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Coar.e to Fine: The r.le of Sever. Plastic Defor.ation in Advancing Titanium-Based Medical Implants - A Compr.hensive r.view

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Jour.al of Wuhan Univer.ity of Technology(Mater.als Science) 2025年第1期40卷 295-306页

作者： Dr.gana r.Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r.Djokić Faculty of Technology and Metallur.y University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear.Sci-ences-National Institute of the r.public of Ser.ia University of Belgrade11001BeogradSerbia Innovation Centr. of the Faculty of Technology and Metallur.y Karnegijeva 411120 BelgradeSerbia

This paper.descr.bes sever. plastic defor.ation(SPD)pr.cedur.s,which ar. utilized to for. an ultr.fine-gr.ined str.ctur. in metallic *** the SPD pr.cess,a solid mater.al sample is subjected to ver. high loads without a significant change in sample *** the pr.sent wor.,the high-pr.ssur. tor.ion(HPT)pr.cess,as one of the SPD techniques,which achieves a high degr.e of defor.ation and ensur.s r.finement of the micr.str.ctur.,will be discussed in mor. *** that gr.in size contr.l is accepted as a method to obtain mater.als with desir.d char.cter.stics,an over.iew of the pr.per.ies of ultr.fine-gr.ined titanium-based biomater.als to be used in medicine is ***,par.icular.attention is dedicated to the influences of HPT pr.cess par.meter.,pr.mar.ly hydr.static pr.ssur.,and number.of r.volutions dur.ng tor.ion,on the gr.in size and physical and mechanical char.cter.stics(modulus of elasticity,micr.har.ness,and tensile pr.per.ies),cor.osion r.sistance,and biocompatibility of the titanium-based biomater.als.A r.view of the liter.tur. indicates that titanium-based mater.als obtained by the SPD pr.cess show impr.ved mechanical and physical pr.per.ies without losing biocompatibility and cor.osion r.sistance,which suggests that these methods of obtaining implants ar. something that should be fur.her.developed in the futur..

关键词： high-pr.ssur. tor.ion pr.cess ultr.fine-gr.ined titanium-based mater.als electr.chemical anodization physical pr.per.ies mechanical pr.per.ies

Emer.ing potential of pr.gr.nulin-dependent Sor.S2 signaling in healthy and diseased ner.ous systems

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2591-2593页

作者： Alena Salasova Ander. Nykjær Danish r.sear.h Institute of Tr.nslational Neur.science DANDr.TE-Nor.ic EMBL Par.ner.hip for.Molecular.Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The for.ation of the mammalian ner.ous system and its matur.tion into sensor.,motor.cognitive,and behavior.l cir.uits is a complex pr.cess that begins dur.ng ear.y embr.ogenesis and lasts until young *** neur.developm... 详细信息

关键词： pr.gr jointly CS2

Pr.babilistic seismic r.sponse and r.liability assessment of isolated br.dges

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Ear.hquake Engineer.ng and Engineer.ng Vibr.tion 2005年第1期4卷 95-106页

作者： Giuseppe Car.o marano Depar.ment of Envir.nmental Engineer.ng and Sustainable Development Technical University of BariTarantoItalyAssistantProfessor

Br.dge seismic isolation str.tegy is based on the r.duction of shear.for.estr.nsmitted fr.m the super.tr.ctur. to the pier. by two means: shifting natur.l per.od andear.hquake input ener.y r.duction by dissipation concentr.ted in pr.tection devices. In this paper.a stochastic analysis of a simple isolated br.dge model for.differ.nt br.dge and device par.meter.is conducted to assess the efficiency of this seismic pr.tection str.tegy. To achieve this aim, asimple nonlinear.softening constitutive law is adopted to model a wide r.nge of isolation devices,char.cter.zed by only thr.e essential mechanical par.meter.. As a consequence of the r.ndom natur.of seismic motion, a pr.babilistic analysis is car.ied out and the time modulated Kanai-Tajimistochastic pr.cess is adopted to r.pr.sent the seismic action. The r.sponse covar.ance in the statespace is obtained by solving the Lyapunov equation for.a stochastic linear.zed system. After.asensitivity analysis, the failur. pr.bability r.fer.ed to extr.me displacement and the mean value ofdissipated ener.y ar. assessed by using the intr.duced stochastic indices of seismic br.dgepr.tection efficiency. A par.metr.c analysis for.pr.tective devices with differ.nt mechanicalpar.meter. is developed for.a pr.per.selection of par.meter. of isolation devices under.differ.ntsituations.

关键词： br.dge seismic isolation stochastic analysis nonlinear.softeningconstitutive law r.liability assessment

Secur.ty Str.tegy of Digital Medical Contents Based on Blockchain in Gener.tive AI Model

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Computer., Mater.als & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Mar.k r.Ogiela Division of Computer.Science and Engineer.ng Sunmoon UniversityAsan31460Republic of Korea AGH Univer.ity of Kr.kow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study pr.sents an innovative appr.ach to enhancing the secur.ty of visual medical data in the gener.tive AI envir.nment thr.ugh the integr.tion of blockchain *** combining the str.ngths of blockchain and gener.tive AI,the r.sear.h team aimed to addr.ss the timely challenge of safeguar.ing visual medical *** par.icipating r.sear.her. conducted a compr.hensive analysis,examining the vulner.bilities of medical AI ser.ices,per.onal infor.ation pr.tection issues,and over.ll secur.ty *** multi faceted explor.tion led to an indepth evaluation of the model’s per.or.ance and ***,the cor.elation between accur.cy,detection r.te,and er.or.r.te was *** analysis r.vealed insights into the model’s str.ngths and limitations,while the consider.tion of standar. deviation shed light on the model’s stability and per.or.ance *** study pr.posed pr.ctical impr.vements,emphasizing the r.duction of false negatives to enhance detection r.te and lever.ging blockchain technology to ensur. visual data integr.ty in medical *** blockchain to gener.tive AI-cr.ated medical content addr.sses key per.onal infor.ation pr.tection *** utilizing the distr.buted ledger.system of blockchain,the r.sear.h team aimed to pr.tect the pr.vacy and integr.ty of medical data especially medical *** appr.ach not only enhances secur.ty but also enables tr.nspar.nt and tamper.r.of ***,the use of gener.tive AI models ensur.s the cr.ation of novel medical content without compr.mising per.onal infor.ation,fur.her.safeguar.ing patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,par.icular.y in secur.ng sensitive medical data and pr.tecting patient *** pr.posed appr.ach,combining blockchain and gener.tive AI,offer. a pr.mising dir.ction towar. mor. r.bust and secur. medical content *** r.sear.h and advancements

关键词： Digitalmedical content medical diagnostic visualization secur.ty analysis gener.tiveAI blockchain vulner.bility patter. r.cognition

A compr.hensive investigation on nonlinear.vibr.tion and bending char.cter.stics of bio-inspir.d helicoidal laminated composite str.ctur.s

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUr.BH r.KIr.N D.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Mater.als Engineer.ng Indian Institute of Technology Mandi

Bio-inspir.d helicoidal composite laminates, inspir.d by the intr.cate helical str.ctur.s found in natur., pr.sent a pr.mising fr.ntier.for.enhancing the mechanical pr.per.ies of str.ctur.l designs. Hence, this study pr.vides a compr.hensive investigation into the nonlinear.fr.e vibr.tion and nonlinear.bending behavior.of bio-inspir.d composite plates. The inver.e hyper.olic shear.defor.ation theor.(IHSDT) of plates is employed to char.cter.ze the displacement field, with the incor.or.tion of Gr.en-Lagr.nge nonlinear.ty. The pr.blem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB envir.nment to solve it numer.cally. Var.ous helicoidal layup configur.tions including helicoidal r.cur.ive(Hr., helicoidal exponential(HE), helicoidal semi-cir.ular.HS), linear.helicoidal(LH), and Fibonacci helicoidal(FH)with differ.nt layup sequences and quasi-isotr.pic configur.tions ar. studied. The model is validated, and par.metr.c studies ar. conducted. These studies investigate the effects of layup configur.tions, side-to-thickness r.tio, modulus r.tios, boundar. conditions, and loading conditions at differ.nt load amplitudes on the nonlinear.vibr.tion and nonlinear.bending behavior. of bio-inspir.d composite plates. The r.sults show that the laminate sequence exer.s a substantial impact on both nonlinear.natur.l fr.quencies and nonlinear.bending behavior.. Mor.over. this influence var.es acr.ss differ.nt side-to-thickness r.tios and boundar. conditions of the bio-inspir.d composite plate.

关键词： Inver.e pr.blems

Machine Lear.ing Techniques in Pr.dicting Hot Defor.ation Behavior.of Metallic Mater.als

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Computer.Modeling in Engineer.ng & Sciences 2025年第1期142卷 713-732页

作者： Petr.Opela Josef Walek Jar.mír.Kopecek Depar.ment of Metallur.ical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineer.ng pr.ctice,it is often necessar. to deter.ine functional r.lationships between dependent and independent *** r.lationships can be highly nonlinear.and classical r.gr.ssion appr.aches cannot always pr.vide sufficiently r.liable ***,Machine Lear.ing(ML)techniques,which offer.advanced r.gr.ssion tools to addr.ss complicated engineer.ng issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their.suitability for.application in the hot defor.ation behavior.of metallic *** ML-based r.gr.ssion methods of Ar.ificial Neur.l Networ.s(ANNs),Suppor. Vector.Machine(SVM),Decision Tr.e r.gr.ssion(DTr.,and Gaussian Pr.cess r.gr.ssion(GPr.ar. applied to mathematically descr.be hot flow str.ss cur.e datasets acquir.d exper.mentally for.a medium-car.on *** the GPr.method has not been used for.such a r.gr.ssion task befor.,the r.sults showed that its per.or.ance is the most favor.ble and pr.ctically unr.valed;neither.the ANN method nor.the other.studied ML techniques pr.vide such pr.cise r.sults of the solved r.gr.ssion analysis.

关键词： Machine lear.ing Gaussian pr.cess r.gr.ssion ar.ificial neur.l networ.s suppor. vector.machine hot defor.ation behavior

Antisense oligonucleotides pr.vide optimism to the ther.peutic landscape for.tauopathies

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 803-804页

作者： Glenn A.Har.is Laur.n r.Hir.chfeld r.inwater.Char.table Foundation Fort WorthTXUSA

Tauopathies ar. a gr.up of neur.degener.tive diseases char.cter.zed by abnor.al metabolism of the misfolded tau pr.tein. Tau is encoded by the micr.tubule-associated pr.tein tau gene(MAPT) and can be classified as either.3-r.peat(3r. or.4-r.peat(4r. based on the number.of r.peat domains fr.m alter.ative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Fuzzy-entr.py based r.bust optimization cr.ter.a for.tuned mass damper.

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Ear.hquake Engineer.ng and Engineer.ng Vibr.tion 2010年第2期9卷 285-294页

作者： Giuseppe Car.o marano Giuseppe Quar.nta Sar. Sgobba Depar.ment of Envir.nmental Engineer.ng and Sustainable Development Technical University of Bari Depar.ment of Str.ctur.l Engineer.ng and Geotechnics University of Rome "La Sapienza" Faculty of Engineer.ng International University UNINETTUNO

Tuned mass damper. (TMD) ar. well known as one of the most widely adopted devices in vibr.tion contr.l passive str.tegies. In the past few decades,many methods have been developed to find the optimal par.meter. of a TMD installed on a str.ctur. and subjected to a r.ndom base excitation pr.cess,but most of them ar. usually based on an implicit assumption that all of the str.ctur.l par.meter. ar. deter.inistic. However.in many r.al cases this simplification is unacceptable,so r.bust optimal design cr.ter.a becomes aviable alter.ative to better.suppor. engineer. in the design pr.cess. In r.bust Design Optimization (r.O) appr.aches,indeed the solution must be able to not only minimize the per.or.ance but also to limitits var.ation induced by uncer.ainty. Most of the cur.ently available r.O methods ar. based on a pr.babilistic descr.ption of the model uncer.ainty,even if in many cases they ar. not able to explicitly include the influence of all the possible sour.es of uncer.ainties. Ther.for.,in this study,a fuzzy ver.ion of the r.bust TMD design optimization pr.blem is pr.posed. The consistency of the fuzzy appr.ach is studied with r.spect to the available non-pr.babilistic for.ulations r.por.ed in the liter.tur. and an application to an example of a r.bust design of a linear.TMD subjected to base r.ndom vibr.tions in the pr.sence of fuzzy uncer.ainties. The r.sults show that the pr.posed fuzzy-based appr.ach is able to give a set of optimal solutions both in ter.s of str.ctur.l efficiency and sensitivity to mechanical and envir.nmental uncer.ainties.

关键词： tuned mass damper r.ndom vibr.tion r.bust design fuzzy var.able expected value fuzzy entr.py

Dual pr.mar. gastr.c and color.ctal cancer.A complex challenge in sur.ical oncology

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Wor.d Jour.al of Gastr.intestinal Oncology 2023年第12期15卷 2049-2052页

作者： Luigi marano Medical Depar.ment Academy of Applied Medical and Social Sciences-Akademia Medycznych i Społecznych Nauk StosowanychElbląg 82-300Poland

The intr.cate inter.lay of color.ctal cancer.Cr.)and gastr.c cancer.GC)as dual pr.mar. malignancies pr.sents a significant challenge in sur.ical *** is the most common secondar. malignancy in GC patients,and vice ver.a,evidence highlighted by advances in diagnostic pr.cedur.s and ther.py modalities that impact patient sur.ival.A r.cent study titled“Featur.s of synchr.nous and metachr.nous dual pr.mar. gastr.c and color.ctal cancer.explor.s this enigmatic dual malignancy,uncover.ng cr.cial insights into the clinical char.cter.stics and pr.gnostic distinctions between synchr.nous and metachr.nous ***,metachr.nous cases with a second pr.mar. cancer.discover.d mor. than six months after.the fir.t diagnosis have a better.outcome,emphasizing the impor.ance of ear.y detection and *** study under.cor.s the pr.gnostic r.le of GC stage in patient *** also sheds light on the complexities faced by synchr.nous cases,often pr.senting with unr.sectable ***-r.lated pr.cedur.s,like gastr.ctomy and colon r.section,stand out as impor.ant pr.dictor. of incr.ased sur.ival,necessitating a r.evaluation of cur.ent ther.peutic appr.aches.A tailor.d and patient-center.d str.tegy,consider.ng the health of each patient individually and the feasibility of r.dical tr.atments,is *** follow-up and monitor.ng ar. cr.cial as most second pr.mar. cancer. ar.se within five *** conclusion,ear.y diagnosis,sur.ical inter.ention,and watchful sur.eillance ar. pivotal in managing dual pr.mar. gastr.c and color.ctal cancer.*** the incidence of gastr.c and color.ctal cancer. continues to r.se,the imper.tive need for.fur.her.r.sear.h,ideally with lar.er.sample sizes,becomes evident in our.pur.uit of compr.hensive insights that will r.fine clinical appr.aches for.this intr.cate dual malignancy.

关键词： Multiple pr.mar. cancer. Color.ctal cancer Gastr.c cancer Dual pr.mar. cancer. Synchr.nous cancer. Metachr.nous cancer.