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Cytotoxicity Tests for.Evaluating Medical Devices: An Aler. for.the Development of Biotechnology Health Pr.ducts

Jour.al of Biomedical Science and Engineer.ng 2017年第9期10卷 431-443页

作者： M. N. P. vidal J. M. Gr.njeir. National Institute of Quality Contr.l in Health of the Oswaldo Cr.z Foundation (INCQS/FIOCr.Z) Manguinhos Brasil Fluminense Feder.l Univer.ity Post-Graduation Program in Biotechnology Niterói Brazil Quality and Metr.logy of the National Institute of Metr.logy Quality and Technology Directory of Metrology Applied to Life Sciences Rio de Janeiro Brazil The Br.zilian Br.nch of Institute of Biomater.als Tribocorrosion and Nanomedicine (IBTN) Rio de Janeiro Brazil

The r.sks and damages r.lated to the use of pr.ducts, technologies and ser.ices of sanitar. inter.st can be due to defects or.manufactur.ng failur.s. Cer.ain pr.ducts alr.ady contain a cer.ain degr.e of r.sk, which r.quir.s str.ct quality contr.l in their.pr.duction, distr.bution and use, as well as in the disposal of their.waste in the envir.nment. With continuous development in science and technology, medical devices must under.o intr.der.al ir.itation and testing for.sensitization, cytotoxicity, and acute systemic toxicity. In health car., biotechnology aims to pr.vide technology-based pr.ducts or.pr.cesses r.lated to ener.y, food, and health, which ar. capable of stimulating new businesses, expanding expor.s, integr.ting the value chain and stimulating new demands for.innovative pr.ducts and pr.cesses, taking into account health policies. The pr.sent ar.icle was pr.par.d by a bibliogr.phical sur.ey of the electr.nic databases PubMed, Lilacs, and Bir.me. Cell cultur. testing can be successfully employed, as it is r.pr.ducible, r.pid, sensitive, and financially accessible for.per.or.ing in vitr. toxicity testing. Thus, it has been possible to optimize the development phase of new pr.ducts by decr.asing animal use or.even r.placing them in cer.ain tests. Some in vitr. assays validated by the Or.anization for.Economic Cooper.tion and Development in the ar.a of health pr.ducts have alr.ady r.placed animal testing.

关键词： Biotechnology Medical Devices Biomater.als Biocompatibility Health Pr.ducts In Vitr. Cytotoxicity Assay

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由于水井枯竭,全球粮食供应面临威胁

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英语沙龙（高中） 2013年第9期 20-21页

作者： John vidal 不详

知名的资源分析专家、美国地球政策研究所负责人莱斯特·布朗前不久在一篇论文中提到,包括超过地球一半人口的18个国家在内,由于过度使用地下水,使地下水位达到了＂水峰值＂——这也意味着地下水无法重新蓄满,粮食产量会因此逐年减少,... 详细信息

知名的资源分析专家、美国地球政策研究所负责人莱斯特·布朗前不久在一篇论文中提到,包括超过地球一半人口的18个国家在内,由于过度使用地下水,使地下水位达到了＂水峰值＂——这也意味着地下水无法重新蓄满,粮食产量会因此逐年减少,全球粮食供应正面临着前所未有的严峻形势。

关键词：粮食供应水井地下水位资源分析过度使用粮食产量负责人研究所

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Design and fabr.cation of gas cell tar.ets for.labor.tor. astr.physics exper.ments on the Or.on high-power.laser.facility

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High Power.Laser.Science and Engineer.ng 2017年第3期5卷 62-66页

作者： C.Spindloe D.Wyatt S.Astbur. G.F.Swadling T.Clayson C.Stehlé J.M.Foster.E.Gumbr.ll r.Char.es C.N.Danson P.Br.mmitt F.Suzuki-vidal Cur.ent addr.ss： Lawr.nce Liver.or. National Labor.tor. California 94550 USA

This paper.descr.bes the design and fabr.cation of a r.nge of ‘gas cell' micr.tar.ets pr.duced by the Tar.et Fabr.cation Gr.up in the Centr.l Laser.Facility(CLF) for.academic access exper.ments on the Or.on laser.facility at the Atomic Weapons Establishment(AWE). The exper.ments wer. car.ied out by an academic consor.ium led by Imper.al College London. The under.ying tar.et methodology was an evolution of a r.nge of tar.ets used for.exper.ments on r.diative shocks and involved the fabr.cation of a pr.cision machined cell containing a number.of aper.ur.s for.inter.ction foils or.diagnostic windows. The inter.or.of the cell was gas-filled befor. laser.ir.adiation. This paper.details the assembly pr.cesses, thin film r.quir.ments and micr.-machining pr.cesses needed to pr.duce the tar.ets. Also descr.bed is the implementation of a gas-fill system to pr.duce tar.ets that ar. filled to a pr.ssur. of 0.1–1 bar. The paper.discusses the challenges that ar. posed by such a tar.et.

关键词： astr.physics micr.tar.ets

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Action of pr.topor.hyr.n-IX (PP-IX) in the lifespan of <i>Dr.sophila melanogaster.lt;/i>deficient in endogenous antioxidants, Sod and Cat

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Open Jour.al of Animal Sciences 2013年第4期3卷 1-7页

作者： Emilio Pimentel Luz M. vidal Mar.ha Patr.cia Cr.ces Mar.usz Kr.ysztof Janczur Depar.amento de Biología Instituto Nacional de Investigaciones Nucleares (ININ) Ocoyoacac México Facultad de Ciencias Universidad Autónoma del Estado de México Toluca México

Pr.topor.hyir.n-IX (PP-IX) is a pr.cur.or.of the biosynthesis of the hemo gr.up, most of the cytochr.mes and the chlor.phylls. The PP-IX is used for.medical pur.oses, and r.cently a r.por. indicated that it exhibits a dual action since it can decr.ase or.incr.ase the genetic damage caused by N-nitr.so-N-ethylur.a (ENU) in somatic cells of Dr.sophila. PP-IX is known to be able to act as an anti-or.pr.-oxidant agent. The aim of the pr.sent r.sear.h was to study the r.le of PP-IX on the lifespan of Dr.sophila melanogaster. taking into account the fact that incr.asing levels of r.S can acceler.te the aging pr.cess. The Canton-S str.in (CS) was used as well as Sod and Cat which ar. deficient in the endogenous enzymes, super.xide dismutase and catalase, r.spectively. Gr.ups of females and males wer. tr.ated separ.tely with 5 mg/ml of PP-IX solution. The compar.son of sur.ival cur.es indicates that this pigment extended the lifespan of CS. In contr.st, Sod str.in showed that the opposite effect and had no effect in Cat str.in. The fact that PP-IX r.duces the mean lifespan in Sod deficient str.in might suggest a pr.-oxidant action of PP-IX, and consequently the cumulating of r.S as a super.xide could have a mutagenic effect as was shown r.cently. The r.sults pr.sented evidence of the dual effect of PP-IX.

关键词： Pr.topor.hyr.n IX (PP-IX) Lifespan Sod Cat r.active Oxygen Species Longevity Dr.sophila melanogaster

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Sensitivity,specificity and pr.dictive values of anter.or.chamber.tap in cases of bacter.al endophthalmitis

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Eye and Vision 2017年第1期4卷 100-105页

作者： Car. Sjoholm-Gomez de Liano vidal F.Sober.n-Ventur. Guiller.o Salcedo-Villanueva Abr.l Santos-Palacios Jose Luis Guer.er.-Nar.njo Jans Fr.mow-Guer.a Ger.r.o Gar.ía-Aguir.e Vir.ilio Mor.les-Canton r.ul Velez-Montoya r.tina Depar.ment Asociación para Evitar la Ceguera en MexicoHospital“Dr.Luis Sanchez Bulnes”IAPMexico CityMexico Univer.idad Popular.Autonoma del Estado de Puebla PueblaMexico Ophthalmology Depar.ment Macula Retina ConsultantsMexico CityMexico

Backgr.und:To assess the sensitivity,specificity,positive pr.dictive value and negative pr.dictive value of anter.or.chamber.tap for.the diagnosis of bacter.al endophthalmitis on a population with high ***:r.tr.spective,single centr.,case ser.es *** r.viewed all medical r.cor.s with clinical diagnosis of bacter.al endophthalmitis in our.hospital fr.m Januar. 1st,2000 to December.31st *** each r.cor.,we documented gener.l demogr.phic data,best cor.ected visual acuity and vitr.ous and aqueous tap micr.biological *** cases wer. fur.her.divided accor.ing to the endophthalmitis aetiology to per.or. individual calculations of sensitivity,specificity,positive pr.dictive value,negative pr.dictive value,accur.cy and *** used the r.sults of the vitr.ous tap as the gold standar. for.diagnosis of bacter.al *** excluded those r.cor.s in which the aqueous and vitr.ous samples wer. not taken simultaneously or.had an incomplete micr.biological *** wer. assessed with chi squar.d statistics,with an alpha value of 0.05 for.statistical ***:A total of 190 cases fulfilled the inclusion/exclusion *** cultur. r.te fr.m vitr.ous samples was 64.74%.Positive cultur. r.te fr.m aqueous sample was 32.11%.Bacter.a isolated fr.m aqueous samples matched those isolated fr.m vitr.ous samples 78.68%of the *** over.ll sensitivity was 38.21%,specificity:75.51%,positive pr.dictive value:79.66%,negative pr.dictive value:32.74%(p=0.08).Subgr.up analysis showed that anter.or.chamber.taps in cases of post-sur.ical endophthalmitis had a moder.te to low sensitivity(37.73%),high specificity(93%)and high positive pr.dictive value(95%)(pr.or.chamber.tap ar. low and should not be used for.cr.tical ther.peutic decisions in patients with suspected bacter.al *** cases of post-sur.ical endophthalmitis,the r.sult of an anter.or.chamber.tap

关键词： Aqueous humour Endophthalmitis Anter.or.chamber.tap Diagnostic test Vitr.ous tap Aqueous sampling Sensibility Sensitivity

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Exper.mental Analysis of Voice and Data Tr.nsmission Par.meter. for.Mobile Ter.inals in Cellular.Data Networ.s

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Wir.less Engineer.ng and Technology 2011年第1期2卷 9-14页

作者： Montser.at Jiménez-Licea Ser.io vidal-Beltr.n José Luis López-Bonilla 不详

This wor. pr.sents the exper.mental r.sults r.lated to per.or.ance measur.ments in GSM and GPr. cellular.data networ.s. Two Mobile Ter.inals wer. used, in or.er.to take place the scenar.o. Power.Level, Power.vs Time, ... 详细信息

关键词： GSM GPr. Cellular Networ.s

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Techniques for.Deter.ining the Tr.atment Costs of Cer.ical Cancer. A Systematic r.view

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Open Jour.al of Obstetr.cs and Gynecology 2019年第2期9卷 117-128页

作者： Candice Amor.m de Ar.újo Lima Santos Ar.ani Impier. Souza Suely Ar.uda vidal Instituto de Medicina Integr.l Pr.fessor.Fer.ando Figueir.—IMIP Recife Brazil Faculdade Per.ambucana de Saúde—FPS Recife Brazil

Backgr.und: Uter.ne cer.ical cancer.(UCC) r.pr.sents a public health pr.blem in many par. of the wor.d. The use of new technologies is leading to incr.ased tr.atment costs, r.sulting in a substantial economic impact wor.dwide. Standar.ization of economic evaluation methods is needed to impr.ve compar.sons between jur.sdictions. Objective: To identify the methods used to measur. the cost of tr.ating invasive UCC, and to sear.h for.cor.elations between cancer.tr.atment expenditur.s and local economies. Methods: We sear.hed ar.icles in MEDLINE, LILACS, and SciELO with no language r.str.ctions, and included publications fr.m Januar. 01, 2007 to December.31, 2016. Studies wer. included if they descr.bed the annual dir.ct cost of invasive cer.ical cancer.and detailed the costing method. Complete economic evaluations wer. excluded. r.sults wer. descr.bed in 2016 inter.ational dollar.. r.sults: Of 1581 studies initially r.viewed, 13 ar.icles wer. included in the analysis. Six ar.icles used a bottom-up;six used a top-down appr.ach and one used both. Annual cost per.patient var.ed fr.m I$ 2146.22 (Poland) to 34,351.54 (Sweden). Middle-income countr.es (MIC) spent median 72.52% of its GDP per.capita on the tr.atment of invasive cer.ical cancer. while high-income countr.es (HIC) spent median 30.12% (p = 0.032). No significant differ.nce was found when separ.ted by costing method. Conclusions: We found that, for.the tr.atment costs of invasive UCC, the per.entages of GDP per.capita wer. statistically higher.in MIC than in HIC. However. no significant differ.nce was found between costing methods, and the top-down appr.ach could be used.

关键词： Cer.ical Cancer Costs and Cost Analysis Costing Method Systematic r.view

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碳酸钙填料市场趋势与发展

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江苏地质科技情报 1995年第2期 23-24页

作者： vidal,Jr

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Quantification of Al-goethite fr.m diffuse r.flectance spectr.scopy and magnetic methods

Quantification of Al-goethite from diffuse reflectance spect...

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中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： Zhaoxia Jiang Qingsong Liu Claudio Colombo vidal Bar.on Jose Tor.ent Pengxiang Hu State Key Labor.tor. of Lithospher.c Evolution Institute of Geology and GeophysicsChinese Academy of Sciences Univer.ity of the Chinese Academy of Sciences Univer.ita del Molise Dip.di Agr.coltur. Alimentazione ed Ambientev.De SanctisI-86100 Campobasso (CB)Italy Depar.amento de Agr.nom?a Universidad de CordobaEdificio C4Campus de RabanalesE-14071 CordobaSpain

As one of the most abundant ir.n oxides in soils, the pr.sence and natur. of goethite is contr.lled by the soil conditions and bur.al histor.. The visible diffuse r.flectance spectr.scopy(Dr.) is a useful tool for.quantifying goethite. However. aluminium(Al) substitution for.goethite is ver. common in soils and the effects of Al content on the Dr. pr.per.ies of goethite have not been fully r.solved. In this study, two ser.es of Al substituted goethites(Al-goethite) and 20 Chinese loess/palaeosol samples wer. investigated using both Dr. and magnetic methods to test the feasibility of quantifying Al-goethite with the Dr. *** show that the peak positions and amplitudes of the goethite Dr. band ar. significantly influenced by Al substitution. Specifically, the goethite concentr.tion pr.xy, the amplitude of the Dr. band, is r.latively stable only when Al substitution r.nged between about 4 and16 mol per.cent. Pr.ctically, in or.er.to r.solve the difficulty in measur.ng Al content in natur.l samples, the unblocking temper.tur.(T b) is pr.posed as the pr.xy for.Al substitution of goethite. When T b of Al-goethite was above 250 K, the amplitude of Dr. can be used to r.liably tr.ce the goethite concentr.tion var.ation in natur.l samples. For.example, the Dr. spectr. for.the Chinese loess–palaeosol samples suppor. the idea that only haematite is enhanced via pedogenesis. In contr.st, the or.gin of goethite seems to be mostly r.lated to the aeolian inputs.

关键词： Envir.nmental magnetism Magnetic miner.logy and petr.logy r.ck and miner.l magnetism

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透镜天线:一种新型电子扫描方法

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雷达与对抗 1981年第2期 9-15页

作者： Y.MICHEL r.PAUCHAr. P.vidal 郑启心

为了避免机械扫描天线所产生的波束惯性效应,研制了许多电子扫描天线结构。本文描述了一种新型电子扫描方法。它与相控阵天线不同,不需要离散的移相器。这一称为透镜天线(r.dant-r.d?me Antenne)的系统使用了电磁透镜,用电子方法来改变... 详细信息

为了避免机械扫描天线所产生的波束惯性效应,研制了许多电子扫描天线结构。本文描述了一种新型电子扫描方法。它与相控阵天线不同,不需要离散的移相器。这一称为透镜天线(r.dant-r.d?me Antenne)的系统使用了电磁透镜,用电子方法来改变光轴的方向。本文描述了透镜天线方法的原理及其证实这种方法益处的实验结果。

关键词：透镜天线平面扫描平面内馈源相移定向天线电子扫描天线反向偏压新型电子扫描方法

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