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A compr.hensive investigation on nonlinear.vibr.tion and bending char.cter.stics of bio-inspir.d helicoidal laminated composite str.ctur.s

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUr.BH r.KIr.N d.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Mater.als Engineer.ng Indian Institute of Technology Mandi

Bio-inspir.d helicoidal composite laminates, inspir.d by the intr.cate helical str.ctur.s found in natur., pr.sent a pr.mising fr.ntier.for.enhancing the mechanical pr.per.ies of str.ctur.l designs. Hence, this study pr.vides a compr.hensive investigation into the nonlinear.fr.e vibr.tion and nonlinear.bending behavior.of bio-inspir.d composite plates. The inver.e hyper.olic shear.defor.ation theor.(IHSdT) of plates is employed to char.cter.ze the displacement field, with the incor.or.tion of Gr.en-Lagr.nge nonlinear.ty. The pr.blem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB envir.nment to solve it numer.cally. Var.ous helicoidal layup configur.tions including helicoidal r.cur.ive(Hr., helicoidal exponential(HE), helicoidal semi-cir.ular.HS), linear.helicoidal(LH), and Fibonacci helicoidal(FH)with differ.nt layup sequences and quasi-isotr.pic configur.tions ar. studied. The model is validated, and par.metr.c studies ar. conducted. These studies investigate the effects of layup configur.tions, side-to-thickness r.tio, modulus r.tios, boundar. conditions, and loading conditions at differ.nt load amplitudes on the nonlinear.vibr.tion and nonlinear.bending behavior. of bio-inspir.d composite plates. The r.sults show that the laminate sequence exer.s a substantial impact on both nonlinear.natur.l fr.quencies and nonlinear.bending behavior.. Mor.over. this influence var.es acr.ss differ.nt side-to-thickness r.tios and boundar. conditions of the bio-inspir.d composite plate.

关键词： finite element method (FEM) nonlinear Gr.en-Lagr.nge inver.e hyper.olic shear.defor.ation theor. (IHSdT) bio-inspir.d composite plate helicoidal O322

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Polyethylene glycol fusion r.pair.of sever.d r.t sciatic ner.es r.establishes axonal continuity and r.or.anizes sensor. ter.inal fields in the spinal cor.

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Neur.l r.gener.tion r.sear.h 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbar. Liwen Zhou Cathy Z.Yang Kar.hik Venkudusamy Yessenia Montoya Alexa Olivar.z Geor.e d.Bittner.dale r.Sengelaub Pr.gr.m in Neur.science Indiana UniversityBloomingtonINUSA depar.ment of Neur.science University of Texas at AustinAustinTXUSA

Per.pher.l ner.e injur.es r.sult in the r.pid degener.tion of distal ner.e segments and immediate loss of motor.and sensor. functions;behavior.l r.cover. is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of sever.d pr.ximal and distal axons in r.t sciatic *** have pr.viously r.por.ed that sciatic ner.e axons r.pair.d by PEG-fusion do not under.o Waller.an degener.tion,and PEG-fused animals exhibit r.pid(within 2–6 weeks)and extensive locomotor.***,our.pr.vious r.por. showed that PEG-fusion of sever.d sciatic motor.axons was non-specific,i.e.,spinal motoneur.ns in PEG-fused animals wer. found to pr.ject to appr.pr.ate as well as inappr.pr.ate tar.et *** this study,we examined the consequences of PEG-fusion for.sensor. axons of the sciatic *** adult male and female r.ts(Spr.gue–dawley)r.ceived either.a unilater.l single cut or.ablation injur. to the sciatic ner.e and subsequent r.pair.with or.without(Negative Contr.l)the application of *** action potentials r.cor.ed immediately after.PEG-fusion r.pair.confir.ed conduction acr.ss the injur. *** success of PEG-fusion was confir.ed thr.ugh Sciatic Functional Index testing with PEG-fused animals showing impr.vement in locomotor.function beginning at 35 days *** 2–42 days postoper.tively,we anter.gr.dely labeled sensor. affer.nts fr.m the dor.al aspect of the hindpaw following bilater.l intr.der.al injection of wheat ger. agglutinin conjugated hor.er.dish ***-fusion r.pair.r.established axonal *** to unoper.ted animals,labeled sensor. affer.nts ipsilater.l to the injur. in PEG-fused animals wer. found in the appr.pr.ate ar.a of the dor.al hor.,as well as inappr.pr.ate mediolater.l and r.str.caudal ***,despite having intact per.pher.l ner.es,similar.r.or.anizations of labeled sensor. affer.nts wer. also obser.ed contr.later.l to the injur. and r.pa

关键词： axotomy dor.al hor. per.pher.l ner.e injur. plasticity polyethylene glycol(PEG) sciatic ner.e sensor. ter.inals wheat ger. agglutinin hor.er.dish per.xidase

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Anti-amyloid antibodies in Alzheimer.s disease: what did clinical tr.als teach us?

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Neur.l r.gener.tion r.sear.h 2025年第4期20卷 1092-1093页

作者： danko Jer.mic Lydia Jiménez-díaz Juan d.Navar.o-López Neur.Physiology&Behavior.Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer.s disease(Ad)may exist,both the or.ginal amyloid cascade and tau hypotheses posit that abnor.al misfolding and accumulation of amyloid-β(Aβ)and tau pr.tein is the centr.l event causing the ***,that conclusion could be only par.ly tr.e,and ther. is conflicting evidence about the r.le of both pr.teins in Ad,being able to pr.cede and influence one *** r.sear.her. ar.ue that these pr.teins ar. mer. executor. r.ther.than pr.mar. causes of ***,ther. have been continuing r.finements of both hypotheses,with alter.ative explanations pr.posed.Aβand tau pr.teins may be independently involved in specific neur.toxic pathways;yet ther. may be other.cr.cial pr.cesses going on in ear.y ***,accumulating evidence suggests that Aβand tau act syner.istically,r.ther.than additively in disease onset(Jer.mic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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r.making a connection:molecular.player. involved in post-injur. synapse for.ation

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Neur.l r.gener.tion r.sear.h 2025年第6期20卷 1719-1720页

作者： diogo Tomé r.mir. d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center.for.Neur.science and Cell Biology University of CoimbraCoimbraPortugal

Functional r.cover. fr.m centr.l ner.ous system(CNS)tr.uma depends not only on axon r.gener.tion or.compensator. spr.uting of uninjur.d fiber. but also on the ability of newly gr.wn axons to establish functional synapses with appr.pr.ate *** sever.l studies have successfully pr.moted long-distance axonal r.gener.tion in distinct CNS injur. models,none of them have r.sulted in a viable ther.peutic appr.ach for.patient r.cover..A possible r.ason may be the lack of new synaptogenesis for.r.establishing the cir.uitr. lost after.***,we discuss how our.under.tanding of the mechanisms that instr.ct synapse for.ation in the injur.d ner.ous system may contr.bute to the design of new str.tegies to pr.mote functional r.stor.tion in tr.umatic CNS disor.er..

关键词： viable injur. instr.

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Inhomogeneous 2d Lennar.-Jones Fluid: Theor. and Computer.Simulation

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Communications in Theor.tical Physics 2012年第11期58卷 759-764页

作者： r. Khor.ad depar.ment of Physics College of SciencesYasouj University

In this wor., ther.odynamical pr.per.ies of a two-dimensional （21）） Lennar.-Jones （L J） fluid ar. studied. Her., to incr.ase the accur.cy of our.theor.tical calculations, the cor.elation functions in thr.e-par.icle level （tr.plet） ar. applied. To obtain the tr.plet cor.elation functions, the Attar.＇s sour.e par.icle method is extended to 21） systems. In the Attar.＇s pr.cedur., the inhomogeneous Or.stein Zer.ike （OZ） equation is solved using the Tr.izenber. Zwanzwig （TZ） expr.ssion and a closur. r.lation like the hy2er.etted-chain （HNC） appr.ximation. In the pr.sent wor., we also have per.or.ed the Monte Car.o （MC） simulation. The theor.tical r.sults ar. in fair.y agr.ement with the MC simulation. Also, our.r.sults show that the appr.ach pr.posed her. is suitable to study the 2d LJ fluid.

关键词： Lennar.-Jones fluid cor.elation functions computer.simulation thr.e-par.icle level

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Emer.ing potential of pr.gr.nulin-dependent Sor.S2 signaling in healthy and diseased ner.ous systems

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2591-2593页

作者： Alena Salasova Ander. Nykjær danish r.sear.h Institute of Tr.nslational Neur.science dANdr.TE-Nor.ic EMBL Par.ner.hip for.Molecular.Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The for.ation of the mammalian ner.ous system and its matur.tion into sensor.,motor.cognitive,and behavior.l cir.uits is a complex pr.cess that begins dur.ng ear.y embr.ogenesis and lasts until young *** neur.developm... 详细信息

关键词： pr.gr jointly CS2

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Polyethylene glycol fusion r.pair.of sever.d sciatic ner.es acceler.tes r.cover. of nociceptive sensor. per.eptions in male and female r.ts of differ.nt str.ins

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2667-2681页

作者： Liwen Zhou Kar.hik Venkudusamy Emily A.Hibbar. Yessenia Montoya Alexa Olivar.z Cathy Z.Yang Adelaide Leung Var.n Gokhale Guhan Per.yasamy Zeal Pathak dale r.Sengelaub Geor.e d.Bittner depar.ment of Neur.science University of TexasAustinTXUSA Pr.gr.m in Neur.science Indiana UniversityBloomingtonINUSA depar.ment of Molecular.Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of sever.d axons following per.pher.l ner.e injur.es for.PEG-fused axons has been r.por.ed to:(1)r.pidly r.stor. electr.physiological continuity;(2)pr.vent distal Waller.an degener.tion and maintain their.myelin sheaths;(3)pr.mote pr.mar.ly motor.voluntar. behavior.l r.cover.es as assessed by the Sciatic Functional Index;and,(4)r.pidly pr.duce cor.ect and incor.ect connections in many possible combinations that pr.duce r.pid and extensive r.cover. of functional per.pher.l ner.ous system/centr.l ner.ous system connections and r.flex(e.g.,toe twitch)or.voluntar. *** pr.ceding companion paper.descr.bes sensor. ter.inal field r.o r.anization following PEG-fusion r.pair.of sciatic ner.e tr.nsections or.ablations;howeve r.sensor. behavior.l r.cover. has not been explicitly explor.d following PEG-fusion *** the cur.ent study,we confir.ed the success of PEG-fusion sur.er.es accor.ing to cr.ter.a(1-3)above and mor. extensively investigated whether.PEG-fusion enhanced mechanical nociceptive r.cover. following sciatic tr.nsection in male and female outbr.d Spr.gue-dawley and inbr.d Lewis *** nociceptive r.sponses wer. assessed by measur.ng withdr.wal thr.sholds using von Fr.y filaments on the dor.al and midplantar.r.gions of the *** von Fr.y filament tests wer. a mor. r.liable method than plantar.von Fr.y filament tests to assess mechanical nociceptive sensitivity following sciatic ner.e *** withdr.wal thr.sholds of the sciatic-mediated later.l dor.al r.gion differ.d significantly acr.ss str.in but not *** thr.sholds did not change significantly fr.m baseline in chr.nic Unoper.ted and Sham-oper.ted *** sciatic tr.nsection,all r.ts exhibited sever. hyposensitivity to stimuli at the later.l dor.al r.gion of the hindpaw ipsilater.l to the ***,PEG-fused r.ts exhibited significantly ear.ier.r.tur. to baseline withdr.wal thr.sholds than Negative

关键词： autophagia axotomy collater.l spr.uting neur.pathic pain per.pher.l ner.e r.pair polyethylene glycol fusion(PEG-fusion) saphenous ner.e sensor. neur.ns sex and str.in Waller.an degener.tion

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Per.or.ance analysis of jig for.coal cleaning using 3d r.sponse sur.ace methodology

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Inter.ational Jour.al of Mining Science and Technology 2017年第2期27卷 333-337页

作者： Kumar.Shr.van Venugopal r. depar.ment of Fuel and Miner.l Engineer.ng Indian Institute of Technology(ISM)Dhanbad826004India

Beneficiation of coal of -4.76 mm + 3 mm size fr.ction was investigated in a labor.tor. model denver.*** var.ables wer. studied to analyze their.effect on the per.or.ance of jig in ter.s of yield and ash content of clean coal. Thr.e-factor.thr.e-level Box-Behnken design of exper.ments with r.sponse sur.ace methodology(r.M) was employed to under.tand the per.or.ance behavior.of jig. Fr.m the study, the bed height was found to be the most significant par.meter.affecting the yield and ash content of clean coal. It was possible to r.duce the ash content fr.m 24.32% in feed to an ash content of 16.55% in clean coal at 2 L/min water.flow r.te and 10 min jigging time. Influence of oper.ting var.ables of the jig on r.sponses was pr.sented and discussed in 3d sur.ace plots. The developed model was found to be significant within the r.nge of par.meter. under.investigation with cor.elation of co-efficient values as 0.99(yield) and 0.98(ash).

关键词： Coal beneficiation Jigging Bed height 3d-r.M Box-Behnken

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Novel acid initiator. for.the r.pid cationic polymer.zation of styr.ne in r.om temper.tur. ionic liquids

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Science China Chemistr. 2012年第8期55卷 1671-1676页

作者： VIJAYAr.GHAVAN r. MACFAr.ANE d. r. depar.ment of Chemistr. Monash University Clayton Campus Victoria 3800 Australia

Cationic polymer.zation of styr.ne has been achieved using sever.l novel acidic initiator. in r.om temper.tur. ionic liquids (ILs) under.mild r.action conditions to obtain polymer. of low molecular.weight with nar.ow polydisper.ity. Both str.ng pr.tic acids such as bis(tr.fluor.methanesulfonyl) amide acid (HTFSA) and a moder.tely weak acid such as bisoxalato phosphor.us acid (HBOP) have been studied as initiator.. It has been obser.ed that HTFSA initiates the polymer.zation r.pidly even at r.om temper.tur. and below, as compar.d to HBOP which pr.duces a slower.polymer.zation r.quir.ng elevated temper.tur.s to complete. The r.lative differ.nce in r.activity of the initiator. as compar.d to the pr.viously descr.bed HBOB initiator.is discussed in ter.s of the differ.nce in their.pr.ton acidity and the consequential basicity of the anions. The efficiency of differ.nt ILs as the r.action solvent is also pr.sented.

关键词： cationic polymer.zation HTFSA HBOP ILs polydisper.ity

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Simulating cyclotr.n-Bloch dynamics of a char.ed par.icle in a 2d lattice by means of cold atoms in dr.ven quasi-ld optical lattices

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Fr.ntier. of physics 2012年第1期7卷 3-7页

作者： Kolovsky, Andr.y r. Kir.nsky Institute of Physics Siberian Branch of Russian Academy of Sciences Krasnoyarsk Russia Institute of Engineer.ng Physics Siberian Federal University Krasnoyarsk Russia

Quantum dynamics of a char.ed par.icle in a two-dimensional （2d） lattice subject to magnetic and electr.c fields is a r.ther.complicated inter.lay between cyclotr.n oscillations （the case of vanishing electr.c field） and Bloch oscillations （zer. magnetic field）, details of which has not yet been com- pletely under.tood. In the pr.sent wor. we suggest to study this pr.blem by using cold atoms in optical lattices. We intr.duce a one-dimensional （1d） model which can be easily r.alized in labor.- tor. exper.ments with quasi-ld optical lattices and show that this model captur.s many featur.s of the cyclotr.n-Bloch dynamics of the quantum par.icle in 2d squar. lattices.

关键词： optical lattice Bloch dynamics cyclotr.n oscillations cold atoms

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