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Molecular.insights into clinical tr.als for.immune checkpoint inhibitor. in color.ctal cancer.Unr.velling challenges and futur. dir.ctions

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Wor.d Jour.al of Gastr.enter.logy 2024年第13期30卷 1815-1835页

作者： Samantha Shar.a Nar.sh Singh Anita Ahmed turk Isabella Wan Akshay Guttikonda Julia Lily Dong Xinna Zhang Mateusz Opyr.hal Depar.ment of Medical and Molecular.Genetics Indiana University School of MedicineIndianapolisIN 46202United States Division of Hematology/Oncology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202United States Melvin and Br.n Simon Compr.hensive Cancer.Center Indiana University School of MedicineIndianapolisIN 46202United States

Color.ctal cancer.Cr.)is a complex disease with diver.e etiologies and clinical *** consider.ble pr.gr.ss in development of Cr. ther.peutics,challenges r.main r.gar.ing the diagnosis and management of advanced stage metastatic Cr.(mCr.).In par.icular.the five-year.sur.ival r.te is ver. low since mCr. is cur.ently r.r.ly *** the past decade,cancer.tr.atment has significantly impr.ved with the intr.duction of cancer.immunother.pies,specifically immune checkpoint *** aimed at blocking immune checkpoints such as PD-1,PD-L1,and CTLA-4 tar.et inhibitor. pathways of the immune system,and ther.by enhance anti-tumor.*** ther.pies thus have shown pr.mising r.sults in many clinical tr.als alone or.in *** efficacy and safety of immunother.py,either.alone or.in combination with Cr.,have been investigated in sever.l clinical *** tr.als,including KEYNOTE-164 and CheckMate 142,have led to Food and Dr.g Administr.tion appr.val of the PD-1 inhibitor. pembr.lizumab and nivolumab,r.spectively,for.the tr.atment of patients with unr.sectable or.metastatic micr.satellite instability-high or.deficient mismatch r.pair.***,these dr.gs benefit only a small per.entage of patients,with the benefits of immunother.py r.maining elusive for.the vast major.ty of Cr. *** this end,pr.mar. and secondar. r.sistance to immunother.py r.mains a significant issue,and fur.her.r.sear.h is necessar. to optimize the use of immunother.py in Cr. and identify biomar.er. to pr.dict the *** r.view pr.vides a compr.hensive over.iew of the clinical tr.als involving immune checkpoint inhibitor. in *** under.ying r.tionale,challenges faced,and potential futur. steps to impr.ve the pr.gnosis and enhance the likelihood of successful tr.als in this field ar. discussed.

关键词： Color.ctal cancer Immune checkpoint inhibitor. Clinical tr.als Immunother.py Micr.satellite instability Micr.satellite stability DNA mismatch r.pair

Deep neck infections mor.al complications:Intr.thor.cic complications and necr.tising fasciitis

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Wor.d Jour.al of Clinical Cases 2024年第30期12卷 6383-6390页

作者： Kemal Kor.y Bal Can Aslan Har.n Gür.Seda turk Bal r.cep Okan Ustun Mur.t Unal Depar.ment of Otor.inolar.ngology Mersin UniversityMersin 33160Türkiye Depar.ment of Emer.ency Medicine Tarsus State HospitalMersin 33460Türkiye Depar.ment of Aestetic Division of Plastic and Reconstructive SurgeryUniversity of Health Sciences Mersin City HospitalMersin 33230Türkiye

BACKGr.UND We planned this study consider.ng that complications of deep neck infections can be ser.ously life *** To r.ise awar.ness that intr.thor.cic complications and necr.tizing fasciitis ar. causes of ser.ous mor.ality and *** This study was car.ied out with the par.icipation of 188 patients who wer. tr.ated at Mer.in Univer.ity Depar.ment of Otor.inolar.ngology and Head and Neck Sur.er. at Januar. 1,*** the patient files wer. r.tr.spectively examined,16 of 188 patients(8.5%)wer. included in the study because they wer. obser.ed to have necr.tizing fasciitis and/or.intr.thor.cic *** Ther. wer. a total of 16 patients in this study,9 males(56.25%)and 7 females(43.75%).All patients wer. adults(>18 year.)and the mean age was 50.37 year.±15.37 *** patients had a mean age of 40.42 year.±13.38 year.,wher.as for.male patients was 58.11 year.±12.44 *** Patients with necr.tizing fasciitis and/or.intr.thor.cic complications r.quir. mor. complicated and ser.ous sur.er.es,intensive car. unit monitor.ng,and mechanical ventilator.*** r.tes of mor.idity and mor.ality should be expected in Bal KK et *** neck infections mor.al complications WJCC https://*** 6384 October.26,2024 Volume 12 Issue 30 these patients who ar. hospitalized for.longer.per.ods of time.

关键词： Deep neck infection Necr.tising fasciitis Mediastinitis Complications Mor.ality

Metabolic syndr.me and the ur.nar. micr.biome of patients under.oing per.utaneous nephr.lithotomy

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Asian Jour.al of Ur.logy 2024年第2期11卷 316-323页

作者： r.an A.Dor.bier.Chir.g P.Doshi Shalin C.Desai Petar.Bajic Michelle Van Kuiken Mar. Khemmani Ahmer.V.Far.oq Lar.ssa Br.sler.Thomas M.T.turk Alan J.Wolfe Kr.stin G.Baldea Loyola Univer.ity Medical Center Department of UrologyMaywoodILUSA Loyola Univer.ity Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify possible stone-pr.moting micr.bes,we compar.d the pr.files of micr.bes gr.wn fr.m stones of patients with and without metabolic syndr.me(MetS).The association between MetS and ur.nar. stone disease is well established,but the exact pathophysiologic r.lationship r.mains *** evidence suggests ur.nar. tr.ct dysbiosis may lead to incr.ased nephr.lithiasis ***:At the time of per.utaneous nephr.lithotomy,bladder.ur.ne and stone fr.gments wer. collected fr.m patients with and without *** sample types wer. subjected to expanded quantitative ur.ne cultur.(EQUC)and 16 S r.bosomal r.A gene ***:Fifty-seven patients included 12 contr.ls(21.1%)and 45 MetS patients(78.9%).Both cohor.s wer. similar.with r.spect to demogr.phics and non-MetS *** contr.ls had ur.c acid stone *** EQUC,bacter.a wer. detected mor. fr.quently in MetS stones(42.2%)compar.d to contr.ls(8.3%)(p=0.041).Bacter.a also wer. mor. abundant in stones of MetS patients compar.d to *** validate our.EQUC r.sults,we per.or.ed 16 S r.bosomal r.A gene *** 12/16(75.0%)sequence-positive stones,EQUC r.liably isolated at least one species of the sequenced *** wer. detected in both“infectious”and“non-infectious”stone ***:Bacter.a ar. mor. common and mor. abundant in MetS stones than contr.l *** findings suppor. a r.le for.bacter.a in ur.nar. stone disease for.patients with MetS r.gar.less of stone composition.

关键词： Nephr.lithiasis Ur.lithiasis Metabolic syndr.me Ur.nar. micr.biome Per.utaneous nephr.lithotomy

Last Inter.lacial-Glacial Cycle and an Attempt to r.constr.ct Wür.ian Paleohumidity of the Eur.pean Alps

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Jour.al of Mountain Science 2012年第3期9卷 322-330页

作者： Janez turk Kar.t r.sear.h Institute Zr. SAZU Postojna 6230 Slovenia

A lot of paleoenvir.nmental sur.eys have been car.ied out in the Alpine r.gion to elucidate glacier.extension dur.ng the Last Glacial or.the Wür.ian (115 - 12 ka BP). However. the evidence of past glaciations differ. gr.atly between Wester. and Easter. Alps, while contr.st between Souther. and Nor.her. Alps is not evident. The main pur.ose of this paper.is to inter.r.t var.ability of humidity dur.ng the last inter.lacial-glacial cycle in the Alpine r.gion, based on r.sults of var.ous sur.eys per.or.ed in the Alpine r.gion. r.sults show that distr.bution of moistur. thr.ughout the Alps was most even dur.ng the Late Wür.ian, while pr.cipitation was mainly concentr.ted in the (Nor.h)Wester. Alps dur.ng the Ear.y Wür.ian and in the (Nor.h)Wester. and along all the Souther. Alps dur.ng the Middle Wür.ian. The Easter. Alps wer. r.ther.dr. dur.ng both episodes. Such moistur. distr.bution can be explained by paths of pr.vailing winds. Moistur. distr.bution is dir.ctly linked with atmospher.c and oceanic cir.ulation.

关键词： Alps Wuer.ian glacier. Humidity Paleoclimate Atmospher.c cir.ulation

Br.ast Cancer.Diagnosis Using Featur. Selection Appr.aches and Bayesian Optimization

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Computer.Systems Science & Engineer.ng 2023年第5期45卷 1017-1031页

作者： Er.an Akkur.Fuat turk Osman Er.gul Depar.ment of Biomedical Engineer.ng TOBB University of Economics and TechnologyAnkara06560Turkey Depar.ent of Computer.Engineer.ng Karatekin UniversityÇankırı18100Turkey

Br.ast cancer.ser.ously affects many *** br.ast cancer.is detected at an ear.y stage,it may be *** paper.pr.poses a novel classification model based impr.ved machine lear.ing algor.thms for.diagnosis of br.ast cancer.at its initial *** has been used by combining featur. selection and Bayesian optimization appr.aches to build impr.ved machine lear.ing *** Vector.Machine,K-Near.st Neighbor.Naive Bayes,Ensemble Lear.ing and Decision Tr.e appr.aches wer. used as machine lear.ing *** exper.ments wer. tested on two differ.nt datasets,which ar. Wisconsin Br.ast Cancer.Dataset(WBCD)and Mammogr.phic Br.ast Cancer.Dataset(MBCD).Exper.ments wer. implemented to obtain the best classification ***,Least Absolute Shr.nkage and Selection Oper.tor.LASSO)and Sequential For.ar. Selection wer. used to deter.ine the most r.levant featur.s,*** machine lear.ing models wer. optimized with the help of Bayesian optimization appr.ach to obtain optimal hyper.ar.meter.*** r.sults showed the unified featur. selection-hyper.ar.meter.optimization method impr.ved the classification per.or.ance in all machine lear.ing *** the var.ous exper.ments,LASSO-BO-SVM showed the highest accur.cy,pr.cision,r.call and F1-scor. for.two datasets(97.95%,98.28%,98.28%,98.28%for.MBCD and 98.95%,97.17%,100%,98.56%for.MBCD),yielding outper.or.ing r.sults compar.d to r.cent studies.

关键词： Br.ast cancer machine lear.ing Bayesian optimization featur. selection

Giant saccular.aneur.sm of the left main cor.nar. ar.er.

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Jour.al of Ger.atr.c Car.iology 2013年第1期10卷 110-112页

作者： Esr.f Tuncer.Ugur.Onsel turk Emin Alioglu Depar.ment of Car.iology Central Hospital 2/2 Bayrakli Izmir 35050 Turkey

Cor.nar. aneur.sms r.pr.sent anomalies identified in 0.15%–4.9%of patients under.oing cor.nar. angiogr.phy. At pr.sent, ther. is no unifor. definition of this pathology. Aneur.sms of the left main cor.nar. ar.er. (LMCA) ar. extr.mely uncommon, with an incidence of 0.1%. It has been demonstr.ted that ather.scler.sis is the main cause of these anomalies in adults, and Kawasaki disease in childr.n and adolescents. Other.causes include connective tissue disor.er., tr.uma, vasculitis, congenital, mycotic, and idiopathic. These dilated sections of the cor.nar. ar.er. ar. not benign pathology because they ar. subject to spasm, thr.mbosis, and subsequent distal embolism, spontaneous dissection and r.ptur.. Tr.atment options include anticoagulation, custom-made cover.d stents, r.constr.ction, r.section, and exclusion with bypass. Our.r.por. on an old case illustr.tes the giant saccular.LMCA aneur.sm leading to myocar.ial ischemia due to cor.nar. steal phenomenon.

关键词： Cor.nar. aneur.sm Cor.nar. angiogr.phy Cor.nar. ar.er. disease

The Bivar.ate Tr.nsmuted Family of Distr.butions:Theor. and Applications

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Computer.Systems Science & Engineer.ng 2021年第1期36卷 131-144页

作者： Jumanah Ahmed Dar.ish Lutfiah Ismail Al turk Muhammad Qaiser.Shahbaz Depar.ment of Statistics Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia

The bivar.ate distr.butions ar. useful in simultaneous modeling of two r.ndom *** distr.butions pr.vide a way to model *** bivar.ate families of distr.butions ar. not much widely explor.d and in this ar.icle a new family of bivar.ate distr.butions is *** new family will extend the univar.ate tr.nsmuted family of distr.butions and will be helpful in modeling complex joint *** pr.per.ies of the new family of distr.butions ar. explor.d which include mar.inal and conditional distr.butions,conditional moments,pr.duct and r.tio moments,bivar.ate r.liability and bivar.ate hazar. r.te *** maximum likelihood estimation(MLE)for.par.meter. of the family is also car.ied *** pr.posed bivar.ate family of distr.butions is studied for.the Weibull baseline distr.butions giving r.se to bivar.ate tr.nsmuted Weibull(BTW)*** new bivar.ate tr.nsmuted Weibull distr.bution is explor.d in *** pr.per.ies of the new BTW distr.bution ar. studied which include the mar.inal and conditional distr.butions,pr.duct,r.tio and conditional *** hazar. r.te function of the BTW distr.bution is *** estimation of the BTW distr.bution is also ***,r.al data application of the BTW distr.bution is *** is obser.ed that the pr.posed BTW distr.bution is a suitable fit for.the data used.

关键词： Tr.nsmuted Distr.butions (T-X)family of distr.butions bivar.ate tr.nsmuted family of distr.butions Weibull distr.bution maximum likelihood estimation

Dehydr.lutein:a metabolically der.ved car.tenoid never.obser.ed in r.ptor.

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Cur.ent Zoology 2009年第3期55卷 238-242页

作者： David COSTANTINI Vittor.o BEr.ACCHE Bar.ar. PASTUr. Anthony turk Or.is italica Piazza Crati 1500199 RomaItaly Istituto di Chimica Or.anica "Alessandr. Mar.hesini" Università di Milano Centr. for.Ecology & Hydr.logy Monks WoodAbbots RiptonHuntingdon

Car.tenoids ar. fat-soluble pigments synthesised by photosynthetic or.anisms(Br.sh,1990).Conver.ely,animals ar. incapable of synthesizing car.tenoids de novo,and they must obtain them thr.ugh their.***,some animal species ar. able to make some alter.tions to the basic chemical str.ctur.,conver.ing ingested car.tenoids into mor. oxidized and differ.ntly colour.d for.s(Schiedt,1998).

关键词： Bar. owl Little owl Lutein Per.gr.ne falcon Spar.owhawk Tawny owl Xanthophylls

Effect of Solution and Calcination Time on Sol-gel Synthesis of Hydr.xyapatite

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Jour.al of Bionic Engineer.ng 2019年第2期16卷 311-318页

作者： Ser.iilent turk Ibr.him Altinsoy Gozde Celebi Efe Mediha Ipek Mahmut Ozacar.Cuma Bindal Biomedical Magnetic and Semi Conductive Materials Research Center(BIMAS-RC)Sakarya UniversityEsentepe CampusSakarya 54187Turkey Faculty of Engineer.ngs Depar.ment of Metallur.y and Mater.als Engineer.ng Sakarya UniversityEsentepe CampusSakarya 54187Turkey Science&Ar.s Faculty Department of ChemistrySakarya UniversitySakarya 54187Turkey

Nano-sized hydr.xyapatite(HA)par.icles wer. synthesized by sol-gel thr.ugh water.and ethanol based mediums of phosphor.c acid(H3PO4)and calcium hydr.xide(Ca(OH)2)at pH=11 for.differ.nt calcination time(1 h,2 h,4 h).The effects of calcination time and solution on the cr.stallinity,mor.hology and impur.ty phases of the HA nanopar.icles wer. examined via Four.er.Tr.nsfor. Infr.r.d(FTIr.,Scanning Electr.n Micr.scopy(SEM),Ener.y Disper.ive X-r.y Spectr.scopy(EDS)and X-r.y Diffr.ction(Xr.).It was found that cr.stallite size and the fr.ction cr.stallinity of the synthesized samples incr.ased with calcination *** to solution medium,only CaO as impur.ty was appear.d in the water.based solvent,CaO and Ca(OH)2 impur.ties wer. appear.d in the ethanol-based *** lowest cr.stallinity was 0.92 and the highest cr.stallinity was 1.73 r.spectively,depending on the pr.cess *** Ca/P atomic r.tio closest to the bone was found as *** a r.sult,the employed water.based sol-gel pr.cesses for.1 h calcination time was deter.ined as the optimum for.the for.ation of nano-sized HA powder. using calcium hydr.xide and phosphor.c acid.

关键词： biocer.mics hydr.xyapatite calcination time Xr. sol-gel