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Pr.dicting Vir.logical Failur. with Immunological Cr.ter.a in Fir.t Line Ar. Patients in a r.sour.e Poor.Setting

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Wor.d Jour.al of AIDS 2014年第4期4卷 413-421页

作者： Kr.shnar.j r.ja Chockalingam Chandr.sekar.O. r. Kr.shnar.jasekhar.Nar.yanan r.vichandr.n Satagopan Kumar.Gur.samy Manohar.n Ir.dayar.j Amala Shar.ila Gover.ment Hospital of thor.cic Medicine (GHtM) Tambaram Sanatorium Chennai India Consultant Karpagam Faculty of Medical Sciences and Research and I-TECH Coimbatore India

Indr.duction: National Aids contr.l Or.anisation in India implementing National AIDS contr.l?pr.gr.m uses WHO’s immunological cr.ter.a to scr.en vir.logical failur.. Using immunological cr.ter.a to detect vir.logical failur. has to be assessed. Pr.dicting vir.logical failur. with immunological cr.ter.a in r.sour.e limited settings had low sensitivity. Factor. that influence the outcome ar. studied. Methods: r.tr.spective study in ter.iar. car. centr. for.HIV and tB, Chennai, India. Out of 35,044 on Ar. between Januar. 2008 and September.2009, 452 suspected immunological failur.s wer. r.fer.ed. 273 scr.ened for.vir.logical failur..?Fr.quency, sensitivity/specificity, positive/negative pr.dictive values, chi-squar. test, odds-r.tio, independent sample t test for.vir.l load gr.ater.than 10,000 and 1000 of each immunological cr.ter.on using Epi-Info and SPSS ver.ion 19. r.sults: 172 had vir.logical failur. (62.09%). Aver.ge age of failed was 37.33. Single cr.ter.a’s sensitivity was 60 to 84 for.detecting vir.lological failur.. two or.mor. cr.ter.a had specificity 55 to 79. Combination of two or.mor. cr.ter.a incr.ased odds r.tio for.vir.logical failur.. Positive pr.dictive value was above 63 for.all cr.ter.a. PPV was above 80 to the cr.ter.on all thr.e positive. Conclusions: Ar. naive patients with >95% adher.nce the sensitivity of immunological cr.ter.a to detect vir.logical failur. is thr.e times than ear.ier.studies. Combination of cr.ter.a is mor. significantly associated with vir.logical failur.. Odds r.tio doubled for.two or.mor. combination of cr.ter.a. Immunological cr.ter.a is affor.able/acceptable for.scr.ening vir.logical failur., with adher.nce > 95% and longer.the dur.tion of Ar..

关键词： Ar. Immunological Failur. Vir.logical Failue Immunological Cr.ter.a r.sour.e Limited Settings

Local pr.ssur. and density distr.bution in methane hydr.teice Ih system

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Local pressure and density distribution in methane hydrateic...

Vibr.tion-Based Fault Diagnosis Study on a Hydr.ulic Br.ke System Using Fuzzy Logic with Histogr.m Featur.s

thir. Confer.nce of the Asian Consor.ium for.Computational Mater.als Science

作者： O.S.Subbotin t.Ikeshoji V.r.Belosludov J.Kudoh r.V.Belosludov Y.Kawazoe Institute of Inor.anic Chemistr. SB RASNovosibirskRussia r.sear.h Institute for.Computational Sciences National Institute of Advanced Industrial Science and Technology （AIST）TsukubaJapan Institute of Inor.anic Chemistr. SB RASNovosibirskRussia Center for Northeast Asia Studies of Tohoku UniversitySendaiJapan Center.for.Nor.heast Asia Studies of tohoku Univer.ity SendaiJapan Institute for.Mater.als r.sear.h Tohoku UniversitySendaiJapan Institute for.Mater.als r.sear.h Tohoku UniversitySendaiJapan

＜正＞Effect of self-pr.ser.ation of gas hydr.tes was explor.d over.many year. but ther. is no complete under.tanding how can hydr.tes exist in their.ther.odynamic instability r.gion. We ar. suggesting the micr.scopic-level model of methane hydr.te cluster. immer.ed in ice matr.x. Due to differ.nces in ther.al expansion of methane hydr.te and Ice Ih the additional pr.ssur. appear. in the hydr.te phase and this moves it into its stability field. MD simulations wer. per.or.ed to find local pr.ssur. and density pr.files. r.sults ar. well confir.ing our.assumption.

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Str.ctur.l Dur.bility & Health Monitor.ng 2022年第4期16卷 383-396页

作者： Alamelu Manghai t Mar.muthu Jegadeeshwar.n r.kkiyannan Lakshmipathi Jakkamputi Sugumar.n Vaithiyanathan Sakthivel Gnanasekar.n School of Mechanical Engineer.ng Vellore Institute of TechnologyChennai600127India Centr. for.Automation School of Mechanical EngineeringVellore Institute of TechnologyChennai600127India

the r.quir.ment of fault diagnosis in the field of automobiles is gr.wing higher.day by *** r.liability of human r.sour.es for.the fault diagnosis is *** ar. one of the major.cr.tical components in automobiles that r.quir. closer.and active *** r.sear.h wor. demonstr.tes a fault diagnosis technique for.monitor.ng the hydr.ulic br.ke system using vibr.tion *** signals of a r.tating element contain dynamic infor.ation about its health ***,the vibr.tion signals wer. used for.the br.ke fault diagnosis *** study was car.ied out on a br.ke fault diagnosis exper.mental *** vibr.tion signals under.differ.nt fault conditions wer. acquir.d fr.m the setup using an *** condition monitor.ng of the hydr.ulic br.ke system using the vibr.tion signal was pr.cessed using a machine lear.ing *** machine lear.ing appr.ach has thr.e phases,namely,featur. extr.ction,featur. selection,and featur. *** featur.s wer. extr.cted fr.m the vibr.tion *** pr.minent featur.s wer. selected using the decision *** selected featur.s wer. classified using a fuzzy *** histogr.m featur.s and the fuzzy classifier.combination pr.duced maximum classification accur.cy than that of the statistical featur.s.

关键词： Machine lear.ing histogr.m featur.s decision tr.e fuzzy logic member.hip function confusion matr.x

Novel biomar.er. and the futur. of tar.eted ther.pies in cholangiocar.inoma:a nar.ative r.view

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Hepatobiliar. Sur.er. and Nutr.tion 2022年第2期11卷 253-266页

作者： Nishant Munugala Shishir.K.Maithel r.chna t.Shr.ff Depar.ment of Medicine University of ArizonaTucsonAZUSA Division of Sur.ical Oncology Emory UniversityWinship Cancer InstituteAtlantaGAUSA Division of Hematology and Oncology Department of GI Medical OncologyUniversity of Arizona Cancer CenterTucsonAZUSA

Backgr.und and Objectives:Cholangiocar.inoma is a highly aggr.ssive and heter.genous gr.up of biliar. malignancies ar.sing fr.m any site in the biliar. tr.e,compr.sing 15%of all pr.mar. liver.*** natur. of the disease and nonspecific pr.sentation leads to late diagnosis and ultimately poor.outcomes for.*** gemcitabine and cisplatin has been the standar. of car. for.cholangiocar.inoma(CCA)since 2010,with a median over.ll sur.ival of 11.7 *** five-year.sur.ival for.CCA r.mains 5-10%,r.vealing a clear.need for.impr.ved tr.atment ***:this tar.eted r.view highlights the r.le of next gener.tion sequencing in CCA and the clinically r.levant tumor.biomar.er. that have become the focus of ther.peutic *** Content and Findings:these tumor.biomar.er. or.actionable mutations hold the potential to enable ear.ier.diagnosis,pr.vide pr.gnostic infor.ation,and guide tr.atment decisions for.patients with ***,the FGFr. fusion and IDH1 mutation have shown consider.ble pr.mise in development of tar.eted *** tr.als with inhibitor. tar.eting FGFr. fusion and IDH1 mutation have cr.ated expectations that these dr.gs will soon enter.clinical *** biomar.er. including Kr.S and B-r.f pr.tooncogenes,Her./neu genes,and Br.A1 and 2 tumor.suppr.ssor.genes have also been touted as potential tar.ets for.futur. ther.pies,with ear.y data showing pr.mise for.new dr.g ***:the discover. of these actionable mutations and identification of tar.eted ther.pies have challenged the notion of a“one-size fits all”for.tr.atment of CCA,and gener.ted optimism that these novel tr.atments will soon be available for.patients with CCA.

关键词： Cholangiocar.inoma(CCA) tar.eted ther.pies IDH FGFr. fusion tumor.biomar.er.

Detonation initiated disintegr.tion of coal par.icle due to the maxi- mum str.in ener.y theor.

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Jour.al of Coal Science & Engineer.ng(China) 2013年第4期19卷 435-440页

作者： Patadiya D M Jaisankar.S Sheshadr. t S Depar.ment of Aer.space Engineer.ng Indian Institute of Science Bangalore India

Fr.gmentation behaviour.of coal par.icles subjected to detonation wave is being studied. Detonation wave is initiated by a plasma car.r.dge at one end of a detonation tube. Coal par.icles ar. subjected to a shock whose temper.tur. depends on the Mach number.of the detonation wave. temper.tur. shock is found to gener.te ther.al str.sses which may fr.gment the coal par.icles. A non-dimensional mathematical model for.the heat tr.nsfer.pr.cess in the coal par.icle is pr.posed. ther.al str.sses ar. calculated at var.ous times and r.dii while maximum str.in ener.y theor. is used to under.tand the failur. behavior.viz., the time, temper.tur. and location of fr.ctur.. A physical model for.coal par.icle fr.gmentation when subjected to detonation wave is also pr.posed. the study suggests that detonation combustion of coal is qualitatively differ.nt fr.m conventional method.

关键词： coal par.icle detonation wave spontaneous fr.gmentation

VAr.AtIONAL Pr.PEr.IES OF tHE INtEGr.tED MEAN CUr.AtUr.S OF tUBES IN SYMMEtr.C SPACES

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Chinese Annals of Mathematics,Ser.es B 2002年第1期23卷 53-62页

作者： X.GUAL-Ar.AU r.MASó A.M.NAVEIr. Depar.amentdeMatemàtiques CampusRiuSec.UniversitatJaumeI.12071-CastellóSpain Depar.amentodeGeometr.aytopología UniversidaddeValencia46100-Burjasot(Valencia)Spain

Let Pt denote the tubular.hyper.ur.ace of r.dius t ar.und a given compatible submanifold in a symmetr.c space of ar.itr.r. r.nk. the author. will obtain some r.lations between the integr.ted mean cur.atur.s of P, and their.der.vatives with r.spect to f. Mor.over. the author. will emphasize the differ.nces between the r.sults obtained for.r.nk one and ar.itr.r. r.nk symmetr.c spaces.

关键词： Integr.ted mean cur.atur.s Symmetr.c spaces tubes Geodesic balls totally geodesic submanifold Pr.ncipal or.it Var.ational pr.blems

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Entr.py gener.tion for.mixed convection flow in ver.ical annulus with two r.gions hydr.magnetic viscous and Cu-Ag water.hybr.d nanofluid thr.ugh por.us zone: a compar.tive numer.cal study

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Pr.pulsion and Power.r.sear.h 2022年第3期11卷 401-415页

作者： t.r.him J.Hasnain N.Abid Z.Abbas Depar.ment of Mathematics The Islamia University of BahawalpurBahawalpur63100Pakistan Depar.ment of Computer.Sciences Bahria UniversityIslamabad44000Pakistan

the pr.mar. deter.ination of this study is a numer.cal investigation of the entr.pygener.tion (EG) in the steady two-r.gion flow of viscous fluid and hybr.d nanofluid (NF) in along-infinite ver.ical annulus having a clear.r.gion as well as por.us media. Stoke’s and single-phase NF models ar. used to study the viscous fluid and hybr.d nanofluid (HNF) heat tr.nsfer.evelopments, r.spectively. two types of nanopar.icles ar. taken, such as copper.(Cu) and sil-ver.(Ag) within base fluid water.to make it a HNF. Dar.y-Br.nkman law is also used to examinethe flow thr.ugh the por.us zone in the annulus. Necessar. quantities have been used in thesystem of equations to tr.nsfer.them into non-dimensional for.s. For.momentum and ener.ytr.nspor., the numer.cal r.sults ar. evaluated for.var.ous model par.meter. and ar. examinedvia the shooting method in MAtHEMAtICA. It is noted that the momentum and ener.y tr.ns-por. ar. mor. significant when two immiscible fluids in a clear.ver.ical annulus ar. taken. thefindings also indicate that two-phase momentum and heat flow ar. gr.ater.when a NF is used in r.gion-II and lower.when a HNF is used. the temper.tur. (in r.gion-II) falls with a high na-nomater.als volume fr.ction (see Figur. 4) while it is incr.ased when the Har.man number.isincr.ased. Mor.over. velocity declines with incr.ment in nanomater.als volume fr.ction. thus,higher.ther.al conductivity can be accomplished by using a magnetic field.

关键词： two-phase flow Hybr.d nanofluid Viscous fluid Por.us zone Ver.ical annulus Entr.py gener.tion

献血者初筛检验在血站血液检测中的重要性分析

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系统医学 2018年第16期3卷 30-31,50页

作者：赵海萍江阴市红十字血站检验科江苏江阴214431

目的分析献血者初筛检验在血站血液检测中的重要性。方法选取2017年1月—2018年3月于该血站献血的部队与学校献血者932人、乡镇街道献血者932人作为研究对象,其中部队与学校献血者未进行血液ALt项目检测,为研究组,乡镇街道献血者先进行... 详细信息

目的分析献血者初筛检验在血站血液检测中的重要性。方法选取2017年1月—2018年3月于该血站献血的部队与学校献血者932人、乡镇街道献血者932人作为研究对象,其中部队与学校献血者未进行血液ALt项目检测,为研究组,乡镇街道献血者先进行速率法ALt筛查,而后再进行其他血液项目检测,为对照组,对比两组献血者的检测结果。结果研究组报废率为3.54%,高于对照组的0.43%(χ~2=23.190 0,Pt筛查阳性血液样本为(54.11±7.23)U/L,阴性血液样本为(24.57±6.23)U/L,各项数据与实验室检测数据比较差异无统计学意义(t=0.4111、0.094 3,P>0.05)。结论献血者初筛检验过程中,即使是低危献血者,也应进行常规血液项目检测不应省略速率法ALt筛查,可有效提升血液检验的可靠性,提升血液质量,确保临床输血安全。

关键词：献血初筛检验血站血液检测血液质量

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LOCALLY NONLINEAr.StOCHAStIC ANALYSIS OF OFFSHOr. Str.CtUr.S

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China Ocean Engineer.ng 1988年第3期2卷 1-10页

作者： Y.t.Leung Y.K.Cheung Depar.ment of Civil Engineer.ng Univer.ity of Hong Kong Hong Kong Pr.fessor Hong Kong Senior.Lectur.r

this paper. pr.sents a simple method for.the stochastic dynamic analysis of some offshor. platfor.s with localized nonlinear.ty. the tr.nsfer.function of the platfor. with initial linear.stiffness is fir.t deter.ined, and the nonlinear.iter.tion is per.or.ed on the condensed stiffness matr.x only. Computational effor.s ar. r.duced. this method can be used to analyze a fixed platfor. on nonlinear.foundation and a guyed tower.platfor. having nonlinear.guylines.

关键词： LOCALLY NONLINEAr.StOCHAStIC ANALYSIS OF OFFSHOr. Str.CtUr.S