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Asian Jour.al of Ur.logy 2024年第1期11卷 128-133页

作者： Iman Shamohammadi Seyedmohammad Kazemeyni Mohammadali sadighi Tar. Hasanzadeh Alir.za Dizavi Depar.ment of Ur.logy Nemazee HospitalShiraz University of Medical ScienceShirazIran Depar.ment of Ur.logy Shariati HospitalTehran University of Medical ScienceTehranIran

Objective: Accor.ing to the high pr.valence of COVID-19 and the subsequent r.sk of men's sexual health, we decided to investigate the efficacy of tadalafil on impr.vement of men with er.ctile dysfunction caused by ***: In this study, 70 outpatients who wer. r.cover.d fr.m COVID-19 without acute r.spir.tor. distr.ss syndr.me with negative polymer.se chain r.action test and a complaint of er.ctile dysfunction wer. divided into two gr.ups: 35 patients who r.ceived tadalafil 5 mg daily and 35 who r.ceived placebo. For.each patient, basic assessment of sexual function was per.or.ed using the 5-item ver.ion of the Inter.ational Index of Er.ctile Function (IIEF-5) questionnair.. Then, tr.atment was star.ed fr.m 2 months after.complete r.cover. of COVID-19 with negative polymer.se chain r.action test for.3 months. At the end of the tr.atments, the patients wer. r.-evaluated for.sexual function using the complete ver.ion of IIEF questionnair.. Finally, the r.sults befor. and after.tr.atment in the inter.ention gr.up wer. compar.d with those of the contr.l ***: Tr.atment with both tadalafil and placebo impr.ved the patients' sexual function cr.ter.a compar.d to the baseline. However. this impr.vement was significantly higher.in the inter.ention gr.up with tadalafil than the contr.l gr.up with placebo (pr.tion of tadalafil 5 mg seems to be effective and safe for.impr.vement of er.ctile dysfunction caused by COVID-19.

关键词： Tadalafil Er.ctile dysfunction COVID-19 Sexual function

单宁酸改性互穿网络水凝胶促进断裂跟腱术后的组织重塑

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中国组织工程研究 2025年第4期29卷 721-729页

作者：张博张振江东北京大学第三医院运动医学科北京市100191

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿... 详细信息

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿网络水凝胶,表征水凝胶的微观形貌、力学性能、黏附性能、体外释药性能与生物相容性。②取30只SD大鼠,采用随机数字表法分为假手术组、手术组与水凝胶组,每组10只,后2组建立右后肢跟腱断裂模型,手术组采用改良Kessler.将断裂跟腱重新缝合,水凝胶组采用相同术式缝合断裂跟腱后将单宁酸改性互穿网络水凝胶贴片完全缠绕包裹于断端接合处。术后4周,对断裂跟腱进行影像学检查、组织学评价、生物力学测试及炎症因子水平检测。结果与结论:①扫描电镜下可见单宁酸改性互穿网络水凝胶呈多孔微观结构,孔径为3-10μm,并且水凝胶具备良好的体外释药性能、黏附强度与拉伸强度;CCK-8检测与活/死染色显示,该水凝胶对大鼠骨髓间充质干细胞增殖活性无明显影响,具备良好的生物相容性。②Mr.成像显示,与手术组比较,水凝胶组大鼠跟腱呈均一低信号,跟腱前后径厚度减小,与周围组织分界更为明确,表现更接近假手术组。苏木精-伊红与Masson染色显示,手术组大鼠跟腱纤维排列松散混乱,细胞密度增加且排布杂乱,伴有明显炎性细胞浸润,部分区域出现腱内骨化;水凝胶组大鼠跟腱纤维排列有序,细胞密度降低且排布规整,炎性细胞浸润明显减少。手术组大鼠跟腱的拉伸强度低于假手术组(Pr.A表达升高(Pr.A表达降低。③结果表明,单宁酸改性互穿网络水凝胶可显著抑制局部炎症反应、促进断裂跟腱组织重塑。

关键词：单宁酸水凝胶互穿网络跟腱断裂组织重塑组织再生

Synthesis of chir.l phosphine der.vatives thr.ugh a copper.I）-catalyzed desymmetr.c SNAr.r.action

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Science China Chemistr. 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-bo Li Qi Zhang Jun-Zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang Yin Key Labor.tor. of Fluor.ne and Nitr.gen Chemistr. and Advanced Mater.als Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Labor.tor. of Elemento-Or.anic Chemistr. and Tianjin Key Labor.tor. of Biosensing and Molecular.r.cognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Labor.tor. of Sustainable Chemical Tr.nsfor.ations

Axially chir.l phosphines ar. a class of extr.mely impor.ant ligands in asymmetr.c catalysis. Her.in, an unpr.cedented copper.I）-catalyzed asymmetr.c SNAr.r.action with HP（S）r.is uncover.d, which deliver. a ser.es of axially chir.l phosphine der.vatives in high yields with excellent enantioselectivity. Fur.her.or., the diaster.oselective r.action with the kinetic r.solution of r.cemic HP（S）Ar. pr.ceeds smoothly, pr.viding the pr.ducts with moder.te diaster.oselectivity and excellent enantioselectivity. Contr.l exper.ments indicate that HP（S）Ph2is much mor. active than HPPh2and HP（O）Ph2as the pr.nucleophile in the pr.sent r.action. It is found that the SNAr.r.action （the fir.t SNAr. pr.ceeds in a desymmetr.c manner. pr.viding the desir.d chir.l pr.ducts while a continued SNAr.r.action （the second SNAr. slightly occur. in a kinetic r.solution manner.in the pr.sent catalytic system, which enhances the ee of the desir.d chir.l pr.ducts. DFTcalculations suppor. a concer.ed r.action pathway r.ther.than a step-wise mechanism. Finally, axially chir.l olefin-phosphines pr.duced by the pr.sent method wor. as suitable ligands in Pdcatalyzed asymmetr.c allylic substitution with C-, N-, and O-nucleophiles and r.-catalyzed asymmetr.c addition of ar.lbor.nic acid to benzil.

关键词：

CFD simulation of bubbly tur.ulent Tayor.Couette flow

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Chinese Jour.al of Chemical Engineer.ng 2016年第6期24卷 719-727页

作者： Xi Gao bo Kong r.Dennis Vigil Depar.ment of Chemical & Biological Engineer.ng 2114 Sweeney Hall Iowa State University

Bubbly gas-liquid Taylor.Couette vor.ex flow has been the subject of sever.l r.cent investigations both because of inter.st in bubble-induced dr.g r.duction and because such devices have potential applications to a var.ety of chemical and biochemical pr.cessing pr.blems. In or.er.to quantitatively descr.be the hydr.dynamics of highly tur.ulent two phase Taylor.Couette flow, a r.gor.us two-fluid computational fluid dynamics （CFD） model was developed and compar.d with pr.viously published exper.mental data. This model includes a compr.hensive descr.ption of the constitutive closur. for.inter.phase for.es and tur.ulence was simulated using both the k- and k-to models. In addition, the mechanism by which the disper.ed fluid attains a non-unifor. r.dial and axial distr.bution is analyzed and the r.lative impor.ance of var.ous inter.hase for.es is discussed. Lastly the model was validated by compar.son of simulation pr.dictions with exper.mental data, and it is shown that the CFD model cor.ectly pr.dicts phase velocity, velocity fluctuation, and gas distr.bution, and may pr.vide guidance for.r.actor.design and scale-up.

关键词： Taylor.Couette flowTwo-phase flowBubbleCFD

迈向自主知识体系的中国式现代化:以文化形态为视角

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长白学刊 2025年第1期 147-156页

作者：洪波绍兴文理学院马克思主义学院浙江绍兴312000 浙江省习近平新时代中国特色社会主义思想研究基地浙江绍兴312000

知识体系是一个文明全部知识的总和并构成文明的核心。中国式现代化知识体系植根于中华优秀传统文化,它以独特的基本观念和基于“两个结合”的方法论自觉建构了现代化知识体系的中国表达,创造了人类文明新形态,实现了对西方现代化范式... 详细信息

知识体系是一个文明全部知识的总和并构成文明的核心。中国式现代化知识体系植根于中华优秀传统文化,它以独特的基本观念和基于“两个结合”的方法论自觉建构了现代化知识体系的中国表达,创造了人类文明新形态,实现了对西方现代化范式的超越,彰显了中华文化的主体性。经由“两个结合”铸就的中国式现代化的文化形态,实现了现代化概念的“术语革命”,彰显了现代化的“道路之新”,推进了现代化叙事的“范式转换”,展现出普遍的文明意义,为人类文明进步作出了重大贡献。

关键词：中国式现代化自主知识体系文化形态人类文明新形态 “两个结合”

医药卫生职业教育数字化资源的开发与利用研究

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职业技术 2025年第1期24卷 74-79页

作者：崔博高等教育出版社有限公司北京100029

通过深入分析教育信息化与数字化资源的关系,揭示了数字化资源在医药卫生职业教育中的重要作用。通过总结国际数字化资源开发与利用的经验,分析国内现状,结合医药卫生职业教育的特殊需求,提出优化策略。结果显示,数字化资源有效促进了... 详细信息

通过深入分析教育信息化与数字化资源的关系,揭示了数字化资源在医药卫生职业教育中的重要作用。通过总结国际数字化资源开发与利用的经验,分析国内现状,结合医药卫生职业教育的特殊需求,提出优化策略。结果显示,数字化资源有效促进了教育资源共享、个性化学习和学生实践能力的提升。因此,构建完善的数字化资源开发体系、推广智能化服务,对于推动医药卫生职业教育的创新发展具有重要意义。

关键词：医药卫生专业职业教育数字化资源

r.moval of PCDD/Fs and PCBs fr.m sediment by oxygen fr.e Pyr.lysis

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Jour.al of Envir.nmental Sciences 2006年第5期18卷 989-994页

作者： HU Zhan-bo Saman Wijesekar. r.G. r.nald r. Navar.o WU De-yi ZHANG Da-lei Masatoshi Matsumur. KONG Hai-nan School of Envir.nmental Science and Engineer.ng Shanghai Jiaotong University Shanghai 200240 China Gr.duate School of Life and Envir.nmental Sciences University of Tsukuba Tsukuba-shi 305-8572 Japan Guangxi Univer.ity Nanning 530004 China

Few studies have dealt on the evaluation of volatilization and decomposition r.actions of dioxins fr.m sediment by oxygen fr.e pyr.lysis. In this study, the per.or.ance of pyr.lysis on the r.moval of dioxins fr.m sediment was investigated. Dioxin concentr.tions of the r.w sediment and the solid r.sidues after.pyr.lysis wer. analyzed at differ.nt conditions. r.sults showed a r.moval efficiency of 99.9999% for.total dioxins at 800℃ and r.tention time of 30 min. All the polychlor.nated dibenzo-fur.ns （PCDFs） have been r.moved and wer. not for.ed in the solid r.sidues at the r.tention time r.nge of 30-90 min at 800℃. Close to 100% r.moval of polychlor.nated dibenzo-p-dioxins （PCDDs） was also achieved. Only tr.ce PCDDs wer. detected in the solid yields at a r.tention time of 60 min. The highest r.moval efficiency of polychlor.nated biphenyls （PCBs） was mor. than 99.9994% at a r.tention time of 30 min. Dur.ng cooling per.od following pyr.lysis, however. the concentr.tion of total dioxins in solid r.sidues incr.ased 130 times as compar.d to that of the r.w sediment under.air.atmospher.. This confir.ed that some complex r.actions do occur.to for. PCDD/Fs and PCBs fr.m 800 to 400℃ in the pr.sence of oxygen. Oxygen-fr.e atmospher. ther.for. can pr.vent for.ation of dioxin dur.ng ther.al pr.cess thus gener.ting clean solid r.sidues.

关键词： dioxins pyr.lysis oxygen fr.e sediment PCBs

我国中小学法治教育的实践探索、现实问题与优化路径

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北京教育学院学报 2025年第1期39卷 34-40页

作者：李勃同济大学马克思主义学院上海200082

当前我国中小学生法治教育已初步构建起涵盖组织领导机制、制度保障体系、课程结构设置、教学策略优化以及社会实践活动等多维度内容的实施框架,但仍存在教育形式化、课程无序化、实践活动虚浮化等问题。为此,应在整体上探索中小学法治... 详细信息

当前我国中小学生法治教育已初步构建起涵盖组织领导机制、制度保障体系、课程结构设置、教学策略优化以及社会实践活动等多维度内容的实施框架,但仍存在教育形式化、课程无序化、实践活动虚浮化等问题。为此,应在整体上探索中小学法治教育新的范式与路径:依托社会力量,组建中小学法治教育联盟,应对教育形式化问题;通过一体化设计法治教育课程内容与方式,应对法治教育课程无序化问题;挖掘法治教育课外活动价值内涵,解决法治教育实践活动虚浮化问题。

关键词：中小学法治教育法治教育联盟法治素养价值观

Neur.pathophysiology of COVID-19

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Wor.d Jour.al of Neur.science 2021年第2期11卷 116-123页

作者： I. abi E. Iwuozo E. abi J. r. Ediale Depar.ment of Physiology Faculty of Basic Medical Sciences College of Health Sciences Benue State University Makurdi Nigeria Neur.logy Unit Internal Medicine Department Benue State University Teaching Hospital Makurdi Nigeria Depar.ment of Biochemistr. Faculty of Science University of Agriculture Makurdi Nigeria

The COVID-19 pandemic has str.ined health systems all over.the wor.d. The SAr.-CoV-2 which causes the disease is a cor.na vir.s that pr.dominantly affects the r.spir.tor. systems. Since the outbr.ak of the novel disease in December. 2019 the scientific wor.d has intensified effor.s to elucidate its pathophysiology, mode of tr.nsmission, clinical manifestations, best mode of pr.vention and tr.atment options. Ver. little is known about its neur.pathophysiology even though a significant number.0} of patients come down with obvious neurological signs and symptoms. The virus has been reported to affect the nerves, muscles, the special senses and the central nervous system with a wide range of clinical manifestations. The mechanisms by which the virus causes all these are still not clear. This article attempts to review and articulate all possible existing theories surrounding the neurological effects of COVID-19.

关键词： COVID-19 SAr.-CoV-2 Char.oly body Cytokine Stor. Agnosia Ageusia

STUDY OF THr.E-DIMENSIONAL SEPAr.TION OF boUNDAr. LAYEr.OVEr.BLUNT boDIES

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Jour.al of Hydr.dynamics 2009年第1期21卷 100-107页

作者： ATMANI r. Br.MA A. ASKOVIC r. Labor.toir. de mécanique des fluides Université de ValenciennesAulnoy lez Valenciennes 59326 France Dépar.ement de Mécanique Université de BiskraBiskra 07000 Algérie

In the case of thr.e-dimensional flows, the separ.tion can be defined in mor. than one way. Discussions about thr.e-dimensional boundar. layer.separ.tion in the liter.tur. have found a r.tional extension of the zer. skin fr.ction. Attempts have been made to establish the identity of “separ.tion lines”. Among definitions, these may be found：（1） envelopes of limiting str.amlines, （2） lines dividing flow which has come fr.m differ.nt r.gions, （3） lines of singular.ties （pr.blems of topology）, （4） lines on which some component of the skin fr.ction vanishes. Each of these is valid under.cer.ain conditions, but none is univer.ally valid. In the pr.sent wor., we use the definition （4）, i.e. at low incidence of a blunt body the separ.tion line is identified as the zer. of the mer.dian skin fr.ction component （Wang 1975）. So the separ.tion line on a flattened spher.id （6：3：1） at 6° of incidence is calculated, as well as exper.mentally deter.ined by using the electr.chemical method, which allows to follow the evolution of the par.etal velocity gr.dient.

关键词： thr.e-dimensional flows separ.tion boundar. layer. blunt bodies