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The impact of heter.geneity and por. networ. char.cter.stics on single and multi-phase fluid pr.pagation in complex por.us media:An X-r.y computed tomogr.phy study

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Petr.leum Science 2024年第3期21卷 1719-1738页

作者： Shohr.h Ir.ji Tales r.dr.gues De Almeida Eddy r.idiaz Munoz Mateus Basso Alexandr. Campane vidal Depar.ment of Mechanical Engineer.ng(FEM) State University of Campinas(UNICAMP)CampinasSP13083-860Brazil Depar.ment of Geology and Natur.l r.sour.es Geosciences Institute(IG)State University of Campinas(UNICAMP)CampinasSP.13083-855.Brazil Lr.P/COPPE/COPPETEC/UFr. Rua Moniz Aragao 360Bloco 4 Cidade UniversitariaRio de Janeiro21941-594Brazil Center.of Ener.y and Petr.leum Studies(CEPETr.) State University of Campinas(UNICAMP)CampinasSP13083-896Brazil

This study investigates the impact of por. networ. char.cter.stics on fluid flow thr.ugh complex and heter.geneous por.us media,pr.viding insights into the factor. affecting fluid pr.pagation in such ***,high-r.solution or.micr. X-r.y computed tomogr.phy(CT)imaging techniques wer. utilized to examine outcr.p str.matolite samples of the Lagoa Salgada,consider.d flow analogous to the Br.zilian Pr.-salt car.onate *** petr.physical r.sults compr.sed two distinct str.matolite depositional facies,the columnar.and the fine-gr.ined *** gener.ting por. networ. model(PNM),the study quantified the r.lationship between key featur.s of the por.us system,including por. and thr.at r.dius,thr.at length,coor.ination number.shape factor.and por. *** study found that the less dense por. networ. of the columnar.sample is typically char.cter.zed by lar.er.por.s and wider.and longer.thr.ats but with a weaker.connection of thr.ats to *** facies exhibited less var.ability in the r.dius of the por.s and thr.ats in compar.son to thr.at ***,a ser.es of cor. flooding exper.ments coupled with medical CT scanning was designed and conducted in the plug samples to assess flow pr.pagation and satur.tion *** study r.vealed that the heter.geneity and pr.sence of disconnected or.dead-end por.s significantly impacted the flow patter.s and ***-phase flow patter.s and oil satur.tion distr.bution r.veal a pr.fer.ntial and heter.geneous displacement that mainly swept displaced fluid in some r.gions of plugs and bypassed it in *** r.lation between satur.tion pr.files,por.sity pr.files,and the number.of fluid flow patter.s for.the samples was *** for.the columnar.plug sample was the enhancement in r.cover. factor.after.shifting to lower.salinity water.injection(SB)obser.ed.

关键词： Por. networ. model Heter.geneous por.us media Flow patter.s Dead-end por.s

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Methodology for.the Study of the Quality of CFr. Dr. Dr.lling Based on Macr.geometr.cal and Dimensional Deviations

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Wor.d Jour.al of Engineer.ng and Technology 2016年第3期4卷 200-205页

作者： J. Salguer. S. r. Fer.andez-vidal P. Mayuet J. M. Vazquez-Mar.inez M. Alvar.z M. Mar.os Mechanical Engineer.ng and Industr.al Design Depar.ment University of Cadiz Cadiz Spain

Commonly, Car.on Fiber.r.infor.ed Plastics (CFr.) aer.space elements need to be machined (dr.lling) for.subsequent assembly oper.tions, mainly r.veting, taking a cr.tical impor.ance the quality r.quir.ments of the holes. Some of the adjustment defects that can be pr.duced dur.ng the dr. dr.lling of CFr. ar. r.lated to macr.geometr.cal (diameter. D, and cylindr.city, DC) deviations. This paper.r.por.s on the r.sults of a study of the influence of the cutting par.meter. V (cutting speed) and f (feedr.te) on the D and DC deviations in the dr. dr.lling of CFr.. A par.icular.pr.cedur. based on plastic hole r.plicas has been per.or.ed. Diameter. deviations wer. acceptable in all the cases studied. Because of this, DC is the contr.lling factor.for.accepting the dr.lled holes. In the studied r.nge, lowest cutting speeds and highest feedr.tes have allowed obtaining the minimum cylindr.city deviation.

关键词： Dr. Dr.lling CFr. Macr.geometr.cal Deviations Cylindr.city Diameter

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Inter.lay between mesenchymal str.mal cells and the immune system after.tr.nsplantation: implications for.advanced cell ther.py in the r.tina

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Neur.l r.gener.tion r.sear.h 2024年第3期19卷 542-547页

作者： Mar.a Nor.e-Muñoz David Gar.ía-Ber.al Diego Gar.ía-Ayuso Manuel vidal-Sanz Mar.a Agudo-Bar.iuso Gr.po de Investigación Oftalmología Exper.mental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain Gr.po de Investigación Tr.splante Hematopoyético y Ter.pia celular Departamento de Bioquímica e Inmunología.Facultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain

Advanced mesenchymal str.mal cell-based ther.pies for.neur.degener.tive diseases ar. widely investigated in pr.clinical *** str.mal cells ar. well positioned as ther.peutics because they addr.ss the under.ying mechanisms of neur.degener.tion,namely tr.phic factor.depr.vation and *** studies have focused on the beneficial effects of mesenchymal str.mal cell tr.nsplantation on neur.nal sur.ival or.functional ***,little attention has been paid to the inter.ction between mesenchymal str.mal cells and the host immune system due to the immunomodulator. pr.per.ies of mesenchymal str.mal cells and the long-held belief of the immunopr.vileged status of the centr.l ner.ous ***,we r.view the cr.sstalk between mesenchymal str.mal cells and the immune system in gener.l and in the context of the centr.l ner.ous system,focusing on r.cent wor. in the r.tina and the impor.ance of the type of tr.nsplantation.

关键词： adaptive immunity cell ther.py centr.l ner.ous system immune system innate immunity mesenchymal str.mal cells neur.r.gener.tion pr.clinical studies r.tina tr.nsplantation

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Investigation of por. geometr. influence on fluid flow in heter.geneous por.us media:A por.-scale study

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Ener.y Geoscience 2024年第1期5卷 72-88页

作者： r.min Soltanmohammadi Shohr.h Ir.ji Tales r.dr.gues de Almeida Mateus Basso Eddy r.idiaz Munoz Alexandr. Campane vidal Ingr.m School of Engineer.ng Texas State UniversitySan MarcosTX78666USA Depar.ment of Mechanical Engineer.ng(FEM) State University of Campinas(UNICAMP)CampinasSP13083-855Brazil Depar.ment of Geology and Natur.l r.sour.es Geosciences Institute(IG)State University of Campinas(UNICAMP)CampinasSP13083-855Brazil Center.of Ener.y and Petr.leum Study(CEPETr.) State University of Campinas(UNICAMP)CampinasSP13083-855Brazil

Br.zilian pr.-salt r.ser.oir. ar. r.nowned for.their.intr.cate por. networ.s and vuggy natur.,posing significant challenges in modeling and simulating fluid flow within these car.onate *** possessing excellent petr.physical pr.per.ies,such as high por.sity and per.eability,these r.ser.oir. typically exhibit a notably low r.cover. factor.sometimes falling below 10%.Pr.vious r.sear.h has indicated that var.ous enhanced oil r.cover.(EOr.methods,such as water.alter.ating gas(WAG),can substantially augment the r.cover. factor.in pr.-salt r.ser.oir.,r.sulting in impr.vements of up to 20%.Never.heless,the fluid flow mechanism within Br.zilian car.onate r.ser.oir.,char.cter.zed by complex por. geometr.,r.mains *** study examines the behavior.of fluid flow in a similar.heter.geneous por.us mater.al,utilizing a plug sample obtained fr.m a vugular.segment of a Br.zilian str.matolite outcr.p,known to shar. analogies with cer.ain pr.-salt *** conducted single-phase and multi-phase cor. flooding exper.ments,complemented by medical-CT scanning,to gener.te flow str.amlines and evaluate the efficiency of water.***,micr.-CT scanning of the cor. sample was per.or.ed,and two cr.ss-sections fr.m hor.zontal and ver.ical plates wer. *** cr.ss-sections wer. then employed as geometr.es in a numer.cal simulator.enabling us to investigate the impact of por. geometr. on fluid *** of the por.-scale modeling and exper.mental data unveiled that the pr.sence of dead-end por.s and vugs r.sults in a significant por.ion of the fluid r.maining stagnant within these ***,the injected fluid exhibits channeling-like behavior.leading to r.pid br.akthr.ugh and low ar.al swept ***,the numer.cal simulation r.sults demonstr.ted that,ir.espective of the size of the dead-end r.gions,the pr.ssur. var.ation within the dead-end vugs and por.s is *** the str.matolite's favor.ble petr.physica

关键词： Por.-scale modeling Por. geometr. Flow str.amlines Computational modeling Digital r.ck analysis

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Taur.ne: a pr.mising nutr.ceutic in the pr.vention of r.tinal degener.tion

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Neur.l r.gener.tion r.sear.h 2024年第3期19卷 606-610页

作者： Diego Gar.ía-Ayuso Johnny Di Pier.omenico Ana Mar.ínez-Vacas Manuel vidal-Sanz Ser.e Picaud Mar.a PVillegas-Pér.z Gr.po de Investigación Oftalmología Exper.mental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaEspaña Sor.onne Univer.ité INSERMCNRSInstitut de la VisionParisFrance

Taur.ne is consider.d a non-essential amino acid because it is synthesized by most ***,dietar. intake of taur.ne may be necessar. to achieve the physiological levels r.quir.d for.the development,maintenance,and function of cer.ain *** may be especially impor.ant for.the *** concentr.tion of taur.ne in the r.tina is higher.than that in any other.tissue in the body and taur.ne deficiency causes r.tinal oxidative str.ss,apoptosis,and degener.tion of photor.ceptor. and r.tinal ganglion *** plasma taur.ne levels may also under.ie r.tinal degener.tion in humans and ther.for.,taur.ne administr.tion could exer. r.tinal neur.pr.tective *** has antioxidant,anti-apoptotic,immunomodulator.,and calcium homeostasis-r.gulator. *** r.view summar.zes the r.le of taur.ne in r.tinal health and disease,wher. it appear. that taur.ne may be a pr.mising nutr.ceutical.

关键词： amino acid anti-inflammator. antioxidant gamma-aminobutyr.c acid nutr.ceutical photor.ceptor.degener.tion r.tina r.tinitis pigmentosa taur.ne

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西班牙抗结核药物所致严重肝毒性反应

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结核与肺部疾病杂志 2005年第3期8卷 90-95页

作者： J. r. Tost r. vidal J. Cayla D. Diaz-Cabanela A. Jimenez J. M. Br.quetas 马玙 Hospital de Ter.assa Barcelona Departamento de Medicina Universidad Autonoma de Barcelona Barcelona Hospital Valle de Hebr.n Barcelona Agenda de Salut Publica de Bar.elona Barcelona CHU Juan Canalejo La Coruna Unitat de Malalties del Tor.x Dr.ssanes Barcelona Hospital del Mar Barcelona Spain Study Gr.up for.Sever. Hepatotoxicity due to Anti-tuber.ulosis Dr.gs in Spain

目的:判定抗结核药物引起的严重肝毒性反应的发生频率及发生急性肝功能衰竭或死亡的预报指标。方法﹕西班牙肺科学会成员对1997-2001年18家医院的资料进行回顾性研究。严重肝毒性反应界定为,无临床症状者转氨酶有10倍升高或胆汁郁滞参数... 详细信息

目的:判定抗结核药物引起的严重肝毒性反应的发生频率及发生急性肝功能衰竭或死亡的预报指标。方法﹕西班牙肺科学会成员对1997-2001年18家医院的资料进行回顾性研究。严重肝毒性反应界定为,无临床症状者转氨酶有10倍升高或胆汁郁滞参数3倍增加;有肝炎症状者则为肝功能参数增加或发生肝功能衰竭。采用logistic 回归分析计算比值比(Or.及其95%可信区间(CI)研究其预报因素。结果﹕3510 例中共有166 例发生肝毒性反应,其中90 例(2.56%)为活动性结核病治疗所致。11 例(10.3%)发生急性肝功能衰竭,其中3 例进行了肝移植。总体病死率为4.7%(5 例,其中3 例与饮酒或肝毒性药物有关)。预后不良的预报指标为总胆红素>2mg/dl(Or.9.4 , 95%CI : 1.0-85.5) 及血清肌肝>1.5mg/dl(Or.32.1,95%CI:2.4-424.6)。结论﹕抗结核药物引起的严重肝毒性反应死亡率较高。必须进行经常性的临床检查及临床实验室观察以预防其发生。

关键词：结核病异烟肼利福平吡嗪酰胺重症肝炎急性肝功能衰竭抗结核药物毒性反应西班牙 logistic回归分析药物所无临床症状预报因素活动性结核病

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Mindfulness tr.ining in medical education as a means to impr.ve r.silience,empathy,and mental health in the medical pr.fession

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Wor.d Jour.al of Psychiatr. 2024年第4期14卷 489-493页

作者： Edison Iglesias de Oliveir. vidal Luiz Fer.ando Alvar.nga r.beir. Mar.o Antonio de Car.alho-Filho Fer.anda Bono Fukushima Inter.al Medicine Depar.ment Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckebach Institute for.Education and Tr.ining LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands Asser.iva Mindfulness Botucatu 18603-970SPBrazil Sur.ical Specialties and Anesthesiology Depar.ment Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high r.tes of depr.ssion,bur.out,and incr.ased r.sk of suicide among medical students,r.sidents,and physicians in compar.son with other.car.er. signal a mental health cr.sis within our.*** contend that this cr.sis coupled with the inadequate acquisition of inter.er.onal skills dur.ng medical education r.sults fr.m the inter.ction between a challenging envir.nment and the mental capital of ***,we posit that mindfulness-based pr.ctices ar. instr.mental for.the development of major.components of mental capital,such as r.silience,flexibility of mind,and lear.ing skills,while also ser.ing as a pathway to enhance empathy,compassion,self-awar.ness,conflict r.solution,and r.lational ***,the evidence base suppor.ing the effectiveness of mindfulness-based inter.entions has been incr.asing over.the year.,and a gr.wing number.of medical schools have alr.ady integr.ted mindfulness into their.*** we acknowledge that mindfulness is not a panacea for.all educational and mental health pr.blems in this field,we ar.ue that ther. is cur.ently an unpr.cedented oppor.unity to gather.momentum,spr.ad and study mindfulness-based pr.gr.ms in medical schools ar.und the wor.d as a way to addr.ss some longstanding shor.comings of the medical pr.fession and the health and educational systems upon which it is r.oted.

关键词： Mindfulness Medical education Mental capital Mental health Medical students r.silience

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Tailings Dam Mining, Theor.tical Consider.tions, and Cir.ular.Economy: A r.view

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Jour.al of Geoscience and Envir.nment Pr.tection 2024年第9期12卷 77-92页

作者： Eduar.o da r.sa Aquino vidal Félix Navar.o Tor.es Ir.yn Laur.nce Paniz Instituto Tecnolgico Vale - Miner.o Ouro Preto Brazil

Mining in tailings dams has emer.ed as a str.tegic alter.ative for.mining companies for.both economic and envir.nmental r.asons. Owing to technological limitations in r.cent decades, many of these dams have high metal contents, emphasizing the need to evaluate the quality of these r.sidues, especially consider.ng the technological advancements in cur.ent concentr.tion plants. An economic viability analysis associated with r.using these mater.als is cr.cial. Fr.m an envir.nmental point of view, impr.ving mining techniques for.dams by consider.ng both safety and feasibility is an advantageous option in decommissioning pr.cesses and alignment in the cir.ular.economy. In this context, r.pr.senting these tailings in ter.s of gr.de quality and gr.nulometr., as well as the associated contaminants, is essential. Geostatistical estimation and simulation methods ar. valuable tools for.modeling tailings bodies, but they r.quir. a r.liable sampling campaign to ensur. acceptably low er.or.. Fr.m an oper.tional per.pective, tailings r.cover. can be conducted via dr. methods, such as mechanical excavation, or.hydr.ulic methods, such as dr.dging or.hydr.ulic blasting. Dr.dging is a commonly used method, and cutter.suction dr.dger., which r.quir. pumping to tr.nspor. fr.gmented mater.al, ar. the most commonly used tools. In this paper. some pr.ctical applications of geostatistical methods for.r.sour.e quantification in tailings dams will be discussed. Additionally, the main mining methods for.tailings r.cover. in dams will be pr.sented. Emphasis will be given to the dr.dging method, along with the key analysis par.meter. for.sizing dr.dger., pumps, and pipelines.

关键词： Mining in Tailings Dams Geostatistical Methods Gr.de Quality Dr.dging

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Debar.omyces hansenii supplementation in low fish meal diets pr.motes gr.wth,modulates micr.biota and enhances intestinal condition in juvenile mar.ne fish

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Jour.al of Animal Science and Biotechnology 2024年第1期15卷 253-276页

作者： Ignasi Sanahuja Alber.o r.iz Joana P.Fir.ino Felipe E.r.yes-López Juan B.Or.iz-Delgado Eva Vallejos-vidal Lluis Tor. Dar.el Tovar.r.mír.z Isabel M.Cer.zo Miguel A.Mor.ñigo Car.en Sar.squete Enr.c Gisber. Aquacultur. Pr.gr.m Institute of Agrifood Research and Technology(IRTA)La Rapita 43540Spain Centr. de Biotecnologia Acuicola Universidad de Santiago de ChileSantiagoChile Instituto de Ciencias Mar.nas de Andalucia(ICMAN-CSIC) Avda.Republica Saharaui no 2Campus Universitario Rio San PedroPuerto RealCadiz 11510Spain Nucleo de Investigaciones Aplicadas en Ciencias Veter.nar.as y Agr.nomicas Facultad de Medicina Veterinaria y AgronomiaUniversidad de Las AmericasSantiagoChile Depar.ment of Cell Biology Physiologyand ImmunologyUniversitat Autonoma de BarcelonaBarcelonaSpain Centr. de Investigaciones Biologicas del Nor.este SC CIBNORLa PazMexico Depar.ment of Micr.biology Instituto de Biotecnologia Y Desarrollo Azul(IBYDA)Faculty of SciencesUniversity of Malaga29010 MalagaSpain SCBI Bioinformatic UnitUniversity of Malaga29590 MalagaSpain

Backgr.und The development of a sustainable business model with social acceptance,makes necessar. to develop new str.tegies to guar.ntee the gr.wth,health,and well-being of far.ed *** hansenii is a yeast species that can be used as a pr.biotic in aquacultur. due to its capacity to i)pr.mote cell pr.lifer.tion and differ.n-tiation,ii)have immunostimulator. effects,iii)modulate gut micr.biota,and/or.iv)enhance the digestive *** pr.vide inside into the effects of *** on juveniles of gilthead seabr.am(Spar.s aur.ta)condition,we inte-gr.ted the evaluation of the main key per.or.ance indicator. coupled with the integr.tive analysis of the intestine condition,thr.ugh histological and micr.biota state,and its tr.nscr.ptomic *** After.70 days of a nutr.tional tr.al in which a diet with low levels of fishmeal(7%)was supplemented with 1.1%of ***(17.2×10^(5) CFU),an incr.ase of ca.12%in somatic gr.wth was obser.ed together.with an impr.ve-ment in feed conver.ion in fish fed a yeast-supplemented *** ter.s of intestinal condition,this pr.biotic modu-lated gut micr.biota without affecting the intestine cell or.anization,wher.as an incr.ase in the staining intensity of mucins r.ch in car.oxylated and weakly sulphated glycoconjugates coupled with changes in the affinity for.cer.ain lectins wer. noted in goblet *** in micr.biota wer. char.cter.zed by the r.duction in abundance of sever.l gr.ups of Pr.teobacter.a,especially those char.cter.zed as oppor.unistic *** micr.ar.ays-based tr.nscr.p-tomic analysis found 232 differ.ntial expr.ssed genes in the anter.or.mid intestine of ***,that wer. mostly r.lated to metabolic,antioxidant,immune,and symbiotic *** Dietar. administr.tion of *** enhanced somatic gr.wth and impr.ved feed efficiency par.m-eter.,r.sults that wer. coupled to an impr.vement of intestinal condition as histochemical and tr.nscr.ptomic tools *** pr.biotic ye

关键词： Debar.omyces hansenii Intestine condition Low fish meal diet Micr.biota Tr.nscr.ptomics Yeast pr.biotic

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Multi-tissue tr.nscr.ptomics of a unique monozygotic discor.ant twin case of sever. pr.gr.ssive osseous heter.plasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alber.o Gomez-Car.alla Mar.a Jose Cur.as-Tuala Sar. Pischedda Mir.am Cebey-Lopez Jose Gomez-r.al Ir.ne r.ver.-Cale Jacobo Par.o-seco Xabier.Bello Sandr. Viz-Lasher.s Antonio Justicia-Gr.nde Julian Montoto-Louzao Alba Camino-Mer. Isabel Fer.eir.s-vidal Maximo Fr.ga Jose r.ntunez r.dolfo Gomez Feder.co Mar.inon-Tor.es Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Tr.nslational Pediatr.cs and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Labor.tor.o de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Gr.up Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Depar.ment of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centr. de Investigacion Biomedica en r.d de Enfer.edades r.spir.tor.as(CIBEr.ES) MadridSpain

Pr.gr.ssive osseous heter.plasia(POH)is an ultr.-r.r. autosomal dominant disabling disor.er.char.cter.zed by heter.topic ossification(HO).It is caused by heter.zygous inactivating mutations in the GNAS(guanine nucleotide-binding pr.tein alpha-stimulating activity polypeptide)***,the molecular.mechanisms under.ying HO r.main poor.y *** a tr.atment for.POH is not yet available,the identification of the mechanisms dr.ving POH in affected tissues using gene expr.ssion may be of gr.at help to under.stand the molecular.basis of POH and develop new ther.peutic appr.aches.

关键词： stimulating dr.ving asi

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