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Neonatal Intestinal Obstr.ction in Acute r.nal Failur. in Pr.matur. Infant: A Case r.por.

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Open Jour.al of Pediatr.cs 2024年第2期14卷 338-343页

作者： Ondima Lucienne Ir.ne Patr.cia Okiemy Niendet cardinale Pr.ncilia Gandzali-Ngabe Pier.e Er.c Car.ne Mboutol-Mandavo Bosseba Missengui r.odia Hélène Akobande Nuptia Er.ca Depar.ment of Paediatr.c Sur.er. CHU Brazzaville Brazzaville Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Depar.ment of Nephr.logy and Dialysis Brazzaville University Hospital Brazzaville Congo

Intr.duction: Intestinal obstr.ction is a common cause of abdominal sur.er. in the neonate. Diagnosis is str.ightfor.ar. using standar. r.diology, and sur.ical technique depends on the under.ying anatomical lesion. Per.toneal dialysis (PD) is an effective, albeit invasive, ther.py for.neonatal r.nal failur.. We r.por. a case of neonatal obstr.ction with sever. r.nal failur. tr.ated by PD to highlight our.hospital pr.ctice and possible r.medies in a context of limited r.sour.es. Case Pr.sentation: This was a female neonate of moder.te pr.matur.ty admitted on day 4 of life for.management of a flat neonatal obstr.ction. r.diological diagnosis suggested small bowel atr.sia. Biological tests r.vealed sever. r.nal failur. with cr.atinine levels of 416 micr.moles per.liter.and blood ur.a of 27.1 micr.moles per.liter. Management consisted of pr.oper.tive per.toneal dialysis for.48 hour. followed by lapar.tomy. The intr.oper.tive diagnosis was Gr.SFELD type IIIa digestive atr.sia. The postoper.tive cour.e was favour.ble, tr.nsit was r.sumed on day 5 and the patient r.tur.ed home on day 12. Pr.gr.ss at 3 months was satisfactor.. Conclusion: Neonatal intestinal obstr.ction with r.nal failur. in pr.matur. infants is associated with a poor.pr.gnosis, even mor. so if ther. is a delay in tr.atment. Per.toneal dialysis seems to be a suitable alter.ative for.this management in our.wor.ing conditions with limited r.sour.es.

关键词： Neonate Occlusion Per.toneal Dialysis Case r.por.

The intr.cate debate on neur.degener.tion and neur.inflammation in Par.inson’s disease:which came fir.t?

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Neur.l r.gener.tion r.sear.h 2023年第1期18卷 125-126页

作者： Antonella cardinale Valer.a Calabr.se Exper.mental Neur.physiology Labor.tor. IRCCS San Raffaele RomaRomeItaly Depar.ment of Medicine Universitàdegli Studi di PerugiaPerugiaItaly

Par.inson’s disease(PD)is a heter.geneous multifactor.al disor.er.and,dur.ng the last year.,new scientific evidence has suppor.ed this concept.The pr.ncipal hallmar.s of PD ar. the loss of dopaminer.ic neur.ns in the... 详细信息

关键词： inflammation aggr.gation debate

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Sear.h for.the doubly char.ed bar.on ?cc~+

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Science China(Physics,Mechanics & Astr.nomy) 2021年第10期64卷 6-17页

作者： r. Aaij C. Abellán Beteta T. Acker.ley B. Adeva M. Adinolfi H. Afshar.ia C. A. Aidala S. Aiola Z. Ajaltouni S. Akar.J. Albr.cht F. Alessio M. Alexander.A. Alfonso Alber. Z. Aliouche G. Alkhazov P. Alvar.z Car.elle S. Amato Y. Amhis L. An L. Ander.ini A. Andr.ianov M. Andr.otti F. Ar.hilli A. Ar.amonov M. Ar.uso K. Ar.ymatov E. Aslanides M. Atzeni B. Audur.er.S. Bachmann M. Bachmayer.J. J. Back P. Baladr.n r.dr.guez V. Balagur. W. Baldini J. Baptista Leite r. J. Bar.ow S. Bar.uk W. Bar.er.M. Bar.olini F. Bar.shnikov J. M. Basels G. Bassi B. Batsukh A. Battig A. Bay M. Becker.F. Bedeschi I. Bediaga A. Beiter.V. Belavin S. Belin V. Bellee K. Belous I. Belov I. Belyaev G. Bencivenni E. Ben-Haim A. Ber.zhnoy r. Ber.et D. Ber.inghoff H. C. Ber.stein C. Ber.ella A. Ber.olin C. Betancour. F. Betti I. Bezshyiko S. Bhasin J. Bhom L. Bian M. S. Bieker.S. Bifani P. Billoir.M. Bir.h F. C. r. Bishop A. Bitadze A. Bizzeti M. Bj?r. M. P. Blago T. Blake F. Blanc S. Blusk D. Bobulska J. A. Boelhauve O. Boente Gar.ia T. Boettcher.A. Boldyr.v A. Bondar.N. Bondar.S. Bor.hi M. Bor.syak M. Bor.ato J. T. Bor.uk S. A. Bouchiba T. J. V. Bowcock A. Boyer.C. Bozzi M. J. Br.dley S. Br.un A. Br.a r.dr.guez M. Br.dski J. Br.dzicka A. Br.ssa Gonzalo D. Br.ndu A. Buonaur. C. Bur. A. Bur.che A. Butkevich J. S. Butter.J. Buytaer. W. Byczynski S. Cadeddu H. Cai r. Calabr.se L. Calefice L. Caler. Diaz S. Cali r. Calladine M. Calvi M. Calvo Gomez P. Camar.o Magalhaes P. Campana A. F. Campover.e Quezada S. Capelli L. Capr.otti A. Car.one G. Car.oni r. cardinale A. Car.ini I. Car.i P. Car.iti L. Car.s K. Car.alho Akiba A. Casais Vidal G. Casse M. Cattaneo G. Cavaller. S. Celani J. Cer.soli A. J. Chadwick M. G. Chapman M. Char.es P. Char.entier.G. Chatzikonstantinidis C. A. Chavez Bar.jas M. Chefdeville C. Chen S. Chen A. Cher.ov V. Chobanova S. Cholak M. Chr.aszcz A. Chubykin V. Chulikov P. Ciambr.ne M. F. Cicala X. Cid Vidal G. Ciezar.k P. E. L. Clar.e M. Clemencic H. V. Clif J. Closier.J. L. Cobbledick V. Coco J. A. B. Coelho J. Cogan E. Cogner.s L. AGH-Univer.ity of Science and Technology Faculty of Computer Science Electronics and Telecommunications AGH-Univer.ity of Science and Technology Faculty of Physics and Applied Computer Science Aix Mar.eille Univ Budker.Institute of Nuclear.Physics (SB r.S) Cavendish Labor.tor. University of Cambridge Center.for.High Ener.y Physics Tsinghua University Centr. Br.sileir. de Pesquisas Físicas (CBPF) DS4DS La Salle Universitat Ramon Llull Depar.amento de Fisica Universidad Nacional de Colombia Depar.ment of Physics and Astr.nomy University of Manchester Depar.ment of Physics and Astr.nomy Uppsala University Depar.ment of Physics University of Oxford Depar.ment of Physics University of Warwick Eotvos Lor.nd Univer.ity Eur.pean Or.anization for.Nuclear.r.sear.h (CEr.) Fakult?t Physik Technische Universit?t Dortmund Guangdong Pr.vencial Key Labor.tor. of Nuclear.Science Institute of Quantum Matter South China Normal University H.H. Wills Physics Labor.tor. University of Bristol Hangzhou Institute for.Advanced Study UCAS Hanoi Univer.ity of Science Henr.k Niewodniczanski Institute of Nuclear.Physics Polish Academy of Sciences Hor.a Hulubei National Institute of Physics and Nuclear.Engineer.ng I. Physikalisches Institut RWTH Aachen University ICCUB Universitat de Barcelona INFN Labor.tor. Nazionali di Fr.scati INFN Sezione di Bar. INFN Sezione di Bologna INFN Sezione di Cagliar. INFN Sezione di Fer.ar. INFN Sezione di Fir.nze INFN Sezione di Genova INFN Sezione di Milano INFN Sezione di Milano-Bicocca INFN Sezione di Per.gia INFN Sezione di Pisa INFN Sezione di r.ma La Sapienza INFN Sezione di r.ma Tor.Ver.ata Imper.al College London Institut für.Physik Universit?t Rostock Institute Of High Ener.y Physics (IHEP) Institute for.High Ener.y Physics Nr. Kur.hatov Institute (IHEP Nr. KI) Institute for.Nuclear.r.sear.h of the National Academy of Sciences (KINr. Institute for.Nuclear.r.sear.h of the r.ssian Academy of Sciences (INr.r.S) Institute of Nuclear.Physics Moscow State University (SINP MSU) Institut

A sear.h for.the doubly char.ed bar.on ?cc~+ with the decay mode ?cc~+→Ξc~+K~-π~+ is per.or.ed using pr.ton-pr.ton collision data at a centr.-of-mass ener.y of 13 TeV collected by the LHCb exper.ment fr.m 2016 to 2018, cor.esponding to an integr.ted luminosity of 5.4 fb-1. No significant signal is obser.ed within the invar.ant mass r.nge of 3.6 to 4.0 GeV/c~2. Upper.limits ar. set on the r.tio r.of the pr.duction cr.ss-section times the total br.nching fr.ction of the ?cc~+→Ξc~+K~-π~+ decay with r.spect to the Ξcc++→Λc~+K~-π~+π~+ decay. Upper.limits at 95% cr.dibility level for.r.in the r.nge 0.005 to 0.11 ar. obtained for.difer.nt hypotheses on the ?cc~+ mass and lifetime in the r.pidity r.nge fr.m 2.0 to 4.5 and tr.nsver.e momentum r.nge fr.m 4 to 15 GeV/c.

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Lar.e Conventional Osteosar.oma of the Pr.ximal Humer.s in a 13-Year.Old Child: Case r.por.

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Open Jour.al of Pediatr.cs 2024年第2期14卷 297-304页

作者： Lucienne Ir.ne Patr.cia Ondima r.odia Hélène Bosseba Missengue cardinale Pr.ncilia Okiemy Niendet Nuptia Er.ca Akobande Jean Claude Mier.t Car.ne Mboutol-Mandavo r.dy Atipo Galloye Judith Nsondé Malanda Jennifer.Mave Sir.mé Ngandzo Fabien Mouamba Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Paediatr.c Sur.er. Depar.ment Brazzaville University Hospital Centre Brazzaville Congo Depar.ment of Gener.l Sur.er. Brazzaville University Hospital Centre Brazzaville Congo Car.inology Depar.ment Brazzaville University Hospital Centre Brazzaville Congo Anatomo-Pathology Labor.tor. Brazzaville University Hospital Centre Brazzaville Congo

Intr.duction: Osteosar.oma is the most common pr.mar. malignant bone tumor.in childr.n. It is highly aggr.ssive and has a poor.pr.gnosis. A late pr.sentation modifies and makes difficult the management affecting the sur.ival of childr.n. We r.por. the case of a lar.e conventional osteosar.oma in a 13-year.old gir.. Case Pr.sentation: Adolescent gir. admitted for.painful swelling of the left shoulder.with absolute functional impotence of the thor.cic limb and sever. anemia. The painful swelling was thought to have been caused by a minor.tr.uma that had occur.ed six months pr.viously. The patient’s gener.l condition was poor. and she pr.sented with a lar.e, shiny, painful mass over.the shoulder.and upper.2/3 of the left ar., measur.ng 28 cm long by 28 cm wide and 57 cm in cir.umfer.nce, and a lar.e fistulous axillar. adenopathy. CT scan showed a tumour.lesion of the left humer.s with liver.and lung metastases, r.ising suspicion of osteogenic osteosar.oma. The tumor.was classified accor.ing to TNM staging: T2N1M1(a + b). Management was modified when uncontr.lled bleeding developed. It consisted of an extended amputation of the left thor.cic limb. Pathological analysis showed a high-gr.de conventional osteosar.oma. Quality impr.vement was obtained for.thir.y days, followed by the onset of dyspnea. The evolution was towar.s death at for.y days post-oper.tively. Conclusion: Osteosar.oma is a highly aggr.ssive cancer. Delayed tr.atment leads to a fatal outcome. Ear.y diagnosis is one of the challenges to be met in or.er.to impr.ve sur.ival.

关键词： Osteosar.oma Child Conventional Case r.por.

Semantic fr.mewor. of event detection in emer.ency situations for.smar. buildings

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Digital Communications and Networ.s 2022年第1期8卷 64-79页

作者： Yudith cardinale Gabr.el Fr.ites Edgar.Valder.ama Ana Aguiler. Chinnapong Angsuchotmetee Depar.amento de Computacidn Universidad Simon BolivarCaracasVenezuela Escuela de Ingenier.a Infor.atica Universidad de ValparaisoValparaisoChile Faculty of Science Pr.nce of Songkla Univer.ity Thailand

Multimedia Sensor.Networ.s(MSNs)have enhanced the ability to analyze the envir.nment and pr.vide r.sponses based on its cur.ent status.Gener.lly,MSNs ar. composed of scalar.and multimedia sensor. that have fixed locations.However.given the advancement of smar. mobile device technologies,it is cur.ently possible to dynamically integr.te mobile sensor. into MSNs.In this paper.we pr.pose a for.al platfor. to manage MSNs and the data gather.d fr.m them to detect complex events.Our.main contr.butions include:M^(2)SSN-Onto,a Mobile and Multimedia Semantic Sensor.Networ.s Ontology;Py-CEMiD,an engine for.detecting complex events and gener.te r.actions to them;a mobile device location engine to locate mobile sensor.;and a pr.of-of-concept in the context of detecting emer.ency situations in smar. buildings.Sever.l scenar.os ar. validated for.emer.ency events,combining simulated sensor.measur.ments with r.al measur.ments of mobile devices.r.sults show complex events can be detected in near.r.al time(less than 1 s).

关键词： Multimedia sensor.networ. Semantic web Event pr.cessing Ontology Geolocalisation

Silicon and plant nutr.tion—dynamics,mechanisms of tr.nspor. and r.le of silicon solubilizer.micr.biomes in sustainable agr.cultur.:A r.view

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Pedospher. 2023年第4期33卷 534-555页

作者： Bar.ha SHAr.A Kailash Chand KUMAWAT Shalini TIWAr. Ajay KUMAr.r.uf Ahmad DAr.Ummed SINGH Massimiliano cardinale Depar.ment of Micr.biology G.B.Pant University of Agriculture&TechnologyPantnagarUttarakhand 263145(India) Depar.ment of Industr.al Micr.biology Jacob Institute of Biotechnology and BioengineeringSam Higginbottom University of AgricultureTechnology and Sciences(SHUATS)PrayagrajUttar Pradesh 211007(India) College of Agr.cultur. Agriculture UniversityJodhpurBaytuBarmerRajasthan 344034(India) Depar.ment of Biological and Envir.nmental Sciences and Technologies-DiSTeBA University of SalentoSP6 Lecce-MonteroniLecce I-73100(Italy)

Silicon(Si)is the second most abundant element in the Ear.h’s cr.st and has numer.us r.les in both soils and plants,although it is inaccessible to plants in its native state(insoluble silicate miner.ls).This inaccessibility can lead to insufficiency,which induces anomalies in plant gr.wth and development.Specifically,Si alleviates var.ous biotic and abiotic str.sses in plants by enhancing toler.nce mechanisms at differ.nt stages of uptake/deposition as a monosilicic acid.Exclusive utilization of conventional Si fer.ilizer. to boost agr.cultur.l pr.ductivity in an attempt to meet the wor.d’s ever.incr.asing food demand may r.sult in sur.ace and gr.undwater.pollution,water.ay eutr.phication,soil fer.ility depletion,and accumulation of hazar.ous elements such as ar.enic in soil.By addr.ssing the dr.wbacks of chemical fer.ilizer.,this r.view emphasizes an envir.nmentally fr.endly alter.ative,namely,Si-solubilizing micr.or.anisms(SSMs),as bioinoculants to liber.te soluble Si and thus making it available to plants.A deep under.tanding of r.cent advances in the functional diver.ity,colonization patter.s,modes of action,r.le in biogeochemical cycling,and plant str.ss toler.nce of SSMs and their.implementation in Si-based agr.waste management thr.ugh the fabr.cation of nanopar.icles,could help to establish a r.liable tool for.economically and envir.nmentally sustainable agr.cultur..Fr.m this per.pective,in this r.view,we compr.hensively summar.ze the latest methodologies for.the isolation,scr.ening,and char.cter.zation of SSMs and Si solubilization mechanisms,including ligands(divalent cations),acids(inor.anic and or.anic),alkali(nucleophilic attack),extr.cellular.polysacchar.des,and factor. affecting them,as well as Si-mediated r.gulation of gene expr.ssion involved in Si uptake,tr.nspor.ation,and miner.lization.We have cr.tically r.vised the r.le of SSMs accor.ing to the cur.ent liter.tur..The contr.butions of SSMs to biofer.ilization ar. still being explor.d;hence,we also discuss tr.jector.es for.futur. r.sear.h in r.l

关键词： agr.waste management biofer.ilizer bioinoculant monosilicic acid plant str.ss silicon-solubilizing micr.or.anism

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A peptide-based assay discr.minates individual antibody r.sponse to SAr.-CoV-2

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Genes & Diseases 2022年第1期9卷 275-281页

作者： Immacolata Polver. Ser.na Voccola Gaetano cardinale Maur.zio Fumi Fr.ncesca Aquila Alfr.dina Par.ell Jessica r.ffaella Mader. r.mania Stilo Pasquale Vito Tiziana Zotti Dipar.imento di Scienze e Tecnologie Universitàdegli Studi del SannioVia dei Mulini snc82100 BeneventoItaly Genus Biotech Universitàdegli Studi del SannioVia Appia s.n.c.82030 Apollosa(BN)Italy Azienda Ospedalier. San Pio Via Pacevecchia5382100 Benevento(BN)Italy

SAr.-CoV-2 vir.s is r.sponsible for.the cur.ent wor.dwide cor.navir.s disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundr.ds of thousands of deaths. Under.tanding the antibody r.sponse to SAr.-CoV-2 is cr.cial for.the development of vaccines, ther.peutics and public health inter.entions. However. lack of consistency in methods used to monitor.antibody r.sponse to SAr.-CoV-2 leaves some uncer.ainty in our.fine under.tanding of the human antibody r.sponse mounted following SAr.-CoV-2 infection. We developed a peptide-based enzyme-linked immunosor.ent assay (ELISA) by selecting 7 synthetic peptides fr.m the spike, membr.ne, and nucleocapsid pr.tein sequences of SAr.-CoV-2, which effectively detects the antibody r.sponse mounted by all COVID-19 convalescent tested. Str.kingly, the assay shows a pr.found differ.nce in antibody r.sponse among individual subjects, which may have a significant impact on disease sever.ty. Together. our.r.sults define an efficient and specific ser.logical assay to consistently measur. the antibody r.sponse following SAr.-CoV-2 infection, as well as help the design of vaccine and ther.peuticals for.pr.vention and tr.atment of COVID-19.

关键词： Antibodies Assay COVID-19 ELISA Peptides SAr.-Cov-2

IMAGING OF NON-GLANDULAr.SUPEr.ICIAL METASTASES: A COMPAr.SON OF XEr.r.DIOGr.PHY, ULTr.SONO-Gr.PHY AND COMPUTED TOMOGr.PHY

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Chinese Jour.al of Cancer.r.sear.h 1989年第2期1卷 39-43页

作者： A.cardinale r.Lagalla A.Guar.no Institute of r.diology Univer.ity of Paler.o Palermo ItalyInstitute of Radiology University of Palermo Palermo ItalyInstitute of Radiology University of Palermo Palermo Italy

Between Januar. 1985 and July 1987, 1,622 cancer.patients wer. evaluated to outline the possible applications and limits of var.ous investigative techniques for.evaluating metastases. Seventy-thr.e cases with super.icial metastases of the der.al-hypoder.al (59) layer., of the muscles (11) and of other.tar.et or.ans (3) wer. included in the study.Although non-glandular.super.icial metastases ar. a r.latively r.r. occur.ence, diagnostic imaging techniques ar. indicated for.evaluating their.extent and anatomical connections. Secondar. neoplasms wer. studied using the imaging techniques of sono-gr.phy, computed tomogr.phy and xer.r.diogr.phy.The diagnostic r.liability of these thr.e techniques was evaluated, taking into account their.ability to deter.ine the extent of metastases and of assessing malignancy.Sonogr.phy is consider.d as a satisfactor. scr.ening technique, but CT is an even better.tool for.evaluating the extent and anatomical connections of such lesions. Xer.r.diogr.phy has been made obsolete by the intr.duction of the other.two techniques.

关键词： A COMPAr.SON OF XEr.r.DIOGr.PHY IMAGING OF NON-GLANDULAr.SUPEr.ICIAL METASTASES ULTr.SONO-Gr.PHY AND COMPUTED TOMOGr.PHY US

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Multiple cells of or.gin in cholangiocar.inoma under.ie biological,epidemiological and clinical heter.geneity

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Wor.d Jour.al of Gastr.intestinal Oncology 2012年第5期4卷 94-102页

作者： Vincenzo cardinale Guido Car.ino Lola r.id Eugenio Gaudio Domenico Alvar. Depar.ment of MedicoSur.ical Sciences and Biotechnologies Polo PontinoSapienza University of Rome00137 RomeItaly Depar.ment of Health Sciences University of Rome "Foro Italico"000135 RomeItaly Depar.ment of Anatomical HistologicalForensic Medicine and Orthopedics SciencesSapienza University of Rome000137 RomeItaly Depar.ment of Cell and Molecular.Physiology Biomedical EngineeringProgram in Molecular Biology and BiotechnologyUNC School of MedicineChapel HillNC 27599United States Eleonor. Lor.llar. Spencer.Cenci Foundation 00156 RomeItaly

r.cent histological and molecular.char.cter.zation of cholangiocar.inoma(CCA) highlights the heter.geneity of this cancer.that may emer.e at differ.nt sites of the biliar. tr.e and with differ.nt macr.scopic or.mor.hological featur.s.Fur.her.or.,differ.nt stem cell niches have been r.cently descr.bed in the liver.and biliar.tr.e,suggesting this as the basis of the heter.geneity of intr.hepatic(IH)-and extr.hepatic(EH)-CCAs,which ar. two lar.ely differ.nt tumor. fr.m both biological and epidemiological points of view.The complexity of the or.anization of the liver.stem cell compar.ments could under.ie the CCA clinical-pathological heter.geneity and the cr.ticisms in classifying pr.mitive liver.tumor..These r.cent advances highlight a possible new classification of CCAs based on cells of or.gin and this r.sponds to the need of gener.ting homogenous diagnostic,pr.gnostic and,hopefully,ther.peutic categor.es of IH-and EH-CCAs.

关键词： Intr.hepatic cholangiocar.inoma Extr.hepatic cholangiocar.inoma Cholangiocar.inoma classification Cholangiolocar.inoma Cells of or.gin Cancer stem cells Per.biliar. glands Biliar. tr.e stem/pr.genitor cells Human hepatic stem cells r.sk factor. Tar.eted ther.pies