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Effects of long-ter. estr.gen r.placement ther.py on beta-amyloid pr.cur.or.pr.tein and mr.A expr.ssion in ovar.ectomized r.t hippocampus

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Neur.l r.gener.tion r.sear.h 2009年第1期4卷 48-52页

作者： bo Jiang Er.uan Liao Liming Tan r.chun Dai Zhijie Xiao Depar.ment of Neur.logy Xiangya Second Hospital of Central South University Changsha 410011 Hunan Province China Institute of Endocr.ne and Metabofic Disease Xiangya Second Hospital of Central South University Changsha 410011 Hunan Province China

BACKGr.UND： In vitr. cultur.s of neur.l stem cells have shown that estr.gen can r.gulate beta-amyloid pr.cur.or.pr.tein （β-APP） metabolism and r.duce amyloid-beta pr.duction. OBJECTIVE： To investigate the effects of long-ter. or.l administr.tion of compound nylestr.ol or.low-dose 17beta-estr.diol on β-APP and mr.A expr.ssion in the hippocampus of ovar.ectomized （OVX） r.ts. DESIGN, TIME AND SETTING： This r.ndomized and contr.lled exper.ment was per.or.ed at the Animal Labor.tor. and Labor.tor. of Endocr.ne and Metabolic Disease, Xiangya Second Hospital of Centr.l South Univer.ity between Apr.l 2003 and May 2004. MATEr.ALS： Accor.ing to body mass, 50 six-month-old female Spr.gue-Dawley r.ts wer. r.ndomly divided into five gr.ups （n = 10 per.gr.up）： nor.al contr.l, sham oper.tion, OVX model, 17beta-estr.diol （Sigma, USA）, and compound nylestr.ol tablet （Labor.tor. of Endocr.ne and Metabolic Disease, Xiangya Second Hospital of Centr.l South Univer.ity） gr.ups. METHODS： r.ts in OVX plus 17beta-estr.diol and OVX plus compound nylestr.ol tablet gr.ups under.ent ovar.ectomy. On the second day after.sur.er., r.ts wer. intr.gastr.cally given 17beta-estr.diol （100 μg/kg）, once per.day or.compound nylestr.ol tablet （0.5 mg/kg） and levonor.estr.l （0.15 mg/kg） ever. 2 days. MAIN OUTCOME MEASUr.S： β-APP expr.ssion in the hippocampus of OVX r.ts was deter.ined using immunohistochemistr. （SABC method） and β-APP mr.A expr.ssion was analyzed by in situ hybr.dization. The r.sults wer. quantitatively analyzed using cell counting and aver.ge optical density. r.SULTS： The number.and optical density of β-APP-positive neur.ns in ever. subr.gion of the hippocampus of OVX r.ts was dr.matically incr.ased compar.d with nor.al and sham oper.tion gr.ups following 35 weeks of administr.tion （P 〈 0.05）. Levels of β-APP wer. decr.ased following or.l administr.tion of compound nylestr.ol or.17beta-estr.diol. In situ hybr.dization showed that long-ter. estr.gen deficiency and or.l administr.

关键词： ovar.ectomized r.ts compound nylestr.ol tablet 17beta-estr.diol cer.br.l hippocampus beta-amyloid pr.cur.or.pr.tein

Effect of Pulse Width and Fr.quency of Bias DC Voltage on the Micr.str.ctur. of Pur. Cr.Coatings by Magnetr.n Sputter.Ion Plating

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稀有金属材料与工程 2012年第S1期41卷 371-374页

作者： Li Hongtao Jiang Bailing Niu Yi Yang bo Cao Zheng Xian Univ Technol Sch Mat Sci & Engn Xian 710048 Peoples R China

Pur. Cr.coatings wer. deposited onto the pieces of silicon wafer.at differ.nt pulse width and fr.quency of bias voltage by magnetr.n sputter.ion *** micr.str.ctur. and pr.fer.ntial or.entation of pur. Cr.coatings wer. analyzed by SEM and Xr. *** show that the diffusion ability of atoms on the coating sur.ace was impr.ved due to the substr.te temper.tur. r.se effect caused by the ion bombar.ment with the pulse width ***,the effect of fr.quency of bias DC voltage on the micr.str.ctur. of pur. Cr.coatings was par.icular.y *** bombar.ment ions action on the coating sur.ace wer. mor. unifor.ly and mor. disper.ed compar.d with the nucleation r.te of Cr.atoms and the density of pur. Cr.coatings both impr.ved with the fr.quency incr.ased ar. the main r.asons that the micr.str.ctur. of pur. Cr.coatings changed fr.m dense,gr.nular.columnar.gr.in outcr.ps to unifor.ity,small nano-cr.stalline par.icles.

关键词： pulse width fr.quency magnetr.n sputter.ng micr.str.ctur. pr.fer.ntial or.entation

Effects of basicity and MgO content on the viscosity of the SiO_2-CaO-MgO-9wt%Al_2O_3 slag system

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Inter.ational Jour.al of Miner.ls,Metallur.y and Mater.als 2014年第4期21卷 353-362页

作者： Yun-ming Gao Shao-bo Wang Chuan Hong Xiu-juan Ma Fu Yang Key Labor.tor. for.Fer.ous Metallur.y and r.sour.es Utilization of the Ministr. of Education Wuhan University of Science and Technology

The effects of basicity and MgO content on the viscosity of SiO2-CaO-MgO-9wt%Al2O3 slags with basicity fr.m 0.4 to 1.0 and MgO content fr.m 13wt%to 19wt%wer. investigated using the r.tating cylinder.method. A cor.elation between the viscosity and the slag str.ctur. was deter.ined by Four.er.tr.nsfor. infr.r.d （FTIr. spectr.scopy. It is indicated that the complex networ. str.ctur. of the slag melt is depolymer.zed into simpler.networ. units with incr.asing basicity or.MgO content, r.sulting in a continuous decr.ase in viscosity of the slag. The viscosity is str.ngly dependent on the combined action of basic oxide components in the slag. Under.the pr.sent exper.mental conditions, incr.asing the basicity is found to be mor. effective than incr.asing the MgO content in decr.asing the viscosity of the slag. At higher.temper.tur.s, the incr.ase of basicity or.MgO content does not appr.ciably decr.ase the viscosity of the slag, as it does at lower.tem-per.tur.s. The calculated activation ener.y of viscous flow is between 154 and 200 kJ＆#183;mol-1, which decr.ases with an incr.ase in basicity fr.m 0.4 to 1.0 at a fixed MgO content in the r.nge of 13wt%to 19wt%.

关键词： slags viscosity basicity magnesia activation ener.y Four.er.tr.nsfor. infr.r.d spectr.scopy

Study of photometr.c phase cur.e:assuming a cellinoid ellipsoid shape for.aster.id(106)Dione

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r.sear.h in Astr.nomy and Astr.physics 2017年第9期17卷 61-70页

作者： Yi-bo Wang Xiao-Bin Wang Donald E Pr.y Ao Wang Yunnan Obser.ator.es Chinese Academy of SciencesKunming 650216China Univer.ity of Chinese Academy of Sciences Beijing 100049China Key Labor.tor. for.the Str.ctur. and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Center.for.Astr.nomical Mega-Science Chinese Academy of SciencesBeijing 100012China Sugar.oaf Mountain Obser.ator. South DeerfieldMA 01373USA

We car.ied out new photometr.c obser.ations of aster.id （106） Dione at thr.e appar.tions （2004, 2012 and 2015） to under.tand its basic physical pr.per.ies. Based on a new br.ghtness model, new photometr.c obser.ational data and published data of （106） Dione wer. analyzed to char.cter.ze the mor.hology of Dione＇s photometr.c phase cur.e. In this br.ghtness model, a cellinoid ellipsoid shape and thr.e-par.meter.（H, G1, G2） magnitude phase function system wer. involved. Such a model can not only solve the phase function system par.meter. of （106） Dione by consider.ng an asymmetr.c shape of an aster.id, but also can be applied to mor. aster.ids, especially those without enough photometr.c data to solve the convex shape. Using a Mar.ov Chain Monte Car.o （MCMC） method, Dione＇s absolute magnitude of H = 7.66＋0.03-0.03 mag, and phase function par.meter. G1 = 0.682＋0.077-0.077 and G2 = 0.081＋0.042-0.042 wer. obtained. Simultaneously, Dione＇s simplistic shape, or.entation of pole and r.tation per.od wer. also deter.ined pr.liminar.ly.

关键词： aster.ids gener.l photometr.c phase cur.e -- aster.ids individual (106) Dione - techniques: photometr.c - Mar.ov Chain Monte Car.o method

The Influence of Tr.ns-1,4-poly(butadiene-co-isopr.ne) Copolymer.r.bber.(TBIr. with Differ.nt Molecular.Weights on the Nr.TBIr.Blends

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Chinese Jour.al of Polymer.Science 2019年第10期37卷 966-973,I0003页

作者： Hao Wang r.-Guo Wang Yun-Sheng Ma bo Luan Ai-Hua He Shandong Pr.vincial Key Labor.tor. of Olefin Catalysis and Polymer.zation Key Laboratory of Rubber-plastics(Ministry of Education)School of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao 266042China Shandong Huaju Polymer.Mater.al Co. Ltd.Binzhou 256500China

The molecular.weight of a polymer.is of pr.me impor.ance and gr.atly influences the pr.cessing and mechanical pr.per.ies of the polymer. Tr.ns-1,4-poly(butadiene-co-isopr.ne) multi-block copolymer.r.bber.(TBIr. exhibit outstanding fatigue r.sistance, low heat build-up and good abr.sion r.sistance, and ar. expected to be desir.ble candidate for.high per.or.ance tir.. Study on the influence of TBIr.with differ.nt molecular.weights on the str.ctur. and pr.per.ies of TBIr.and natur.l r.bber.Nr./TBIr.blends is essential to under.tand its contr.bution to the gr.atly impr.ved dynamic pr.per.ies of the r.bber.vulcanizates. TBIr.with differ.nt molecular.weights char.cter.zed by 1H-NMr. 13C-NMr. GPC, and DSC wer. highly tr.ns-1,4-copolymer. with similar.chain sequence distr.bution and cr.stalline tr.ns-1,4-polyisopr.ne(TPI) blocks. The gr.en str.ngth and modulus of TBIr.incr.ased with the incr.asing molecular.*** Nr.TBIr.compounds filled with 40 phr.car.on black wer. chemically cur.d by sulfur.for.the pr.par.tion of Nr.TBIr.*** compatibility between Nr.and TBIr. filler.distr.bution, cr.sslinking bond and density, and pr.per.ies of Nr.TBIr.vulcanizates wer. studied. The Nr.TBIr.vulcanizates showed incr.asing tensile str.ngth, har.ness, modulus, r.bound, abr.sion r.sistance, and flexur.l fatigue pr.per.ies with incr.asing molecular.weight of TBIr. Fur.her.or., they pr.sented significant impr.vement in flexur.l fatigue r.sistance when compar.d with that of Nr.vulcanizate. The contr.bution mechanism of TBIr.on the Nr.TBIr.blends was discussed. The TBIr.with a wide r.nge of molecular.weight ar. ideal r.bber. for.high per.or.ance tir.s.

关键词： Tr.ns-1,4-poly(butadiene-co-isopr.ne)copolymer.r.bber Natur. r.bber Blends Molecular.weight Fatigue r.sistance

Native amine-dir.cted site-selective C(sp^3)-H ar.lation of pr.mar. aliphatic amines with ar.l iodides

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Chinese Chemical Letter. 2020年第5期31卷 1327-1331页

作者： Pr.nab KPr.manick Zhibing Zhou Zhenlin Hou Yufei Ao bo Yao MOE Key Labor.tor. of Cluster.Science Beijing Key Laboratory of Photoelectronic-Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 102488China Beijing National Labor.tor. for.Molecular.Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

Dir.ct C(sp3)-H functionalization of N-unpr.tected aliphatic amines r.pr.sents one of the most efficient and str.ightfor.ar. str.tegies for.amine *** some r.cent pr.gr.ss in this field,the NH2-dir.cted y-C(sp3)-H ar.lation of pr.mar. aliphatic amines exceptα-amino ester. r.mained an unmet *** this r.por.,we established a simple and efficient method for.site-selective C(sp3)-H ar.lation of pr.mar. aliphatic amines by ar.l *** the pr.sence of only 5 mol%Pd(OAc)2,a wide r.nge of aliphatic amines including O-benzyl and O-silyl amino alcohols wer. ar.lated at y-or.-positions by ar.l iodides containing a br.ad scope of functional *** synthetic application of this method had also been demonstr.ted by lar.e-scale synthesis,the synthesis of a fingolimod analogue,and the conjugation with natur.l D-menthol and fluor.scent 1,8-naphthalimide.

关键词： Pr.mar. aliphatic amine Amino ether C(sp3)-H ar.lation Palladium catalysis Fr.e amino gr.up

Steganogr.phy Based on BaselineSequential JPEG Compr.ssion

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Wuhan Univer.ity Jour.al of Natur.l Sciences 2006年第2期11卷 370-372页

作者： DENG Beixing YANG bo LIN Ling LI Xing Depar.ment of Electr.nic Engineer.ng Tsinghua University Beijing 100084 China School of Infor.ation Guangdong University of Foreign Studies Guangzhou 510490 Guangdong China

Infor.ation hiding in Joint Photogr.phic Exper.s Gr.up （JPEG） compr.ssed images ar. investigated in this paper. Quantization is the sour.e of infor.ation loss in JPEG compr.ssion pr.cess. Ther.for., infor.ation hidden in images is pr.bably destr.yed by JPEG compr.ssion. This paper.pr.sents an algor.thm to r.liably embed infor.ation into the JPEG bit str.ams in the pr.cess of JPEG encoding. Infor.ation extr.ction is per.or.ed in the pr.cess of JPEG decoding. The basic idea of our.algor.thm is to modify the quantized dir.ct cur.ent （DC） coefficients and non zer. alter.ating cur.enl （AC） coefficients to r.pr.sent one bit infor.ation （0 or.1 ）. Exper.mental r.sults on gr.y images using baseline sequential JPEG encoding show that the cover.images （images without scor.t infor.ation） and the stego-images （images with secr.t infor.ation） ar. per.eptually indiscer.ible.

关键词： infor.ation hiding infor.ation extr.ction JPEG compr.ssion

Exper.mental study on smelting r.duction of car.on-bear.ng manganese br.quettes in slag bath

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Jour.al of Ir.n and Steel r.sear.h Inter.ational 2018年第4期25卷 417-425页

作者： bo Zhang Da-ping Wang Bin Chen Zhen-jian Su Zheng-liang Xue School of Metallur.ical and Mater.al Engineer.ng Hunan University of Technology Zhuzhou 412007 Hunan China The State Key Labor.tor. of r.fr.ctor.es and Metallur.y Wuhan Univer.ity of Science and Technology Wuhan 430081 Hubei China

The r.duction of car.on-bear.ng manganese br.quettes in a slag bath was exper.mentally investigated at temper.tur.s r.nging fr.m 1550 to 1650 ℃. both the inter.al temper.tur. and the micr.str.ctur. evolution of the br.quettes wer. analyzed by differ.ntial ther.al analysis, scanning electr.n micr.scopy and ener.y-disper.ive spectr.m analysis, and the smelting r.duction mechanism of the car.on-bear.ng manganese br.quettes in the slag bath was fur.her.elabor.ted. The r.sults indicated that the smelting r.duction of the br.quettes in the slag bath could be divided into thr.e stages, and the aggr.gation and gr.wth of the metallic par.icles dur.ng the r.duction wer. significantly affected by the slag temper.tur.. Under.the exper.mental conditions, the r.duction speed at the initial stage of the car.on-bear.ng manganese br.quettes smelting r.duction was contr.lled by the chemical r.action, wher.as the r.action speeds at both the middle and following stages wer. limited by gaseous diffusion.

关键词： Slag bath Smelting r.duction Car.on-bear.ng br.quette Kinetics

Ur.nar. and sexual function changes in benign pr.static hyper.lasia patients befor. and after.tr.nsur.thr.l columnar.balloon dilatation of the pr.state

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Wor.d Jour.al of Clinical Cases 2022年第20期10卷 6794-6802页

作者： Dong-Peng Zhang Zheng-bo Pan Hai-Tao Zhang Depar.ment of Ur.logy Tianjin HospitalTianjin 300211China Depar.ment of Ur.logy Taizhou Municipal HospitalTaizhou 318000Zhejiang ProvinceChina

BACKGr.UND Tr.nsur.thr.l columnar.balloon dilatation of the pr.state(TUCBDP) is a new sur.ical tr.atment, but its efficacy r.mains contr.ver.ial because of limited clinical *** To investigate the clinical effect of TUCBDP for.benign pr.static hyper.lasia(BPH).METHODS Over.ll, 140 patients with BPH who under.ent sur.ical tr.atment wer. included in the study. A r.ndom number.table was used to divide the par.icipants into study and contr.l gr.ups(n = 70 per.gr.up). The study gr.up under.ent TUCBDP. The pr.state r.section sur.ical time, intr.oper.tive blood loss, bladder.ir.igation time, catheter.indwelling time, length of hospital stay, Inter.ational Pr.state Symptom Scor.(IPSS), maximum ur.ne flow r.te(Qmax), r.sidual ur.ne volume(r.V), changes in the Inter.ational Er.ctile Function Scor.(ⅡEF-5) scor., ser.m pr.state-specific antigen(PSA), quality of life(QOL) scor., and sur.ical complications wer. compar.d in both *** The oper.tion time, intr.oper.tive blood loss volume, bladder.flushing time, ur.nar. catheter.indwelling time, and length of hospital stay wer. significantly lower.in the study gr.up than in the contr.l gr.up(P r. wer. no significant differ.nces in the IPSS, Qmax, and r.V measur.ments between the study and contr.l gr.ups(P > 0.05). However. at 3 mo post-sur.er., the IPSS and r.V measur.ments wer. both lower.P r. higher.P r.d to the pr.-sur.er. r.sults in both gr.ups. The ⅡEF-5 scor.s befor. and 3 mo after.sur.er. wer. not significantly differ.nt between the study and contr.l gr.ups(P > 0.05). At 1 mo after.sur.er., the ⅡEF-5 scor. was higher.in the study gr.up than in the contr.l gr.up(P r.m PSA levels and QOL scor.s befor. tr.atment and at 1 and 3 mo after.tr.atment wer. not significantly differ.nt between the study and contr.l gr.ups(P > 0.05). However. lower.ser.m PSA levels and QOL scor.s wer. obser.ed after.1 and 3 mo of tr.atment compar.d to pr.-tr.atment leve

关键词： Benign pr.static hyper.lasia Quality of life Lower.ur.nar. tr.ct symptoms Sexual dysfunction Tr.nsur.thr.l columnar.balloon dilatation of the pr.state Tr.nsur.thr.l r.section of the pr.state