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Electr.n tr.jector. evaluation in laser.plasma inter.ction for.effective output beam

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Chinese Physics B 2010年第6期19卷 344-348页

作者： P. Zobdeh r. sadighi-bo.abi H. Afar.deh Depar.ment of Physics Qom Branch Islamic Azad University Qom Iran Depar.ment of Physics Sharif University of Technology 11365-9567 Tehran Iran Depar.ment of Physics Amirkabir University of Technology Tehran Iran

Using the ellipsoidal cavity model, the quasi-monoener.etic electr.n output beam in laser.plasma inter.ction is descr.bed. By the cavity r.gime the quality of electr.n beam is impr.ved in compar.son with those gener.ted fr.m other.methods such as per.odic plasma wave field, spher.idal cavity r.gime and plasma channel guided acceler.tion. Tr.jector. of electr.n motion is descr.bed as hyper.olic, par.bolic or.elliptic paths. We find that the self-gener.ted electr.n bunch has a smaller.ener.y width and mor. effective gain in ener.y spectr.m. Initial condition for.the ellipsoidal cavity is deter.ined by laser.plasma par.meter.. The electr.n tr.jector. is influenced by its position, ener.y and cavity electr.static potential.

关键词： electr.n intense laser plasma acceler.tor laser.wake field bubble r.gime wave br.aking

Cor.elation between anxiety, depr.ssion, and social str.ss in young patients with thor.columbar.spine fr.ctur.s

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Wor.d Jour.al of Psychiatr. 2025年第1期15卷 83-92页

作者： bo Wang Da Shi Yin-Di Sun bo Dong Joint War. of Or.hopedics Depar.ment of TCM Honghui HospitalXi'an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Pain War. of Or.hopedics Depar.ment of TCM Honghui HospitalXi'an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina

BACKGr.UND Tr.umatic injur.es,such as falling,car.accidents,and cr.shing mostly cause spinal fr.ctur.s in young and middle-aged people,and>50%of them ar. thor.columbar.*** kind of fr.ctur. is easily combined with ser.ous injur.es to per.pher.l ner.es and soft tissues,which causes par.lysis of the lower.limbs if ther. is no timely r.habilitation *** patients with thor.columbar.fr.ctur.s find it difficult to r.cover.after.the oper.tion,and they ar. pr.ne to depr.ssion,low self-esteem,and other.negative *** To investigate the association between anxiety,depr.ssion,and social str.ss in young patients with thor.columbar.spine fr.ctur.s and the effect on r.habilitation *** This study r.tr.spectively analyzed 100 patients admitted to the or.hopedic depar.ment of Honghui Hospital,Xi’an Jiaotong Univer.ity who under.ent thor.columbar.spine fr.ctur. sur.er. fr.m Januar. 2022 to June *** gener.l data of the patients wer. assessed with the Hamilton anxiety scale(HAMA),Hamilton depr.ssion scale(HAMD),life events scale,and social suppor. r.ting scale(SSr.)to identify the cor.elation between anxiety,depr.ssion scor.s,and social str.ss and social *** Japanese Or.hopedic Association(JOA)was utilized to evaluate the r.habilitation outcomes of the patients and to analyze the effects of anxiety and depr.ssion scor.s on *** Accor.ing to the scor.s of HAMD and HAMA in all patients,the pr.valence of depr.ssion in patients was 39%(39/100),and the pr.valence of anxiety was 49%(49/100).Patients wer. categor.zed into non-depr.ssion(n=61)and depr.ssion(n=39),non-anxiety(n=51),and anxiety(n=49)*** significant differ.nces in gender.occupation,Pittsbur.h Sleep Quality Index(PSQI)scor.,and monthly family income wer. obser.ed between the non-depr.ssion and depr.ssion gr.ups(Pr.nce in occupation and PSQI scor. was found between the non-anxiety and anxiety *** depr.ssion(r.0

关键词： Patients with thor.columbar.fr.ctur.s Anxiety Depr.ssion Social pr.ssur. Social suppor.

Cur.umin in gastr.c cancer.tr.atment:A commentar. on mechanistic insights and futur. dir.ctions

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Wor.d Jour.al of Gastr.intestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei Wen-bo Cao Sai-Jun Mo Zhi-Yan Sun Depar.ment of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Depar.ment of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Depar.ment of Special Ser.ice No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al pr.sents a compr.hensive investigation into the ther.-peutic potential of cur.umin for.gastr.c cancer.GC).Using networ. phar.a-cology,the r.sear.her. identified 48 cur.umin-r.lated genes,31 of which over.ap with GC *** genes,including ESr.,EGFr.CYP3A4,MAPK14,CYP1A2,and CYP2B6,ar. linked to poor.sur.ival in GC *** docking con-fir.ed str.ng binding affinity of cur.umin to these *** vitr. exper.ments demonstr.ted that cur.umin effectively inhibits the gr.wth and pr.lifer.tion of BGC-823,suggesting its ther.peutic potential in GC thr.ugh multiple tar.ets and pathways.

关键词： Cur.umin Gastr.c cancer Networ. phar.acology Mechanism of action In vitr. exper.ments

FK506 contr.butes to per.pher.l ner.e r.gener.tion by inhibiting neur.inflammator. r.sponses and pr.moting neur.n sur.ival

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Neur.l r.gener.tion r.sear.h 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan bo Ma Wenyong Xie Na Han Depar.ment of Tr.uma and Or.hopedics Peking University People’s HospitalBeijingChina National Center.for.Tr.uma Medicine Peking University People’s HospitalBeijingChina Key Labor.tor. of Tr.uma and Neur.l r.gener.tion(Peking Univer.ity) Ministry of EducationBeijingChina Tr.uma Medicine Center Peking University People’s HospitalBeijingChina Depar.ment of Or.hopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacr.limus)is a systemic immunosuppr.ssant appr.ved by the *** and Dr.g ***506 has been shown to pr.mote per.pher.l ner.e r.gener.tion,however.its pr.cise mechanism of action and its pathways r.main *** this study,we established a r.t model of sciatic ner.e injur. and found that FK506 impr.ved the mor.hology of the injur.d sciatic ner.e,incr.ased the number. of motor.and sensor. neur.ns,r.duced inflammator. r.sponses,mar.edly impr.ved the conduction function of the injur.d ner.e,and pr.moted motor.function *** findings suggest that FK506 pr.motes per.pher.l ner.e str.ctur. r.cover. and functional r.gener.tion by r.ducing the intensity of inflammation after.neur.nal injur. and incr.asing the number.of sur.iving neur.ns.

关键词： FK506 inflammation motor.neur.ns ner.e r.gener.tion neur.n per.pher.l ner.e injur. sensor. neur.ns

AAV2-PDE6B r.stor.s r.tinal str.ctur. and function in the r.tinal degener.tion 10 mouse model of r.tinitis pigmentosa by pr.moting phototr.nsduction and inhibiting apoptosis

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Neur.l r.gener.tion r.sear.h 2025年第8期20卷 2408-2419页

作者： r.iqi Qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng Han bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Br.nch of National Clinical r.sear.h Center.for.Ocular.Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

r.tinitis pigmentosa is a gr.up of inher.ted diseases that lead to r.tinal degener.tion and photor.ceptor.cell ***,ther. is no effective tr.atment for.r.tinitis pigmentosa caused by PDE6B ***-associated vir.s(AAV)-mediated gene ther.py is a pr.mising str.tegy for.tr.ating r.tinitis *** aim of this study was to explor. the molecular.mechanisms by which AAV2-PDE6B r.scues r.tinal *** do this,we injected r.tinal degener.tion 10(r.10)mice subr.tinally with AAV2-PDE6B and assessed the ther.peutic effects on r.tinal function and str.ctur. using dar.-and light-adapted electr.r.tinogr.m,optical coher.nce tomogr.phy,and ***-independent acquisition-mass spectr.metr.-based pr.teomic analysis was conducted to investigate pr.tein expr.ssion levels and pathway enr.chment,and the r.sults fr.m this analysis wer. ver.fied by r.al-time polymer.se chain r.action and wester. ***2-PDE6B injection significantly upr.gulated PDE6βexpr.ssion,pr.ser.ed electr.r.tinogr.m r.sponses,and pr.ser.ed outer.nuclear.layer.thickness in r.10 *** expr.ssed pr.teins between wild-type and r.10 mice wer. closely r.lated to visual per.eption,and tr.ating r.10 mice with AAV2-PDE6B r.stor.d differ.ntially expr.ssed pr.tein expr.ssion to levels similar.to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differ.ntially expr.ssed pr.teins whose expr.ssion was most significantly alter.d by AAV2-PDE6B injection wer. enr.ched in phototr.nsduction ***,the phototr.nsductionr.lated pr.teins Pde6α,r.m1,r.o,Aldh1a1,and r.p1 exhibited opposite expr.ssion patter.s in r.10 mice with or.without AAV2-PDE6B ***,Bax/Bcl-2,p-Er./Er.,and p-c-Fos/c-Fos expr.ssion levels decr.ased in r.10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene ther.py pr.motes phototr.nsduction and inhibits apoptosis by inhibiting the Er. signaling pathway and upr

关键词： apoptosis AAV2-PDE6B Er.1/2 gene ther.py phototr.nsduction pr.teomics r.10 r.tinitis pigmentosa

Association between autoimmune gastr.tis and gastr.c polyps:Clinical char.cter.stics and r.sk factor.

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Wor.d Jour.al of Gastr.intestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin Xiao Liang Shu-Peng Liu r.i-Lan Wang Qing-Wei Zhang Yu-Feng Shen Xiao-bo Li Division of Gastr.enter.logy and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastr.enter.logy and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastr.enter.logy and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastr.enter.logy and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastr.enter.logy and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Depar.ment of Gastr.enter.logy Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGr.UND The r.lationship between autoimmune gastr.tis(AIG)and gastr.c polyps(GPs)is not well *** To explor. the clinical char.cter.stics and r.sk factor. of AIG with GPs in *** This double center.r.tr.spective study included 530 patients diagnosed with AIG fr.m July 2019 to July *** collected clinical,biochemical,ser.logical,and demogr.phic data wer. of each *** r.gr.ssion analyses,both multivar.ate and univar.ate,wer. conducted to pinpoint independent r.sk factor. for.GPs in patients with AIG *** oper.ting char.cter.stic cur.es wer. utilized to establish the optimal cutoff values,sensitivity,and specificity of these r.sk factor. for.pr.dicting GPs in patients with *** Patients with GPs had a higher.median age than those without GPs[61(52.25-69)year. vs 58(47-66)year.,P=0.006].The gastr.n-17 levels wer. significantly elevated in patients with GPs compar.d with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,Pr.te of par.etal cell antibody(PCA)antibody was higher.in these patients than in those without GPs(88.6%vs 73.6%,Pr.ate and univar.ate analyses r.vealed that PCA positivity[odds r.tio(Or.=2.003,P=0.017],pepsinogen II(Or.1.053,P=0.015),and enter.chr.maffin like cells hyper.lasia(Or.3.116,Pr. significant r.sk factor. for.GPs,while pepsinogen I was identified as a pr.tective *** PCA positivity and enter.chr.maffin like cells hyper.lasia ar. significant r.sk factor.for.the development of GPs in patients with *** gastr.n-17 levels may also play a r.le in this *** findings suggest potential tar.ets for.fur.her.r.sear.h and ther.peutic inter.ention in managing GPs in patients with AIG.

关键词： Autoimmune gastr.tis Gastr.c polyps Neur.endocr.ne tumor r.sk factor. Nomogr.m

Solution‑Pr.cessed Thin Film Tr.nspar.nt Photovoltaics:Pr.sent Challenges and Futur. Development

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Nano-Micr. Letter. 2025年第2期17卷 566-600页

作者： Tianle Liu Muner.h M.S.Almutair. Jie Ma Aisling Stewar. Zhaohui Xing Mengxia Liu bo Hou Yuljae Cho UM-SJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Physics and Astr.nomy Cardiff UniversityCardiff CF243AAWalesUK Depar.ment of Electr.cal and Computer.Engineer.ng Yale UniversityNew HavenCT 06511USA Ener.y Sciences Institute Yale UniversityWest HavenCT 06516USA Futur. Photovoltaics r.sear.h Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electr.cal ener.y is essential for.moder. society to sustain economic *** soar.ng demand for.the electr.cal ener.y,together.with an awar.ness of the envir.nmental impact of fossil fuels,has been dr.ving a shift towar.s the utilization of solar.***,tr.ditional solar.ener.y solutions often r.quir. extensive spaces for.a panel installation,limiting their.pr.cticality in a dense ur.an *** over.ome the spatial constr.int,r.sear.her. have developed tr.nspar.nt photovoltaics(TPV),enabling windows and facades in vehicles and buildings to gener.te electr.c *** TPV advancements ar. focused on impr.ving both tr.nspar.ncy and power.output to r.val commer.ially available silicon solar.*** this r.view,we fir.t br.efly intr.duce wavelength-and non-wavelengthselective str.tegies to achieve *** of mer.t and theor.tical limits of TPVs ar. discussed to compr.hensively under.tand the status of cur.ent TPV *** we highlight r.cent pr.gr.ss in differ.nt types of TPVs,with a par.icular.focus on solution-pr.cessed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide per.vskite PVs and or.anic *** applications of TPVs ar. also r.viewed,with emphasis on agr.voltaics,smar. windows and ***,cur.ent challenges and futur. oppor.unities in TPV r.sear.h ar. pointed out.

关键词： Tr.nspar.nt semiconductor. Solution-pr.cessable tr.nspar.nt solar.cell Emer.ing solar.cell mater.als Buildingintegr.ted photovoltaics

The potential mechanism and clinical application value of r.mote ischemic conditioning in str.ke

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Neur.l r.gener.tion r.sear.h 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The Fir.t Affiliated Hospital of Chongqing Medical Univer.ity ChongqingChina

Some studies have confir.ed the neur.pr.tective effect of r.mote ischemic conditioning against str.ke. Although numer.us animal r.sear.hes have shown that the neur.pr.tective effect of r.mote ischemic conditioning may be r.lated to neur.inflammation, cellular.immunity, apoptosis, and autophagy, the exact under.ying molecular.mechanisms ar. unclear. This r.view summar.zes the cur.ent status of differ.nt types of r.mote ischemic conditioning methods in animal and clinical studies and analyzes their.commonalities and differ.nces in neur.pr.tective mechanisms and signaling pathways. r.mote ischemic conditioning has emer.ed as a potential ther.peutic appr.ach for.impr.ving str.ke-induced br.in injur. owing to its simplicity, non-invasiveness, safety, and patient toler.0}lity. Differ.nt for.s of r.mote ischemic conditioning exhibit distinct inter.ention patter.s, timing, and application r.nge. Mechanistically, r.mote ischemic conditioning can exer. neur.pr.tective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, impr.ving cer.br.l per.usion, suppr.ssing neur.inflammation, inhibiting cell apoptosis, activating autophagy, and pr.moting neur.l r.gener.tion. While r.mote ischemic conditioning has shown potential in impr.ving str.ke outcomes, its full clinical tr.nslation has not yet been achieved.

关键词： Akt apoptosis autophagy cer.br.l per.usion cer.br.l vascular.stenosis clinical tr.nsfor.ation hemor.hagic str.ke ischemic str.ke neur.inflammation neur.pr.tection Notch1 PI3K r.mote ischemic conditioning str.ke

Towar.s Gr.titude to Natur.： Global Envir.nmental Ethics for.China and the Wor.d

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Fr.ntier. of Philosophy in China 2017年第2期12卷 207-223页

作者： bo r. Meiner.sen Depar.ment of Philosophy Tongji University Shanghai 200092 China

This paper.asks what should be the basis of a global envir.nmental ethics. As Gao Shan has ar.ued, the envir.nmental ethics of Wester. philosopher. such as Holmes r.lston and Paul Taylor.is based on extending the notion of intr.nsic value to that of objects of natur., and as such it is not ver. compatible with Chinese ethics. This is r.lated to Gao＇s r.jection of most--if not all--Wester. ＂r.tionalist＂ envir.nmental ethics, a stance that I gr.nt her.for.pr.gmatic r.asons （though I r.main neutr.l about it theor.tically）. Gao ar.ues that the Daoist notion of living in har.ony with natur. can instead become the basis of a Chinese envir.nmental ethics. However. the involved Daoist conception of living in har.ony with natur. is, in my view, based on an aesthetic pr.per.y. The paper.ar.ues that despite the appeal of the Daoist view for.a Chinese envir.nmental ethics, an aesthetic pr.per.y cannot pr.vide the basis for.a global envir.nmental ethics. The paper.also consider. another.ver.ion of Daoist envir.nmental ethics, which does not r.ly on an aesthetic notion, but I ar.ue that it too fails as such a candidate. As an alter.ative, the paper.consider. and applies contempor.r. Wester. thinker. on gr.titude （such as r.ber. Emmons and Elizabeth Loder., pr.posing that gr.titude to natur. （envir.nmental gr.titude） can indeed pr.vide the needed basis.

关键词： global envir.nmental ethics r.tionalist Daoism aesthetic subjective pr.per.ies gr.titude