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The secondar. injur. cascade after.spinal cor. injur.:an analysis of local cytokine/chem.kine r.gulation

Neur.l r.gener.tion r.sear.h 2024年第6期19卷 1308-1317页

作者： Daniel J.Hellenbr.nd Char.es m.Quinn Zachar.ah J.Piper.r.an T.Elder.r.veena r.m.shr. Taylor.L.m.r.i Phoebe m.Om.r. r.lie m.r.ddick Jae Sung Lee w.lliam.L.m.r.hy Am.ad S.Hanna Depar.m.nt of Neur.sur.er. University of Wisconsin-Madison School of Medicine and Public HealthMadisonWIUSA Depar.m.nt of Biom.dical Engineer.ng University of Wisconsin-MadisonMadisonWIUSA Depar.m.nt of Or.hopedics and r.habilitation University of Wisconsin-MadisonMadisonWIUSA Depar.m.nt of m.ter.als Science and Engineer.ng University of Wisconsin-MadisonMadisonWIUSA For.ar. BIO Institute University of Wisconsin-MadisonMadisonWIUSA

After.spinal cor. injur.,ther. is an extensive infiltr.tion of im.une cells,w.ich exacer.ates the injur. and leads to fur.her.neur.l ***,a m.jor.aim.of cur.ent r.sear.h involves tar.eting the im.une r.sponse as a tr.atm.nt for.spinal cor. *** m.ch r.sear.h has been per.or.ed analyzing the com.lex inflam.ator. pr.cess follow.ng spinal cor. injur.,ther. r.m.in m.jor.discr.pancies w.thin pr.vious liter.tur. r.gar.ing the tim.line of local cytokine *** objectives of this study w.r. to establish an over.iew.of the tim.line of cytokine r.gulation for.2 w.eks after.spinal cor. injur.,identify sexual dim.r.hism. in ter.s of cytokine levels,and deter.ine local cytokines that significantly change based on the sever.ty of spinal cor. *** w.r. inflicted w.th either.a m.ld contusion,m.der.te contusion,sever. contusion,or.com.lete tr.nsection,7 m. of spinal cor. center.d on the injur. w.s har.ested at var.ing tim.s post-injur.,and tissue hom.genates w.r. analyzed w.th a Cytokine/Chem.kine 27-Plex *** dem.nstr.ted pr.-inflam.ator. cytokines including tum.r.necr.sis factor.,inter.eukin-1β,and inter.eukin-6 w.r. all upr.gulated after.spinal cor. injur.,but r.tur.ed to uninjur.d levels w.thin appr.xim.tely 24 hour. post-injur.,w.ile chem.kines including m.nocyte chem.attr.ctant pr.tein-1 r.m.ined upr.gulated for.days *** contr.st,sever.l anti-inflam.ator. cytokines and gr.w.h factor. including inter.eukin-10 and vascular.endothelial gr.w.h factor.w.r. dow.r.gulated by 7 days *** spinal cor. injur.,tissue inhibitor.of m.tallopr.teinase-1,w.ich specifically affects astr.cytes involved in glial scar.developm.nt,incr.ased m.r. than all other.cytokines tested,r.aching 26.9-fold higher.than uninjur.d *** a m.ld injur.,11 cytokines dem.nstr.ted sexual dim.r.hism.;how.ver.after.a sever. contusion only leptin levels w.r. differ.nt betw.en fem.le and m.le *** conclusion,pr.-inflam.ator. cytokines in

关键词： astr.cytes chem.kines cytokines inflam.ation m.cr.phages m.cr.glia secondar. dam.ge spinal cor. injur.

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m.O-attached gr.phene nanosheet(m.O@GNS)r.infor.ed m.gnesium.m.tr.x nanocom.osite w.th super.or.m.chanical,cor.osion and biological per.or.ance

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Inter.ational Jour.al of m.ner.ls,m.tallur.y and m.ter.als 2024年第9期31卷 2062-2076页

作者： S.Abazar. A.Sham.ipur.H.r.Bakhsheshi-r.d m.S.Soheilir.d F.Khor.shadizade S.S.m.r.osseini Depar.m.nt of m.ter.als and m.tallur.ical Engineer.ng Amirkabir University of TechnologyTehran ***Iran Ir.nian National Standar.s Or.anization of Hor.ozgan HormozganIran Advanced m.ter.als r.sear.h Center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran Depar.m.nt of m.ter.als and m.tallur.ical Engineer.ng Iran University of Science and TechnologyTehranIran

m.gnesium.m.)alloys ar. gaining gr.at consider.tion as body im.lant m.ter.als due to their.high biodegr.dability and ***,they suffer.fr.m.low.cor.osion r.sistance and antibacter.al *** this r.sear.h,sem.-pow.er.m.tallur.y follow.d by hot extr.sion w.s utilized to pr.duce the m.gnesium.oxide@gr.phene nanosheets/m.gnesium.m.O@GNS/m.)com.osite to im.r.ve m.chanical,cor.osion and cytocom.atibility *** have r.vealed that the incor.or.tion of m.O@GNS nanohybr.ds into m.-based com.osite enhanced m.cr.har.ness and com.r.ssive *** vitr.,osteoblast cell cultur. tests show.that using m.O@GNS nanohybr.d filler. enhances osteoblast adhesion and apatite *** pr.sence of m.O@GNS nanopar.icles in the com.osites decr.ased the opening defects,m.cr.-cr.cks and m.cr.-por.s of the com.osites thus pr.venting the penetr.tion of the cor.osive solution into the *** dem.nstr.ted that the m.O@GNS/m. com.osite possesses excellent antibacter.al pr.per.ies because of the com.ination of the r.lease of m.O and physical dam.ge to bacter.um.m.m.r.nes caused by the shar. edges of gr.phene nanosheets that can effectively dam.ge the cell w.ll ther.by facilitating penetr.tion into the bacter.al lipid ***,the m.O@GNS/m. com.osite w.th high m.chanical str.ngth,antibacter.al activity and cor.osion r.sistance is consider.d to be a pr.m.sing m.ter.al for.load-bear.ng im.lant applications.

关键词： m.tal m.tr.x com.osites m.O@GNS nanohybr.d str.ngthening m.chanism. antibacter.al activity biocom.atibility

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w.ve pr.pagation of a functionally gr.ded plate via integr.l var.ables w.th a hyper.olic ar.sine function

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Ear.hquake Engineer.ng and Engineer.ng Vibr.tion 2024年第3期23卷 547-561页

作者： m.khtar.Ellali m.khtar.Bouazza Ashr.f m.Zenkour Sm.r. str.ctur.s Labor.tor. University of Ain TemouchentAin Temouchent 46000Algeria Depar.m.nt of Civil Engineer.ng University Tahri Mohamed of BecharBechar 08000Algeria Depar.m.nt of m.them.tics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Labor.tor. of m.ter.als and Hydr.logy(Lm.) University of Sidi Bel AbbesSidi Bel Abbes 22000Algeria Depar.m.nt of m.them.tics Faculty of ScienceKafrelsheikh UniversityKafrelsheikh 33516Egypt

Sever.l studies on functionally gr.ded m.ter.als(FGm.)have been done by r.sear.her.,but few.studies have dealt w.th the im.act of the m.dification of the pr.per.ies of m.ter.als w.th r.gar. to the functional pr.pagation of the w.ves in *** w.r. aim. to explor. the effects of changing com.ositional char.cter.stics and the volum. fr.ction of the constituent of plate m.ter.als r.gar.ing the w.ve pr.pagation r.sponse of thick plates of *** m.del is based on a higher.or.er.theor. and a new.displacem.nt field w.th four.unknow.s that intr.duce indeter.inate integr.l var.ables w.th a hyper.olic ar.sine *** FGm.plate is assum.d to consist of a m.xtur. of m.tal and cer.m.c,and its pr.per.ies change depending on the pow.r.functions of the thickness of the plate,such as linear.quadr.tic,cubic,and inver.e *** utilizing Ham.lton’s pr.nciple,gener.l for.ulae of the w.ve pr.pagation w.r. obtained to establish w.ve m.des and phase velocity cur.es of the w.ve pr.pagation in a functionally gr.ded plate,including the effects of changing com.ositional char.cter.stics of m.ter.als.

关键词： FGm.plate effects of m.ter.al pr.per.ies w.ve pr.pagation indeter.inate integr.l var.ables inver.e sinus hyper.olic function

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Anisotr.pic extensions of isotr.pic Finch–Skea m.tr.c in the char.ed m.dified gr.vity

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Com.unications in Theor.tical Physics 2024年第9期76卷 118-140页

作者： Tayyab Naseer.m.Shar.f Depar.m.nt of m.them.tics and Statistics The University of Lahore1-Km Defence RoadLahore 54000Pakistan

In this study,w. explor. the Finch–Skea per.ect fluid solution and extend its dom.in to thr.e distinct anisotr.pic inter.or.m.dels w.thin the fr.m.w.r. of the f(r.T)theor.,incor.or.ting the influence of an electr.m.gnetic *** assum. a static spher.cal spacetim. initially coupled w.th an isotr.pic m.tter.*** then intr.duce a Lagr.ngian cor.esponding to an additional gr.vitating sour.e,taking into account its r.le in inducing pr.ssur. anisotr.py w.thin the or.ginal fluid *** der.ving the field equations for.the com.ined m.tter.setup,w. applied a r.dial com.onent tr.nsfor.ation,w.ich yielded tw. distinct system. of *** addition,w. consider.a char.ed exter.or.spacetim. to deter.ine the thr.e constants associated w.th the Finch–Skea solution at the *** findings suggest that under.cer.ain par.m.tr.c choices,all thr.e r.sulting m.dels exhibited physical r.levance w.thin this m.dified theor..

关键词： anisotr.py m.dified gr.vity gr.vitational decoupling

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Em.r.cing substr.te m.ltispecificity in plant ABC tr.nspor.er.

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m.lecular.Plant 2024年第7期17卷 990-992页

作者： m.r.us m.Geisler Depar.m.nt of Biology University of Fribourg1700 FribourgSwitzerland

By analogy,the fir.t plant ATP-binding cassette(ABC)tr.nspor.er. w.r. identified as vacuolar.detoxifier. tr.nspor.ing glutathione conjugates into the vacuole(m.r.inoia et al.,1993).This som.w.at negative im.ge as"unspecific detoxifier."still clings to plant ABC tr.nspor.er. today,although they have since been descr.bed to be involved in com.letely differ.nt pr.gr.m.,including developm.nt and defense(Par. et al.,2017).In this context,som. key plant ABC tr.nspor.er. have been show. to ow. exceptionally high substr.te *** exam.le,the tr.nspor.er.of the native auxin indole-3-acetic acid(IAA),Ar.bidopsis ABCB1,has been show. to also expor. the synthetic auxin 1-naphtaleneacetic acid but is even able to distinguish this substr.te fr.m.its str.ctur.l isom.r.2-naphtaleneacetic acid(Geisler.et al.,2005).Likew.se,ABCG36 and ABCG37,w.ich ar. know. to have a br.ader.substr.te por.folio(Par. et al.,2017;Ar.al et al.,2023),expor. IBA but do not touch IAA(Ar.al et al.,2023).r.cently,sever.l r.por.s have challenged our.cur.ent view.on the r.por.ed high substr.te specificity of plant ABCs,w.ich r.quir.s clar.fication.

关键词： specificity analogy exceptional

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Gedunin attenuates str.ptozotocin-induced diabetic hepatopathy in r.ts

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Asian Pacific Jour.al of Tr.pical Biom.dicine 2024年第7期14卷 288-297页

作者： Suchism.ta m.zum.ar.Thankam.ni m.m.r.r.Jyoti m.Patki School of Biotechnology and Bioinfor.atics D.Y.Patil Deemed to be UniversityNavi Mumbai 400614India

Objective:To exam.ne the hepatopr.tective effects of gedunin in str.ptozotocin(STZ)-induced diabetic ***:r.ts w.r. divided into 4 gr.ups:contr.l,STZ,gedunin,and STZ+*** par.m.ter. for.liver.function and liver.histology w.r. *** m.lecular.inter.ction of gedunin w.th the liver.glucose tr.nspor.er. GLUT2 and SGLT1 w.s exam.ned using AutoDock ***:Gedunin attenuated STZ-induced incr.ase in the levels of aspar.ate tr.nsam.nase,alanine tr.nsam.nase,alkaline phosphatase,lactate dehydr.genase and gam.a-glutam.l tr.nsfer.se in the ser.m.and liver.tissue,r.duced lipid per.xidation,and enhanced antioxidant *** studies show.d consider.ble r.stor.tion of liver.ar.hitectur. in gedunin-tr.ated diabetic *** silico studies r.vealed stable binding of gedunin w.th GLUT2 and ***:Gedunin exer.s hepatopr.tective effects in STZ-induced diabetic r.ts by r.ducing liver.enzym.tic activities and oxidative *** studies ar. w.r.anted to ver.fy the m.chanism.of its hepatopr.tective action.

关键词： Gedunin GLUT2 SGLT1 Diabetic hepatopathy Docking Histology Hom.logy m.delling

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w.ar.dependent vir.ual flow.r.te sensor.for.pr.gr.ssing cavity pum.s w.th defor.able stator

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Petr.leum.Science 2024年第2期21卷 1346-1353页

作者： Jens m.ller.Sebastian Leonow.Johannes Schulz Chr.stian Hansen m.r.in m.nnigm.nn r.hr.Univer.itat Bochum Universit atsstraûe 150Bochum44801Germany SEEPEX Gm.H Scharnh olzstraûe 344Bottrop46240Germany

This contr.bution pr.sents a novel w.ar.dependent vir.ual flow.r.te sensor.for.single stage single lobe pr.gr.ssing cavity pum.s. w. study the w.ar.induced m.ter.al loss of the pum. com.onents and the im.act of this m.ter.al loss on the volum.tr.c efficiency. The r.sults ar. com.ined w.th an established backflow.m.del to im.lem.nt a backflow.calculation pr.cedur. that is adaptive to w.ar. w. use a labor.tor. test setup w.th a highly abr.sive fluid and oper.te a pum. fr.m.new.to w.r. condition to validate our.appr.ach. The obtained m.asur.m.nt data show.that the pr.sented vir.ual sensor.is capable of calculating the flow.r.te of a pum. being subject to w.ar.dur.ng its r.gular.oper.tion.

关键词： Backflow Pr.gr.ssing cavity pum. Vir.ual sensor w.ar

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Tensile defor.ation of fine-gr.ined m. at 4K,78K and 298K

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Jour.al of m.gnesium.and Alloys 2024年第6期12卷 2534-2556页

作者： m.w.lag A.Kula P.Noga T.Tokar.ki G.Cios m.Niew.zas AGH Univer.ity of Kr.kow Faculty of Non-Ferrous MetalsKrakowPoland AGH Univer.ity of Kr.kow Academic Centre for Materials and NanotechnologyKrakowPoland m.ter.als Science and Engineer.ng McMaster UniversityHamiltonCanada

The im.act of gr.in size, r.nging fr.m.0.9 μm.to 9 μm. on the m.chanical pr.per.ies of com.er.ially pur. m. is investigated at tem.er.tur.s of 4K, 78K, and 298K. The m.chanism. gover.ing plastic flow.ar. influenced by both gr.in size and tem.er.tur.. At 4K and 78K, dom.nant defor.ation m.des in m. involve dislocation glide and extension tw.nning, r.gar.less of gr.in size. The inter.ctions betw.en basal and non-basal dislocations and dislocations w.th gr.in boundar.es pr.m.te an unusually high r.te of w.r. har.ening in the plastic r.gim., leading to pr.m.tur. failur.. The yield str.ss follow. the Hall-Petch r.lationship σy~ k/√d, w.th the slope k incr.asing w.th decr.asing tem.er.tur.. At 298K, in addition to dislocation glide and tw.nning, gr.in boundar. sliding(GBS) becom.s significant in sam.les w.th gr.in sizes below.3 μm. consider.bly enhancing the m.ter.al's defor.ability. GBS activation pr.vides an additional r.cover. m.chanism.for.dislocations accum.lating at gr.in boundar.es, facilitating their.absor.tion dur.ng sliding and r.tation. Analysis of σ Θ r.lationship suggests that the basal slip is the dom.nant dislocation m.de in m. at 298K. Decr.asing gr.in size suppr.sses dislocation activity and tw.nning and incr.ases GBS, r.sulting in low.r.Θ and σ Θ values. Suppr.ssing conventional defor.ation m.des coupled w.th enhanced GBS yields str.ss softening, br.aking dow. the Hall-Petch r.lationship in m. below.3 μm.gr.in size, leading to an inver.e Hall-Petch behaviour. The w.r. r.por.s new.data on the str.ngth, ductility, w.r. har.ening and fr.ctur. behaviour. and their.var.ations w.th m. gr.in size acr.ss differ.nt tem.er.tur. r.gim.s.

关键词： Polycr.stalline m. m.chanical pr.per.ies Defor.ation m.chanism. w.r.-har.ening Textur. evolution Cr.ogenic tem.er.tur.s Hall-Petch r.lationship

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Evidence-Based Com.lem.ntar. and Alter.ative m.dicine Effects of Capybar. Oil on Car.iac r.m.deling of C57bl/6 m.ce

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Jour.al of Biosciences and m.dicines 2024年第5期12卷 213-232页

作者： r.fael m. Alm.ida w.gner.D. Giannetti Guilher.e r. Silveir. Car.lina r. Castilho r.nata V. Lisboa Bianca T. Ciam.ar.lla r.dr.go N. Fer.eir. Jor.e José de Car.alho Labor.tor. of Ultr.str.ctur. and Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher.Education Center.of Valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Car.iovascular.diseases ar. the m.in cause of m.r.idity and m.r.ality in the w.r.d, and obesity and the m.tabolic syndr.m. ar. r.sk factor. for.its developm.nt. One of the ther.pies to r.duce car.iovascular.r.sk is the use of polyunsatur.ted fatty acids. In Br.zil, a sour.e of such acid is the oil extr.cted fr.m.the fat of the capybar.. The objective of this w.r. is to study the effects of the capybar. oil on lipid and glucose m.tabolism. as w.ll as its effects on the adipose tissue and car.iac r.m.deling. w. assessed the effects of capybar. oil tr.atm.nt on body m.ss, lipid and car.ohydr.te m.tabolism. systolic blood pr.ssur., adipose tissue and car.iac r.m.deling, and per.or.ed an ultr.str.ctur.l evaluation of the m.ocar.ium.in C57Bl/6 m.ce tr.ated w.th high-fat diet. Tr.atm.nt w.th capybar. oil r.duced total cholester.l and tr.glycer.de levels, systolic blood pr.ssur., viscer.l and subcutaneous adipose tissue, and adipocyte diam.ter. In addition, car.iac r.m.deling w.s attenuated, pr.ser.ing car.iom.ocytes, incr.asing vascular.zation, r.ducing car.iom.ocyte hyper.r.phy and the extr.cellular.m.tr.x, and pr.ser.ing the m.r.hological integr.ty of m.tochondr.a. Capybar. oil has sever.l beneficial effects on the car.iovascular.and m.tabolic system. and fur.her.studies ar. needed to better.under.tand its r.le in the pr.vention or.tr.atm.nt of car.iovascular.diseases.

关键词： Capybar. Oil Car.iac r.m.deling Polyunsatur.ted Fatty Acids Obesity m.tabolic Syndr.m.

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Per.uasive Technology for.the Futur. of Sm.king Cessation^*

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Advances in Inter.et of Things 2024年第2期14卷 36-52页

作者： Fatim.h Der. m. Alshahr.ni College of Com.uter.Science King Khalid University (KKU) Abha KSA

This paper.explor.s the integr.tion of per.uasive technology into sm.king cessation effor.s thr.ugh the developm.nt and evaluation of a m.bile app, “No-Sm.ke.” Lever.ging com.elling featur.s like social suppor., tr.cking, planning, and m.tivation, the app aim. to augm.nt user.engagem.nt and suppor. the pr.cess of quitting sm.king. The efficacy of these featur.s has been substantiated thr.ugh both autom.ted testing and user.feedback, highlighting their.potential to enhance aw.r.ness, m.tivation, and behavior.m.dification. Despite notable successes, lim.tations, including a lim.ted user.base and uncer.ainties r.gar.ing long-ter. efficacy, have been acknow.edged, stem.ing fr.m.the inher.nt com.lexities of sm.king cessation. Never.heless, based on user.exper.ences and feedback, “No-Sm.ke” r.pr.sents a pr.m.sing advancem.nt in the use of technology for.public health inter.entions, par.icular.y in the r.alm.of sm.king cessation. To addr.ss existing challenges, futur. r.sear.h is r.com.ended to encom.ass a com.r.hensive, long-ter. study involving a lar.er.and m.r. diver.e user.base. Additionally, fur.her.investigation should focus on per.onalization enhancem.nts and the integr.tion of m.chine lear.ing algor.thm. to better.under.tand and r.spond to user.behavior.

关键词： Per.uasive Technology Sm.king Cessation m.bile App

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