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Phar.acologically tested aldose r.ductase inhibitor. isolated fr.m plant sour.es—A concise r.por.

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中国天然药物 2012年第5期10卷 388-400页

作者： D. K. Patel r. kumar K. Sair.m S. Hemalatha Phar.acognosy r.sear.h Labor.tor. Department of Pharmaceutics Institute of Technology Banaras Hindu University

Aldose r.ductase (Ar., a cytosolic, monomer.c oxidor.ductase, is a key enzyme in the polyol pathway which contr.ls the conver.ion of glucose to sor.itol. The accumulation of sor.itol by the activation of Ar.enzymes in lens, r.tina, and sciatic ner.es leads to the cause of diabetic defects r.sulting in var.ous secondar. complications, viz. r.tinopathy, neur.pathy, nephr.pathy and Alzheimer.s disease. Thus, r.duction of the polyol pathway flux by Ar.inhibitor. could be a potential ther.peutic opening in the tr.atment and pr.vention of diabetic complications. At pr.sent, the Ar.inhibitor. belong to two differ.nt chemical classes. One is the hydantoin der.vatives, such as Sor.inil, Dilantin, and Minalr.stat, and the other.is the car.oxylic acid der.vatives, such as Epalr.stat, Alr.statin, and Tolr.stat. However. it is known that most of these synthethic compounds have unacceptable side-effects. Well known medicinal plants like Chr.santhemum indicum, Chr.santhemum mor.folium, Pr.nus mume, Myr.ia multiflor., Centella asiatica, and Salacia r.ticulata, Salacia oblonga, and Salacia chinensis exhibited potent Ar.inhibitor. activity. The pr.sent r.view summar.zes the list of plant mater.al, and their.isolated phytoconstituents which have been tested for.their.Ar.inhibitor. activity. This litr.atur. r.view cover. the per.od to 2011, and a total of 72 plants ar. listed.

关键词： Aldose r.ductase Catar.cts Enzyme Human r.combinant Ar Medicinal plants Phytoconstituents Polyol pathway r.t lens Ar r.t lens

Advancements in thr.e-dimensional titanium alloy mesh scaffolds fabr.cated by electr.n beam melting for.biomedical devices: mechanical and biological aspects

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Science China Mater.als 2018年第4期61卷 455-474页

作者： Kr.shna Chaitanya Nune Shujun Li r. Devesh kumar Misr. Biomater.als Science and Engineer.ng Labor.tor. Metallur.ical Materials and Biomedical Engineering Department University of Texas at El Paso TX 79968 USA Institute of Metals r.sear.h Chinese Academy of Sciences Shenyang 11016 China

We elucidate her. the pr.cess-str.ctur.-pr.per.y r.lationships in thr.e-dimensional（3 D） implantable titanium alloy biomater.als pr.cessed by electr.n beam melting（EBM） that is based on the pr.nciple of additive manufactur.ng. The conventional methods for.pr.cessing of biomedical devices including fr.eze casting and sinter.ng ar. limited because of the difficulties in adaptation at the host site and differ.nce in the micr./macr.str.ctur., mechanical, and physical pr.per.ies with the host tissue. In this r.gar., EBM has a unique advantage of pr.cessing patient-specific complex designs, which can be either.obtained fr.m the computed tomogr.phy（CT） scan of the defect site or.thr.ugh a computer.ided design（CAD） pr.gr.m. This r.view intr.duces and summar.zes the evolution and under.ying r.asons that have motivated 3 D pr.nting of scaffolds for.tissue *** over.iew compr.ses of two par.s for.obtaining ultimate functionalities. The fir.t par. focuses on obtaining the ultimate functionalities in ter.s of mechanical pr.per.ies of 3 D titanium alloy scaffolds fabr.cated by EBM with differ.nt char.cter.stics based on design, unit cell, pr.cessing par.meter., scan speed, por.sity, and heat tr.atment. The second par. focuses on the advancement of enhancing biological r.sponses of these 3 D scaffolds and the influence of sur.ace modification on cell-mater.al inter.ctions. The over.iew concludes with a discussion on the clinical tr.als of these 3 D por.us scaffolds illustr.ting their.potential in meeting the cur.ent needs of the biomedical industr..

关键词： Electr.n beam melting 3D pr.nting tissue engineer.ng mechanical pr.per.ies biocompatibility

Identification of ear.hquake induced str.ctur.l damage based on synchr.extr.cting tr.nsfor.

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Ear.hquake Engineer.ng and Engineer.ng Vibr.tion 2024年第2期23卷 475-487页

作者： r.shan kumar Gaur.v kumar Wei Zhao Ar.ind r.Yadav Gang Yu Jayendr. kumar Evans Amponsah Depar.ment of Electr.nic and Infor.ation Technology Miami College of Henan UniversityHenan 475004China Alliance Univer.ity Alliance College of Engineering and DesignBanglore 562106India Depar.ment of Electr.nics and Comm Parul UniversityVadodra 391760India School of Electr.cal Engineer.ng University of JinanJinan 250022China Depar.ment of Electr.nics and Comm NIT JamshedpurJamshedpur 831014India Depar.ment of Civil engineer.ng Kwame Nkrumah University of Science and TechnologyKumasi 10959Ghana

Sever.l popular.time-fr.quency techniques,including the Wigner.Ville distr.bution,smoothed pseudo-Wigner.Ville distr.bution,wavelet tr.nsfor.,synchr.squeezing tr.nsfor.,Hilber.-Huang tr.nsfor.,and Gabor.Wigner.tr.nsfor.,ar. investigated to deter.ine how well they can identify damage to *** this wor.,a synchr.extr.cting tr.nsfor.(SET)based on the shor.-time Four.er.tr.nsfor. is pr.posed for.estimating post-ear.hquake str.ctur.l *** per.or.ance of SET for.ar.ificially gener.ted signals and actual ear.hquake signals is examined with existing *** other.tested techniques,SET impr.ves fr.quency r.solution to a gr.at extent by lower.ng the influence of smear.ng along the time-fr.quency ***,inter.r.tation and r.adability with the pr.posed method ar. impr.ved,and small changes in the time-var.ing fr.quency char.cter.stics of the damaged buildings ar. easily detected thr.ugh the SET method.

关键词： cr.ss-ter. damage detection ear.hquake signal synchr.extr.cting tr.nsfor. time-fr.quency

Optical pr.per.ies of excitons in str.ined Ga_x In_1-x As/GaAs quantum dot: effect of geometr.cal confinement on exciton g-factor

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Chinese Optics Letter. 2013年第8期11卷 80-86页

作者： N. r. Senthil kumar A. John Peter.Chang Woo Lee Depar.ment of Physics RVS School of Engineering College Depar.ment of Physics Govt.Arts College Depar.ment of Chemical Engineer.ng and Gr.en Ener.y Center College of EngineeringKyung Hee University

Taking into account anisotr.py, nonpar.bolicity of the conduction band, and geometr.cal confinement, we discuss the heavy-hole excitonic states in a str.ined GaxIn1-xAs/GaAs quantum dot for.var.ous Ga alloy contents. The str.ined quantum dot is consider.d as a spher.cal InAs dot sur.ounded by a GaAs bar.ier.mater.al. The dependence of the effective excitonic g-factor.as a function of dot r.dius and Ga ion content is numer.cally measur.d. Inter.and optical ener.y with and without the par.bolic effect is computed using str.ctur.l confinement. The inter.and matr.x element for.differ.nt Ga concentr.tions is also calculated. The oscillator.str.ngth of inter.and tr.nsitions on the dot r.dius is studied at differ.nt Ga concentr.tions in the GaxIn1-xAs/GaAs quantum dot. Heavy-hole excitonic absor.tion spectr. ar. r.cor.ed for.var.ous Ga alloy contents in the GaxIn1-xAs/GaAs quantum dot. r.sults show that oscillator.str.ngth diminishes when dot size decr.ases because of the dominance of the quantum size effect. Fur.her.or., exchange enhancement and exchange sDlitting incr.ase as exciton confinement iner.ases.

关键词： GaAs effect of geometr.cal confinement on exciton g-factor Optical pr.per.ies of excitons in str.ined Gax In1-x As/GaAs quantum dot