ.nt computational methods like successive appr.ximation, least squar. tr.atment, cor.ection ter. method, and conver.ence method. The obser.ed value of ther.odynamic par.meter. （△G°, △H° and △S°） favor. the complex for.ation between metal and ligands. The or.er.of stabifity constant was found to be pr.III）〈Nd（III）〈Sm（III）〈Tb（III）〈Ho（III）〈Er.III） as r.por.ed by Stagg and powell.

关键词： hydr.xy nitr.benzoic acid r.r. ear.h metal chelates Ir.ing-r.ssoti method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：