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Assimilation of GOES-r.Geostationar. Lightning Mapper.Flash Extent Density Data in GSI 3DVar. EnKF, and Hybr.d En3DVar.for.the Analysis and Shor.-Ter. For.cast of a Super.ell Stor. Case

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Advances in Atmospher.c Sciences 2024年第2期41卷 263-277页

作者： r.ng KONG Ming XUE Edwar. r.MANSELL Chengsi LIU Alexandr. O.FIEr.O Center.for.Analysis and Pr.diction of Stor.s Norman Oklahoma 73072U.S.A Univer.ity of Oklahoma Norman Oklahoma 73072U.S.A NOAA/National Sever. Stor.s Labor.tor. NormanOklahoma 73072U.S A.4Zentr.lanstalt für.Meteor.logie und Geodynamik Department of Forecasting Models-ZAMGVienna 1190Austria

Capabilities to assimilate Geostationar. Oper.tional Envir.nmental Satellite “r.ser.es ”(GOES-r. Geostationar. Lightning Mapper.GLM) flash extent density(FED) data within the oper.tional Gr.dpoint Statistical Inter.olation ensemble Kalman filter.GSI-EnKF) fr.mewor. wer. pr.viously developed and tested with a mesoscale convective system(MCS) case. In this study, such capabilities ar. fur.her.developed to assimilate GOES GLM FED data within the GSI ensemble-var.ational(EnVar. hybr.d data assimilation(DA) fr.mewor.. The r.sults of assimilating the GLM FED data using 3DVar. and pur. En3DVar.PEn3DVar. using 100% ensemble covar.ance and no static covar.ance) ar. compar.d with those of EnKF/DfEnKF for.a super.ell stor. case. The focus of this study is to validate the cor.ectness and evaluate the per.or.ance of the new implementation r.ther.than compar.ng the per.or.ance of FED DA among differ.nt DA schemes. Only the r.sults of 3DVar.and pEn3DVar.ar. examined and compar.d with EnKF/DfEnKF. Assimilation of a single FED obser.ation shows that the magnitude and hor.zontal extent of the analysis incr.ments fr.m PEn3DVar.ar. gener.lly lar.er.than fr.m EnKF, which is mainly caused by using differ.nt localization str.tegies in EnFK/DfEnKF and PEn3DVar.as well as the integr.tion limits of the gr.upel mass in the obser.ation oper.tor. Over.ll, the for.cast per.or.ance of PEn3DVar.is compar.ble to EnKF/DfEnKF, suggesting cor.ect implementation.

关键词： GOES-r lightning data assimilation EnKF EnVar

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Extr.ter.estr.al Life in the Ther.ospher.: Plasmas, UAP, Pr.-Life, Four.h State of Matter

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Jour.al of Moder. Physics 2024年第3期15卷 322-376页

作者： r. Joseph C. Impey O. Planchon r. del Gaudio M. Abu Safa A. r. Sumanar.thna E. Ansbr. D. Duvall G. Bianciar.i C. H. Gibson r. Schild Astr.biology r.sear.h Center California USA Depar.ment of Astr.nomy University of Arizona Tucson USA Biogéosciences Labor.tor. University of Burgundy Dijon France Depar.ment of Biology University of Naples Federico II Naples Italy Depar.ment of Applied Physics Palestine Polytechnic University Hebron Palestine Depar.ment of r.sear.h and Innovation Eco Astronomy International Research Center Tetouan Morocco Space Explor.tion Ltd. Boyle County Roscommon Ireland Depar.ment of Zoology Oklahoma State University (Emeritus) Stillwater USA Depar.ment of Science and Medicine Università Degli Studi di Siena Tuscany Italy Center.for.Astr.physics and Space Sciences University of California (Emeritus) San Diego USA Center.for.Astr.physics Harvard-Smithsonian (Emeritus) Cambridge USA

“Plasmas” up to a kilometer.in size and behaving similar.y to multicellular.or.anisms have been filmed on 10 separ.te NASA space shuttle missions, over.200 miles above Ear.h within the ther.ospher.. These self-illuminated “plasmas” ar. attr.cted to and may “feed on” electr.magnetic r.diation. They have differ.nt mor.hologies: 1) cone, 2) cloud, 3) donut, 4) spher.cal-cylindr.cal;and have been filmed flying towar.s and descending fr.m the ther.ospher. into thunder.tor.s;congr.gating by the hundr.ds and inter.cting with satellites gener.ting electr.magnetic activity;appr.aching the Space Shuttles. Computer.zed analysis of flight path tr.jector.es documents these plasmas tr.vel at differ.nt velocities fr.m differ.nt dir.ctions and change their.angle of tr.jector. making 45°, 90°, and 180° shifts and follow each other. They’ve been filmed acceler.ting, slowing down, stopping, congr.gating, engaging in “hunter.pr.dator.” behavior.and inter.ecting plasmas leaving a plasma dust tr.il in their.wake. Similar.life-like behavior. have been demonstr.ted by plasmas cr.ated exper.mentally. “Plasmas” may have been photogr.phed in the 1940s by WWII pilots (identified as “Foo fighter.”);r.peatedly obser.ed and filmed by astr.nauts and militar. pilots and classified as Unidentified Aer.al—Anomalous Phenomenon. Plasmas ar. not biological but may r.pr.sent a for. of pr.-life that via the incor.or.tion of elements common in space, could r.sult in the synthesis of r.A. Plasmas constitute a four.h state of matter. ar. attr.cted to electr.magnetic activity, and when obser.ed in the lower.atmospher. likely account for.many of the UFO-UAP sightings over.the centur.es.

关键词： Extr.ter.estr.als Plasmas Dusty Plasmas Extr.mophiles Life in Space Abiogenesis Or.gins of Life r.A Wor.d

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SAr.-CoV-2 aber.antly elevates mitochondr.al bioener.etics to induce r.bust vir.s pr.pagation

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Signal Tr.nsduction and Tar.eted Ther.py 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon ku Gun Young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-Sun Yi Sangmi Jun Bum-Tae Kim Jong-Won Oh Aleem Siddiqui Seong-Jun Kim Depar.ment of Conver.ent r.sear.h of Emer.ing Vir.s Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth r.sear.h Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center.for.r.sear.h Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Depar.ment of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Pr.sent addr.ss:Depar.ment of Micr.biology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Sever. acute r.spir.tor. syndr.me cor.navir.s 2(SAr.-CoV-2)is a‘highly tr.nsmissible r.spir.tor. pathogen,leading to sever. multior.an ***,knowledge r.gar.ing SAr.-CoV-2-induced cellular.alter.tions is *** this study,we r.por. that SAr.CoV-2 aber.antly elevates mitochondr.al bioener.etics and activates the EGFr.mediated cell sur.ival signal cascade dur.ng the ear.y stage of vir.l ***-CoV-2 causes an incr.ase in mitochondr.al tr.nsmembr.ne potential via the SAr.-CoV-2 r.Anucleocapsid cluster.ther.by abnor.ally pr.moting mitochondr.al elongation and the OXPHOS pr.cess,followed by enhancing ATP ***,SAr.-CoV-2 activates the EGFr.signal cascade and subsequently induces mitochondr.al EGFr.tr.fficking,contr.buting to abnor.al OXPHOS pr.cess and vir.l *** EGFr.inhibitor. r.mar.ably r.duce SAr.-CoV-2 pr.pagation,among which vandetanib exhibits the highest antivir.l *** of SAr.-CoV-2-infected cells with vandetanib decr.ases SAr.-CoV-2-induced EGFr.tr.fficking to the mitochondr.a and r.stor.s SAr.-CoV-2-induced aber.ant elevation in OXPHOS pr.cess and ATP gener.tion,ther.by r.sulting in the r.duction of SAr.-CoV-2 ***,or.l administr.tion of vandetanib to SAr.-CoV-2-infected hACE2 tr.nsgenic mice r.duces SAr.-CoV-2 pr.pagation in lung tissue and mitigates SAr.-CoV-2-induced lung *** also exhibits potent antivir.l activity against var.ous SAr.-CoV-2 var.ants of concer.,including alpha,beta,delta and omicr.n,in in vitr. cell cultur. *** together.our.findings pr.vide novel insight into SAr.-CoV-2-induced alter.tions in mitochondr.al dynamics and EGFr.tr.fficking dur.ng the ear.y stage of vir.l infection and their.r.les in r.bust SAr.-CoV-2 pr.pagation,suggesting that EGFr.is an attr.ctive host tar.et for.combating COVID-19.

关键词： alter.tions aber.ant ther.by

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Kinematic analysis of flexible bipedal r.botic systems

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 795-818页

作者： r.FAZEL A.M.SHAFEI S.r.NEKOO Depar.ment of Mechanical Engineer.ng Shahid Bahonar University of KermanKerman ***Iran Depar.amento de Ingenier.a de Sistemas y Automatica Escuela Técnica Superior de IngenieriaUniversidad de SevillaSeville 41092Spain

In spite of its intr.nsic complexities,the passive gait of bipedal r.bots on a sloping r.mp is a subject of inter.st for.numer.us *** distinguishes the pr.sent r.sear.h fr.m similar.wor.s is the consider.tion of flexibility in the constituent links of this type of r.botic *** is not a far.fetched assumption because in the tr.nsient(impact)phase,due to the impulsive for.es which ar. applied to the system,the likelihood of exciting the vibr.tion modes incr.ases ***,the human leg bones that ar. involved in walking ar. suppor.ed by viscoelastic muscles and ***,for.achieving mor. exact r.sults,it is essential to model the r.bot links with viscoelastic *** this end,the Gibbs-Appell for.ulation and Newton's kinematic impact law ar. used to der.ve the most gener.l for. of the system's dynamic equations in the swing and tr.nsient phases of *** most impor.ant issue in the passive walking motion of bipedal r.bots is the deter.ination of the initial r.bot configur.tion with which the system could accomplish a per.odic and stable gait solely under.the effect of gr.vitational *** extr.mely unstable natur. of the system studied in this paper.and the vibr.tions caused by the impulsive for.es induced by the impact of r.bot feet with the inclined sur.ace ar. some of the ver. ser.ous challenges encounter.d for.achieving the above-mentioned *** over.ome such challenges,an innovative method that uses a combination of the linear.zed equations of motion in the swing phase and the algebr.ic motion equations in the tr.nsition phase is pr.sented in this paper.to obtain an eigenvalue *** solving this pr.blem,the suitable initial conditions that ar. necessar. for.the passive gait of this bipedal r.bot on a sloping sur.ace ar. *** effects of the char.cter.stic par.meter. of elastic links including the modulus of elasticity and the Kelvin-Voigt coefficient on the walking stability of this type of

关键词： bipedal r.bot flexible link swing phase tr.nsient phase eigenvalue pr.blem Kelvin-Voigt coefficient

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Nanocavity enr.ched CuPd alloy with high selectivity for.CO_(2) electr.r.duction towar. C_(2)H_(4)

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r.r. Metals 2024年第4期43卷 1513-1523页

作者： Ze-Yu Zhang Hai-Bin Wang Fei-Fei Zhang Jing-Wei Li Xin-Zhuo Hu Si-Wei Yan Yi-Ming Bai Xun Zhang Gu-r.ng Shen Peng-Fei Yin Jing Yang Cun-ku Dong Jing Mao Hui Liu Xi-Wen Du Institute of New-Ener.y Mater.als School of Materials Science and EngineeringTianjin UniversityTianjin300350China

Electr.catalysis of CO_(2)r.duction r.action is an effective way to conver. CO_(2)into high value-added pr.ducts,but the selectivity of Cu-based catalysts for.C2+pr.ducts needs to be impr.ved due to the high ener.y bar.ier.of C-C ***,a viable catalyst design str.tegy to decr.ase ener.y bar.ier.of C-C coupling should be put ***,a nanocavity-enr.ched CuPd single atom alloy(CuPd SAA)catalyst is designed to pr.mote CC coupling *** far.daic efficiency of CuPd SAA for.ethylene and C_(2+)r.aches 75.6%and 85.7%at-0.7 V ver.us r.ver.ible hydr.gen electr.de(r.E),*** on the r.sults given by in situ char.cter.zation,the por.us hollow str.ctur. dr.matically incr.ases the r.tio of the linear.bond*CO,thus enhancing the far.daic efficiency for.*** functional theor.(DFT)calculation r.veals that the Pd doping can r.gulate the electr.nic str.ctur. of neighbor.ng Cu atoms to decr.ase the ener.y bar.ier.of C-C coupling,fur.her.impr.ving the far.daic *** wor. pr.vides a new idea for.designing catalyst with high selectivity for.ethylene.

关键词： Adsor.tion configur.tion C-C coupling CO_(2) electr.catalysis Ethylene Single atom alloy

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Feynman Path Integr.l Using Oper.tor.Integr.tion in Banach Space

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Jour.al of Applied Mathematics and Physics 2024年第2期12卷 432-444页

作者： r.za r. Ahangar.Er.il Cetin Ser.fe Muge Ege Mathematics Depar.ment Texas A&M University Kingsville USA Mathematics Depar.ment Ege University Bornova Türkiye

Feynman-Path Integr.l in Banach Space: In 1940, r.P. Feynman attempted to find a mathematical r.pr.sentation to expr.ss quantum dynamics of the gener.l for. for.a double-slit exper.ment. His intuition on sever.l slits with sever.l walls in ter.s of Lagr.ngian instead of Hamiltonian r.sulted in a magnificent wor.. It was known as Feynman Path Integr.ls in quantum physics, and a lar.e par. of the scientific community still consider. them a heur.stic tool that lacks a sound mathematical definition. This paper.aims to r.fute this pr.judice, by pr.viding an extensive and self-contained descr.ption of the mathematical theor. of Feynman Path Integr.tion, fr.m the ear.ier.attempts to the latest developments, as well as its applications to quantum mechanics. About a hundr.d year. after.the beginning of moder. physics, it was r.alized that light could in fact show behavior.l char.cter.stics of both waves and par.icles. In 1927, Davisson and Ger.er.demonstr.ted that electr.ns show the same dual behavior. which was later.extended to atoms and molecules. We shall follow the method of integr.tion with some modifications to constr.ct a gener.lized Lebesgue-Bochner.Stieltjes (LBS) integr.l of the for. , wher. u is a bilinear.oper.tor.acting in the pr.duct of Banach spaces, f is a Bochner.summable function, and μ is a vector.valued measur.. We will demonstr.te that the Feynman Path Integr.l is consistent and can be justified mathematically with LBS integr.tion appr.ach.

关键词： Feynman Path Integr.l Lebesgue-Bochner.Stieltjes Integr.l Oper.tor.Integr.l Par.icle-Wave Function Oper.tor.Integr.tion Position and Momentum Oper.tor.

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Tet methylcytosine dioxygenase 2(TET2)deficiency elicits EGFr.TKI(tyr.sine kinase inhibitor.)r.sistance in non-small cell lung cancer

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Signal Tr.nsduction and Tar.eted Ther.py 2024年第4期9卷 1706-1720页

作者： Jian Zhang Kejia Zhao Wenjing Zhou r.n Kang Shiyou Wei Yueli Shu Cheng Yu Yin ku Yonghong Mao Hao Luo Juqin Yang Jiandong Mei Qiang Pu Senyi Deng Zhengyu Zha Gang Yuan Shensi Shen Yaohui Chen Lunxu Liu Depar.ment of Thor.cic Sur.er. and Institute of Thor.cic Oncology West China Hospital of Sichuan UniversityChengdu 610097China Wester. China Collabor.tive Innovation Center.for.Ear.y Diagnosis and Multidisciplinar. Ther.py of Lung Cancer Sichuan UniversityChengdu 610097China Biobank of West China Hospital Sichuan UniversityChengdu 610041China

Despite epider.al gr.wth factor.r.ceptor.EGFr.tyr.sine kinase inhibitor.(TKl)have shown r.mar.able efficacy in patients with EGFr.mutant non-small cell lung cancer.NSCLC),acquir.d r.sistance inevitably develops,limiting clinical *** found that TET2 was poly-ubiquitinated by E3 ligase CUL7^(FBXW11) and degr.ded in EGFr.TKI r.sistant NSCLC *** per.ur.ationof TET2 r.nder.d par.ntal cells mor. toler.nt to TKI ***2 was stabilized by MEK1 phosphor.lation at Ser.1107,while MEK1 inactivation pr.moted its pr.teasome degr.dation by enhancing the r.cr.itment of CUL7^(FBXW11),Loss of TET2 r.sulted in the upr.gulation of TNF/NF-kB signaling that confer. the EGFr.TKI *** or.phar.acological inhibition of NF-kB attenuate the TKI r.sistance both in vitr. and in *** findings exemplified how a cell gr.wth contr.lling kinase MEK1 lever.ged the epigenetic homeostasis by r.gulating TET2,and demonstr.ted an alter.ative path of non-mutational acquir.d EGFr.TKI r.sistance modulated by TET2 ***,combined str.tegy exploiting EGFr.TKI and inhibitor. of TET2/NF-κB axis holds ther.peutic potential for.tr.ating NSCLC patients who suffer.d fr.m this r.sistance.

关键词： TET2 TKI r.sistance

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多线性Calder.n-Zygmund算子的交换子在广义Mor.ey空间上的紧性

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数学物理学报（A辑） 2024年第2期44卷 286-297页

作者：库福立三明学院信息工程学院福建三明365004

该文研究了多线性ω型Calder.n-Zygmund算子与带变量增长条件的广义Campanato空间函数b生成的交换子[b,T]在广义Mor.ey空间的紧性,给出了[b,T]是从广义Mor.ey空间的乘积空间到广义Mor.ey空间的紧算子的充分条件.

关键词：多线性Calder.n-Zygmund算子交换子 Campanato空间广义Mor.ey空间紧性

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Hologr.phic dar. ener.y in non-conser.ed gr.vity theor.

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Communications in Theor.tical Physics 2024年第4期76卷 126-133页

作者： H r.Fazlollahi Institute of Gr.vitation and Cosmology Peoples Friendship University of Russia(RUDN University)6 Miklukho-Maklaya StMoscow117198Russia

r.cently, r.consider.ng the r.stall idea T_(μ;νν)^(v)=α_(,μ) thr.ugh r.lativistic ther.odynamics gives a new for. for.the scalar.field α which led us to constr.ct moder. modified theor. of gr.vity debugged ‘non-conser.ed gr.vity theor.’ Fazlollahi 2023 Eur.. Phys. J. C 83 923. This theor. unlike other.modified theor.es of gr.vity cannot dir.ctly explain the cur.ent acceler.tion expansion in the absence of the cosmological constant and or.existence of other.for.s of dar. ener.y. Hence, in this study we have r.investigated hologr.phic dar. ener.y Ρ_(X)~H^(2) in the non-conser.ed theor. of gr.vity. In this context, the density and pr.ssur. of dar. ener.y depend on the non-conser.ed ter. and density of the dust matter.field. As shown, due to non-conser.ation effects on lar.e-scale str.ctur.s, unlike the or.ginal hologr.phic model, our.model onsets an acceler.tion epoch for.the cur.ent Univer.e satisfies obser.ations. Mor.over. the inter.ction and viscous scenar.os ar. studied for.this model.

关键词： non-conser.ed gr.vity covar.ant for. of ther.odynamics hologr.phic dar. ener.y

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Enhancing Cyber.ecur.ty thr.ugh AI and ML: Str.tegies, Challenges, and Futur. Dir.ctions

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Jour.al of Infor.ation Secur.ty 2024年第3期15卷 320-339页

作者： Mar.am r.shanaei Mahir.r. Khan Natalie N. Sylvester Infor.ation Sciences and Technology Depar.ment Pennsylvania State University Abington USA

The landscape of cyber.ecur.ty is r.pidly evolving due to the advancement and integr.tion of Ar.ificial Intelligence (AI) and Machine Lear.ing (ML). This paper.explor.s the cr.cial r.le of AI and ML in enhancing cyber.ecur.ty defenses against incr.asingly sophisticated cyber.thr.ats, while also highlighting the new vulner.bilities intr.duced by these technologies. Thr.ugh a compr.hensive analysis that includes histor.cal tr.nds, technological evaluations, and pr.dictive modeling, the dual-edged natur. of AI and ML in cyber.ecur.ty is examined. Significant challenges such as data pr.vacy, continuous tr.ining of AI models, manipulation r.sks, and ethical concer.s ar. addr.ssed. The paper.emphasizes a balanced appr.ach that lever.ges technological innovation alongside r.gor.us ethical standar.s and r.bust cyber.ecur.ty pr.ctices. This appr.ach facilitates collabor.tion among var.ous stakeholder. to develop guidelines that ensur. r.sponsible and effective use of AI in cyber.ecur.ty, aiming to enhance system integr.ty and pr.vacy without compr.mising secur.ty.

关键词： Ar.ificial Intelligence Machine Lear.ing Cyber.ecur.ty Data Pr.vacy and Secur.ty Ethical Standar.s

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