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Pr.venance and Paleoclimate of the Tr.assic to Middle Jur.ssic Adigr.t Sandstone,Blue Nile Basin,Centr.l Ethiopia

Acta Geologica Sinica(English Edition) 2024年第4期98卷 1007-1020页

作者： Bekele BAr.ISA Ayalew DEr.JE Kidanemar.am GIlAMICHAEl Atnafu BAlEMWAl r.phaël.pik Depar.ment of Ear.h Sciences Wollega UniversityNekemteEthiopia Depar.ment of Ear.h Sciences Addis Ababa UniversityAddis AbabaEthiopia Depar.ments of Anthr.pology Geography and GeologyEast Los Angeles CollegeLos AngelesCaliforniaUSA Cr.G(UMr.7358 CNr.&Univer.itéde lor.aine) 15 rue ND des pauvres BP2054501 Vandoeuvre-Lès-Nancy CedexFrance

Miner.logical and geochemical studies have been under.aken on the Tr.assic to lower.Jur.ssic Adigr.t Sandstone of the Blue Nile Basin of centr.l Ethiopia to infer.its sour.e r.ck type,paleoweather.ng,and paleoclimatic *** Adigr.t Sandstone occur. at the basal section of the Mesozoic sedimentar. for.ation and unconfor.ably over.ays the Neopr.ter.zoic–Paleozoic cr.stalline r.cks,or.locally,the Kar.oo sediments in the nor.her. Blue Nile Basin.A miner.logical study r.veals that quar.z(Q),feldspar.(F),and lithic fr.gments(l)ar. the fr.mewor. gr.ins of the *** the QFl diagr.m,the plot of the modal composition of the sandstone mainly falls within the feldspathic ar.nite and quar.zose ar.nite *** geochemical data of the lower.section of the sandstone mainly falls within the ar.ose and subar.ose fields,wher.as the upper.section data falls within the quar.zose and sublithic ar.nite *** and geochemical weather.ng indices indicate that the pr.venances of the Adigr.t Sandstone wer. exposed to pr.nounced weather.ng intensity,wher. the lower.par. of the sandstone was contr.lled by ar.d to semi-ar.d conditions,wher.as the upper.section was linked to humid to semi-humid(tr.pical to subtr.pical)climatic *** and geochemical data also indicate that mafic to inter.ediate basement r.cks wer. the pr.mar. sour.e r.cks of the *** the sediment was assumed to have been r.wor.ed by multi-cyclic sedimentar. *** discr.minant function diagr.m,the r.E patter.,la/Th ***/Yb,and the Th–Hf–Co plot ar. consistent.A compar.son of pr.venance studies for.the Adigr.t Sandstone in the Blue Nile Basin and the Mekele outlier.of nor.her. Ethiopia indicates that the sediment of the for.er.is highly sor.ed,exper.enced higher.weather.ng intensity,and compositionally der.ved fr.m mafic to inter.ediate cr.stalline *** the other.hand,the sediment of the latter.is essentially a weather.ng pr.duct of felsic r.cks.

关键词： miner.logical geochemical paleoweather.ng humid pr.venance Adigr.t Sandstone

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云南德钦白马雪山岩体热历史及其对青藏高原三江地区构造地貌演化的指示意义

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岩石学报 2015年第5期31卷 1348-1360页

作者：肖萍刘静王伟曾令森谢克家 r.phaёl.pik 钟宁地震动力学国家重点实验室中国地震局地质研究所北京100029 大陆构造与动力学国家重点实验室中国地质科学院地质研究所北京100037 河南省有色金属矿产探测工程技术研究中心郑州450016 法国南希Cr.G惰性气体-热年代学实验室巴黎54501

青藏高原三江地区高程缓降、河流及深切峡谷发育,重建其构造-热年代时空演化为把握该地区地形地貌发育演化的内在驱动力提供科学依据。本研究以云南德钦白马雪山岩体为研究对象,开展磷灰石（U-Th）/He及裂变径迹年代学分析,结合已发表的... 详细信息

青藏高原三江地区高程缓降、河流及深切峡谷发育,重建其构造-热年代时空演化为把握该地区地形地貌发育演化的内在驱动力提供科学依据。本研究以云南德钦白马雪山岩体为研究对象,开展磷灰石（U-Th）/He及裂变径迹年代学分析,结合已发表的U-Pb和Ar.Ar.代学结果来重塑该地区的构造-热演化历史和地形演化。研究表明,该地区经历了多期快速冷却事件：三叠世的岩浆侵位活动,早白垩世和中-晚始新世的快速冷却,以及中新世和上新世以来的快速剥蚀。青藏高原隆升致使全球气候变化的同时也导致其周缘地区经受强烈侵蚀：中新世以来（21～11Ma）快速冷却速率为10℃/Myr.而上新世以来（ca.5Ma）冷却速率从10℃/Myr.至15℃/Myr.假定区域现今地温梯度为25～35℃/km,河谷剖面不同位置的侵蚀速率及剥蚀量的空间分布特征进一步表明（靠近澜沧江主干道处侵蚀速率远高于其支流,且对应的年龄相对年轻）,河流下切及溯源侵蚀的多重效应导致该地区快速剥蚀、剥露,地形起伏加大的瞬态地貌演化规律。

关键词：白马雪山岩体热历史地貌演化三江地区青藏高原

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low ser.m albumin pr.dicts ear.y mor.ality in patients with sever. hypoxic hepatitis

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Wor.d Jour.al of Hepatology 2017年第22期9卷 959-966页

作者： pik-Eu Chang Boon-Bee Geor.e Goh Victor.a Ekstr.m Ming-liang Ong Chee-Kiat Tan Depar.ment of Gastr. enter.logy and Hepatology Singapore General Hospital Duke-NUS Medical School

To evaluate the incidence, etiology, and pr.dictor. of mor.ality of sever. hypoxic hepatitis. METHODSWe used computer.zed patient r.cor.s to identify consecutive cases of sever. hypoxic hepatitis admitted to a ter.iar. hospital in Singapor. over.a one-year.per.od. We defined sever. hypoxic hepatitis as elevation of ser.m tr.nsaminases mor. than 100 times upper.limit of nor.al in the clinical setting of car.iac, cir.ulator. or.r.spir.tor. failur. after.exclusion of other.causes of hepatitis. We used multivar.able r.gr.ssion analysis to deter.ine pr.dictor. for.mor.ality. r.SUlTSWe identified 75 cases of sever. hypoxic hepatitis out of 71380 hospital admissions over.one year. pr.viding an incidence of 1.05 cases per.1000 admissions. Median age was 65 year. (r.nge 19-88); 57.3% males. The most common etiologies of sever. hypoxic hepatitis wer. acute myocar.ial infar.tion and sepsis. Fifty-thr.e patients (71%) died dur.ng the hospitalization. The sole independent pr.dictive factor.for.mor.ality was ser.m albumin measur.d at the onset of sever. hypoxic hepatitis. Patients with low ser.m albumin of less than 28 g/l have mor. than five-fold incr.ase r.sk of death (Or.= 5.39, 95%CI: 1.85-15.71). CONClUSIONSever. hypoxic hepatitis is uncommon but has a high mor.ality r.te. Patients with low ser.m albumin ar. at highest r.sk of death.

关键词： Sever. Mor.ality Albumin Incidence Hypoxic hepatitis Pr.dictor. Etiology Pr.gnosis

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青藏高原东南缘芒康地区河流地貌演化的磷灰石U-Th／He记录

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第四纪研究 2015年第2期35卷 433-444页

作者：肖萍刘静王伟钟宁曾令森 r.phael.pik 谢克家中国地震局地质研究所、地震动力学国家重点实验室北京100029 中国地质科学院地质研究所、大陆构造与动力学国家重点实验室北京100037 法国南希Cr.G惰性气体一热年代学实验室法国巴黎河南省有色金属矿产探测工程技术研究中心郑州450016

青藏高原东南缘地处印度与欧亚板块碰撞侧向逃逸的特殊构造部位，地势起伏相对较缓，形成三江并流的独特地貌格局。然而，对于东南缘大尺度地形地貌形成机制与水系演化的认识仍存在很大的分歧。本文获得的澜沧江流域芒康地区5个基岩样... 详细信息

青藏高原东南缘地处印度与欧亚板块碰撞侧向逃逸的特殊构造部位，地势起伏相对较缓，形成三江并流的独特地貌格局。然而，对于东南缘大尺度地形地貌形成机制与水系演化的认识仍存在很大的分歧。本文获得的澜沧江流域芒康地区5个基岩样品磷灰石U-Th／He年龄表明该地区在早一中中新世（23-15Ma）经历了一次区域性冷却事件，且冷却速率在5Ma期间从40℃／Ma降低到28℃／Ma以下。目前可获得的青藏高原东缘一东南缘的低温年代学数据表明：尽管川西一藏东一滇北一带具有相似地貌特征，但高海拔、低起伏地貌面的形成是穿时性的，不能将它作为一个区域上连续的等时面来计算和探讨一个统一的区域抬升启动时间；三江地区地形属于非稳态的过渡型地形，尤其芒康一左贡地区剥蚀速率的差异比较清晰地展示了澜沧江流域地形演化处于非稳态期。此外，河流下切是塑造澜沧江流域的地形地貌主要驱动力之一：干流的侵蚀速率远远高于支流的侵蚀速率；河流下切强烈的地区（如德钦）对应的侵蚀速率及地形起伏度都较大，芒康地区微弱的地形起伏度取决于较低的侵蚀速率。第三纪以来的印度一欧亚板块碰撞导致青藏高原崛起的同时，也对周边尤其藏东南三江地区的地形地貌塑造及气候变化产生重大的影响。

关键词：青藏高原芒康 U-Th/He年龄冷却事件河流纵剖面气候变化侵蚀速率

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The effect of platyspondyly and puber.al gr.wth spur. on the statur. of patients with β-thalassaemia major

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Chinese Medical Jour.al 1998年第8期 59-63页

作者： Chungkai low, Yinwah Kwan, pikto Cheung, Mingchun li, Sauyin Ha Yulung lau and Johan Kar.ber. 

Objective To study the effect of the body pr.por.ion and puber.al gr.wth spur. on the statur. of childr.n with β-thalassaemia *** An abnor.al U:l r.tio was commonly obser.ed in patients with β-thalassaemia major.and may be one factor.contr.buting to the shor. statur. of these patients. Abnor.al puber.y was pr.sent in a significant pr.por.ion of childr.n and the lack of a puber.al gr.wth spur. was found to be detr.mental to adult height.

关键词： The

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Pathogenic and Genetic Diver.ity of Magnepor.he or.zae Populations fr.m Sr. lanka

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r.ce science 2012年第3期19卷 241-246页

作者： Y J P K MITHr.SENA WSS WIJESUNDEr. r.l C WIJESUNDEr. D C WIMAlASIr. r.P N Pr.YANTHI r.ce r.sear.h Centr. BombuwelaKalutara 12024Sri Lanka Depar.ment of Biochemistr. and Molecular.Biology Faculty of MedicineUniversity of Colombo Depar.ment of Plant Sciences Faculty of ScienceUniversity of Colombo

The pr.sent study was under.aken to deter.ine the pathogenic and the genetic diver.ity of the isolates of *** collected fr.m the wet,inter.ediate and dr. zones of Sr. lanka with a view to develop r.ce var.eties confer.ing dur.ble r.sistance to r.ce *** significant mor.hological or.gr.wth var.ations existed amongst the isolates *** genetic diver.ity of isolates deter.ined by car.ying out Pot2 tr.nsposable element based on r.petitive-PCr.r.vealed that the major.ty of isolates （92%） cluster.d into a single gr.up with 45.4% *** existence of nine pathotypes was identified by obser.ing the r.action type of isolates on 16 differ.nt r.ce *** 1 which was distr.buted in all zones affected only one differ.ntial *** 2 which was able to infect six lines was r.str.cted only to the dr. zone of Sr. *** the 16 r.ce lines,seven lines,K3 （pik-h）,C101A51 （Piz5）,K1 （Pita）,C105TTP2l9 （Pita）,K59 （Pit）,Shin （Pish） and WHD-1S-75-1-127 （Pi9） had highly effective blast *** of the isolates of the fungus showed any vir.lence against the seven *** seven blast r.sistant lines can be used in the br.eding pr.gr.mmes in Sr. lanka for.development of lines confer.ing dur.ble r.sistance to r.ce blast.

关键词： r.ce blast genetic diver.ity pathotype

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Effect of WeiJia on car.on tetr.chlor.de induced chr.nic liver.injur.

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Wor.d Jour.al of Gastr.enter.logy 2006年第12期12卷 1912-1917页

作者： pik-Yuen Cheung QiZhang Gan-r.ng Bai Chi-Chun Fong lin Shi Yue-Feng Shi Meng-SuYang Depar.mentofBiology Ya-Ou Zhang Mar.e Chia-Mi lin Ber.ar. Chan Jay Chun Hsiang-Fu Kung Depar.ment of Biology and Chemistr. City University of Hong Kong 83 Tat Chee AvenuKowloonHong Kong SARChina life Science Division Tsinghua University Graduate School at ShenzhenTsinghua CampusUniversity TownShenzhenChina Institute of Molecular.Biology The University of Hong KongPokfulamHong KongSARChina life Tec Enter.r.se limited CentralHong KongSARChina The Centr. for.Emer.ing Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongShatinN.T.Hong Kong SARChina

AIM： To study the effect of WeiJia on chr.nic liver.injur. using car.on tetr.chlor.de （CCh） induced liver.injur. animal model. METHODS： Wistar.r.ts weighing 180-220g wer. r.ndomly divided into thr.e gr.ups： nor.al contr.l gr.up （Gr.up A）, CCh induced liver.injur. contr.l gr.up （Gr.up B） and CCI4 induction with WeiJia tr.atment gr.up （Gr.up C）. Each gr.up consisted of 14 r.ts. liver.damage and fibr.sis was induced by subcutaneous injection with 40% CCh in olive oil at 3 ml/kg body weight twice a week for.eight weeks for.Gr.ups B and C r.ts wher.as olive oil was used for.Gr.up A r.ts. Star.ing fr.m the thir. week, Gr.up C r.ts also r.ceived daily intr.per.toneal injection of *** at a dose of 1.25 μg/kg body weight. Animals wer. sacr.ficed at the fifth week （4 male, 3 female）, and eighth week （4 male, 3 female） r.spectively. Degr.e of fibr.sis wer. measur.d and ser.logical mar.er. for.liver.fibr.sis and function including hyalur.nic acid （HA）, type Ⅳ collagen （CIV）, γ-glutamyl tr.nsfer.se （γ-GT）, alanine aminotr.nsfer.se （AlT） and aspar.ate aminotr.nsfer.se （AST） wer. deter.ined. Alpha smooth muscle actin （α-SMA） and pr.lifer.ting cell nuclear.antigen （PCNA） immunohistochemistr. wer. also per.or.ed. r.SUlTS： CCl4 induction led to the damage of liver.and development of fibr.sis in Gr.up B and Gr.up C r.ts when compar.d to Gr.up A r.ts. The tr.atment of WeiJia in Gr.up C r.ts could r.duce the fibr.sis condition significantly compar.d to Gr.up B r.ts. The effect could be obser.ed after.thr.e weeks of tr.atment and was mor. obvious after.eight weeks of tr.atment. Ser.m HA, CIV,AlT, AST and γ-GT levels after.eight weeks of tr.atment for.Gr.up C r.ts wer. 58±22 μg/l （P〈0.01）, 57±21 μg/l （P〈0.01）, 47±10 U/l （P〈0.01）, 139±13 U/l （P〈0.05） and 52±21 U/l （P〉0.05） r.spectively, similar.to nor.al contr.l gr.up （Gr.up A）, but significantly differ.nt fr.m CCh induced liver.injur. contr.l gr.up （Gr.up B）. An incr.ase in PCNA and decr.ase in α-SMA expr.ssion level was also obs

关键词： WeiJia Car.on tetr.chlor.de liver.fibr.sis

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Impact and clinical usefulness of genetic data in the sur.ical management of color.ctal cancer.liver.metastasis: a nar.ative r.view

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Hepatobiliar. Sur.er. and Nutr.tion 2020年第6期9卷 705-716页

作者： Geor.ios Antonios Mar.onis Mar.in E.Kr.is Jaeyun Jane Wang Car.ten Kamphues Chr.stopher.l.Wolfgang Matthew J.Weiss Depar.ment of Sur.er. Johns Hopkins University School of MedicineBaltimoreMDUSA Depar.ment of Gener.l Visceral and Vascular SurgeryCharite Campus Benjamin FranklinBerlinGermany Depar.ment of Sur.er. Northwell Health Cancer Institute and Zucker School of MedicineLake SuccessNYUSA

Impor.ance:In patients who under.o sur.er. for.color.ctal cancer.liver.metastases(Cr.M),a number.of somatic mutations have been associated with wor.e over.ll(OS)and r.cur.ence-fr.e sur.ival(r.S).Although useful,an association with pr.gnosis does not necessar.ly equate to an impact on sur.ical ***:The aim of this r.view was to investigate whether.the best-studied somatic mutations impact sur.ical management of Cr.M by infor.ing:(I)post-hepatectomy sur.eillance;(II)selection of sur.ical technique;(III)selection of optimal mar.in width;and(IV)selection of patients for.***,we discuss the r.finement of genetic data fr.m over.ll mutation status to specific var.ants,as well as lesser.studied somatic *** r.view:We conducted a computer.zed sear.h using PubMed and Google Scholar.for.r.por.s published so far.using mesh headings and keywor.s r.lated to genetic data and ***:Genetic data may impact sur.ical management of Cr.M in thr.e ***,Kr.S mutations can pr.dict lung ***,Kr.S mutations may help tailor.mar.in ***,Kr.S mutations may help tailor.sur.ical ***:Although genetic data may impact post-hepatectomy sur.eillance,selection of sur.ical technique and optimal mar.in width,their.use to guide sur.ical selection r.mains elusive,as the data cannot suppor. denying sur.er. to patients accor.ing to their.somatic mutation pr.file.

关键词： Somatic mutations Kr.S Br.F P53 SMAD-4 pik3CA color.ctal liver.metastases

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Mechanisms of r.sistance to anti-epider.al gr.wth factor.r.ceptor.inhibitor. in metastatic color.ctal cancer

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Wor.d Jour.al of Gastr.enter.logy 2016年第28期22卷 6345-6361页

作者： Vincenzo Sfor.a Er.ka Mar.inelli For.unato Ciar.iello Valentina Gambar.ella Stefania Napolitano Giulia Mar.ini Car.inia della Cor.e Claudia Car.one Mar.anna l Fer.ar. Alfonso r.ginelli Giuseppina liguor. Giulio Belli Ter.sa Tr.iani Oncologia medica Dipartimento di Medicina Clinica e Sperimentale "F. Magrassi e A. Lanzara" Seconda Università degli Studi di Napoli Depar.ment of Medical Oncology Biomedical Research Institute INCLIVA University of Valencia Depar.ment of Inter.al and Exper.mental Medicine Magrassi-Lanzara Institute of Radiology Seconda Università di Napoli Depar.ment of Pathology Istituto Nazionale Tumori "Fond. Pascale" - IRCCS Depar.ment of Gener.l and Hepato-Pancr.ato-Biliar. Sur.er. S. M. Loreto Nuovo Hospital

The pr.gnosis of patients with metastatic color.ctal cancer.(mCr.) r.main poor.despite the impr.ssive impr.vement of tr.atments obser.ed over.the last 20 year. that led to an incr.ase in median over.ll sur.ival fr.m 6 mo, with the only best suppor.ive car., to appr.ximately 30 mo with the intr.duction of active chemother.py dr.gs and tar.eted agents. The monoclonal antibodies (moAbs) cetuximab and panitumumab, dir.cted against the epider.al gr.wth factor.r.ceptor.(EGFr., undoubtedly r.pr.sent a major.step for.ar. in the tr.atment of mCr., given the r.levant efficacy in ter.s of pr.gr.ssion-fr.e sur.ival, over.ll sur.ival, r.sponse r.te, and quality of life obser.ed in sever.l phase III clinical tr.als among differ.nt lines of tr.atment. However. the anti-EGFr.moAbs wer. shown only to be effective in a subset of patients. For.instance, Kr.S and Nr.S mutations have been identified as biomar.er. of r.sistance to these dr.gs, impr.ving the selection of patients who might der.ve a benefit fr.m these tr.atments. Never.heless, sever.l other.alter.tions might affect the r.sponse to these dr.gs, and unfor.unately, even the r.sponder. eventually become r.sistant by developing secondar. (or.acquir.d) r.sistance in appr.ximately 13-18 mo. Sever.l studies highlighted that the landscape of r.sponsible alter.tions of both pr.mar. and acquir.d r.sistance to anti-EGFr.dr.gs biochemically conver.e into MEK-Er. and pik3CA-AKT pathways. In this r.view, we descr.be the cur.ently known mechanisms of pr.mar. and acquir.d r.sistance to anti-EGFr.moAbs together.with the var.ous str.tegies evaluated to pr.vent, over.ame or.r.ver. them.

关键词： Metastatic color.ctal cancer Epider.al gr.wth factor.r.ceptor r.sistance Mutation Kr.S Nr.S Br.F pik3CA MET Monoclonal antibodies

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Functional char.cter.zation of a novel somatic oncogenic mutation of pik3CB

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Signal Tr.nsduction and Tar.eted Ther.py 2017年第1期2卷 1-9页

作者： Andr.w D Whale lucy Colman letitia lensun Helen l r.ger. Stephen J Shuttlewor.h Kar.s Ther.peutics ltd. Genesis BuildingLibrary AvenueHarwell CampusOxfordshireUK

Class I phosphoinositide 3-kinase(PI3K)enzymes have attr.cted consider.ble attention as dr.g tar.ets in cancer.ther.py over.the last 20 *** signaling pathway tr.gger.d by class I PI3Ks is dysr.gulated in a r.nge of tumor.types,impacting cell pr.lifer.tion,sur.ival and *** oncogenic mutations of pik3CA have pr.viously been *** contr.st,r.por.s of pik3CB mutations have been limited;however.in most cases,those that have been identified have been shown to be activating and *** functional char.cter.zation of a pik3CB catalytic domain mutant,p110β^(E1051K),fir.t discover.d by other. in castr.ter.sistant pr.state cancer.mCr.C),is outlined in this r.por.;our.data suggest that p110β^(E1051K)is a gain-of-function mutation,dr.ving PI3K signaling,tumor.genic cell gr.wth and *** cells expr.ssing p110β^(E1051K)ar. sensitive to p110βinhibition;its char.cter.zation as an oncogenic dr.ver.adds to the r.tionale for.tar.eting p110βand indicates a continuing need to fur.her.develop specific PI3K inhibitor. for.clinical development in cancer.ther.py.

关键词： pik3CB pik3CA char.cter.zation

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