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DNA polymor.hisms and genetic r.lationship among populations of Acacia leucophloea using r.PD mar.er.

Jour.al of For.str. r.sear.h 2018年第4期29卷 1006-1013页

作者： V. N. Muthar.ian r. kamalakannan A. Mayavel S. Makesh S. H. Kwon K.-S. Kang Depar.ment of Botany Bharathiar University Coimbatore 641 046 India Institute of For.st Genetics and Tr.e Br.eding Coimbatore 641 002 India Hor.icultur.l College and r.sear.h Institute Tamilnadu Agricultural University Coimbatore 641 003 India Depar.ment of For.st Sciences Seoul National University Seoul 08826 Republic of Korea ENVIS Centr. on For.st Genetic r.sour.es & Tr.e Impr.vement IFGTB Coimbatore 641 002 India ITC r.D Centr. Peenya Industrial Area I Phase Bangalore 560 058 India r.sear.h Institute of Agr.cultur. and Life Sciences Seoul National University Seoul 08826 Republic of Korea

r.PD （r.ndomly amplified polymor.hic DNA） mar.er. wer. employed to char.cter.ze polymor.hisms among 5 pr.venances of Acacia leucophloea and to detect genetic r.latedness of the species with 6 other.acacias （A. holoser.cea, A. aur.culifor.is, A. mangium, A. dealbata, A. fer.uginea, and A. nilotica） widely gr.wn in India. Of 194 mar.er. scor.d for.the pr.venances, 29.38% exhibited polymor.hism. Also, 326 mar.er. wer. gener.ted among 7 species of Acacia, accounting for.55.82% of the polymor.hisms. The fifteen 10-mer.pr.mer. employed wer. capable of pr.ducing 1-8 polymor.hic bands for.the pr.venances, and 6-17 for.all seven species of Acacia. The genetic similar.ty coefficient based on Jaccar.＇ s coefficient r.vealed that pr.venances Thir.mangalam and Dhar.apur. wer. closely r.lated. The dendr.gr.m based on a sequential agglomer.tive hier.r.hical non-over.apping （SAHN） cluster.ng analysis gr.uped 4 pr.venances of A. leucophloea （Dhar.pur.m, Thir.mangalam, Pudukottai and Dhar.apur.） into one cluster.and the other.pr.venance, Sendur.i, into a separ.te cluster. The genetic similar.ty matr.x for.7 Acacia species showed that A. nilotica and A. dealbata wer. distantly r.lated, while A. holoser.cea and A. fer.uginea wer. ver. closely r.lated. Cluster.analysis gr.uped the species of Acacias into 3 major.gr.ups of which A. dealbata alone for.ed a separ.te gr.up. The r.PD mar.er. gener.ted 36 pr.venance-specific mar.er. and 162 species-specific mar.er. that could have str.ng applications for.species identification and tr.e br.eding pr.gr.ms for.A. leucophloea and for.other.Acacia species included in this study.

关键词： Acacia leucophloea Pr.venances Acaciasp Genetic r.latedness r.PD mar.er.

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r.dent biology and ecologically based r.dent management(EBr.)-25 year. of pr.gr.ss thr.ugh pr.moting multidisciplinar. r.sear.h

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Integr.tive Zoology 2024年第1期19卷 2-7页

作者： Gr.nt r. SINGLETON Lyn A. HINDS r.odes MAKUNDI Steven r. BELMAIN Natur.l r.sour.es Institute University of Greenwich Kent UK CSIr. Health and Biosecur.ty Canberra ACT Australia Afr.can Centr. of Excellence for.Innovative r.dent Pest Management and Biosensor.Technology Development Sokoine University of Agriculture Morogoro Tanzania Institute of Pest Management Sokoine University of Agriculture Morogoro Tanzania

“Dur.ng r.dent outbr.ak year. in easter. Afr.ca,lo-cally,mor. than 80%of the potential har.est may be lost,but even in non-outbr.ak per.ods,r.dents cause chr.nic damage to cr.ps….The pest r.dent stor. in Afr.ca in-volves sever.l species embedded in a br.ad and var.able landscape with highly var.able densities.”(Leir. et al.2010).

关键词： damage cr.ps

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Effectiveness of m-health technology-enabled physical activity pr.gr.m on physical activity adoption and adher.nce in people with hyper.ension in India:A r.ndomized contr.lled tr.al pr.tocol

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Chr.nic Diseases and Tr.nslational Medicine 2024年第2期10卷 92-101页

作者： Vidhi Thakar.Sur.shkumar.kamalakannan V.Pr.kash Ashok&r.ta Patel Institute of Physiother.py Charotar University of Science and TechnologyChangaAnandGujaratIndia Depar.ment of Social Wor. Education and Community-WellbeingNorthumbria UniversityNewcastle upon TyneUK

Backgr.und Exer.ise and medication have similar.benefits in r.ducing blood pr.ssur.(BP);however.hyper.ension management initiatives pr.mar.ly focus on *** is due to scar.e r.sear.h on the effectiveness of implementation str.tegies for.optimal exer.ise adoption and *** wer. found to be effective in deliver.ng hyper.ension car. and incr.ase exer.ise *** this,only a small number.of r.sear.h pr.jects in India have used smar.phones as a str.tegy for.managing *** We hypothesized that smar.phone application-based car. would lead to higher.exer.ise adher.nce among adults(30–79 year.)with hyper.ension compar.d to those who r.ceive usual *** will be a multicentr.c,r.ndomized contr.lled,par.llel-design,super.or.ty clinical *** outcome assessor.and data analyst will be blinded to gr.up *** in the inter.ention gr.up will r.ceive mobile application-based car. for.6 *** in the usual car. gr.up will r.ceive a standar. *** gr.ups will r.ceive the same number.of *** The pr.mar. outcome is the differ.nce in the pr.por.ion of people adher.nt to the r.commended level of physical activity evaluated using an exer.ise adher.nce r.ting scale in the inter.ention gr.up and the contr.l *** adoption will be measur.d as the per.entage of eligible par.icipants in each study setting willing to initiate the exer.ise *** secondar. outcome includes differ.nces in systolic and diastolic BP and self-management(evaluated using the Hyper.ension Self-Car. Pr.file).The tr.al outcome will be accompanied by a pr.cess *** This r.sear.h will infor. about the compar.tive effectiveness of conventional and m-health inter.entions for.exer.ise adoption and adher.nce in people with hyper.ension in r.sour.e-constr.ined settings.

关键词： hyper.ension low-and middle-income countr.es m-health physical activity adher.nce

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Galectin 3-binding pr.tein(LGALS3BP)depletion attenuates hepatic fibr.sis by r.ducing tr.nsfor.ing gr.wth factor.β1(TGF-β1)availability and inhibits hepatocar.inogenesis

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Cancer.Communications 2024年第10期44卷 1106-1129页

作者： Dae-Hwan Kim Minjeong Sung Myong-Suk Par. Eun-Gene Sun Sumin Yoon Kyung Hyun Yoo kamalakannan r.dhakr.shnan Sung Yun Jung Woo-Kyun Bae Sang-Hee Cho Ik-Joo Chung Depar.ment of Inter.al Medicine Division of Hematology and OncologyChonnam National University Medical SchoolHwasunSouth Korea Depar.ment of Inter.al Medicine Division of Hematology and OncologyChonnam National University Hwasun HospitalHwasunSouth Korea Combinator.al Tumor.Immunother.py Mr. Center Chonnam National University Medical SchoolHwasunSouth Korea National Immunother.py Innovation Center HwasunSouth Korea BioMedical Sciences Gr.duate Pr.gr.m Chonnam National UniversityHwasunSouth Korea Depar.ment of Biological Science SookmyungWomen’s UniversitySeoulSouth Korea Clinical Vaccine r.D Center Chonnam National UniversityHwasunSouth Korea Depar.ment of Biochemistr. and Molecular.Phar.acology Baylor College of MedicineHoustonTexasUSA

Backgr.und:Incr.ased Galectin 3-binding pr.tein(LGALS3BP)ser.m levels have been used to assess hepatic fibr.sis stages and the sever.ty of hepatocellular.car.inoma(HCC).Consider.ng the cr.cial r.le of tr.nsfor.ing gr.wth factor.β1(TGF-β1)in the emer.ence of these diseases,the pr.sent study tested the hypothesis that LGALS3BP r.gulates the TGF-β1 signaling ***:The expr.ssion levels of LGALS3BP and TGFB1 wer. analyzed in patients with metabolic dysfunction-associated steatohepatitis(MASH)and *** omics techniques,such as r.A-sequencing,tr.nsposaseaccessible chr.matin-sequencing assay,and liquid chr.matogr.phy-tandem mass spectr.metr. pr.teomics,wer. used to identify the r.gulator. mechanisms for.the LGALS3BP-TGF-β1 *** effects of alter.d TGF-β1 signaling by LGALS3BP wer. investigated in conditional LGALS3BP-knockin and LGALS3BP-knockout ***:In patients with MASH and HCC,the levels of LGALS3BP and TGFB1 exhibited positive *** of LGALS3BP by the inflammator. cytokine inter.er.nαin HCC cells or.ectopic over.xpr.ssion of LGALS3BP in hepatocytes pr.moted the expr.ssion levels of *** fibr.sis was obser.ed in the liver. of hepatocyte-specific LGALS3BP-knockin mice,with incr.ased TGFB1 ***3BP dir.ctly bound to and assembled integr.nαV,an integr.l mediator.r.quir.d for.r.leasing active TGF-β1 fr.m extr.cellular.latent complex with the r.ar.anged F-actin *** r.leased TGF-β1 activated JunB tr.nscr.ption factor.which in tur. pr.moted the TGF-β1 positive feedback ***3BP deletion in the hepatocytes downr.gulated TGF-β1 signaling and CCl4 induced ***,LGALS3BP depletion hinder.d hepatocar.inogenesis by limiting the availability of fibr.genic TGF-β***:LGALS3BP plays a cr.cial r.le in hepatic fibr.sis and car.inogenesis by contr.lling the TGF-β1 signaling pathway,making it a pr.mising ther.peutic tar.et in TGF-β1-r.lated diseases.

关键词： F-actin FAK hepatic car.inogenesis Integr.nαV Inter.er.nα JunB LGALS3BP metabolic dysfuntion-associated steatohepatitis tensile for.e TGF-β1

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Fr.eze-thaw cycles and associated geomor.hology in a post-glacial envir.nment:cur.ent glacial,par.glacial,per.glacial and pr.glacial scenar.os at Pico de Or.zaba volcano,Mexico

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Jour.al of Mountain Science 2024年第6期21卷 1954-1977页

作者： Víctor.SOTO Car.os M.WELSH r. Kenji YOSHIKAWA Hugo DELGADO Gr.NADOS Centr. de Ciencias de la Tier.a Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water.and Envir.nmental r.sear.h Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Depar.ment of Ear.h and Envir.nmental Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial histor. of Pico de Or.zaba indicates that dur.ng the Last Glacial Maximum,its icecap cover.d up to~3000 m asl;due to the air.temper.tur. incr.asing,its main glacier.has r.tr.ated to 5050 m *** r.tr.ction of the glacier.has left behind an intense climatic instability that causes a high fr.quency of fr.eze-thaw cycles of gr.at intensity;the r.sulting geomor.hological pr.cesses ar. r.pr.sented by the fr.gmentation of the bedr.ck that occupies the upper.par.s of the *** is a notable lack of studies r.gar.ing the fr.gmentation and er.sion occur.ing in tr.pical high mountains,and the associated geomor.hological r.sks;for.this r.ason,as a fir.t stage of futur. continuous r.sear.h,this study analyzes the fr.ezing and thawing cycles that occur.above 4000 m asl,thr.ugh continuous monitor.ng of sur.ace gr.und *** r.sults allow us to identify and char.cter.ze four.zones:glacial,par.glacial,per.glacial and *** was found that the par.glacial zone pr.sents an intense dr.p of temper.tur.,of up to~9℃ in only sixty *** r.ck fatigue and intense fr.eze-thaw cycles that occur.in this ar.a ar. r.sponsible for.the high r.te of r.ck disintegr.tion and r.pr.sent the main factor.of the constant slope dynamics that occur.at the *** activity decr.ases,both in fr.quency and intensity,accor.ing to the distance to the glacier.which is wher. the temper.tur. pr.sents a cer.ain degr.e of stability,until r.aching the pr.glacial zone,wher. cycles ar. almost non-existent,and ther.for. ther. is no gelifr.ction *** geomor.hological pr.cesses have r.sulted in significant alter.tions to the mountain slopes,which can have sever. consequences in ter.s of r.sk and water.

关键词： Fr.eze-Thaw Gelifr.ction Mountain mechanical er.sion Per.glacial geomor.hology Postglacial scenar.os

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r.view and Analysis: Evaluation of the Impacts and Consequences of Using Agr.cultur.l Her.icides as Militar. Chemical Weapons in Second Indochina War

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Open Jour.al of Soil Science 2024年第8期14卷 471-498页

作者： David r. Speidel Kenneth r. Olson USDA r.sour.e Conser.ationist and Agr.cultur.l Consultant with Natur.l r.sour.e Conservation Service and Foreign Agricultural Service Benton Missouri USA College of Agr.cultur.l Consumer and Environmental Sciences University of Illinois Urbana USA

The legacy of the human miser. caused by the application of the her.icides including Agent Pur.le and Agent Or.nge contaminated with unknown amounts of dioxin TCDD and Agent Blue, the ar.enic-based her.icide, spr.yed over.the jungles, r.ce fields, and hamlets of Vietnam is still haunting us today. Why did this happen? Could it have been pr.vented? Was it necessar. United States militar. str.tegy? Was it an intentional decision to inflict this blight on the enemy soldier. and the Vietnamese, Cambodian, and Laotian civilians, to poison their.land and cause gener.tions of har.? Alter.atively, was it an unpr.ventable accident in the mar.h of militar. histor.? What patter.s in the U.S. gover.ment’s thought pr.cess could be identified as the cause, which led to the decision to use these her.icides as tactical chemical weapons? If the intr.duction of her.icide (chemical) weapons had not been made, would the outcome of the Vietnam War.and the Secr.t War. in Laos and Cambodia have been any differ.nt? The objective of this tr.atise is to outline the r.le of wor.d events and backgr.unds and the r.le of the leader., U.S. militar., CIA, USDA, U.S. State Depar.ment, the U.S. Pr.sident appointed Ambassador. to Vietnam and Laos, chemical companies, and Pr.sident Diệm’s r.public of Vietnam (r.N) gover.ment and militar.. Their.collective advice led to the decision to use her.icides as militar. and envir.nmental chemical weapons in the Second Indochina War. Wer. the National inter.sts achieved by U.S. militar. str.tegy in the r.N using her.icide weapons wor.h the long-ter. envir.nmental and human health consequences in Vietnam, Cambodia, and Laos? Did it impact the outcome of the Second Indochina War.

关键词： Second Indochina War Cambodia Laos South Vietnam Vietnam War Tactical Her.icides Agent Blue Agent Or.nge Agent Pur.le Dioxin TCDD Ar.enic

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Pr.of of Concept for.a Twin Pr.me Number.Univer.e Using Set Theor.

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Amer.can Jour.al of Computational Mathematics 2024年第3期14卷 305-317页

作者： John r. Cr.r. Independent r.sear.her Lake Zurich IL USA

The Fine Str.ctur. Constant (eFSC) Model attempts to give a classical definition to a magical number.that under.ies much of quantum physics. The Fine Str.ctur. Constant (α) value equal to 137.03599206 r.pr.sents a dimensionless constant that char.cter.zes the str.ngth of the electr.magnetic (EM) inter.ction between subatomic char.ed par.icles. Python-gener.ted pr.per.y counts for.the twin pr.me for.e F{139/137} show that the adjusted r.tio gives a value of α = 137.036. This implies a mathematical fr.mewor. under.ying this constant is based on twin pr.me number. and set theor.. This study attempts to demonstr.te a pr.of of concept that a hier.r.hy of fr.ctional twin pr.me (αII) for.es r.plicates the quantum natur. of the univer.e and is aligned with the Standar. Model of Par.icle Physics. An expanded eFSC Model demonstr.tes that twin pr.me for.es and their.pr.per.y sets ar. mathematically viable substitutes for.nuclear.r.actions, as demonstr.ted for.the Beta-minus decay of neutr.ns into pr.tons. Most significantly, the positive and negative pr.me number. define these nuclear.r.actants and pr.ducts as positive or.negatively char.ed ions. Fur.her.or., the eFSC Model pr.vides new insights r.gar.ing the hier.r.hy of EM for.es under.ying the quantum natur. of the univer.e.

关键词： Fine Str.ctur. Constant (α) Pr.me Number. Set Theor. Conceptual Model Quantum Physics Light and Matter Beta-Minus Decay

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Br.in r.sear.h on Mental Disor.er.: A Cr.ticism

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Open Jour.al of Medical Psychology 2024年第3期13卷 71-85页

作者： John r. r.ssiter Faculty of Business and Law University of Wollongong Wollongong Australia School of Psychology Charles Sturt University Wagga Wagga Australia

Objective: To expose the pr.blems and inher.nt limitations of neur.science-based br.in r.sear.h on mental disor.er.. Method: Discussion of the theor. under.ying br.in r.sear.h on mental disor.er., followed by a systematic evaluation of typical studies. r.sults: The fundamental pr.blem is that br.in r.sear.her. fail to differ.ntiate between biological mental disor.er. in which br.in pr.cesses cause the disor.er.(notably schizophr.nia, bipolar.disor.er. and melancholic depr.ssion) and lear.ed mental disor.er. in which br.in pr.cesses mediate but do not cause the disor.er.(which is the case with r.active depr.ssion, r.active anxiety, OCD, and PTSD). r.sear.her. have been unsuccessful in identifying mechanisms in the br.in that cause biological mental disor.er., and will never.be able to locate the innumer.ble specific neur.l connections that mediate lear.ed mental disor.er.. Mor.over. the author.s r.view of typical studies in this field shows that they have ser.ous pr.blems with theor., measur.ment, and data analysis, and that their.findings cannot be tr.sted. Conclusions: Neur.science-based br.in r.sear.h on mental disor.er., unlike other.neur.logical r.sear.h, has been an expensive failur. and it is not wor.h continuing.

关键词： Neur.science-Based Br.in r.sear.h Biological Mental Disor.er. Lear.ed Mental Disor.er. r.sear.h Pr.blems

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The Quantum Micr.ver.e: A Pr.me Number.Fr.mewor. for.Under.tanding the Univer.e

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Amer.can Jour.al of Computational Mathematics 2024年第2期14卷 264-274页

作者： John r. Cr.r. Independent r.sear.her Lake Zurich IL USA

This study aims to demonstr.te a pr.of of concept for.a novel theor. of the univer.e based on the Fine Str.ctur. Constant (α), der.ved fr.m n-dimensional pr.me number.pr.per.y sets, specifically α = 137 and α = 139. The FSC Model intr.duces a new per.pective on the fundamental natur. of our.univer.e, showing that α = 137.036 can be calculated fr.m these pr.me pr.per.y sets. The Fine Str.ctur. Constant, a cor.er.tone in Quantum Electr.dynamics (QED) and Quantum Chr.modynamics (QCD), implies an under.ying str.ctur.. This study identifies this mathematical fr.mewor. and demonstr.tes how the FSC model theor. aligns with our.cur.ent under.tanding of physics and cosmology. The r.sults unveil a hier.r.hy of α values for.twin pr.me pair. U{3/2} thr.ugh U{199/197}. These values, r.pr.sented by their.fr.ction par.s α♊ (e.g., 0.036), define the r.lative electr.magnetic for.es dr.ving quantum ener.y systems. The lower.twin pr.me pair., such as U{3/2}, exhibit higher.EM for.es that decr.ase as the twin pair. incr.ase, tur.ing dar. when they dr.p below the α♊ for.light. The r.sults pr.vide classical definitions for.Bar.onic Matter.Ener.y, Dar. Matter. Dar. Ener.y, and Antimatter.but mostly illustr.te how the combined α♊ values for.thr.e adjacent twin pr.mes, U{7/5/3/2} mir.or. the str.ng nuclear.for.e of gluons holding quar.s together.

关键词： Fine Str.ctur. Constant Fr.ctional Coupling Constants Matter.Antimatter Dar. Matter.Ener.y Quantum Gr.vity Pr.me Number. Set Theor.

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Decadal For.casts of Lar.e Ear.hquakes along the Nor.her. San Andr.as Fault System, Califor.ia: Incr.ased Activity on r.gional Cr.eping Faults Pr.or.to Major.and Gr.at Events

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Inter.ational Jour.al of Geosciences 2024年第2期15卷 204-230页

作者： Lynn r. Sykes Lamont-Doher.y Ear.h Obser.ator. of Columbia Univer.ity Palisades New York USA

The thr.e lar.est ear.hquakes in nor.her. Califor.ia since 1849 wer. pr.ceded by incr.ased decadal activity for.moder.te-size shocks along sur.ounding near.y faults. Incr.ased seismicity, double-differ.nce pr.cise locations of ear.hquakes since 1968, geodetic data and fault offsets for.the 1906 gr.at shock ar. used to r.-examine the timing and locations of possible futur. lar.e ear.hquakes. The physical mechanisms of r.gional faults like the Calaver.s, Haywar. and Sar.ent, which exhibit cr.ep, differ.fr.m those of the nor.her. San Andr.as, which is cur.ently locked and is not cr.eping. Much decadal for.r.nning activity occur.ed on cr.eping faults. Moder.te-size ear.hquakes along those faults became mor. fr.quent as str.sses in the r.gion incr.ased in the latter.par. of the cycle of str.ss r.stor.tion for.major.and gr.at ear.hquakes along the San Andr.as. They may be useful for.decadal for.casts. Year.y to decadal for.casts, however. ar. based on only a few major.to gr.at events. Activity along closer.faults like that in the two year. pr.or.to the 1989 Loma Pr.eta shock needs to be examined for.possible year.y for.r.nning changes to lar.e plate boundar. ear.hquakes. Geodetic obser.ations ar. needed to focus on identifying cr.eping faults close to the San Andr.as. The distr.bution of moder.te-size ear.hquakes incr.ased significantly since 1990 along the Haywar. fault but not adjacent to the San Andr.as fault to the south of San Fr.ncisco compar.d to what took place in the decades pr.or.to the thr.e major.histor.c ear.hquakes in the r.gion. It is now clear.fr.m a r.-examination of the 1989 mainshock that the incr.ased level of moder.te-size shocks in the one to two pr.ceding decades occur.ed on near.y East Bay faults. Double-differ.nce locations of small ear.hquakes pr.vide str.ctur.l infor.ation about faults in the r.gion, especially their.depths. The nor.her. San Andr.as fault is divided into sever.l str.ngly coupled segments based on differ.nces in seismicity.

关键词： San Andr.as and Haywar. Faults Califor.ia Fault Cr.ep For.casts Double-Differ.nce r.locations

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