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Solid Lipid Nanopar.icles (SLN) and Nanostr.ctur.d Lipid Car.ier. (NLC): Occlusive Effect and Penetr.tion Enhancement Ability

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Jour.al of Cosmetics, Der.atological Sciences and Applications 2015年第2期5卷 62-72页

作者： r. López-garcía A. Ganem-r.nder. División de Estudios de Posgr.do (Tecnología Far.acéutica) Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México Cuautitlán Izcalli Mexico

Objective: This wor. compar.s the occlusive effect and the penetr.tion enhancement ability of solid lipid nanopar.icles (SLN) and nanostr.ctur.d lipid car.ier. (NLC), thr.ugh in vitr. skin. Methods: SLN and NLC wer. pr.par.d by high shear.homogenization and char.cter.zed by size, polydisper.ity index, zeta potential, mor.hology and physical stability. Occlusive effect was assessed by an in vitr. test and by measur.ng TEWL using pig skin. Skin tr.ated with the lipid car.ier. was visualized by SEM. A penetr.tion test thr.ugh skin, followed by tape str.pping, was car.ied out using Nile r.d as a mar.er. r.sults: SLN (200 ± 6 nm) and NLC (192 ± 11 nm) wer. obtained. An occlusion factor.of 36% - 39% was obser.ed for.both systems, while a r.duction in TEWL of 34.3% ± 14.8% and 26.2% ± 6.5% was seen after.tr.atment with SLN and NLC, r.spectively. SEM images showed a film for.ed by the lipid car.ier., r.sponsible for.the occlusion obser.ed. No differ.nces wer. found between the occlusive effect pr.duced by SLN and NLC in both tests. NLC allowed the penetr.tion of a gr.ater.amount of Nile r.d than SLN: 4.7 ± 1.3 μg and 1.7 ± 0.4 μg, r.spectively. Conclusion: Both car.ier. for. a film on the skin, pr.viding an occlusive effect with no differ.nces between these two systems. The penetr.tion of a mar.er.(Nile r.d) into the str.tum cor.eum was quite higher.for.NLC than for.SLN, suggesting an influence of the composition of these par.icles on their.penetr.tion enhancing ability.

关键词： Solid Lipid Nanopar.icles Nanostr.ctur.d Lipid Car.ier. Occlusive Effect Tr.nsepider.al Water Loss Skin Penetr.tion

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Tr.ce Elements Distr.bution in r.d Soils under.Semiar.d Mediter.anean Envir.nment

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Inter.ational Jour.al of Geosciences 2011年第2期2卷 84-97页

作者： J. A. Amor.s Or.iz-Villajos F. J. garcía Navar.o C. J. Sánchez Jiménez C. Pér.z de los r.yes r. garcía Mor.no r. Jiménez Ballesta 不详

This study states the potential tr.ce elements (TE’s) content of r.d soils located at the centr. r.gion of Spain, char.cter.zed by low r.infall and slight acidity over.pr.longed weather.ng per.ods. For.this pur.ose, thr.e soil pr.files fr.m a catena wer. descr.bed, sampled and analyzed. The most notable char.cter.stics ar. the low or.anic matter.content and the pr.dominantly acidic pH. Illite and kaolinite ar. the pr.dominant clay miner.ls. The fer.ility of the soils is sufficient to pr.vide most of the nutr.ents r.quir.d, with ver. suitable potassium levels. The geochemical char.cter. of this soil ar.: only few elements r.main almost invar.able acr.ss the pr.files and over.time, however.the major.ty of them wer. dir.ctly linked with the clay content. These soils ar. char.cter.zed by r.latively low levels of some tr.ce elements such as Sr.(64.35 mg?kg–1), Ba (303.67 mg?kg–1) and Sc (13.14 mg?kg–1);high levels of other.tr.ce elements such as V (103.92 mg?kg–1), Cr.(79.9 mg?kg–1), Cu (15.18 mg?kg–1), Hf (10.26 mg?kg–1), Ni (38 mg?kg–1) and Zr.(337 mg?kg–1);while the levels for.r.r. ear.h elements (r.E’s) such as La (48.36 mg?kg–1), Ce (95.07 mg?kg–1), Th (13.33 mg?kg–1) and Nd (42.65 mg?kg–1) ar. significantly high. The distr.bution of mayor.and tr.ce elements was dir.ctly r.- lated to weather.ng pr.cesses, par.nt mater.al and anthr.pogenic activities.

关键词： Tr.ce Elements Castilla-La Mancha r.gion r.d Soils Soil Geochemistr.

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The Effectiveness of the Havr.liak-Negami Model in Pr.dicting the Master.Cur.es of the Asphalt Blends with SBS Tr.block Copolymer.and Or.anic-Montmor.llonite at Differ.nt Temper.tur.s and Fr.quencies

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Jour.al of Mater.als Science and Chemical Engineer.ng 2024年第7期12卷 23-39页

作者： Mar.a Ángeles Var.as-Her.ández Miguel Ángel Var.as Pedr. r. garcía-Mor.n Humber.o Vázquez-Tor.es Divisin de Ingenier. Qumica y Bioqumica TecNMTecnolgico de Estudios Superiores de Ecatepec Edo. de Mxico Mxico Facultad de Qumica Universidad Nacional Autonma de Mxico Cd. de Mxico Mxico Facultad de Ciencias Bsicas Ingenier. y Tecnologa Universidad Autnoma de Tlaxcala Tlaxcala Mxico Depar.amento de Fsica Universidad Autnoma Metropolitana-Iztapalapa Cd. de Mxico Mxico

The dynamic viscoelastic pr.per.ies of asphalt AC-20 and its composites with Or.anic-Montmor.llonite clay (OMMt) and SBS wer. modeled using the empir.cal Havr.liak-Negami (HN) model, based on linear.viscoelastic theor. (LVE). The HN par.meter., α, β, G0, G∞and τHN wer. deter.ined by solving the HN equation acr.ss var.ous temper.tur.s and fr.quencies. The HN model successfully pr.dicted the r.eological behavior.of the asphalt and its blends within the temper.tur. r.nge of 25˚C - 40˚C. However. deviations occur.ed between 40˚C - 75˚C, wher. the glass tr.nsition temper.tur. Tg of the asphalt components and the SBS polymer.ar. located, r.nder.ng the HN model ineffective for.pr.dicting the dynamic viscoelastic pr.per.ies of composites containing OMMt under.these conditions. Yet, the pr.diction er.or.of the HN model dr.pped to 2.28% - 2.81% for.asphalt and its mixtur.s at 100˚C, a temper.tur. exceeding the Tg values of both polymer.and asphalt, wher. the mixtur.s exhibited a liquid-like behavior. The exponent α and the r.laxation time incr.ased with temper.tur. acr.ss all systems. Incor.or.ting OMMt clay into the asphalt blends significantly enhanced the r.laxation dynamics of the r.sulting composites.

关键词： Asphalt Blends Master.Cur.e Linear.Viscoelasticity Havr.liak-Negami Model

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Beyond neur.degener.tion:engineer.ng amyloids for.biocatalysis

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Neur.l r.gener.tion r.sear.h 2025年第10期20卷 2915-2916页

作者： Andr.a Bar.olomé-Nafr.a Javier.garcía-Par.o Salvador.Ventur. Institut de Biotecnologia i de Biomedicina(IBB)and Depar.ament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Univer.itar. Par. Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibr.ls ar. highly or.anized pr.tein or.peptide aggr.gates,often char.cter.zed by a distinctive supr.molecular.cr.ss-β-sheet *** for.ation and accumulation of these str.ctur.s have been tr.ditionally associated with neur.l or.systemic human diseases,such as Alzheimer.s disease,Par.inson’s disease,type-2 diabetes,or.amyotr.phic later.l scler.sis(Wei et al.,2017;Wittung-Stafshede,2023).

关键词： str.ctur. amyloid

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The emer.ing r.le of mesenchymal stem cell-der.ved extr.cellular.vesicles to amelior.te hippocampal NLr.3 inflammation induced by binge-like ethanol tr.atment in adolescence

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Neur.l r.gener.tion r.sear.h 2025年第4期20卷 1153-1163页

作者： Susana Mellado Mar.a JoséMor.llo-Bar.ues Car.a Per.iñá-Clér.gues Fr.ncisco garcía-garcía Victor.a Mor.no-Manzano Consuelo Guer.i Mar.a Pascual Depar.ment of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinfor.atics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neur.nal and Tissue r.gener.tion Labor.tor. Príncipe Felipe Research CenterValenciaSpain

Our.pr.vious studies have r.por.ed that activation of the NLr.3(NOD-,Lr.-and pyr.n domain-containing pr.tein 3)-inflammasome complex in ethanol-tr.ated astr.cytes and chr.nic alcohol-fed mice could be associated with neur.inflammation and br.in *** stem cell-der.ved extr.cellular.vesicles(MSC-EVs)have been shown to r.stor. the neur.inflammator. r.sponse,along with myelin and synaptic str.ctur.l alter.tions in the pr.fr.ntal cor.ex,and alleviate cognitive and memor. dysfunctions induced by binge-like ethanol tr.atment in adolescent *** the ther.peutic r.le of the molecules contained in mesenchymal stem cell-der.ved extr.cellular.vesicles,the pr.sent study analyzed whether.the administr.tion of mesenchymal stem cell-der.ved extr.cellular.vesicles isolated fr.m adipose tissue,which inhibited the activation of the NLr.3 inflammasome,was capable of r.ducing hippocampal neur.inflammation in adolescent mice tr.ated with binge *** demonstr.ted that the administr.tion of mesenchymal stem cell-der.ved extr.cellular.vesicles amelior.ted the activation of the hippocampal NLr.3 inflammasome complex and other.NLr. inflammasomes(e.g.,pyr.n domain-containing 1,caspase r.cr.itment domain-containing 4,and absent in melanoma 2,as well as the alter.tions in inflammator. genes(inter.eukin-1β,inter.eukin-18,inducible nitr.c oxide synthase,nuclear.factor.kappa B,monocyte chemoattr.ctant pr.tein-1,and C–X3–C motif chemokine ligand 1)and mir.As(mir.21a-5p,mir.146a-5p,and mir.141-5p)induced by binge-like ethanol tr.atment in adolescent *** analysis fur.her.r.vealed the involvement of mir.21a-5p and mir.146a-5p with inflammator. tar.et genes and NOD-like r.ceptor.signaling *** together.these findings pr.vide novel evidence of the ther.peutic potential of MSC-der.ved EVs to amelior.te the hippocampal neur.inflammator. r.sponse associated with NLr.3 inflammasome activation induced by binge dr.nking in adolescence.

关键词： adolescence binge-like ethanol tr.atment extr.cellular.vesicles hippocampus mesenchymal stem cells neur.inflammation NOD-,Lr.-and pyr.n domain-containing pr.tein 3(NLr.3)

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FTIr.ATr.and Multivar.ate Calibr.tion for.the Pr.diction of Biodiesel Concentr.tion in Petr.diesel Blends

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Amer.can Jour.al of Analytical Chemistr. 2013年第7期4卷 343-347页

作者： A. Guer.er. F. Anguebes M. Castelán V. Mor.les r. garcía A. V. Cór.ova J. C. Zavala Colegio de Postgr.duados Campus Córdoba Carretera Fed. Córdoba-Veracruz km 348 Amatlán de los Reyes Veracruz México Colegio de Postgr.duados Campus Tabasco Periférico Carlos A. Molina s/n Cárdenas México Facultad de Química Universidad Autónoma del Carmen Col. Benito Juárez Ciudad del Carmen México

The incr.asing use of petr.diesel-biodiesel fuel blends thr.ughout the wor.d r.quir.s fast, economic and efficient analytical techniques that can be used for.the quality contr.l of these fuels. In this wor., we developed an analytical method for.deter.ining the concentr.tion of Afr.can palm biodiesel in blends with petr.diesel;the method is based on infr.r.d spectr.scopy (FTIr.ATr.. To build a pr.diction model, nineteen petr.diesel-biodiesel blends wer. pr.par.d in tr.plicate with biodiesel concentr.tions for.0%-100% by weight. The blends wer. analyzed using Four.er.tr.nsfor. infr.r.d spectr.scopy, the spectr.l finger.r.nt data wer. used to build a pr.diction model thr.ugh PLS r.gr.ssion. The optimal number.of pr.ncipal components (PCs), the standar. er.or.of calibr.tion (SEC), the standar. validation er.or.(SEV), the cor.elation coefficient of calibr.tion (r.Cal) and the validation cor.elation coefficient (r.Val) wer. used to validate the pr.dictive ability of the model. The r.sults show that the model obtained in this wor. has a good ability for.deter.ining the concentr.tion of Afr.can palm biodiesel in petr.diesel-biodiesel blends.

关键词： Afr.can Palm FTIr.ATr Chemometr.c Tools Par.ial Least Squar.s r.gr.ssion Petr.diesel-Biodiesel Blends

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Dendr.tic spine degener.tion:a pr.mar. mechanism in the aging pr.cess

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Neur.l r.gener.tion r.sear.h 2025年第6期20卷 1696-1698页

作者： Gonzalo Flor.s Leonar.o Aguilar.Her.ández Fer.ado garcía-Dolor.s Humber.o Nicolini Andr.a Judith Vázquez-Her.ández Hir.m Tendilla-Beltr.n Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias For.nses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

r.cent r.por.s suggest that aging is not solely a physiological pr.cess in living beings;instead, it should be consider.d a pathological pr.cess or.disease(Amor.m et al., 2022). Consequently, this pr.cess involves a wide r.nge of factor., spanning fr.m genetic to envir.nmental factor., and even includes the gut micr.biome(GM)(Mayer.et al., 2022). All these pr.cesses coincide at some point in the inflammator. pr.cess, oxidative str.ss, and apoptosis, at differ.nt degr.es in var.ous or.ans and systems that constitute a living or.anism(Mayer.et al., 2022;Aguilar.er.ández et al., 2023).

关键词： aging pr.cess str.ss

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r.assessing the AMPK-MTOr.1 balance in autophagy in the centr.l ner.ous system

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Neur.l r.gener.tion r.sear.h 2025年第11期20卷 3209-3210页

作者： Mar.a garcía-Juan Mar.o Villa Ir.ne Benito-Cuesta Lar. Or.ónez-Gutiér.ez Fr.ncisco Wandosell Centr. de Biología Molecular.Sever. Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Depar.ment of Clinical Neur.science CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Depar.amento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centr. de Investigación Biomédica en r.d de Enfer.edades Neur.degener.tivas(CIBEr.ED) MadridSpain

Autophagy is a cellular.degr.dation and r.cycling system,indispensable for.cellular.and or.an development,homeostasis,and *** cellular.pr.cess is evolutionar.ly highly conser.ed to quality contr.l of many pr.teins and dysfunctional or.anelles,which finally r.cycle components as amino *** pr.cess is effective dur.ng nor.al physiology as par. of anabolism and plays an additional impor.ant r.le dur.ng star.ation(Dikic and Elazar.2018).Differ.nt types of autophagy have been char. cter.zed based on their.dynamic,mechanism of action,tar.et substr.tes,and pr.tein *** of them ar. macr.autophagy(her.after.called"autophagy"),micr.a utophagy,and chape r.ne-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system her.after

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Coar.e to Fine: The r.le of Sever. Plastic Defor.ation in Advancing Titanium-Based Medical Implants - A Compr.hensive r.view

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Jour.al of Wuhan Univer.ity of Technology(Mater.als Science) 2025年第1期40卷 295-306页

作者： Dr.gana r.Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r.Djokić Faculty of Technology and Metallur.y University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear.Sci-ences-National Institute of the r.public of Ser.ia University of Belgrade11001BeogradSerbia Innovation Centr. of the Faculty of Technology and Metallur.y Karnegijeva 411120 BelgradeSerbia

This paper.descr.bes sever. plastic defor.ation(SPD)pr.cedur.s,which ar. utilized to for. an ultr.fine-gr.ined str.ctur. in metallic *** the SPD pr.cess,a solid mater.al sample is subjected to ver. high loads without a significant change in sample *** the pr.sent wor.,the high-pr.ssur. tor.ion(HPT)pr.cess,as one of the SPD techniques,which achieves a high degr.e of defor.ation and ensur.s r.finement of the micr.str.ctur.,will be discussed in mor. *** that gr.in size contr.l is accepted as a method to obtain mater.als with desir.d char.cter.stics,an over.iew of the pr.per.ies of ultr.fine-gr.ined titanium-based biomater.als to be used in medicine is ***,par.icular.attention is dedicated to the influences of HPT pr.cess par.meter.,pr.mar.ly hydr.static pr.ssur.,and number.of r.volutions dur.ng tor.ion,on the gr.in size and physical and mechanical char.cter.stics(modulus of elasticity,micr.har.ness,and tensile pr.per.ies),cor.osion r.sistance,and biocompatibility of the titanium-based biomater.als.A r.view of the liter.tur. indicates that titanium-based mater.als obtained by the SPD pr.cess show impr.ved mechanical and physical pr.per.ies without losing biocompatibility and cor.osion r.sistance,which suggests that these methods of obtaining implants ar. something that should be fur.her.developed in the futur..

关键词： high-pr.ssur. tor.ion pr.cess ultr.fine-gr.ined titanium-based mater.als electr.chemical anodization physical pr.per.ies mechanical pr.per.ies

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Descr.ption of the Factor. Associated with Tr.gger.Finger.in Patients Tr.ated at Petr.leos Mexicanos “Pemex”

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Jour.al of Biosciences and Medicines 2023年第7期11卷 151-159页

作者： Fer.ando Bar.osa-Villar.eal Cuahutémoc Már.uez-Espr.ella r.dr.go Dávila-Díaz Mar.o A. Cuer.o-Ver.ar. Blanca Y. Ar.mbula-Sánchez Alber.o I. Cahuana-Quispe Victor.A. Esquivel-Chávez Car.os E. garcía-Cór.ova Ana P. Campollo-López Maur.cio Gutier.ez-Alvar.z Jesus r. garcía-Cor.al Alfr.do Chama-Nar.njo Daniel de Luna-Gallar.o r.car.o A. Pulido-López Isaac F. r.cio-España Esteban I. Campos-Ser.a Car.os I. Navar.o-Delgadillo José C. Mar.ínez-López Victor.H. Avalos-Gómez Alejandr. Cr.z-Zar.te Depar.ment of Plastic and r.constr.ctive Sur.er. Hospital Central Sur Petróleos Mexicanos Mexico City Mexico

Backgr.und: The tr.gger.finger. also known as stenosing tenosynovitis of the flexor.tendon, is a common cause of hand disability;This can r.sult in significant limitations in cer.ain daily living activities. It is possible to tr.at this condition with conser.ative or.sur.ical methods. Methods: This is a r.tr.spective, obser.ational, cr.ss-sectional and descr.ptive study. The sour.e population consisted of all patients with a diagnosis of tr.gger.finger.who had been tr.ated in the depar.ment of plastic and r.constr.ctive sur.er. of our.institution between 2020 and 2023. The pr.mar. objective of this study is to deter.ine the pr.valence and char.cter.ze the clinical and sur.ical char.cter.stics of the population affected by tr.gger.finger.in our.hospital. r.sults: The total population was 237 patients, of which 165 wer. women (70%) and 72 men (30%). The most affected hand was the r.ght hand, with a total of 158 patients (67%). In the r.ght hand, the middle finger.was the most affected (45%). Of the 237 patients, 80 of them had obesity (34%), 86 had type 2 diabetes mellitus (36%), 95 had systemic ar.er.al hyper.ension (40%). Open technique was per.or.ed in 190 (80%) patients, while per.utaneous technique was per.or.ed in 47 (20%) of them. Conclusion: The female sex was twice as fr.quent, and the middle finger.and thumb wer. the most affected. Most of the patients r.ceived sur.ical tr.atment with open appr.ach and per.utaneous appr.ach in 20% of them.

关键词： Tr.gger.Finger Tendinopathy

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