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全膝置换术中行髌骨置换与未置换的比较随机试验的简要追踪报道

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中华骨科杂志 2010年第6期30卷 I0005-I0009页

作者： r. stephen j. burnett j.lienne L. Boone Seth D. r.senzweig Kar.n Steger.May r.ber. L. Bar.ack 陈云苏(译) 张先龙(译) Investigation per.or.ed at the Depar.ment of Or.hopaedic Sur.er. Tulane University New Orleans Louisiana and the Department of Orthopaedic Surgery Washington University School of Medicine and Barnes-Jewish Hospital St. Louis Missouri 上海交通大学附属第六人民医院骨科 200233

全膝置换术中髌骨是否置换存在争议。本研究比较了行髌骨置换和未行髌骨置换的全膝置换术的长期临床结果，是以前报告的更新。86例（118膝）患者接受初次全膝置换术，并被随机分成两组：一组行髌骨置换，而另一组未行髌骨置换。结果评... 详细信息

全膝置换术中髌骨是否置换存在争议。本研究比较了行髌骨置换和未行髌骨置换的全膝置换术的长期临床结果，是以前报告的更新。86例（118膝）患者接受初次全膝置换术，并被随机分成两组：一组行髌骨置换，而另一组未行髌骨置换。结果评价标准包括：根据KneeSociety临床等级系统所得评分、髌股特定41题患者问卷调查所得评分、患者满意度、全膝（global）痛和膝前痛评分、影像学发现、并发症和翻修率等。57例（78膝）患者最少随访10年。两组患者在关节活动度、KneeSociety评分、满意度、全膝痛或膝前痛方面无显著差异。髌骨未置换组患者膝关节翻修率在118膝中占12％，而髌骨置换组占9％。髌骨未置换组中7例患者（占12％）和髌骨置换组2例患者（占3％）由于髌股方面的问题接受了翻修手术。基于这些发现，我们得出结论：对患者所接受的全膝置换术类型，不论是否行髌骨置换，其结果相似。

关键词：初次全膝置换术髌骨置换随机试验患者满意度追踪临床结果关节翻修关节活动度

Stability Analysis and Per.or.ance Evaluation of Additive Mixed-Pr.cision r.nge-Kutta Methods

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Communications on Applied Mathematics and Computation 2024年第1期6卷 705-738页

作者： Ben burnett Sigal Gottlieb Zachar. j.Gr.nt Center.for.Scientific Computing and Data Science r.sear.h UMass DartmouthNorth DartmouthMassachusettsUSA CSME Michigan State UniversityEast LansingMichiganUSA

Additive r.nge-Kutta methods designed for.pr.ser.ing highly accur.te solutions in mixed-pr.cision computation wer. pr.viously pr.posed and *** specially designed methods use r.duced pr.cision for.the implicit computations and full pr.cision for.the explicit *** this wor.,we analyze the stability pr.per.ies of these methods and their.sensitivity to the low-pr.cision r.unding er.or.,and demonstr.te their.per.or.ance in ter.s of accur.cy and *** develop codes in FOr.r.N and j.lia to solve nonlinear.systems of ODEs and PDEs using the mixed-pr.cision additive r.nge-Kutta(MP-Ar.)*** conver.ence,accur.cy,and r.ntime of these methods ar. *** show that for.a given level of accur.cy,suitably chosen MP-Ar. methods may pr.vide significant r.ductions in r.ntime.

关键词： Mixed pr.cision r.nge-Kutta methods Additive methods Accur.cy

NADPH oxidase： r.cent evidence for.its r.le in er.ctile dysfunction

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Asian j.ur.al of Andr.logy 2008年第1期10卷 6-13页

作者： Liming j.n Ar.hur.L.burnett Depar.ment of Ur.logy The James Buchanan Brady Urological Institute Johns Hopkins Medical Institutions Baltimore MD 21287 USA

Impor.ant r.les for.r.active oxygen species （r.S） in physiology and pathophysiology have been incr.asingly r.cognized. Under.nor.al conditions, r.S ser.e as signaling molecules in the r.gulation of cellular.functions. However. enhanced r.S pr.duction as a r.sult of the activation of nicotinamide adenine dinucleotide phosphate （NADPH） oxidase contr.butes significantly to the pathogeneses of vascular.diseases. Although it has become evident that incr.ased r.S is associated with er.ctile dysfunction （ED）, the sour.es of r.S in the penis r.main lar.ely unknown. In r.cent year., emer.ent evidence suggests the possible r.le of NADPH oxidase in inducing ED. In this r.view, we examine the r.lationship between r.S and ED in differ.nt disease models and discuss the cur.ent evidence basis for.NADPH oxidase-der.ve＇d r.S in ED.

关键词： r.active oxygen species er.ctile function super.xide penis nitr.c oxide

4D imaging of void nucleation,gr.wth,and coalescence fr.m lar.e and small inclusions in steel under.tensile defor.ation

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j.ur.al of Mater.als Science & Technology 2022年第28期123卷 168-176页

作者： Yi Guo Timothy L.burnett Samuel A.McDonald Michael Daly Andr.w H.Sher.y Philip j.Wither. Shenyang National Labor.tor. for.Mater.als Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Henr. r.yce Institute Department of MaterialsUniversity of ManchesterM139PLUK Eur.pean Synchr.tr.n r.diation Facility(ESr.) 6 rue J Horowitz38000 GrenobleFrance National Nuclear.Labor.tor. Chadwick HouseBirchwood ParkWarringtonWA36AEUK

Samples of SA508 gr.de 3 nuclear.pr.ssur. vessel fer.itic steel wer. subj.cted to tensile str.ining whilst being simultaneously imaged in 3D in r.al time using high r.solution,high fr.me r.te time-lapse synchr.tr.n computed tomogr.phy(CT).This enabled dir.ct obser.ation of void development fr.m nucleation,thr.ugh gr.wth to coalescence and final failur. validating many infer.nces made post-mor.em or.by theor.tical models,as well as r.ising new *** spar.e,lar.e inclusions wer. found to nucleate voids at essentially zer. plastic str.in(consistent with zer. inter.acial str.ngth);these became incr.asingly elongated with *** contr.st,a high density of small spher.cal voids wer. found to nucleate fr.m the sub-micr.n cementite par.icles at lar.er.str.ins(>200%)only in the centr. of the necked(high tr.axiality)*** inter.acial str.ngth appr.aching 2100 MPa was infer.ed and soon after.their.nucleation,these small voids coalesce to for. inter.al micr.cr.cks that lead to the final failur. of the *** sur.r.singly,under.these conditions of gener.lly low tr.axial constr.int the lar.e voids ar. simply cut acr.ss and appear.to play no significant r.le in deter.ining the final *** implications of these r.sults ar. discussed in ter.s of ductile fr.ctur. behaviour.and the Gur.on model for.ductile fr.ctur..

关键词： Void gr.wth Ductile fr.ctur. Synchr.tr.n X-r.y tomogr.phy 4D imaging Bainitic steel

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重载流多芯电缆周围的磁场I.理论模型

上海交通大学学报 2002年第2期36卷 237-242页

作者：傅正财杜亚平 j.burnett 上海交通大学电力学院上海200030 香港理工大学屋宇设备工程学系

多芯电力电缆在低压配电系统中常被用作配电干线 .这种重载流电缆周围的极低频磁场可能干扰附近敏感电子设备的正常运行 ,甚至影响暴露于该场下的人体的健康 .为分析这种磁场的分布特性 ,建立了多芯电缆周围磁场的载流平行螺旋线模型 ,... 详细信息

多芯电力电缆在低压配电系统中常被用作配电干线 .这种重载流电缆周围的极低频磁场可能干扰附近敏感电子设备的正常运行 ,甚至影响暴露于该场下的人体的健康 .为分析这种磁场的分布特性 ,建立了多芯电缆周围磁场的载流平行螺旋线模型 ,并推导了周围磁场的简化计算公式 .基于所提出的理论模型对电缆周围磁场的特性进行了分析 ,发现在电缆的半径方向上磁场随距离衰减的速度大于指数衰减速度 .在平行于电缆轴线的直线上和在电缆的同轴圆周线上 ,磁场的幅值和相角都随观测点的位置周期变化 .理论计算结果表明 ,常用规格的多芯电力电缆在载额定电流的情况下 ,距电缆 2 m外空间中的磁场已小于有关国际标准的限值 .

关键词：重载流理论模型多芯电力电缆极低频磁场电磁兼容低压配电系统

A Lysozyme Concentr.tion, pH, and Time-Dependent Isother.al Tr.nsfor.ation Diagr.m r.veals Fibr.us Amyloid and Non-Fibr.us, Amor.hous Aggr.gate Species

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Open j.ur.al of Biophysics 2014年第2期4卷 39-50页

作者： Lisa C. burnett Benj.min j. burnett Bin Li Samuel T. Dur.ance Shaohua Xu Depar.ment of Biological Sciences Florida Institute of Technology Melbourne Florida USA Depar.ment of Chemical Engineer.ng Florida Institute of Technology Melbourne Florida USA Space Life Sciences Labor.tor. Kennedy Space Center Titusville Florida USA Depar.ment of Biological Sciences Florida Institute of Technology Melbourne Florida USA Space Life Sciences Labor.tor. Kennedy Space Center Titusville Florida USA Depar.ment of Physics and Space Sciences Florida Institute of Technology Melbourne Florida USA Space Life Sciences Labor.tor. Kennedy Space Center Titusville Florida USA Depar.ment of Physics and Space Sciences Florida Institute of Technology Melbourne Florida USA

Deposition of aggr.gated pr.tein is associated with many human diseases. The mechanism by which pr.tein aggr.gate species cause cellular.death r.mains unclear. A pr.file r.vealing pr.tein aggr.gation pr.ducts under.a diver.e set of conditions allows the sear.h of novel aggr.gate pr.ducts and potential pathogens. To achieve this end, an isother.al tr.nsfor.ation diagr.m (ITD) of lysozyme aggr.gation was constr.cted. AFM, TEM, and Thioflavin T binding assays wer. used to analyze the aggr.gate species synthesized under.a br.ad r.nge of pH values, pr.tein concentr.tions, and incubation times. Four.states wer. found: 1) soluble pr.tein species;2) insoluble amyloid fiber.;3) insoluble amor.hous aggr.gates;and 4) pr.tein hydr.gels. The hydr.gel-a r.ses fr.m aggr.gated amyloid fiber.. This wor. is par. of an effor. to constr.ct an ar.ay of ITDs r.por.ing aggr.gation pr.per.ies of many disease r.levant pr.teins, including amyloid beta, tau, α-synuclein, and other. involved in pr.tein aggr.gation diseases. In addition, we pr.pose hydr.gel cyto toxicity as a potential novel mechanism in the pathogenesis of amyloid diseases.

关键词： Phase Diagr.m Alzheimer.s Disease Pr.on Dementia Pr.tein Aggr.gation Self-Assembly Hydr.gel Gel Amor.hous Aggr.gate

Epidur.l Blood Patch for.Tr.atment of Postdur.l Punctur. Headache in a Patient with Spinal Fusion and r.cent Implantation of Intr.thecal Pain Pump

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Open j.ur.al of Anesthesiology 2013年第3期3卷 168-169页

作者： Chistopher.j. burnett Andr.w j. White Mar.us D. Vulcan Division of Anesthesiology Scott & White Memorial Hospital Temple College of Medicine Texas A&M University College Station USA.

We pr.sent an inter.sting case r.por. of a 49-year.old female who pr.sented with symptoms of post-dur.l punctur. headache following implantation of an intr.thecal pain pump. Her.histor. was complicated by pr.vious multi-level spinal fusion with har.war.. The patient was evaluated and felt to be a candidate for.epidur.l blood patch, which she elected to pr.ceed with. Under.fluor.scopic guidance epidur.l blood patch was successfully per.or.ed. Immediately following the pr.cedur. the patient noted significant impr.vement in the headache and six hour. following the pr.cedur. was headache fr.e and r.mained so at follow up thr.e weeks later.

关键词： Epidur.l Blood Patch Intr.thecal Pain Pump Spinal Fusion

SAr.of tr.cyclic sulfones as γ-secr.tase inhibitor.

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Science China Chemistr. 2011年第11期54卷 1688-1701页

作者： COLE David ASBEr.M Ted BAr. Tom BENNETT Chad burnett Duane A. CLADEr.j.hn DOMALSKI Mar.in Gr.ENLEE William j. HYDE Lynn j.SIEN Huber. McBr.Ar.Mar. McKITTr.CK Br.an PISSAr.ITSKI Dmitr. r.j.GOPALAN Mur.li SASIKUMAr.Thavalakulamgar. Mer.k r.sear.h Labor.tor.es 2015 Galloping Hill RoadKenilworth New Jersey 07033 USA

Novel tr.cyclic sulfones as γ-secr.tase inhibitor. have been r.por.ed by this labor.tor. for.the tr.atment of Alzheimer.s disease. Compounds in this ser.es have compar.ble or.better.in vitr. activities and in vivo efficacies than sulfonamide analogues r.- por.ed pr.viously by this labor.tor.. Based on the pr.viously r.por.ed tr.cyclic sulfone scaffold, additional SAr.studies of C r.ng wer. car.ied out. Var.ous C-r.ng str.ctur.s including cyclohexane, pyr.n, and piper.dine wer. toler.ted. Additionally, the 7- and 8- positions of the C-r.ng wer. identified as the best sites to intr.duce substituent for.modulating the phar.acokinetic pr.per.ies of compounds fr.m this ser.es.

关键词： tr.cyclic sulfones T-secr.tase Alzheimer.s disease inhibitor.

Factor. associated with incr.ased incidence of sever. toxicities following yttr.um-90 r.sin micr.spher.s in the tr.atment of hepatic malignancies

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Wor.d j.ur.al of Gastr.enter.logy 2016年第10期22卷 3006-3014页

作者： j.hn D r.ber.on II Andr.w M Mc Donald Cr.ig j.Baden Chee Paul Lin r.j.mon j.cob Omer.L burnett III School of Medicine University of Alabama at Birmingham Birmingham AL 35294-3412 United States Depar.ment of r.diation Oncology University of Alabama at Birmingham Birmingham AL 35233 United States Center.for.Clinical and Tr.nslational Science University of Alabama at Birmingham Birmingham AL 35205 United States

AIM: To fur.her.define var.ables associated with incr.ased incidences of sever. toxicities following administr.tion of yttr.um-90 (90Y) ***: Fifty-eight patients under.oing 79 tr.atments wer. r.tr.spectively assessed for.development of clinical and labor.tor. toxicity incidence following 90Y administr.tion. Sever. toxicity events wer. defined using Common Ter.inology Cr.ter.a for.Adver.e Events ver.ion 4.03 and defined as gr.de ≥ 3. Univar.ate logistic r.gr.ssion analyses wer. used to evaluate the effect of differ.nt factor. on the incidence of sever. toxicity events. Multicollinear.ty was assessed for.all factor. with P r.on cor.elation matr.ces. All factor. not excluded due to multicollinear.ty wer. included in a multivar.ate logistic r.gr.ssion model for.each measur.ment of sever. ***: Sever. (gr.de ≥ 3) toxicities occur.ed following 21.5% of the 79 tr.atments included in our.analysis. The most common sever. labor.tor. toxicities wer. sever. alkaline phosphatase (17.7%), albumin (12.7%), and total bilir.bin (10.1%) toxicities. Decr.ased pr.-tr.atment albumin (Or.= 26.2, P = 0.010) and incr.ased pr.-tr.atment inter.ational nor.alized r.tio (INr. (Or.= 17.7, P = 0.048) wer. associated with development of sever. hepatic toxicity. Incr.ased pr.-tr.atment aspar.ate aminotr.nsfer.se (AST; Or.= 7.4, P = 0.025) and decr.ased pr.-tr.atment hemoglobin (Or.= 12.5, P = 0.025) wer. associated with sever. albumin toxicity. Incr.asing pr.-tr.atment model for.end-stage liver.disease (MELD) scor. (Or.= 1.8, P = 0.033) was associated with sever. total bilir.bin toxicity. Color.ctal adenocar.inoma histology was associated with sever. alkaline phosphatase toxicity (Or.= 5.4, P = 0.043).CONCLUSION: Clinicians should car.fully consider.pr.-tr.atment albumin, INr. AST, hemoglobin, MELD, and color.ctal histology when choosing appr.pr.ate candidates for.90Y micr.spher. ther.py.

关键词： Yttr.um-90 micr.spher.s Liver.metastases Multivar.ate analysis Toxicity incidence Color.ctal adenocar.inoma