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Unr.veling the mechanism of action of Shangxia Liangji for.ula for.tr.ating insomnia:a metabolomics and networ. phar.acology appr.ach

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Tr.ditional Medicine r.sear.h 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang bo Ouyang Depar.ment of Infor.ation The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Depar.ment of Neur.logy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Depar.ment of Gastr.scopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Depar.ment of Tr.ditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Backgr.und:Insomnia is a pr.valent clinical condition and Shangxia Liangji for.ula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF r.mains ***:The mouse model of insomnia was established by intr.per.toneal injection of ***-two mice wer. r.ndomly divided into a negative contr.l gr.up,model gr.up,SXLJF gr.up(18.72 g/kg/day),and positive contr.l gr.up(diazepam,2 mg/kg)and tr.ated with the cor.esponding dr.gs for.7 consecutive *** open field test and pentobar.ital-induced sleeping test wer. ***-MS-based untar.eted metabolomics and networ. phar.acology wer. applied to explor. the potential tar.ets of SXLJF for.tr.ating ***,key tar.ets wer. validated using ***:Behavior.l tests demonstr.ted that SXLJF r.duced the total distance,aver.ge velocity,centr.l distance,and sleep latency,and pr.longed sleep *** and networ. phar.acology r.vealed potential tar.ets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyr.sine hydr.xylase(TH)and tyr.sine metabolism emer.ed as cr.cial metabolic pathways and tar.ets,***-qPCr.r.sults suppor.ed the r.le of TH in the mechanism of SXLJF in tr.ating ***:In conclusion,TH and tyr.sine metabolism may r.pr.sent significant tar.ets and pathways for.SXLJF in tr.ating insomnia.

关键词： Shangxia Liangji for.ula insomnia metabolomics networ. phar.acology tyr.sine hydr.xylase tyr.sine metabolism

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Activator.assisted electr.less deposition of copper.nanostr.ctur.d films

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Inter.ational Jour.al of Miner.ls,Metallur.y and Mater.als 2014年第2期21卷 196-203页

作者： Var.ha r. Mehto r. K. Pandey Depar.ment of Physics Barkatullah University NIIT Univer.ity

This paper.showed simple and effective synthesis of copper.nanopar.icles within contr.lled diameter.using dir.ct electr.less deposition on glass substr.tes, following the sensitization and activation steps. Electr.less-deposited metals, such as Cu, Co, Ni, and Ag, and their.alloys had many advantages in micr.- and nanotechnologies. The str.ctur.l, mor.hological, and optical pr.per.ies of copper.deposits wer. char.cter.zed using X-r.y diffr.ction （Xr.）, atomic for.e micr.scopy （AFM）, and UV-Vis spectr.scopy. The str.ctur.l data was fur.her.analyzed using the r.etveld r.finement pr.gr.m. Str.ctur.l studies r.veal that the deposited copper.pr.fer. a （111） or.entation. AFM studies suggest the deposited mater.als for. compact, unifor., and nanocr.stalline phases with a high tendency to self-or.anize. The data show that the par.icle size can be contr.lled by contr.lling the activator.concentr.tion. The absor.tion spectr. of the as-deposited copper.nanopar.icles r.veal that the plasmonic peak br.adens and exhibits a blue shift with decr.asing par.icle size.

关键词： nanostr.ctur.d mater.als thin films copper electr.less plating deposition

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(K_(0.5)Na_(0.5))Nb_(1-x)Ta_(x)O_(3)铁电性的第一性原理研究

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原子与分子物理学报 2025年第4期42卷 138-146页

作者：褚新建雷博程刘晨曦刘纪博新疆科技学院信息科学与工程学院库尔勒841000 新疆大学物理科学与技术学院新疆固体物理与器件重点实验室乌鲁木齐830046 西安工业大学光电工程学院西安710032

随着铅基陶瓷的大量使用,造成了严重的环境和健康问题,为了能够找寻替代铅基陶瓷的材料,人们开始了对无铅陶瓷材料的探索.(K_(0.5)Na_(0.5))Nbo_(3)材料由于其优异的铁电压电性能,成为了无铅陶瓷材料的代表,但是碱性组分在高温下的高挥... 详细信息

随着铅基陶瓷的大量使用,造成了严重的环境和健康问题,为了能够找寻替代铅基陶瓷的材料,人们开始了对无铅陶瓷材料的探索.(K_(0.5)Na_(0.5))Nbo_(3)材料由于其优异的铁电压电性能,成为了无铅陶瓷材料的代表,但是碱性组分在高温下的高挥发性使其应用范围受到了极大的限制.基于这样的考虑,本文基于密度泛函理论的第一性原理方法,探究了(K_(0.5)Na_(0.5))Nb_(1-x)TaxO_(3)(x=0.125,0.25,0.375,0.5,0.625,0.75,0.875,1)九种体系的铁电性能,结果表明:随着Ta浓度的增加,晶格常数发生了突变,由此猜测KNN材料随着Ta浓度的增加,发生了正交-单斜的相变;Ta的掺入能够降低KNN材料的烧结难度,且随着Ta浓度的增加,形成难度逐渐降低;掺杂体系中,Ta-4f轨道与Na-3p,K-4p以及O-2s轨道电子发生了杂化,使导带底Nb-4d与Na-3p电子的态密度峰向高能区移动,禁带宽度呈现增加的趋势;在分析KNN材料铁电性作用机理时发现KNN的铁电极化类型是离子位移型极化,且在[001]方向上不具有极化能力.分析掺杂后各个体系的极化强度,发现随着Ta浓度的增加,极化强度逐渐降低,但是在低浓度掺杂时极化有向上增加的趋势,这可能是体系在低浓存在着正交与单斜的准同型相界(Mor.hotr.pic phase boundar.,MPB)导致的,由此可以判断,低浓度掺杂有利于提高KNN材料的铁电性能.

关键词：第一性原理钙钛矿结果 KNN 铁电性

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Syntheses, Char.cter.zation and Anti-HIVActivity of Char.e Tr.nsfer.eter.polycomplexes

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Chemical r.sear.h in Chinese Univer.ities 2001年第2期17卷 127-133页

作者： LIU Shu-xia, LI Yang-guang, HAN Zeng-bo, HUANG r.-dan and WANG En-bo (Depar.ment of Chemistr., Nor.heast Nor.al Univer.sity, Changchun 130024, P. r. China) ZENG Yi and LI Ze-lin (Chinese Academy of Pr.ventive Medicine, Beijing 100050, P. r. China) NE Nor.al Univ Dept Chem Changchun 130024 Peoples R China Chinese Acad Pr.vent Med Beijing 100050 Peoples R China

Each of Keggin type heter.polytungstosilicic and heter.polytungstoger.anic acids r.acted with 8-quinolinol, p-aminodimethylaniline and pyr.dine, r.spectively, yielding six char.e tr.ns- fer.heter.polycomplexes (CTHPCs), which wer. pur.fied and char.cter.zed by elemental analy- sis, Ir. UV and 183W NMr. The anti-HIV-1 activities of CTHPCs wer. evaluated by ELISA of HIV-P24 antigen. The toxicity against MT-4 cells was measur.d by MTT. The r.sults show that median inhibitor. concentr.tion (IC50) for.each CTHPC to inhibit HIV-P24 antigen in cell cultur. was lower.than 5 μg/mL, while median toxicity concentr.tion (IC50) against MT-4 cells was higher.than 268 μg/mL. The following mechanisms might be consider.d for.their.anti-HIV- 1 activity, namely, (1) inhibiting the penetr.tion of HIV- 1 vir.s into tar.et cells for.it can blockade CD4 r.ceptor.of MT-4 cells and (2) inhibition of syncytium for.ation.

关键词： Heter.polycomplexes Synthesis Anti-HIV activity Mechanism

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Gut-br.in axis as a br.dge in obesity and depr.ssion:Mechanistic explor.tion and ther.peutic pr.spects

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Wor.d Jour.al of Psychiatr. 2025年第1期15卷 12-20页

作者： r.i-Ying Fang Xiao-r.i Pan Xin-Xing Zeng Zheng-Zheng Li bo-Fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A r.cent study by Wang et al,published in the Wor.d Jour.al of Psychiatr.,pr.vided pr.ventative and ther.peutic str.tegies for.the comor.idity of obesity and *** gut-br.in axis,which acts as a two-way communication system between the gastr.intestinal tr.ct and the centr.l ner.ous system,plays a pivotal r.le in the pathogenesis of these *** suggests that metabolic bypr.ducts,such as shor.-chain fatty acids,lipopolysacchar.de and bile acids,which ar. gener.ted by the gut micr.biota,along with neur.tr.nsmitter. and inflammator. mediator. within the gut-br.in axis,modulate the host's metabolic pr.cesses,neur.nal r.gulation,and immune r.sponses thr.ugh diver.e *** inter.ction between obesity and depr.ssion via the gut-br.in axis involves disr.ptions in the gut micr.biota balance,inflammator. immune r.sponses,and alter.tions in the neur.endocr.ne *** the gut-br.in axis,for.example,thr.ugh a ketogenic diet,the use of pr.biotics,and the supplementation of antioxidants,offer. new r.medial appr.aches for.obesity and *** r.sear.h that explor.s the mechanisms of the gut-br.in axis is needed to pr.vide mor. evidence for.clinical tr.atment.

关键词： Gut-br.in axis Obesity Depr.ssion Gut micr.biota Mechanism

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Moment r.distr.bution Effect of the Continuous Glass Fiber.r.infor.ed Polymer.Concr.te Composite Slabs Based on Static Loading Exper.ment

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Str.ctur.l Dur.0}lity & Health Monitor.ng 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang Jing-Shui Zhen bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui Huang Offshor. Oil Engineer.ng Co.Ltd. Tianjin300461China Depar.ment of Br.dge Engineer.ng School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment r.distr.bution in continuous glass fiber.r.infor.ed polymer.GFr.)-concr.te composite slabs caused by concr.te cr.cking and steel bar.yielding in the negative bending moment *** exper.mental bending moment r.distr.bution test was conducted on continuous GFr.-concr.te composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs wer. for.ed by combining GFr. pr.files with a concr.te layer.and suppor.ed on steel beams to cr.ate two-span continuous composite slab *** methods,epoxy r.sin bonding,and stud connection,wer. used to connect the composite slabs with the steel *** exper.mental findings showed that the specimen connected with epoxy r.sin exhibited two moments r.distr.bution phenomena dur.ng the loading pr.cess:concr.te cr.cking and steel bar.yielding at the inter.al *** contr.st,the composite slab connected with steel beams by studs exhibited only one-moment r.distr.bution phenomenon thr.ughout the loading *** the concr.te at the inter.al suppor. cr.cked,the bending moment decr.ased in the inter.al suppor. section and incr.ased in the midspan *** the steel bar. yielded,the bending moment fur.her.decr.ased in the inter.al suppor. section and incr.ased in the mid-span *** GFr. pr.files do not exper.ence cr.cking,ther. was no significant decr.ase in the bending moment of the mid-span *** test specimens exper.enced compr.ssive failur. of concr.te at the mid-span *** r.sults showed good agr.ement between the calculated and exper.mental values of bending moments in the mid-span section and inter.al suppor. *** pr.posed model can effectively pr.dict the moment r.distr.bution behavior.of continuous GFr.-concr.te composite slabs.

关键词： Moment r.distr.bution GFr.-concr.te composite slabs bending moment exper.mental study analysis model

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Seismic behavior.of var.able fr.quency pendulum isolator

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Ear.hquake Engineer.ng and Engineer.ng Vibr.tion 2008年第2期7卷 193-205页

作者： V. r. Panchal r. S. Jangid Depar.ment of Civil Engineer.ng Indian Institute of TechnologyBombayPowaiMumbai 400076India

Ear.hquake per.or.ance of a flexible one-stor. building isolated with a var.able fr.quency pendulum isolator.（VFPI） under.near.fault and far.field gr.und motions is investigated. The fr.ctional for.es mobilized at the inter.ace of the VFPI ar. assumed to be velocity dependent. The inter.ction between fr.ctional for.es of the VFPI in two hor.zontal dir.ctions is duly consider.d and coupled differ.ntial equations of motion of the isolated system in the incr.mental for. ar. solved iter.tively. The r.sponse of the system with bi-dir.ctional inter.ction is compar.d with those without inter.ction. In addition, the effects of velocity dependence on the r.sponse of the isolated system ar. also investigated. Mor.over. a par.metr.c study is car.ied out to cr.tically examine the influence of impor.ant par.meter. on bi-dir.ctional inter.ction effects of the fr.ctional for.es of the VFPI. These par.meter. ar.： the super.tr.ctur. time per.od, fr.quency var.ation factor.（FVF） and fr.ction coefficient of the VFPI. Fr.m the above investigations, it is obser.ed that the dependence of the fr.ction coefficient on r.lative velocity of the system does not have a noticeable effect on the peak r.sponse of the system isolated with VFPI, and that the bi-dir.ctional inter.ction of fr.ctional for.es of the VFPI is impor.ant and if neglected, isolator.displacements will be under.stimated and the super.tr.ctur. acceler.tion and base shear.will be over.stimated.

关键词： base isolation bi-dir.ctional inter.ction super.tr.ctur. flexibility near.fault gr.und motion fr.ction coefficient far.field gr.und motion VFPI

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Human-Like r.bot Sensing Mediated by body Heat

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Jour.al of Bionic Engineer.ng 2014年第1期11卷 82-89页

作者： r. Andr.w r.ssell Depar.ment of Electr.cal and Computer.Systems Engineer.ng Monash University Clayton VIC 3800 Australia

This paper.pr.sents a novel r.botic sensor.system that can monitor.volatile chemicals and air.low. The system is modelled on char.cter.stics of the human body that ar. thought to have a significant influence on the human odour.and air.low senses. In par.icular. the effect of buoyant air.low due to body heat acts to gather.volatile chemicals over.lar.e ar.as of the human body and car.y them to the nose. It is postulated that this effect incr.ases the r.ceptive ar.a for.human olfaction. In addition, the inter.ction between r.sing air.heated by the body and exter.al air.low pr.duces a temper.tur. distr.bution about head height that can be used to infer.air.low dir.ction and magnitude. A heated sensor.system was constr.cted to investigate these effects and the r.sulting sensor.was mounted on a mobile r.bot. The design of the sensor.system is descr.bed. r.sults ar. pr.sented which demonstr.te its ability to measur. air.low dir.ction and detect chemical signals over.a wider.r.ceptive field compar.d with an unheated sensor.

关键词： sensing volatile chemicals sensing air.low human body heat biomimetic r.bots

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Ser.iceability analysis of deep under.r.und openings dr.ven in jointed-r.ck

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Inter.ational Jour.al of Mining Science and Technology 2017年第6期27卷 1019-1024页

作者： Abdellah Wael r. Mining and Metallur.ical Engineer.ng Depar.ment Faculty of Engineering University of Assiut Assiut 71515 Egypt

The per.or.ance of under.r.und excavations is inevitably influenced by r.ck mass char.cter.stics, pr.sence of joints and their.geometr.cal pr.per.ies, depth below sur.ace and state of in-situ str.ss field. The objective of this paper.is to investigate the behaviour.of deep under.r.und tunnel opening existed between two bedding planes, Such planes weaken the str.ngth of r.ck mass and may cause r.ck slippage/r.tation along them. Ther.for., the state of str.ss-displacement, after.tunnel opening has been intr.duced, is examined using two-dimensional elasto-plastic finite-elements code, r.^(2D). The r.sults indicate that, ther. is significant dr.p in the nor.al str.ss along joints over.tunnel opening; slip occur. due to r.ver.al in the dir.ction of shear.str.ss(e.g., inwar. shear.displacement is pr.duced) and ther. is discontinuity in the str.ngth contour. of r.ck sur.ounding tunnel after.they have been inter.ected by bedding planes.

关键词： State of str.ss-displacement Bedding planes Tunnel per.or.ance Depth of failur. zones Stability analysis

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Study on Tr.bological Pr.per.ies of Ir.adiated Cr.sslinking UHMWPE Nano-Composite

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Jour.al of Bionic Engineer.ng 2009年第1期6卷 7-13页

作者： Lei Xiong, Dang-sheng Xiong, Jia-bo JinDepar.ment of Mater.als Science and Engineer.ng, Nanjing Univer.ity of Science and Technology, Nanjing 210094, P. r. China [a]Depar.ment of Mater.als Science and Engineer.ng Nanjing University of Science and Technology Nanjing 210094 P. R. China

Ultr. High Molecular.Weight Polyethylene(UHMWPE)has been widely used as a bear.ng mater.al for.ar.ificial joint r.placement over.for.y *** is usually cr.sslinked by gamma r.ys ir.adiation befor. its implantation into human *** this study,UHMWPE and UHMWPE/nano-hydr.xyapatite(n-HA)composite wer. pr.par.d by vacuum hot-pr.ssing *** pr.par.d mater.als wer. ir.adiated by gamma r.ys in vacuum and molten heat tr.ated in vacuum just after.*** effect of filling n-HA with gamma ir.adiation on tr.bological pr.per.ies of UHMWPE was investigated by using fr.ction and wear.exper.mental machine(model MM-200)under.deionized water.***-mor.hology of wor. sur.ace was obser.ed by metallogr.phic *** angle and har.ness of the mater.als wer. also *** r.sults show that contact angle and har.ness ar. changed by filling n-HA and gamma *** coefficient and wear.r.te under.deionized water.lubr.cation ar. r.duced by filling *** fr.ction coefficient is incr.ased and wear.r.te is r.duced significantly by gamma *** wor. sur.ace of unfilled mater.al is mainly char.cter.zed as adhesive wear.and abr.sive wear.and that of n-HA filled mater.al is mainly char.cter.zed as abr.sive *** gamma ir.adiation,the degr.es of adhesive and abr.sive wear.for.unfilled mater.al and abr.sive wear.of n-HA filled mater.al ar. significantly *** and filled mater.als after.ir.adiation ar. mainly shown as slight fatigue *** r.sults indicate that UHMWPE and UHMWPE/n-HA ir.adiated at the dose of 150 kGy can be used as bear.ng mater.als in ar.ificial joints for.its excellent wear.r.sistance compar.d to or.ginal UHMWPE.

关键词： tr.bological pr.per.ies ir.adiated cr.sslinking UHMWPE n-HA ar.ificial joints

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