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Heter.geneity of matur. oligodendr.cytes in the centr.l ner.ous system

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Neur.l r.gener.tion r.sear.h 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Gr.h Moein Yaqubi Qiao-Ling Cui Jo Anne Str.tton G.r.Wayne Moor. Jack P.Antel Neur.immunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Depar.ment of Neur.logy Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Matur. oligodendr.cytes for. myelin sheaths that ar. cr.cial for.the insulation of axons and efficient signal tr.nsmission in the centr.l ner.ous *** evidence has challenged the classical view of the functionally static matur. oligodendr.cyte and r.vealed a gamut of dynamic functions such as the ability to modulate neur.nal cir.uitr. and pr.vide metabolic suppor. to *** the r.cognition of potential heter.geneity in matur. oligodendr.cyte function,a compr.hensive summar. of matur. oligodendr.cyte diver.ity is *** delve into ear.y 20th-centur. studies by r.ber.son and r.o-Hor.ega that laid the foundation for.the moder. identification of r.gional and mor.hological heter.geneity in matur. ***,r.cent mor.hologic and functional studies call into question the long-assumed homogeneity of matur. oligodendr.cyte function thr.ugh the identification of distinct subtypes with var.ing myelination ***,moder. molecular.investigations,employing techniques such as single cell/nucleus r.A sequencing,consistently unveil at least six matur. oligodendr.cyte subpopulations in the human centr.l ner.ous system that ar. highly tr.nscr.ptomically diver.e and var. with centr.l ner.ous system *** and disease r.lated matur. oligodendr.cyte var.ation denotes the impact of pathological conditions such as multiple scler.sis,Alzheimer.s disease,and psychiatr.c ***,caution is war.anted when subclassifying matur. oligodendr.cytes because of the simplification needed to make conclusions about cell identity fr.m tempor.lly confined *** studies lever.ging advanced techniques like spatial tr.nscr.ptomics and single-cell pr.teomics pr.mise a mor. nuanced under.tanding of matur. oligodendr.cyte *** r.sear.h avenues that pr.cisely evaluate matur. oligodendr.cyte heter.geneity with car. to under.tand the mitigating influence of species,sex,centr.l ner.ous system r.gion,age,and disease,

关键词： aging centr.l ner.ous system diseases electr.n micr.scopy heter.geneity immunohistochemistr. myelin sheath natur.l histor. neur.glia oligodendr.glia single-cell gene expr.ssion analysis

Decipher.ng fungal metabolon coupling tandem inver.e-electr.ndemand Diels-Alder.r.action and semipinacol r.ar.angement for.the biosynthesis of spir. polycyclic alkaloids

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Science China Chemistr. 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Labor.tor. of Phytochemistr. and Natur.l Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences Univer.ity of Chinese Academy of Sciences Lab of Computational Chemistr. and Dr.g Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Labor.tor. State Key Labor.tor. of Micr.bial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Labor.tor. of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular.Biology Exper.mental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Labor.tor. for.Wild Plant r.sour.es Kunming Institute of Botany Chinese Academy of Sciences r.sear.h Unit of Chemical Biology of Natur.l Anti-Vir.s Pr.ducts Chinese Academy of Medical Sciences

In the intr.cate pr.cess of natur.l pr.duct biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, compr.sing of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spir. polycyclic alkaloids(+)-notoamide B and its diaster.omer.+)-ver.icolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can contr.l the ster.oselectivity of its 2,3-epoxidation, followed by hydr.gen atom ion at C-17 to gener.te r.active epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-ver.icolamide B ar. pr.duced via tandem nonenzymatic inver.e-electr.n-demand Diels-Alder.r.action and semipinacol r.ar.angement. This pr.vides the fir.t example of metabolon in the biosynthesis of spir.-pr.nylated indole alkaloids.

关键词： metabolon Diels-Alder.r.action semipinacol r.ar.angement biosynthesis notoamides spir. polycyclic alkaloids

Distr.buted Thr.ughput and Ener.y Efficient r.sour.e Optimization When D2D and Massive MIMO Coexist

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Jour.al of Communications and Infor.ation Networ.s 2022年第3期7卷 278-295页

作者： abi Abate Dejen Yihenew Wondie Anna For.ter Sustainable Communication Networ.s Depar.ment Universitat BremenBremen 28195Germany School of Electr.cal and Computer.Engineer.ng Addis Ababa UniversityAddis Ababa 999047Ethiopia

Fifth gener.tion(5G)cellular.networ.s intend to over.ome the challenging demands posed by dynamic ser.ice quality r.quir.ments,which ar. not achieved by single networ. *** futur. cellular.networ.s r.quir. efficient r.sour.e allocation and power.contr.l schemes that meet thr.ughput and ener.y efficiency r.quir.ments when multiple technologies coexist and shar. networ. *** this paper.we optimize the thr.ughput and ener.y efficiency(EE)per.or.ance for.the coexistence of two technologies that have been identified for.the futur. cellular.networ.s,namely,massive multiple-input multiple-output(MIMO)and networ.-assisted device-to-device(D2D)*** such a hybr.d networ.,the co/cr.ss-tier.inter.er.nces between cellular.and D2D communications caused by spectr.m shar.ng is a significant *** this end,we for.ulate the aver.ge sum r.te and EE optimization pr.blem as mixed-integer.non-linear.pr.gr.mming(MINLP).We develop distr.buted r.sour.e allocation algor.thms based on matching theor. to alleviate inter.er.nces and optimize networ. *** is shown in this paper.that the pr.posed algor.thms conver.e to a stable matching and ter.inate after.finite *** simulation r.sults show that the pr.posed algor.thms achieved mor. than 88%of the aver.ge tr.nsmission r.te and 86%of the ener.y efficiency per.or.ance of the optimal matching with lower.complexity.

关键词： device-to-device(D2D) massive MIMO communication inter.er.nce management r.sour.e optimization

Spastin and alsin pr.tein inter.ctome analyses begin to r.veal key canonical pathways and suggest novel dr.ggable tar.ets

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 725-739页

作者： Benjamin r.Helmold Angela Ahr.ns Zachar. Fitzger.ld P.Hande Ozdinler Depar.ment of Neur.logy Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center.for.Molecular.Innovation and Dr.g Discover. Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center.for.Cognitive Neur.logy and Alzheimer.s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinber. School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-ter. tr.atment str.tegies for.r.r. and complex neur.degener.tive diseases is challenging. One of the major.r.adblocks is the extensive heter.geneity among patients. This hinder. under.tanding the under.ying disease-causing mechanisms and building solutions that have implications for.a br.ad spectr.m of patients. One potential solution is to develop per.onalized medicine appr.aches based on str.tegies that tar.et the most pr.valent cellular.events that ar. per.ur.ed in patients. Especially in patients with a known genetic mutation, it may be possible to under.tand how these mutations contr.bute to pr.blems that lead to neur.degener.tion. Pr.tein–pr.tein inter.ction analyses offer.gr.at advantages for.r.vealing how pr.teins inter.ct, which cellular.events ar. pr.mar.ly involved in these inter.ctions, and how they become affected when key genes ar. mutated in patients. This line of investigation also suggests novel dr.ggable tar.ets for.patients with differ.nt mutations. Her., we focus on alsin and spastin, two pr.teins that ar. identified as “causative” for.amyotr.phic later.l scler.sis and her.ditar. spastic par.plegia, r.spectively, when mutated. Our.r.view analyzes the pr.tein inter.ctome for.alsin and spastin, the canonical pathways that ar. pr.mar.ly impor.ant for.each pr.tein domain, as well as compounds that ar. either.Food and Dr.g Administr.tion–appr.ved or.ar. in active clinical tr.als concer.ing the affected cellular.pathways. This line of r.sear.h begins to pave the way for.per.onalized medicine appr.aches that ar. desper.tely needed for.r.r. neur.degener.tive diseases that ar. complex and heter.geneous.

关键词： ALS2 alsin amyotr.phic later.l scler.sis her.ditar. spastic par.plegia neur.degener.tive diseases per.onalized medicine pr.cision medicine pr.tein inter.ctome pr.tein-pr.tein inter.ctions SPAST spastin

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公平竞争审查、新质生产力与企业数字化转型

经济问题 2025年第1期 1-14页

作者：师博郭思琪南京大学数字经济与管理学院江苏苏州215163 西北大学经济管理学院陕西西安710127

数字经济是新质生产力的综合质态。公平竞争审查制度作为高水平社会主义市场经济体制的重要组成部分,能够激发企业创新活力和数字化转型动力,从而推动新质生产力发展。采用双重差分法评估公平竞争审查制度对上市公司数字化转型的影响。... 详细信息

数字经济是新质生产力的综合质态。公平竞争审查制度作为高水平社会主义市场经济体制的重要组成部分,能够激发企业创新活力和数字化转型动力,从而推动新质生产力发展。采用双重差分法评估公平竞争审查制度对上市公司数字化转型的影响。研究发现,该制度能够显著提升行政垄断程度高地区的企业数字化转型水平,并且以促进“底层技术运用”为支点撬动了企业数字化转型,凸显了竞争政策的基础性作用。机制检验表明,公平竞争审查制度能够通过促进创新要素流动、优化信贷资源配给、完善数字发展制度环境打通束缚新质生产力发展的“堵点”和“卡点”,从而驱动企业数字化转型。围绕公平竞争审查标准、方式和目标的异质性分析发现,政策呈现出对民营企业、较小规模企业的所有制和规模“偏好”,并且对于制度性交易成本较高的企业作用更加明显;地区自我审查与外部监督机制较为完善时,政策能够更好发挥作用。最后产业政策的叠加效果检验显示,中央与省级产业政策均与公平竞争审查形成了制度合力,有效市场和有为政府协同推进了企业数字化进程。研究结论能够为公平竞争审查制度促进各类先进生产要素向发展新质生产力集聚提供理论支撑和实证依据。

关键词：高质量发展高水平社会主义市场经济体制数字经济行政性垄断

Scalable Ir.Doped NiFe_(2)O_(4)/TiO_(2)Heter.junction Anode for.Decentr.lized Saline Wastewater.Tr.atment and H_(2)Pr.duction

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Nano-Micr. Letter. 2025年第3期17卷 1-18页

作者： Sukhwa Hong Jiseon Kim Jaebeom Par. Sunmi Im Michael r.Hoffmann Kangwoo Cho Division of Envir.nmental Science and Engineer.ng Pohang University of Science and Technology(POSTECH)Pohang 790−784Korea Linde Labor.tor. California Institute of TechnologyPasadenaCA 91125USA Institute for.Conver.ence r.sear.h and Education in Advanced Technology(I‑Cr.ATE) Yonsei University International CampusIncheon 21983Republic of Korea

Wastewater.electr.lysis cells(WECs)for.decentr.lized wastewater.tr.atment/r.use coupled with H_(2)pr.duction can r.duce the car.on footpr.nt associated with tr.nspor.ation of water.waste,and ener.y *** study r.por.s Ir.doped NiFe_(2)O_(4)(NFI,~5 at%Ir.spinel layer.with TiO_(2)over.ayer.NFI/TiO_(2)),as a scalable heter.junction anode for.dir.ct electr.lysis of wastewater.with cir.umneutr.l pH in a single-compar.ment *** dilute(0.1 M)NaCl solutions,the NFI/TiO_(2)mar.s super.or.activity and selectivity for.chlor.ne evolution r.action,outper.or.ing the benchmar. Ir._(2).r.bust oper.tion in near.neutr.l pH was *** including oper.ndo X-r.y absor.tion spectr.scopy unveiled cr.cial r.les of TiO_(2) which ser.es both as the pr.mar. site for.Cl−chemisor.tion and a pr.tective layer.for.NFI as an ohmic *** electr.lysis of NH4+-laden synthetic wastewater.demonstr.ted that NFI/TiO_(2)not only achieves quasi-stoichiometr.c NH_(4)^(+)-to-N_(2)conver.ion,but also enhances H_(2)gener.tion efficiency with minimal competing r.actions such as r.duction of dissolved oxygen and r.active *** scaled-up WEC with NFI/TiO_(2)was demonstr.ted for.electr.lysis of toilet wastewater.

关键词： Wastewater.electr.lysis cell Ir.doped NiFe_(2)O_(4) r.active chlor.ne species Decentr.lized H_(2)pr.duction On-site wastewater.tr.atment

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托勒密时期的埃及王权形象塑造与身份认同

史学集刊 2025年第1期 109-120页

作者：史海波李智琳吉林大学历史文化学院世界史系吉林长春130012

作为外族统治者的托勒密王朝历代国王,通过采用埃及传统王权符号、沿袭前朝本土法老的外观和王名等方式,在具象层面构建了正统的埃及王权形象。同时,托勒密统治者对埃及本土宗教和仪式表现出虔敬的态度,并以此塑造合法的埃及法老身份,... 详细信息

作为外族统治者的托勒密王朝历代国王,通过采用埃及传统王权符号、沿袭前朝本土法老的外观和王名等方式,在具象层面构建了正统的埃及王权形象。同时,托勒密统治者对埃及本土宗教和仪式表现出虔敬的态度,并以此塑造合法的埃及法老身份,包括神化自身,强调神圣世系的继承,以及宣传恢复国家秩序和维护传统宗教仪式等方式。然而从现实情况来看,托勒密统治者更为重视希腊君主的身份,法老身份只是他们用于维持统治的宣传工具。由于现实中经济、阶层和种族矛盾的存在,包括祭司、权贵和平民在内的埃及臣民对外族法老身份的认同也相对有限。在征服与统治的背景下,不同文明之间很难形成完全的互相认同。

关键词：托勒密时期古埃及王权形象身份认同

Advances in telemedicine for.the management of the elder.y car.iac patient

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Jour.al of Ger.atr.c Car.iology 2021年第9期18卷 759-767页

作者： Nadim El Jamal Ber.ar. abi-Saleh Hussain Isma’eel Division of Car.ology American University of Beirut Faculty of Medicine and Medical CenterBeirutLebanon

Telemedicine is the use of infor.ation and communication technology to deliver.healthcar. at a *** has been r.sor.ed to dur.ng the COVID-19 pandemic to lessen the need for.in-per.on patient car. decr.asing the r.sk of tr.nsmission,and it can be of benefit after.ar. in the management of car.iac *** elder.y population has unique challenges concer.ing the use of telehealth *** thus r.view the advances in telemedicine technologies in tr.ating elder.y car.iac patients including in our.discussion only studies with a mean age of par.icipants above *** monitor.ng of blood pr.ssur.,weight,and symptoms,along with home ECG r.cor.ing has been found to be super.or.to usual in-clinic follow *** r.mote monitor.ng with video confer.ncing with physicians,patient education websites,and applications is also of *** monitor.ng of Implantable Car.iover.er.Defibr.llator.(ICD)and Car.iac r.synchr.nization Ther.py Defibr.llator.(Cr.-D)is also beneficial but can be at the cost of an incr.ase in both appr.pr.ate and inappr.pr.ate *** sensing devices compatible with r.mote monitor.ng have been developed and have been shown to impr.ve car. and *** smar.phone softwar. can detect ar.hythmias using home ECG r.cor.ings and can detect atr.al fibr.llation using smar.phone *** monitor.ng of implanted pacemaker. has shown non-infer.or.ty to in clinic follow *** the other.hand,small-scale questionnair.-based studies demonstr.ted the willingness of the elder.y car.iac patients to use such technologies,and their.satisfaction with their.use and ease of ***-scale studies should fur.her.investigate useability in samples mor. r.pr.sentative of the gener.l elder.y population with mor. diver.e socioeconomic and educational ***,it seems that studying integr.ting multiple technologies into telehealth pr.gr.ms is of gr.at *** effor.s should also be put in validating the te

关键词： ECG Cr. ICD Advances in telemedicine for.the management of the elder.y car.iac patient

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基于数字博物馆接触的青年传统文化认同

新闻与传播评论 2025年第1期78卷 46-65页

作者：韩博刘嘉琪中国社会科学院新闻与传播研究所北京100021

数字文博产品在吸引青年走进“云端”博物馆的同时,也带领他们走近中华优秀传统文化。为探索青年群体从数字博物馆的接触中生成传统文化认同,刻画其表征、影响因素与过程,论文以“云游敦煌”“数字故宫”等17个代表性数字博物馆为样本,... 详细信息

数字文博产品在吸引青年走进“云端”博物馆的同时,也带领他们走近中华优秀传统文化。为探索青年群体从数字博物馆的接触中生成传统文化认同,刻画其表征、影响因素与过程,论文以“云游敦煌”“数字故宫”等17个代表性数字博物馆为样本,以QQ空间中的大规模评论数据为基准材料,采用混合研究设计:第一阶段,利用扎根理论对相关评论内容进行质化研究;第二阶段,随机招募到全国4365个有效青年样本参加线上问卷调查。研究结果显示:数字博物馆接触是促成青年传统文化认同的有力途径。其中,数字博物馆文化情境中的文化展品与文化表征耦合构成吸引青年的基础条件,启动环节在于唤醒青年主体的具身联觉,加工环节在于激活个体内隐文化心理加工过程以形成更深层次的文化感知,最终青年传统文化认同生成或强化的表现主要呈现于认知认同、情感涌现和行为实践三个方面。此外,与原有文化印象的比较和集体文化记忆的勾连,作为调节因素共同影响着青年传统文化认同结果。

关键词：青年数字博物馆传统文化认同扎根理论