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Mater.als Sciences and Applications 2013年第11期4卷 739-745页

作者： Jor.e Luis r.sas-Mendoza L. Per.z-Ar.ieta Miguel Aguilar.Fr.tis Cir. Falcony r. vázquez-arreguín Alejandr. Miguel r.sas-Mendoza Centr. de Investigación en Ciencia Aplicada y Tecnología Avanzada Instituto Politécnico Nacional México D.F. México Centr. de Investigación en Ciencia Aplicada y Tecnología Avanzada Instituto Politécnico Nacional México D.F. México Unidad Pr.fesional Inter.isciplinar.a de Biotecnología Instituto Politécnico Nacional México D.F. México Depar.amento de Física Centro de Investigación de Estudios Avanzados (CINVESTAV-IPN) México D.F. México Unidad Académica de Física Universidad Autónoma de Zacatecas (UAZ) Zacatecas México

A study of the phase tr.nsitions in super.onducting thin films of the Thallium-Bar.um-Calcium-Copper.(TBCCO) system is car.ied out. In par.icular. it was got the Tl-1223 phase. For.this pur.ose, and using the ultr.sonic spr.y pyr.lysis technique, Bar.um-Calcium-Copper.pr.cur.or.films wer. fir.t obtained. Upon deposition of the pr.cur.or.films, and as a second step, they wer. thallium (Tl) diffused in the one-zone fur.ace at 860°C. This methodology r.sulted in super.onducting films that showed a phase tr.nsition as follows: Tl-2223 → Tl-2223 + Tl-2212 → Tl-2212 → Tl-1223, achieved between 2 and 7 hour. of thallium diffusion. The evidence of the phase tr.nsitions was cor.obor.ted by the exper.mental r.sults of X-r.y diffr.ction, ener.y disper.ive spectr.scopy and r.sistance-temper.tur. measur.ments.

关键词： Super.onductor. Thin Films Ultr.sonic Spr.y Pyr.lysis

Dendr.tic spine degener.tion:a pr.mar. mechanism in the aging pr.cess

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neur.l r.gener.tion r.sear.h 2025年第6期20卷 1696-1698页

作者： Gonzalo Flor.s Leonar.o Aguilar.Her.ández Fer.ado Gar.ía-Dolor.s Humber.o nicolini Andr.a Judith vázquez-Her.ández Hir.m Tendilla-Beltr.n Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias For.nses(InCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto nacional de Medicina Genómica(InMEGEn) Mexico CityMexico

r.cent r.por.s suggest that aging is not solely a physiological pr.cess in living beings;instead, it should be consider.d a pathological pr.cess or.disease(Amor.m et al., 2022). Consequently, this pr.cess involves a wide r.nge of factor., spanning fr.m genetic to envir.nmental factor., and even includes the gut micr.biome(GM)(Mayer.et al., 2022). All these pr.cesses coincide at some point in the inflammator. pr.cess, oxidative str.ss, and apoptosis, at differ.nt degr.es in var.ous or.ans and systems that constitute a living or.anism(Mayer.et al., 2022;Aguilar.er.ández et al., 2023).

关键词： aging pr.cess str.ss

A compr.hensive investigation on nonlinear.vibr.tion and bending char.cter.stics of bio-inspir.d helicoidal laminated composite str.ctur.s

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUr.BH r.KIr.n D.SInGH r.vAISH v.S.CHAUHAn School of Mechanical and Mater.als Engineer.ng Indian Institute of Technology Mandi

Bio-inspir.d helicoidal composite laminates, inspir.d by the intr.cate helical str.ctur.s found in natur., pr.sent a pr.mising fr.ntier.for.enhancing the mechanical pr.per.ies of str.ctur.l designs. Hence, this study pr.vides a compr.hensive investigation into the nonlinear.fr.e vibr.tion and nonlinear.bending behavior.of bio-inspir.d composite plates. The inver.e hyper.olic shear.defor.ation theor.(IHSDT) of plates is employed to char.cter.ze the displacement field, with the incor.or.tion of Gr.en-Lagr.nge nonlinear.ty. The pr.blem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB envir.nment to solve it numer.cally. var.ous helicoidal layup configur.tions including helicoidal r.cur.ive(Hr., helicoidal exponential(HE), helicoidal semi-cir.ular.HS), linear.helicoidal(LH), and Fibonacci helicoidal(FH)with differ.nt layup sequences and quasi-isotr.pic configur.tions ar. studied. The model is validated, and par.metr.c studies ar. conducted. These studies investigate the effects of layup configur.tions, side-to-thickness r.tio, modulus r.tios, boundar. conditions, and loading conditions at differ.nt load amplitudes on the nonlinear.vibr.tion and nonlinear.bending behavior. of bio-inspir.d composite plates. The r.sults show that the laminate sequence exer.s a substantial impact on both nonlinear.natur.l fr.quencies and nonlinear.bending behavior.. Mor.over. this influence var.es acr.ss differ.nt side-to-thickness r.tios and boundar. conditions of the bio-inspir.d composite plate.

关键词： Inver.e pr.blems

Diabetic per.pher.l neur.pathy and neur.modulation techniques:a systematic r.view of pr.gr.ss and pr.spects

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neur.l r.gener.tion r.sear.h 2025年第8期20卷 2218-2230页

作者： r.hul Mittal Keelin McKenna Gr.nt Keith Evan McKenna Joana r.n.Lemos Jeenu Mittal Khemr.j Hir.ni Diabetes r.sear.h Institute University of Miami Miller School of MedicineMiamiFLUSA Depar.ment of Otolar.ngology University of Miami Miller School of MedicineMiamiFLUSA Her.er. Wer.heim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

neur.modulation for.diabetic per.pher.l neur.pathy r.pr.sents a significant ar.a of inter.st in the management of chr.nic pain associated with this *** per.pher.l neur.pathy,a common complication of diabetes,is char.cter.zed by ner.e damage due to high blood sugar.levels that lead to symptoms,such as pain,tingling,and numbness,pr.mar.ly in the hands and *** aim of this systematic r.view was to evaluate the efficacy of neur.modulator. techniques as potential ther.peutic inter.entions for.patients with diabetic per.pher.l neur.pathy,while also examining r.cent developments in this *** investigation encompassed an ar.ay of neur.modulation methods,including fr.quency r.ythmic electr.cal modulated systems,dor.al r.ot ganglion stimulation,and spinal cor. *** systematic r.view suggests that neur.modulator. techniques may be useful in the tr.atment of diabetic per.pher.l *** the advantages of these tr.atments will enable physicians and other.healthcar. pr.vider. to offer.additional options for.patients with symptoms r.fr.ctor. to standar. phar.acologic *** these effor.s,we may impr.ve quality of life and incr.ase functional capacity in patients suffer.ng fr.m complications r.lated to diabetic neur.pathy.

关键词： diabetes mellitus diabetic per.pher.l neur.pathy neur.modulation neur.stimulation ther.py non-phar.acological tr.atment pain management

Effect of Br.athwalk on body composition,metabolic and mood state in chr.nic hepatitis C patients with insulin r.sistance syndr.me

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Wor.d Jour.al of Gastr.enter.logy 2007年第46期13卷 6213-6218页

作者： M vázquez-vandyck S r.man JL vázquez L Huacuja G Khalsa r.Tr.yo-Sanr.mán A Pandur. Molecular.Biology in Medicine Civil Hospital of GuadalajaraFray Antonio AlcaldeGuadalaiara JaliscoMéxico Health Sciences University CenterUniversity of GuadalajaraGuadalajara JaliscoMéxico Epidemiology Depar.ment Regional General Hospital No.110Mexican Institute of Social Security and Public Health DepartmentUniversity of GuadalajaraGuadalajara JaliscoMéxico Chr.nic Degener.tive Diseases Institute Health Sciences University CenterUniversity of GuadalajaraGuadalajara JaliscoMéxico Kundalini r.sear.h Institute Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States r.sear.h Unit Health Sciences University CenterUniversity of GuadalajaraGuadalajara JaliscoMéxico

AIM： To identify the anthr.pometr.c, metabolic and mood state in hepatitis C vir.s （HCv）-infected patients fr.m the west of Mexico and to evaluate the effect of 13r.athwalk （13W）, a combination of walking, synchr.nized br.athing and focussed attention, on those patients. METHODS： In an exper.mental study, 17 patients with ser.logical and molecular.diagnosis of HCv, not r.ceiving phar.acological tr.atment, wer. studied. One hour.sessions of 13W wer. pr.cticed 3 times at week for.six months. Body composition was assessed by electr.c impedance. Biochemical pr.files and insulin r.sistance （Ir. r.sk was assessed by conventional methods. Mood state was evaluated with specific and open questions at the beginning and at the end of the pr.gr.m. r.SULTS： Seventy per.ent of patients wer. over.eight or.obese, and 77% of the patients pr.sented with Ir.at the beginning of the study. Impr.vements wer. obser.ed at the 3^r. mo, and statistically significant differ.nces wer. r.cor.ed at the 6^th mo using the fitness scor. （76 vs 83, P 〈 0.01）, in alanine aminotr.nsfer.se （ALT）（106±93 U/L vs 59 ± 32 U/L, P 〈 0.01）, total bilir.bin （0.09 ± 1 mg/dL vs 0.62 ± 0.2 mg/dL, P 〈 0.01）, ALT/ AST r.tio （1.04 vs 0.70, P 〈 0.01）, tr.glycer.des （165 ± 86 mg/dL vs 124 ± 49 mg/dL, P 〈 0.01） and the Ir.r.sk （4.0 vs 2.7）. Most patients （88%） indicated to feel better.at the end of BW （P 〈 0.01）.COnCLUSIOn： Br.athwalk has an impor.ant effect on body composition, lipid pr.file and liver.enzymes. It is also easy, inexpensive and has a beneficial effect on metabolic and mood state in HCv patients.

关键词： Br.athwalk Chr.nic hepatitis C Insulinr.sistance Obesity Quality of life

Semantic Segmentation of Lumbar.ver.ebr.e Using Meijer.ng U-net(MU-net)on Spine Magnetic r.sonance Images

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Computer.Modeling in Engineer.ng & Sciences 2025年第1期142卷 733-757页

作者： Lakshmi S v v Shiloah Elizabeth Dar.anayagam Sunil r.tmin r.j Cyr.l Depar.ment of Computer.Science and Engineer.ng College of Engineering GuindyAnna UniversityChennai600025India Depar.ment of Infor.ation Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower.back pain is one of the most common medical pr.blems in the wor.d and it is exper.enced by a huge per.entage of people *** to its ability to pr.duce a detailed view of the soft tissues,including the spinal cor.,ner.es,inter.er.ebr.l discs,and ver.ebr.e,Magnetic r.sonance Imaging is thought to be the most effective method for.imaging the *** semantic segmentation of ver.ebr.e plays a major.r.le in the diagnostic pr.cess of lumbar.*** is difficult to semantically par.ition the ver.ebr.e in Magnetic r.sonance Images fr.m the sur.ounding var.ety of tissues,including muscles,ligaments,and inter.er.ebr.l discs.U-net is a power.ul deep-lear.ing ar.hitectur. to handle the challenges of medical image analysis tasks and achieves high segmentation *** wor. pr.poses a modified U-net ar.hitectur. namely MU-net,consisting of the Meijer.ng convolutional layer.that incor.or.tes the Meijer.ng filter.to per.or. the semantic segmentation of lumbar.ver.ebr.e L1 to L5 and sacr.l ver.ebr. ***-colour.mask images wer. gener.ted and used as gr.und tr.th for.tr.ining the *** wor. has been car.ied out on 1312 images expanded fr.m T1-weighted mid-sagittal Mr. images of 515 patients in the Lumbar.Spine Mr. Dataset publicly available fr.m Mendeley *** pr.posed MU-net model for.the semantic segmentation of the lumbar.ver.ebr.e gives better.per.or.ance with 98.79%of pixel accur.cy(PA),98.66%of dice similar.ty coefficient(DSC),97.36%of Jaccar. coefficient,and 92.55%mean Inter.ection over.Union(mean IoU)metr.cs using the mentioned dataset.

关键词： Computer.aided diagnosis(CAD) magnetic r.sonance imaging(Mr.) semantic segmentation lumbar.ver.ebr.e deep lear.ing U-net model

Autism spectr.m disor.er.difficulties in diagnosis and micr.r.A biomar.er.

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neur.l r.gener.tion r.sear.h 2025年第10期20卷 2776-2786页

作者： Br.dget Mar.inez Philip v.Peplow Depar.ment of Phar.acology University of Nevada-RenoRenoNVUSA Depar.ment of Medicine University of Nevada-RenoRenoNVUSA Depar.ment of Anatomy University of OtagoDunedinNew Zealand

We per.or.ed a PubMed sear.h for.micr.r.As in autism spectr.m disor.er.that could ser.e as diagnostic biomar.er. in patients and selected 17 ar.icles published fr.m Januar. 2008 to December.2023,of which 4 studies wer. per.or.ed with whole blood,4 with blood plasma,5 with blood ser.m,1 with ser.m neur.l cell adhesion molecule L1-captur.d extr.cellular.vesicles,1 with blood cells,and 2 with per.pher.l blood mononuclear.*** of the studies involved childr.n and the study cohor.s wer. lar.ely *** of the studies had per.or.ed micr.r.A sequencing or.quantitative polymer.se chain r.action assays to measur. micr.r.A *** five studies had used r.al-time polymer.se chain r.action assay to validate micr.r.A expr.ssion in autism spectr.m disor.er.subjects compar.d to *** micr.r.As that wer. validated in these studies may be consider.d as potential candidate biomar.er. for.autism spectr.m disor.er.and include mir.500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and mir.151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood ser.m of childr.n,and mir.15b-5p and-6126 in whole blood of *** impor.ant limitations wer. identified in the studies r.viewed,and need to be taken into account in futur. *** studies ar. war.anted with childr.n and adults having differ.nt levels of autism spectr.m disor.er.sever.ty and consider.tion should be given to using animal models of autism spectr.m disor.er.to investigate the effects of suppr.ssing or.over.xpr.ssing specific micr.r.As as a novel ther.py.

关键词： autism spectr.m disor.er biomar.er blood cells blood plasma blood ser.m diagnosis micr.r.A per.pher.l blood mononuclear.cells ser.m neur.l cell adhesion molecule L1-captur.d extr.cellular.vesicles whole blood

Micr.r.As as potential diagnostic biomar.er. for.bipolar.disor.er

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neur.l r.gener.tion r.sear.h 2025年第6期20卷 1681-1695页

Abnor.al expr.ssion of micr.r.As is connected to br.in development and disease and could pr.vide novel biomar.er. for.the diagnosis and pr.gnosis of bipolar.disor.er. We per.or.ed a PubMed sear.h for.micr.r.A biomar.er. in bipolar.disor.er.and found 18 or.ginal r.sear.h ar.icles on studies per.or.ed with human patients and published fr.m Januar. 2011 to June 2023. These studies included micr.r.A pr.filing in bloodand br.in-based mater.als. Fr.m the studies that had validated the pr.liminar. findings,potential candidate biomar.er. for.bipolar.disor.er.in adults could be mir.140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, mir.19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and mir.7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood ser.m. Two of the studies had investigated the changes in micr.r.A expr.ssion of patients with bipolar.disor.er.r.ceiving tr.atment. One showed a significant incr.ase in plasma mir.134 compar.d to baseline after.4 weeks of tr.atment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other.study had assessed the effects of pr.scr.bed medications which included neur.tr.nsmitter.r.ceptor.ite binder.(dr.g class B) and sedatives, hypnotics, anticonvulsants, and analgesics(dr.g class C) on micr.r.A r.sults. The combined effects of the two dr.g classes incr.ased the significance of the r.sults for.mir.219 and-29c with mir.30e-3p and-526b* acquir.ng significance. Micr.r.As wer. tested to see if they could ser.e as biomar.er. of bipolar.disor.er.at differ.nt clinical states of mania, depr.ssion, and euthymia. One study showed that upr.gulation in whole blood of mir.9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of mir.107,-125a-3p occur.ed in manic and euthymic patients compar.d to contr.ls, r.spectively, and that upr.gulation of mir.106a-5p,-107 was found for.manic compar.d to euthymic patients. In two other.studies using blood plasma,downr.gulation of mir.134 was obser.ed i

关键词： biomar.er bipolar.disor.er blood leukocytes blood plasma blood plasma extr.cellular.vesicles/exosomes blood ser.m br.in tissue br.in tissue extr.cellular.vesicles/exosomes lymphoblastoid cell lines micr.r.A neur.l pr.genitor.cells whole blood

Micr.r.As as potential biomar.er. for.diagnosis of post-tr.umatic str.ss disor.er

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neur.l r.gener.tion r.sear.h 2025年第7期20卷 1957-1970页

Post-tr.umatic str.ss disor.er.is a mental disor.er.caused by exposur. to sever. tr.umatic life ***,ther. ar. no validated biomar.er. or.labor.tor. tests that can distinguish between tr.uma sur.ivor. with and without post-tr.umatic str.ss *** addition,the heter.geneity of clinical pr.sentations of post-tr.umatic str.ss disor.er.and the over.ap of symptoms with other.conditions can lead to misdiagnosis and inappr.pr.ate *** suggests that this condition is a multisystem disor.er.that affects many biological systems,r.ising the possibility that per.pher.l mar.er. of disease may be used to diagnose post-tr.umatic str.ss *** per.or.ed a PubMed sear.h for.micr.r.As(mir.As)in post-tr.umatic str.ss disor.er.PTSD)that could ser.e as diagnostic biomar.er. and found 18 or.ginal r.sear.h ar.icles on studies per.or.ed with human patients and published Januar. 2012 to December.*** included four.studies with whole blood,seven with per.pher.l blood mononuclear.cells,four.with plasma extr.cellular.vesicles/exosomes,and one with ser.m *** of these studies had also used whole *** studies wer. excluded as they did not involve micr.r.A *** of the studies had collected samples fr.m adult male veter.ns who had r.tur.ed fr.m deployment and been exposed to combat,and only two wer. fr.m r.cently tr.umatized adult *** measur.ng mir.A expr.ssion levels,many of the studies had used micr.ar.ay mir.A analysis,mir.A Seq analysis,or.nanoStr.ng *** six studies had used r.al time polymer.se chain r.action assay to deter.ine/validate mir.A expr.ssion in PTSD subjects compar.d to *** mir.As that wer. found/validated in these studies may be consider.d as potential candidate biomar.er. for.PTSD and include mir.3130-5p in whole blood;mir.193a-5p,-7113-5p,-125a,-181c,and-671-5p in per.pher.l blood mononuclear.cells;mir.10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extr.cellular.vesicles/

关键词： biomar.er diagnosis micr.r.A per.pher.l blood mononuclear.cells plasma extr.cellular.vesicles/exosomes post-tr.umatic str.ss disor.er ser.m exosomes whole blood whole plasma

An SPH Fr.mewor. for.Ear.hquake-Induced Liquefaction Hazar. Assessment of Geotechnical Str.ctur.s

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Computer.Modeling in Engineer.ng & Sciences 2025年第1期142卷 251-277页

作者： Sour.bh Mhaski G.v.r.mana Depar.ment of Civil Engineer.ng Indian Institute of Technology DelhiNew Delhi110016India

Ear.hquake-induced soil liquefaction poses significant r.sks to the stability of geotechnical str.ctur.s *** under.tanding of the liquefaction tr.gger.ng,and the post-failur. lar.e defor.ation behaviour.is essential for.designing r.silient *** pr.sent study develops a Smoothed Par.icle Hydr.dynamics(SPH)fr.mewor. for.ear.hquake-induced liquefaction hazar. assessment of geotechnical *** coupled flowdefor.ation behaviour.of soils subjected to cyclic loading is descr.bed using the PM4Sand model implemented in a thr.e-phase,single-layer.SPH fr.mewor..A stagger.d discr.tisation scheme based on the str.ss par.icle SPH appr.ach is adopted to minimise numer.cal inaccur.cies caused by zer.-ener.y modes and tensile ***,non-r.flecting boundar. conditions for.seismic analysis of semi-infinite soil domains using the SPH method ar. *** numer.cal fr.mewor. is employed for.the analysis of cyclic dir.ct simple shear.test,seismic analysis of a level gr.und site,and liquefaction-induced failur. of the Lower.San Fer.ando *** agr.ement for.liquefaction tr.gger.ng and post-failur. behaviour.demonstr.tes that the SPH fr.mewor. can be utilised to assess the effect of seismic loading on field-scale geotechnical *** pr.sent study also ser.es as the basis for.futur. advancements of the SPH method for.applications r.lated to ear.hquake geotechnical engineer.ng.

关键词： Ear.hquake seismic liquefaction str.ss par.icle PM4Sand smoothed par.icle hydr.dynamics(SPH)