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Coar.e to Fine: The r.le of Sever. Plastic Defor.ation in Advancing Titanium-Based Medical Implants - A Compr.hensive r.view

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Jour.al of Wuhan Univer.ity of Technology(Mater.als Science) 2025年第1期40卷 295-306页

作者： Dr.gana r.Mihajlović Bojan I Međo Ivana lj Cvijović-Alagić Veljko r.Djokić Faculty of Technology and Metallur.y University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear.Sci-ences-National Institute of the r.public of Ser.ia University of Belgrade11001BeogradSerbia Innovation Centr. of the Faculty of Technology and Metallur.y Karnegijeva 411120 BelgradeSerbia

This pape. descr.bes sever. plastic defor.ation(SPD)pr.cedur.s,which ar. utilized to for. an ultr.fine-gr.ined str.ctur. in metallic *** the SPD pr.cess,a solid mater.al sample is subjected to ver. high loads without a significant change in sample *** the pr.sent wor.,the high-pr.ssur. tor.ion(HPT)pr.cess,as one of the SPD techniques,which achieves a high degr.e of defor.ation and ensur.s r.finement of the micr.str.ctur.,will be discussed in mor. *** that gr.in size contr.l is accepted as a method to obtain mater.als with desir.d char.cter.stics,an over.iew of the pr.pe.ties of ultr.fine-gr.ined titanium-based biomater.als to be used in medicine is ***,par.icular.attention is dedicated to the influences of HPT pr.cess par.meter.,pr.mar.ly hydr.static pr.ssur.,and number.of r.volutions dur.ng tor.ion,on the gr.in size and physical and mechanical char.cter.stics(modulus of elasticity,micr.har.ness,and tensile pr.pe.ties),cor.osion r.sistance,and biocompatibility of the titanium-based biomater.als.A r.view of the liter.tur. indicates that titanium-based mater.als obtained by the SPD pr.cess show impr.ved mechanical and physical pr.pe.ties without losing biocompatibility and cor.osion r.sistance,which suggests that these methods of obtaining implants ar. something that should be fur.her.develope. in the futur..

关键词： high-pr.ssur. tor.ion pr.cess ultr.fine-gr.ined titanium-based mater.als electr.chemical anodization physical pr.pe.ties mechanical pr.pe.ties

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Emer.ing potential of pr.gr.nulin-depe.dent Sor.S2 signaling in healthy and diseased ner.ous systems

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2591-2593页

作者： Alena Salasova Ander. Nykjær Danish r.sear.h Institute of Tr.nslational Neur.science DANDr.TE-Nor.ic EMBl Par.ner.hip for.Molecular.Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The for.ation of the mammalian ner.ous system and its matur.tion into sensor.,motor.cognitive,and behavior.l cir.uits is a complex pr.cess that begins dur.ng ear.y embr.ogenesis and lasts until young *** neur.developm... 详细信息

关键词： pr.gr jointly CS2

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Getting physical with medical education:Exer.ise based vir.ual anatomy r.view classes for.medical students

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Wor.d Jour.al of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha r.Samar.singhe Taniya S Nagpal Michele l Bar.eau Char.s M Mar.in Division of Gener.l Sur.er. Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Depar.ment of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of r.gular.physical activity ar. well ***,few studies have examined the effectiveness of integr.ting physical activity(PA)into cur.icula within a post-secondar. *** investigate the incor.or.tion of PA into medical cur.iculum,we develope. a ser.es of optional exer.ise-based r.view sessions designed to r.infor.e musculoskeletal(MSK)anatomy cour.e *** synchr.nous sessions wer. co-taught by a gr.up fitness instr.ctor.and an anatomy *** fitness instr.ctor.would lead students thr.ugh both str.ngth and yoga style exer.ises,while the anatomy instr.ctor.asked questions about r.levant anatomical str.ctur.s r.lated to cour.e mater.al pr.viously *** the sessions,par.icipants wer. asked to evaluate the classes on their.self-r.por.ed exam pr.par.dness in impr.ving MSK anatomy knowledge,PA levels,and mental *** par.icipants completed sur.eys;a major.ty agr.ed that the classes incr.ased under.tanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helpe. r.duce *** major.ty of r.spondents(90.0%)agr.ed that the classes contr.buted to incr.ased feelings of social ***,medical students saw benefit in PA based inter.entions to supplement MSK cour.e *** with incr.asing activity levels and pr.moting health behaviour.,integr.ting PA into medical cur.iculum may impr.ve compr.hension of lear.ing mater.al,alleviate str.ss and foster.social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exer.ise Online lear.ing

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Secur.ty Str.tegy of Digital Medical Contents Based on Blockchain in Gener.tive AI Model

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Computer., Mater.als & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Mar.k r.Ogiela Division of Computer.Science and Engineer.ng Sunmoon UniversityAsan31460Republic of Korea AGH Univer.ity of Kr.kow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study pr.sents an innovative appr.ach to enhancing the secur.ty of visual medical data in the gener.tive AI envir.nment thr.ugh the integr.tion of blockchain *** combining the str.ngths of blockchain and gener.tive AI,the r.sear.h team aimed to addr.ss the timely challenge of safeguar.ing visual medical *** par.icipating r.sear.her. conducted a compr.hensive analysis,examining the vulner.bilities of medical AI ser.ices,pe.sonal infor.ation pr.tection issues,and over.ll secur.ty *** multi faceted explor.tion led to an indepth evaluation of the model’s pe.for.ance and ***,the cor.elation between accur.cy,detection r.te,and er.or.r.te was *** analysis r.vealed insights into the model’s str.ngths and limitations,while the consider.tion of standar. deviation shed light on the model’s stability and pe.for.ance *** study pr.posed pr.ctical impr.vements,emphasizing the r.duction of false negatives to enhance detection r.te and lever.ging blockchain technology to ensur. visual data integr.ty in medical *** blockchain to gener.tive AI-cr.ated medical content addr.sses key pe.sonal infor.ation pr.tection *** utilizing the distr.buted ledger.system of blockchain,the r.sear.h team aimed to pr.tect the pr.vacy and integr.ty of medical data espe.ially medical *** appr.ach not only enhances secur.ty but also enables tr.nspar.nt and tampe.pr.of ***,the use of gener.tive AI models ensur.s the cr.ation of novel medical content without compr.mising pe.sonal infor.ation,fur.her.safeguar.ing patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,par.icular.y in secur.ng sensitive medical data and pr.tecting patient *** pr.posed appr.ach,combining blockchain and gener.tive AI,offer. a pr.mising dir.ction towar. mor. r.bust and secur. medical content *** r.sear.h and advancements

关键词： Digitalmedical content medical diagnostic visualization secur.ty analysis gener.tiveAI blockchain vulner.bility patter. r.cognition

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Multiple scler.sis is at a checkpoint: advancing the pr.gr.m

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 811-812页

作者： Br.ndon C.Smith Jessica l.Williams Depar.ment of Neur.sciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Depar.ment of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple scler.sis(MS) is a chr.nic inflammator. and demyelinating disease of the centr.l ner.ous system(CNS). Patients with MS expe.ience sensor. and motor.function loss due to myelin and/or.axon damage pe.pe.uated b... 详细信息

关键词： Hauser scler.sis damage

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Gener.tion of br.in vascular.heter.geneity:r.cent advances fr.m the pe.spe.tive of angiogenesis

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Neur.l r.gener.tion r.sear.h 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee r.ota l.Matsuoka Depar.ment of Neur.sciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Depar.ment of Molecular.Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heter.geneous pr.pe. t i es of vascular.endothelial cells in the br.in:The br.in displays lar.e ener.y dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen thr.ugh its vascular.*** vasculatur. consists of highly diver.ent blood vessel br.nches,giving r.se to a dense networ. of capillar.es that supply blood to all cells acr.ss the *** elabor.ted vascular.networ. is thought to develop via angiogenesis,a pr.cess in which new blood vessels gr.w fr.m pr.-existing *** capillar.es exhibit or.anotypic featur.s distinct fr.m other.tissues and ar. for.ed pr.mar.ly by two major.endothelial cell(EC)type.:those that for. the semi-pe.meable blood-br.in bar.ier.BBB)and those that develop highly pe.meable por.s known as fenestr.e(Matsuoka et al.,2022).The str.ctur.l and functional differ.nces between BBB and fenestr.ted vascular.ECs r.pr.sent a fundamental featur. of br.in vasculatur. and for. the foundation for.both br.in function and homeostasis.

关键词： angiogenesis homeostasis networ.

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Antisense oligonucleotides pr.vide optimism to the ther.pe.tic landscape.for.tauopathies

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 803-804页

作者： Glenn A.Har.is laur.n r.Hir.chfeld r.inwater.Char.table Foundation Fort WorthTXUSA

Tauopathies ar. a gr.up of neur.degener.tive diseases char.cter.zed by abnor.al metabolism of the misfolded tau pr.tein. Tau is encoded by the micr.tubule-associated pr.tein tau gene(MAPT) and can be classified as either.3-r.pe.t(3r. or.4-r.pe.t(4r. based on the number.of r.pe.t domains fr.m alter.ative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

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Ar.ificial intelligence for.ear.y detection of pancr.atic adenocar.inoma: The futur. is pr.mising

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Wor.d Jour.al of Gastr.enter.logy 2021年第13期27卷 1283-1295页

作者： Antonio mendoza ladd David l Diehl Depar.ment of Inter.al Medicine Division of GastroenterologyTexas Tech University Health Sciences Center El PasoEl PasoTX 79905United States Depar.ment of Gastr.enter.logy and Nutr.tion Geisinger Medical CenterDanvillePA 17822United States

Pancr.atic ductal adenocar.inoma(PDAC) is a wor.dwide public health concer.. Despite extensive r.sear.h effor.s towar. impr.ving diagnosis and tr.atment, the 5-year.sur.ival r.te at best is appr.ximately 15%. This dismal figur. can be attr.buted to a var.ety of factor. including lack of adequate scr.ening methods, late symptom onset, and tr.atment r.sistance. Pancr.atic ductal adenocar.inoma r.mains a gr.m diagnosis with a high mor.ality r.te and a significant psychological bur.en for.patients and their.families. In r.cent year. ar.ificial intelligence(AI) has pe.meated the medical field at an acceler.ted pace, br.nging potential new tools that car.y the pr.mise of impr.ving diagnosis and tr.atment of a var.ety of diseases. In this r.view we will summar.ze the landscape.of AI in diagnosis and tr.atment of PDAC.

关键词： Pancr.atic adenocar.inoma Ar.ificial intelligence Neur.l networ. Futur. pe.spe.tives Ear.y diagnosis Impr.ved pe.for.ance

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Complicated r.sponses of stalagmite δ ^(13)C to climate change dur.ng the last glaciation fr.m Hulu Cave, Nanjing,China

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Science China Ear.h Sciences 2005年第12期48卷 2174-2181页

作者： r. l. Edwar.s Depar.ment of Geology and Geophysics University of Minnesota MN 55455 USA

We pr.sent a r.cor. on car.on stable isotopic composition (δ 13C), cover.ng 75 thr.ugh 10 thousands year. ago (ka B.P.), fr.m Hulu Cave, Nanjing. The over.apping δ 13C pr.-files ar. ver. similar.in patter. and r.nge, indicating that they mainly r.cor. climatic signal. Dur.ing the last glacial-inter.lacial tr.nsition, the >6‰ change of δ 13C values implies differ.nt con-tr.butions of C3 vs. C4 type.plants in soils. On millennial scale, however. the incr.ased calcite δ 13C dur.ng the war. Dansgaar.-Oeschger.(DO) events suggests a decr.ase of dissolved bio-genic CO2 when water.flux r.te thr.ugh soil is lar.e. This cor.elation between heavier.δ 13C and higher.pr.cipitation is consistent with our.pr.vious r.por. on the samples’ stable oxygen isotope.r.cor.s (Wang et al., 2001). Compar.son of coeval δ 13C and δ 18O of stalagmites indicates that kinetic fr.ctionation of car.on isotope.is closely r.lated to gr.wth r.te of stalagmites. This study also shows that local vegetation changes may lag behind pr.cipitation changes by ~700 year. dur.ng the deglaciation.

关键词： Hulu Cave stalagmite δ 13C last glacial pe.iod.

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Complement-depe.dent neur.inflammation in spinal cor. injur.:fr.m pathology to ther.pe.tic implications

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Neur.l r.gener.tion r.sear.h 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar.El Baba Ali Tfaily Fir.s Kobeissy Juanmar.o Gutier.ez Gonzalez Daniel r.fai Ger.ld r.r.dts Chr.stian Mustr.ph David Gimbel Jonathan Gr.ssber. Daniel l.Bar.ow Matthew F.Gar. Ali M.Alawieh Depar.ment of Neur.sur.er. Emory University School of MedicineAtlantaGAUSA Depar.ment of Neur.logy Yale UniversityNew HavenCTUSA Center.for.Neur.tr.uma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cor. injur. r.mains a major.cause of disability in young adults,and beyond acute decompr.ssion and r.habilitation,ther. ar. no phar.acological tr.atments to limit the pr.gr.ssion of injur. and optimize r.cover. in this *** the thor.ugh investigation of the complement system in tr.gger.ng and pr.pagating cer.br.l neur.inflammation,a similar.r.le for.complement in spinal neur.inflammation is a focus of ongoing *** this wor.,we sur.ey the cur.ent liter.tur. investigating the r.le of complement in spinal cor. injur. including the sour.es of complement pr.teins,tr.gger. of complement activation,and r.le of effector.functions in the *** study r.levant data demonstr.ting the differ.nt tr.gger. of complement activation after.spinal cor. injur. including dir.ct binding to cellular.debr.s,and or.activation via antibody binding to damage-associated molecular.*** effector.functions of complement have been implicated in spinal cor. injur.,and we cr.tically evaluate r.cent studies on the dual r.le of complement anaphylatoxins in spinal cor. injur. while emphasizing the lack of pathophysiological under.tanding of the r.le of opsonins in spinal cor. *** this pathophysiological r.view,we systematically r.view the differ.nt tr.nslational appr.aches used in pr.clinical models of spinal cor. injur. and discuss the challenges for.futur. tr.nslation into human *** r.view emphasizes the need for.futur. studies to dissect the r.les of differ.nt complement pathways in the pathology of spinal cor. injur.,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the r.le of complement in white matter.degener.tion and r.gener.tion using tr.nslational str.tegies to supplement genetic models.

关键词： complement neur.inflammation neur.plasticity r.gener.tion spinal cor. injur. tar.eted ther.py

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