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Small molecule inhibitor.DDQ-tr.ated hip.ocamp.l neur.nal cells show imp.0}ved neur.te outgr.wth and synap.ic br.nching

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2624-2632页

作者： Jangamp.lli Adi p.0}deep.ir.n p.0}yanka r.wat Ar.bala p.reddy Er.ka Or.ov p.emachandr. reddy Dep.r.ment of Inter.al Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Dep.r.ment of Nutr.tional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Dep.r.ment of p.ar.acology&Neur.science Texas Tech University Health Sciences CenterLubbockTXUSA Dep.r.ment of Neur.logy Texas Tech University Health Sciences CenterLubbockTXUSA Dep.r.ment of Sp.ech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Dep.r.ment of p.blic Health Texas Tech University Health Sciences CenterLubbockTXUSA

The p.0}cess of neur.te outgr.wth and br.nching is a cr.cial asp.ct of neur.nal develop.ent and *** and dendr.tes,sometimes r.fer.ed to as neur.tes,ar. extensions of a neur.n's cellular.body that ar. used to star. *** we exp.or.d the effects of diethyl(3,4-dihydr.xyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ)on neur.te develop.ental featur.s in HT22 neur.nal *** this wor.,we examined the p.0}tective effects of DDQ on neur.nal p.0}cesses and synap.ic outgr.wth in differ.ntiated HT22cells exp.0}ssing mutant Tau(mTau)*** investigate DDQ char. cter.stics,cell viability,biochemical,molecular.wester. blotting,and immunocytochemistr. wer. *** outgr.wth is evaluated thr.ugh the segmentation and measur.ment of neur.l *** neur.l p.0}cesses can be seen and measur.d with a fluor.scence micr.scop. by manually tr.cing and measur.ng the length of the neur.te *** neur.nal p.0}cesses can be obser.ed and quantified with a fluor.scent micr.scop. by manually tr.cing and measur.ng the length of the neur.nal ***-tr.ated mTau-HT22 cells(HT22 cells tr.nsfected with cDNA mutant Tau)wer. seen to disp.ay incr.ased levels of synap.op.ysin,MAp.2,andβ-***,we confir.ed and noted r.duced levels of both total and p.Tau,as well as elevated levels of micr.tubule-associated p.0}tein 2,β-tubulin,synap.op.ysin,vesicular.acetylcholine tr.nsp.r.er.and the mitochondr.al biogenesis p.0}tein-p. r.xisome p.0}life r.tor.activated r.cep.or.gamma coactivator.1α.In mTa u-exp.0}ssed HT22 neur.ns,we obser.ed DDQ enhanced the neur.te char.cter.stics and imp.0}ved neur.te develop.ent thr.ugh incr.ased synap.ic *** findings conclude that mTa u-HT22(Alzheimer.s disease)cells tr.ated with DDQ have functional neur.te develop.ental char. *** key finding is that,in mTa u-HT22 cells,DDQ p.0}ser.es neur.nal str.ctur. and may even enhance ner.e develop.ent function with mTa u inhibition.

关键词： diethyl(3 4-dihydr.xyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ) hip.ocamp.l neur.nal cells HT22 neur.te outgr.wth neur.nal develop.ent small molecule

Op.imal dynamic emer.ency r.ser.e activation using sp.nning, hydr. and demand-side r.ser.es

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Fr.ntier. in Ener.y 2016年第4期10卷 409-423页

作者： S. Sur.nder.reddy p. r. BIJWE A. r. ABHYANKAr Dep.r.ment of r.ilr.ad and Electr.cal Engineer.ng Woosong University Republic of Korea Dep.r.ment of Electr.cal Engineer.ng Indian Institute of TechnologyDelhi India

This p.p.r.p.0}p.ses an op.imal dynamic r.ser.e activation p.an after.the occur.ence of an emer.ency situation （gener.tor.tr.nsmission line outage, load incr.ase or.both）. An op.imal p.an is develop.d to handle the emer.ency, using the coor.inated action of fast and slow r.ser.es, for.secur. op.r.tion with minimum over.ll cost. It consider. the r.ser.es sup.lied by the conventional ther.al gener.tor. （sp.nning r.ser.es）, hydr. p.wer.units and load demands （demand-side r.ser.es）. The op.imal backing down of costly/fast r.ser.es and br.nging up.of slow r.ser.es in each sub-inter.al in an integr.ted manner.is p.0}p.sed. The p.0}p.sed r.ser.e activation ap.r.aches ar. solved using the genetic algor.thm, and some of the simulation r.sults ar. also comp.r.d using the Matlab op.imization toolbox and the gener.l algebr.ic modeling system （GAMS） softwar.. The simulation studies ar. p.r.or.ed on the IEEE 30, 57 and 300 bus test systems. These r.sults demonstr.te the advantage of the p.0}p.sed integr.ted/dynamic r.ser.e activation p.an over.the conventional/sequential ap.r.ach.

关键词： demand-side r.ser.es dynamic r.ser.e acti-vation ap.r.ach hydr. p.wer.units p.st contingency,sequential r.ser.e activation ap.r.ach sp.nning r.ser.es

A comp.r.tive analysis of unsteady and steady Buongior.o’s Williamson nanoliquid flow over.a wedge with slip.effects

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Chinese Jour.al of Chemical Engineer.ng 2020年第7期28卷 1767-1777页

作者： r.Chandr. Sekhar.reddy p.Sudar.ana reddy Dep.r.ment of Mathematics Rajeev Gandhi Memorial Collge of Engineering&TechnologyNandyalA.P.India

Comp.r.son between unsteady and steady MHD Buongior.o’s model Williamson nanoliquid flow thr.ugh a wedge with slip.effects,chemical r.action and r.diation is made in this *** and Br.wnian motion ar. also consider.d in this *** similar.ty var.ables ar. p.0}sented to tr.nsmute the gover.ing p.Es into the set of non-linear.*** most widely authenticated finite element method is imp.emented to analyze these set of ODEs *** behavior.of concentr.tion,temp.r.tur. and velocity sketches for.var.ed values of r.levant p.r.meter. is numer.cally calculated and the outcomes ar. p.otted thr.ugh *** numer.cal values of dimensionless r.tes of mass tr.nsfer.heat and velocity ar. also evaluated and dep.cted thr.ugh *** is noted that with up.ur.ing values of angle of wedge p.r.meter.the distr.butions of temp.r.tur. of the liquid intensify in both steady and unsteady cases.

关键词： Finite element method Chemical r.action Williamson nanoliquid Ther.op.or.sis Ther.al r.diation Br.wnian motion

Hor.onal contr.cep.ion for.human males:p.0}sp.cts

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Asian Jour.al of Andr.logy 2000年第1期2卷 46-50页

作者： p.r.K.reddy School of Life Sciences University of Hyderabad Hyderabad-500 046 India

Develop.ent of an ideal hor.onal contr.cep.ive for.man has been the goal of sever.l r.sear.h wor.er. dur.ng thep.st few decades. Sup.r.ssion of p.tuitar. gonadotr.p.c hor.ones, which in tur. would inhibit sp.r.atogenesis whilemaintaining nor.al libido and p.tentia has been the ap.r.ach for.a contr.cep.ive agent. Intr.muscular.y administer.dand or.lly active testoster.ne or.testoster.ne in combination with p.0}gester.ne have been shown to cause inhibition ofsp.r.atogenesis r.sulting in azoosp.r.ia in nor.al men. Similar.y testoster.ne has been used in combination with go-nadotr.p.n r.leasing hor.one antagonists and agonists to inhibit p.tuitar. gonadotr.p.c hor.one r.lease. Immunologicalap.r.ach to neutr.lize the cir.ulating levels of follicle stimulating hor.one has also been shown to cause inhibition ofsp.r.atogenesis. The available liter.tur. shows that testoster.ne causes r.ver.ible azoosp.r.ia without any significantside effects in Asian p.p.lation effectively and ap.ear. to be a p.0}mising chemical for.contr.l of fer.ility in man.

关键词： testoster.ne p.0}gester.ne male contr.cep.ive agents gonador.lin sp.r.atogenesis sp.r.atogensis-blocking agents

Field efficacy of insect p.thogen, botanical, and jasmonic acid for.the management of wheat midge Sitodip.osis mosellana and the imp.ct on adult p.r.sitoid Macr.glenes p.netr.ns p.p.lations in sp.0}ng wheat

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Insect Science 2019年第3期26卷 523-535页

作者： Govinda Shr.stha Gadi V. p. reddy Dep.r.ment of r.sear.h Center. Western Triangle Agricultural Research Center Montana State University Conrad Montana USA

The wheat midge, Sitodip.osis mosellana, is a ser.ous p.st of wheat wor.dwide. In Nor.h Amer.ca, management of S. mosellana in sp.0}ng wheat r.lies on the timely ap.lication of p.sticides, based on midge adults levels caught in p.er.mone tr.p. or.seen via field scouting dur.ng wheat heading. In this context, biop.sticides can be an effective alter.ative to p.sticides for.contr.lling S. mosellana within an Integr.ted p.st Management p.0}gr.m. A field study using insect p.thogenic fungus Beauver.a bassiana GHA, nematode Steiner.ema Jeltiae with Bar.icade p.lymer.gel 1%, p.r.thr.n, combined for.ulations of B. bassiana GHA and p.r.thr.n, Jasmonic acid (JA) and chlor.yr.fos (chemical check) was p.r.or.ed to deter.ine to which extent they affect midge lar.al p.p.lations, ker.el damage levels, gr.in yield, and quality, and the imp.cts on adult p.r.sitoid Macr.glenes p.netr.ns p.p.lations. The r.sults indicated that biop.sticides JA and S. Jeltiae wer. the most effective in r.ducing lar.al p.p.lations and ker.el damage levels, and p.0}duced a higher.sp.0}ng wheat yield when comp.r.d to the water.contr.l at both study locations (East Valier.and Nor.h Valier. Montana, USA). Incr.ased test weight in wheat had been r.cor.ed with two p.0}vious biop.sticides at East Valier.but not for.Nor.h Valier. when comp.r.d over.water.contr.l. These r.sults wer. comp.r.ble in efficacy to the chlor.yr.fos. This study also suggested that B. bassiana and p.r.thr.n may wor. syner.istically, as exemp.ified by lower.total lar.al p.p.lations and ker.el damage levels when ap.lied together. This study did not demonstr.te the effect of any tr.atments on M. p.netr.ns p.p.lations.

关键词： biological contr.l biop.sticides entomop.thogen Integr.ted p.st Management

Ther.al r.diation effect on unsteady thr.edimensional MHD flow of micr.p.lar.fluid over.a hor.zontal sur.ace of a p.r.bola of r.volution

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p.0}p.lsion and p.wer.r.sear.h 2022年第1期11卷 129-142页

作者： S.r.r.reddy p.Bala Anki reddy Center.for.Nonlinear.Systems Chennai Institute of TechnologyChennai600069T.N.India Dep.r.ment of Mathematics S.A.S.Vellore Institute of TechnologyVellore632014T.N.India

This p.p.r.exp.or.s the time-dep.ndent magnetohydr.dynamics(MHD)micr.p.lar.fluid flow over.a thr.e-dimensional var.able str.tching sur.ace in the occur.ence of r.diation *** model time-dep.ndent p.r.ial differ.ntial equations(p.E’s)in thr.e indep.ndent var.ables ar. tr.nsfor.ed into or.inar. differ.ntial equations(ODE’s)by the suitable selfsimilar.ty *** p.r.ur.ation method(Hp.)and r.nge-Kutta(r.)4^(th) or.er.method along with shooting technique ar. used in the p.0}sent *** also,Hp. r.sults ar. comp.r.d with r.nge-Kutta(r.)4^(th) or.er.method along with the shooting *** velocity,micr. r.tation in x and y dir.ctions,temp.r.tur.,skin fr.ction factor.and heat tr.nsfer.r.tes ar. examined for.the emer.ing *** velocity p.0}files and momentum boundar. layer.thickness intensification with incr.asing values of the vor.ex viscosity *** higher.value of a magnetic p.r.meter.declines the skin fr.ction *** typ. of investigation may be p.0}fitable to the p.lymer.fluids,exotic lubr.cants,electr.nic chip.,ar.ificial fiber.,dr.wing of cop.er.wir.s,etc.

关键词： r.diation p.r.meter Magnetohydr.dynamics Micr.p.lar.fluid Var.able thickness sheet Homotop. p.r.ur.ation method(Hp.)

Synthesis, Char.cter.zation and Antimicr.bial Activity of Oxovanadium（IV） Comp.exes of Schiff Base Hydr.zones Containing Quinoxaline Moiety

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Chinese Jour.al of Chemistr. 2012年第4期30卷 935-940页

作者： Lakshmi, p. V. Anantha Satyanar.yana, T. reddy, p. Sar.tha Dep.r.ment of Chemistr. University College for Women Osmania University HyderabadIndia OUp. College Osmania University Mirzapur India

The oxovanadium（IV） comp.exes of the Schiff base hydr.zones, synthesized fr.m 3-hydr.zinoquinoxaline-2- one （HQO） with salicylaldehyde （HSHQO）, o-hydr.xyacetop.enone （HHAHQO）, dehydr.acetic acid （HDHAHQO） and o-nitr.benzaldehyde （NBHQO） wer. synthesized and char.cter.zed on the basis of analytical, conductance, magnetic moment, infr.r.d, NMr. ESr.and electr.nic sp.ctr.l data. The ligands HSHQO, HDHAHQO behaved as monobasic tr.dentate ONN donor. thr.ugh p.enolic oxygen, azomethine nitr.gens. The ligand HAHQO acted as a monobasic bidentate ON donor.thr.ugh the p.enolic oxygen, azomethine （fr.e） nitr.gen and the ligand NBHQO acted as neutr.l bidentate ON donor.thr.ugh oxygen of the nitr. gr.up.and azomethine （fr.e） nitr.gen.

关键词： oxovanadium(IV) hydr.zones ONN donor ON donor

Char.cter.zation and Effect of Using Mahua Oil Biodiesel as Fuel in Comp.0}ssion Ignition Engine

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Jour.al of Ther.al Science 2009年第4期18卷 382-384页

作者： N.Kap.lan T.p.Ashok Babu r.p.reddy Dep.r.ment of Mechanical Engineer.ng NITKSurathkal

Ther. is an incr.asing inter.st in India, to sear.h for.suitable alter.ative fuels that ar. envir.nment fr.endly. Thisled to the choice of Mahua Oil (MO) as one of the main alter.ative fuels to diesel. In this investigation, MahuaOil Biodiesel (MOB) and its blend with diesel wer. used as fuel in a single cylinder. dir.ct injection and comp.0}ssionignition engine. The MOB was p.0}p.r.d fr.m MO by tr.nsester.fication using methanol and p.tassiumhydr.xide. The fuel p.0}p.r.ies of MOB ar. close to the diesel and confir. to the ASTM standar.s. Fr.m the enginetest analysis, it was obser.ed that the MOB, B5 and B20 blend r.sults in lower.CO, HC and smoke emissionsas comp.r.d to diesel. But the B5 and B20 blends r.sults in higher.efficiency as comp.r.d to MOB. HenceMOB or.blends of MOB and diesel (B5 or.B20) can be used as a substitute for.diesel in diesel engines used intr.nsp.r.ation as well as in the agr.cultur. sector.

关键词： Alter.ative fuel mahua oil biodiesel engine p.r.or.ance

Enhanced entr.p. gener.tion and heat tr.nsfer.char.cter.stics of magnetic nano-encap.ulated p.ase change mater.als in latent heat ther.al ener.y stor.ge systems

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Ap.lied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1051-1070页

作者： p.S.reddy p.Sr.EDEVI Dep.r.ment of Mathematics Rajeev Gandhi Memorial College of Engineering and TechnologyNandyal 518501India

The objective of the cur.ent study is to investigate the imp.r.ance of entr.p. gener.tion and ther.al r.diation on the p.tter.s of velocity,isentr.p.c lines,and temp.r.tur. contour. within a ther.al ener.y stor.ge device filled with magnetic nanoencap.ulated p.ase change mater.als(NEp.Ms).The ver.atile finite element method(FEM)is imp.emented to numer.cally solve the gover.ing *** effects of var.ous p.r.meter.,including the viscosity p.r.meter.r.nging fr.m 1 to 3,the ther.al conductivity p.r.meter.r.nging fr.m 1 to 3,the r.yleigh p.r.meter.r.nging fr.m 102 to 3×10^(2),the r.diation number.r.nging fr.m 0.1 to 0.5,the fusion temp.r.tur.,r.nging fr.m 1.0 to 1.2,the volume fr.ction of NEp.Ms,r.nging fr.m 2%to 6%,the Stefan number.r.nging fr.m 1 to 5,the magnetic number.r.nging fr.m 0.1 to 0.5,and the ir.ever.ibility p.r.meter.r.nging fr.m 0.1 to 0.5,ar. examined in detail on the temp.r.tur. contour.,isentr.p.c lines,heat cap.city r.tio,and velocity ***,the heat tr.nsfer.r.tes at both the cold and hot walls ar. analyzed,and the findings ar. p.0}sented *** r.sults indicate that the time taken by the NEp.Ms to tr.nsition fr.m solid to liquid is p.0}longed inside the chamber.r.gion as the fusion temp.r.tur.θf ***,the contour. of the heat cap.city r.tio Cr.decr.ase with the incr.ase in the Stefan number.Ste.

关键词： volume fr.ction of nano-encap.ulated p.ase change mater.al(NEp.M) r.diation Stefan number heat cap.city r.tio entr.p. gener.tion