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Does topical vancomycin pr.vent fr.ctur.-r.lated infections in closed fr.ctur.s under.oing open r.duction and inter.al fixation?A r.ndomised contr.lled tr.al

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Chinese Jour.al of Tr.umatology 2024年第2期27卷 71-76页

作者： Mohit Gandhi Gopisankar.balaji Jagdish Menon r.ben r.j Thomas Depar.ment of Or.hopaedics Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia Depar.ment of Pr.ventive and Social Medicine Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia

Pur.ose:The r.le of topical vancomycin in fr.ctur.-r.lated infection(Fr.)is *** few studies have r.por.ed their.efficacy in open and high-r.sk extr.mity *** study aimed to assess topical vancomycin's r.le in r.ducing Fr. in closed fr.ctur.s under.oing open sur.ical inter.ention with an ***:This pr.spective r.ndomized cohor. study was car.ied out between Febr.ar. 2021 to Januar. *** with isolated closed fr.ctur.s,who wer. planned for.open r.duction and inter.al fixation within 2 weeks fr.m the time of injur. wer. included for.this *** data collected included age,gender.socioeconomic status,mechanism of injur.,diagnosis,Tscher.e classification,and time inter.al to take up for.*** wer. r.ndomized into the inter.ention and contr.l gr.ups using the block r.ndomization *** contr.l gr.up r.ceived only systemic antibiotic pr.phylaxis,wher.as the inter.ention gr.up r.ceived topical application of vancomycin powder.in the sur.ical wound alongside systemic antibiotic *** pr.mar. outcome measur. was the incidence of Fr. among these *** and r.diological findings and cultur. r.por.s(in cases with infection)wer. r.cor.ed dur.ng the post-oper.tive per.od and at 6 weeks of *** r.levant statistical calculations wer. done using STATA statistical/data analysis-par.llel edition ver.ion 16.0(StataCor. LLC).The quantitative var.ables like age and dur.tion of the sur.er. wer. assessed for.nor.alcy by Shapir.-Wilk W *** independent samples t-test with equal var.ances was applied to the age ***'s exact test was used for.the analysis of the pr.mar. outcome measur.(pr.sence of Fr. following sur.er.),and"r.sk of Fr."and"r.sk differ.nce"between the 2 gr.ups was *** str.ngth of the association between qualitative var.ables was assessed using the Fisher.s exact and Chi-squar. tests,***:Ther. wer. 88 patients included in this *** statistical si

关键词： Infections Antibiotics Vancomycin Fr.ctur.s

Integr.ting Tr.nsfor.er.and Bidir.ctional Long Shor.-Ter. Memor. for.Intelligent Br.ast Cancer.Detection fr.m Histopathology Biopsy Images

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Computer.Modeling in Engineer.ng & Sciences 2024年第10期141卷 443-458页

作者： Pr.sanalakshmi balaji Omar.Alqahtani Sangita Babu Mousmi Ajay Chaur.sia Shanmugapr.ya Pr.kasam Depar.ment of Computer.Science College of Computer ScienceKing Khalid UniversityAbha61451Saudi Arabia College of Science and Ar.s in r.jal Alma King Khalid UniversityAbha61451Saudi Arabia Depar.ment of Infor.ation Technology Muffakham Jah College of Engineering and TechnologyHyderabad500034India Depar.ment of Computer.Science and Business Systems Rajalakshmi Engineering CollegeThandalam602105India

Br.ast cancer.is a significant thr.at to the global population,affecting not only women but also a thr.at to the entir. *** r.cent advancements in digital pathology,Eosin and hematoxylin images pr.vide enhanced clar.ty in examiningmicr.scopic featur.s of br.ast tissues based on their.staining *** cancer.detection facilitates the quickening of the ther.peutic pr.cess,ther.by incr.asing sur.ival *** analysis made by medical pr.fessionals,especially pathologists,is time-consuming and challenging,and ther. ar.ses a need for.automated br.ast cancer.detection *** upcoming ar.ificial intelligence platfor.s,especially deep lear.ing models,play an impor.ant r.le in image diagnosis and ***,the histopathology biopsy images ar. taken fr.m standar. data ***,the gather.d images ar. given as input to the Multi-Scale Dilated Vision Tr.nsfor.er.wher. the essential featur.s ar. ***,the featur.s ar. subjected to the Bidir.ctional Long Shor.-Ter. Memor.(Bi-LSTM)for.classifying the br.ast cancer.*** efficacy of the model is evaluated using diver.ent *** compar.d with other.methods,the pr.posed wor. r.veals that it offer. impr.ssive r.sults for.detection.

关键词： Bidir.ctional long shor.-ter. memor. br.ast cancer.detection featur. extr.ction histopathology biopsy images multi-scale dilated vision tr.nsfor.er

不均匀海底地形影响下柔性板与斜向来浪的相互作用

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 261-275页

作者： Saista Tabssum balaji r.makr.shnan School of Advanced Science-Mathematics VIT-APAmravati744101India Depar.ment of Civil Engineer.ng Indian Institute of TechnologyBombay 400076India

The pr.sent wor. analyzes the inter.ction of oblique waves by a por.us flexible br.akwater.in the pr.sence of a step-type *** physical models for.both scatter.ng and tr.pping cases ar. consider.d and developed within the fr.mewor. of small amplitude water.wave ***’s law is used to model the wave inter.ction with the por.us *** is assumed that the var.ing bottom extends over.a finite inter.al,connected by a finite length of unifor. bottom near.an imper.eable wall,and a semi-infinite length of bottom in the open water.*** boundar. value pr.blem is solved using the eigenfunction expansion method in the unifor. bottom r.gions,while a modified mild-slope equation(MMSE)is used for.the r.gion with the var.ing ***,a mass-conser.ing jump condition is employed to handle the solution at slope discontinuities in the bottom.A system of equations is der.ved by matching the solutions at *** r.flection coefficient and for.e on the br.akwater.and imper.eable wall ar. plotted and analyzed for.var.ous par.meter.,such as the length of the var.ing bottom,depth r.tio,angle of incidence,and flexur.l *** is obser.ed that moder.te values of flexur.l r.gidity and depth r.tio significantly contr.bute to an optimum r.flection coefficient and r.duce the wave for.e on the wall and ***,the outcomes of this study ar. assumed to be applicable in the constr.ction of this type of br.akwater.in coastal r.gions.

关键词： Por.us flexible br.akwater Var.ing bottom Mild-slope equation r.flection coefficient Wave for.e

Downwash air.low distr.bution patter. of hexa-copter.unmanned aer.al vehicles

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Inter.ational Jour.al of Agr.cultur.l and Biological Engineer.ng 2024年第4期17卷 24-34页

作者： Denger. Yallappa r.masamy Kavitha Allimuthu Sur.ndr.kumar.Kannan balaji Balakr.shnan Suthakar.Ayyasamy Par.masivam Mohan Kumar.Yathendr.naik r.vi Nar.yananaik Ashoka Kumar.Kavan Depar.ment of Far. Machiner. and Power.Engineer.ng Agricultural Engineering College and Research InstituteTamil Nadu Agricultural UniversityCoimbatore

In r.cent times,the use of ver.ical take-off and landing(VTOL)multi-r.tor.Unmanned Aer.al Vehicle(UAVs)for.spr.ying chemical pesticides against weeds and pests has r.cently become *** cur.ent aer.al spr.y application r.sear.h is pr.mar.ly focused on examining the influence of UAV spr.ying par.meter. such as flight height,tr.vel speed,r.tor.configur.tion,dr.plet size,payload and wind *** downwash air.low velocity gener.ted by the UAV r.tor.pr.peller.has a significant impact on the dr.plet deposition pr.cess.A test r.g was developed to measur. the downwash air.low patter. gener.ted by the r.tor.pr.peller.of a *** this investigation,a six-r.tor.electr.c autonomous UAV spr.yer.was used to investigate the par.meter. and distr.bution laws of downwash air.low *** downwash air.low velocity was measur.d using por.able anemometer. mounted on the test r.g at r.dial positions viz.,0 m,0.5 m,1 m,1.5 m and 2 m,per.endicular.to(X)and par.llel to the UAV’s flight dir.ction(Y).The exper.ment was conducted at thr.e levels of hover.height,viz.,1 m,2 m and 3 m(Z)and thr.e levels of payload,viz.,0 kg,5 kg,and 10 *** special downwash air.low distr.bution patter. was analysed using the Python pr.gr.mming language(Ver.ion 3.7).r.sults show that the downwash air.low velocity gener.ted by the r.dial position of the UAV r.tor.is evenly distr.buted on the r.tating loop and the standar. deviation of the downwash air.low velocity is less than 0.5 m/*** maximum downwash air.low velocity of 13.8 m/s was obser.ed below the r.tor.at 10 kg payload capacity,1 m hover.height(Z),and 0.5 m in the *** minimum downwash wind field of 0.3 m/s was obser.ed at 0 kg pay load capacity,1 m height,and 2 m in the *** downwash air.low velocity along each position in the r.dial dir.ction of the r.tor.incr.ases initially and then *** downwash air.low distr.bution r.sults helps in mounting of spr.y nozzle configur.tion to dr.ne spr.yer.which helps to

关键词： downwash air payload r.tor.pr.peller flight height distr.bution analysis flight dir.ction

Endoscopic full-thickness plication along with ar.on plasma coagulation for.tr.atment of pr.ton pump inhibitor.dependent gastr.esophageal r.flux disease

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Wor.d Jour.al of Gastr.intestinal Endoscopy 2024年第5期16卷 250-258页

作者： Yogesh Har.ani Shr.ya Butala balaji Mor. Var.n Shukla Anand Patel Depar.ment of Gastr.enter.logy Nobel Gastro HospitalAhmedabad 408409GujaratIndia Depar.ment of Gastr.enter.logy Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia Depar.ment of Phar.acology Mahatma Gandhi Medical College and Research InstitutePuducherry 607402PuducherryIndia Depar.ment of Gastr.enter.logy Noble Institute of GastroenterologyAhmedabad 380009GujratIndia

BACKGr.UND Most endoscopic anti-r.flux inter.entions for.gastr.esophageal r.flux disease(GEr.)management ar. technically challenging to pr.ctice with inadequate data to suppor. it ***,this study was car.ied to evaluate the effectiveness and safety newer.endoscopic full-thickness fundoplication(EFTP)device along with Ar.on Plasma Coagulation to tr.at individuals with *** To evaluate the effectiveness and safety newer.EFTP device along with Ar.on Plasma Coagulation to tr.at individuals with *** This study was a single-center.compar.tive analysis conducted on patients tr.ated at a Noble Institute of Gastr.enter.logy,Ahmedabad,hospital between 2020 and *** r.sear.h aimed to r.tr.spectively analyze patient data on GEr. symptoms and pr.ton pump inhibitor.PPI)dependence who under.ent EFTP using the GEr.-X system along with ar.on plasma coagulation(APC).The pr.mar. endpoint was the mean change in the total gastr.esophageal r.flux disease health-r.lated quality of life(GEr.-Hr.L)scor. compar.d to the baseline measur.ment at the 3-month *** endpoints encompassed enhancements in the over.ll GEr.-Hr.L scor.,impr.vements in GEr. symptom scor.s at the 3 and changes in PPI usage at the 3 and 12-month time *** In this study,patients most wer. in Hill Class II,and over.half had ineffective esophageal *** the EFTP pr.cedur.,ther. wer. significant impr.vements in hear.bur. and r.gur.itation scor.s,as well as GEr.Hr.L scor.s(Pr.ased,with 82.6%not needing PPIs or.pr.kinetics at end of 1 *** significant adver.e events r.lated to the pr.cedur.s wer. obser.ed in either.*** The EFTP along with APC pr.cedur. shows pr.mise in addr.ssing GEr. symptoms and impr.ving patients'quality of life,par.icular.y for.suitable ***,the application of a lone clip with APC yielded super.or.outcomes and exhibited gr.ater.cost-effectiveness.

关键词： Gastr.esophageal r.flux disease Endoscopy Quality of life Endoscopic antir.flux inter.entions r.tr.spective data analysis Gastr.esophageal r.flux disease symptom scor.s Pr.ton pump inhibitor

Biological,pathological,and multifaceted ther.peutic functions of exosomes to tar.et cancer

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Oncology r.sear.h 2024年第1期32卷 73-94页

作者： VIGNESH balaji E DIVYA r.MESH MANISHA CHUNGAN SHAJU AKSHAr. KUMAr.SAMYAK PANDEY r.KSHA NAYAK V.ALKA Sr.SHTI MUNJAL AMIr.SALIMI K.Sr.EDHAr. r.NGANATH PAI SHANKAr.M.BAKKANNAVAr Depar.ment of Phar.acology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Depar.ment of For.nsic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Ser.ices Durham CollegeOshawaOntarioL1G2G5Canada Depar.ment of Phar.aceutical r.gulator. Affair. and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Depar.ment of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Depar.ment of Speech and Hear.ng Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Depar.ment of Phar.acy Pr.ctice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a lar.e number.of intr.cellular.par.icles that employ to cause var.ous diseases and pr.vent sever.l pathological events as well in the human *** is consider.d a“double-edged swor.”,and depending on its biological sour.e,the action of exosomes var.es under.physiological ***,the isolation and char.cter.zation of the exosomes should be per.or.ed accur.tely and the methodology also will var. depending on the exosome ***,the uptake of exosomes fr.m the r.cipients’cells is a vital and initial step for.all the physiological *** ar. differ.nt mechanisms pr.sent in the exosomes’cellular.uptake to deliver.their.car.o to acceptor.*** the exosomal uptake takes place,it r.leases the intr.cellular.par.icles that leads to activate the physiological *** though exosomes have lavish functions,ther. ar. some challenges associated with ever. step of their.pr.par.tion to br.ng potential ther.peutic ***,over.oming the pitfalls would give a desir.d quantity of exosomes with high pur.ty.

关键词： Exosomes Physiology Cancer Ther.peutics Challenges

Hybr.d silver.nanopar.icles:Modes of synthesis and var.ous biomedical applications

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Electr.n 2024年第2期2卷 196-218页

作者： Pr.yanka Singh Shivang Singh balaji Maddiboyina SaiKr.shna Kandalam Tomasz Walski r.ghvendr. A.Bohar. Centr. for.Inter.isciplinar. r.sear.h D.Y.Patil Educational SocietyKolhapurIndia Depar.ment of Inter.al Medicine Rauta Hospital Pvt.LtdGaighatUdayapurNepal Depar.ment of Medical and Scientific Communications Scientific Writing ServicesFreyr Global Regulatory Solutions&ServicesHyderabadTelanganaIndia INSEr. U 1066 ‘Micro et Nanomédecines Biomimétiques-MINT’AngersFrance Univer.itéAnger. UMR-S1066AngersFrance Depar.ment of Biomedical Engineer.ng Wroclaw University of Science and TechnologyWroclawPoland Univer.ity of Galway

In the pr.sent day,ther. is a gr.wing tr.nd of employing new str.tegies to synthesize hybr.d nanopar.icles,which involve combining var.ous functionalities into a single nanocomposite *** moder. methods differ.significantly fr.m the tr.ditional classical appr.aches and have emer.ed at the for.fr.nt of mater.als *** fabr.cation of hybr.d nanomater.als pr.sents an unpar.lleled oppor.unity for.applica-tions in a wide r.nge of ar.as,including ther.py to *** focus of this r.view ar.icle is to shed light on the differ.nt modalities of hybr.d nanopar.icles,pr.viding a concise descr.ption of hybr.d silver.nano-par.icles,explor.ng var.ous modes of synthesis and classification of hybr.d silver.nanopar.icles,and highlighting their.***-tionally,we discussed cor.-shell silver.nanopar.icles and var.ous types of cor. and shell combinations based on the mater.al categor.,such as dielectr.c,metal,or.*** two pr.mar. classes of hybr.d silver.nanopar.icles wer. also ***,var.ous hybr.d nanopar.icles and their.methods of synthesis wer. discussed but we emphasize silica as a suitable candidate for.hybr.dization alongside metal *** choice is due to its hydr.philic sur.ace qualities and high sur.ace char.e,which pr.vide the desir.d r.pulsive for.es to minimize aggr.gation between the metal nanopar.icles in the liquid *** shell encapsulation also pr.vides chemical iner.ness,r.bustness and the adaptability to the desir.d hybr.d ***,among all the mater.als used to coat metal nanopar.icles;silica is highly appr.ved.

关键词： biomedical applications hybr.d silver.nanopar.icles polyvinylpyr.olidone silica shell sur.ace enhanced r.man spectr.scopy

Compar.tive evaluation of ar.ificial intelligence systems'accur.cy in pr.viding medical dr.g dosages:A methodological study

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Wor.d Jour.al of Methodology 2024年第4期14卷 121-130页

作者： Swaminathan r.masubr.manian Sangeetha balaji Tejashr. Kannan Naveen Jeyar.man Shilpa Shar.a Filippo Miglior.ni Suhasini Balasubr.maniam Madhan Jeyar.man Depar.ment of Or.hopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Depar.ment of Or.hopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Depar.ment of Paediatr.c Sur.er. All India Institute of Medical SciencesNew Delhi 110029India Depar.ment of Life Sciences HealthLink Campus UniversityRome 00165Italy Depar.ment of Or.hopaedic and Tr.uma Sur.er. Academic Hospital of Bolzano(SABES-ASDAA)Teaching Hospital of the Paracelsus Medical UniversityBolzano 39100Italy Depar.ment of r.dio-Diagnosis Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia

BACKGr.UND Medication er.or.,especially in dosage calculation,pose r.sks in *** intelligence(AI)systems like ChatGPT and Google Bar. may help r.duce er.or.,but their.accur.cy in pr.viding medication infor.ation r.mains to be *** To evaluate the accur.cy of AI systems(ChatGPT 3.5,ChatGPT 4,Google Bar.)in pr.viding dr.g dosage infor.ation per.Har.ison's Pr.nciples of Inter.al *** A set of natur.l language quer.es mimicking r.al-wor.d medical dosage inquir.es was pr.sented to the AI *** wer. analyzed using a 3-point Liker. *** analysis,conducted with Python and its libr.r.es,focused on basic statistics,over.ll system accur.cy,and disease-specific and or.an system *** ChatGPT 4 outper.or.ed the other.systems,showing the highest r.te of cor.ect r.sponses(83.77%)and the best over.ll weighted accur.cy(0.6775).Disease-specific accur.cy var.ed notably acr.ss systems,with some diseases being accur.tely r.cognized,while other. demonstr.ted significant *** system accur.cy also showed var.able r.sults,under.cor.ng system-specific str.ngths and *** ChatGPT 4 demonstr.tes super.or.r.liability in medical dosage infor.ation,yet var.ations acr.ss diseases emphasize the need for.ongoing *** r.sults highlight AI's potential in aiding healthcar. pr.fessionals,ur.ing continuous development for.dependable accur.cy in cr.tical medical situations.

关键词： Dosage calculation Ar.ificial intelligence ChatGPT Dr.g dosage Healthcar. Lar.e language models

Wave inter.ction with a two-layer.por.us br.akwater.in the pr.sence of step-type bottom

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Acta Mechanica Sinica 2022年第11期38卷 36-47页

作者： Saista Tabssum balaji r.makr.shnan Depar.ment of Civil Engineer.ng Indian Institute of Technology BombayBombay400076India

Oblique wave inter.ction with a two-layer.br.akwater.consisting of per.or.ted fr.nt and back wall in the pr.sence of bottom undulations is *** char.cter.stics ar. studied in the fr.mewor. of small-amplitude wave theor.,and Dar.y’s law is used for.flow past por.us *** var.ing bottom topogr.phy spanned over.a finite inter.al connected by two semi-infinite inter.als of unifor. water.*** expansion method is used to handle the solution in the r.gions of unifor. bottom and a modified mild-slope equation along with jump conditions is employed for.var.ing bottom ***,tr.nsmission,and wave ener.y dissipation coefficients ar. obtained numer.cally by applying the matr.x method to under.tand the effects of sever.l physical quantities such as wavenumber.por.sity,and angle of *** tr.nsmission coefficient r.duces significantly and the wave ener.y dissipation is high for.the pr.sent ***,Br.gg scatter.ng is analyzed in the pr.sence of step-type r.ppled bottom and pr.sented in this paper.

关键词： Two-layer.por.us br.akwater Mild-slope equation Br.gg r.sonance r.flection coefficient Tr.nsmission coefficient