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The sexually dimor.hic expr.ssion of glutamate tr.nspor.er. and their.implication in pain after.spinal cor. injur.

Neur.l r.gener.tion r.sear.h 2025年第11期20卷 3317-3329页

作者： Jennifer.M.Colón-Mer.ado Ar.nza I.Tor.ado-Tapias Ir.s K.Salgado Jose M.Santiago Samuel e.Ocasio r.ver. dina P.Br.cho-r.ncon Luis H.Pagan r.ver. Jor.e D.Mir.nda Depar.ment of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Univer.idad Centr.l del car.be School of MedicineBayamónPRUSA Univer.ity of Puer.o r.co Carolina CampusCarolinaPRUSA Institute of Neur.biology San JuanPRUSA

In addition to the loss of motor.function,~60% of patients develop pain after.spinal cor. *** cellular.molecular.mechanisms ar. not well under.tood,but the data suggests that plasticity within the r.str.l,epicenter.and caudal penumbr. of the injur. site initiates a cellular.olecular.inter.lay that acts as a r.wir.ng mechanism leading to centr.l neur.pathic *** can lead to the for.ation of new connections tr.gger.ng abnor.al sensor. *** excitator. glutamate tr.nspor.er. ar. r.sponsible for.the r.uptake of extr.cellular.glutamate which makes them a cr.tical tar.et to pr.vent neur.nal hyper.xcitability and *** pr.vious studies showed a sexually dimor.hic ther.peutic window for.spinal cor. injur. after.tr.atment with the selective estr.gen r.ceptor.modulator.*** this study,we investigated the anti-allodynic effects of tamoxifen in male and female r.ts with spinal cor. *** hypothesized that tamoxifen exer.s anti-allodynic effects by incr.asing the expr.ssion of glutamate tr.nspor.er.,leading to r.duced hyper.xcitability of the secondar. neur.n or.by decr.asing aber.ant *** and female r.ts r.ceived a moder.te contusion to the thor.cic spinal cor. followed by subcutaneous slow-r.lease tr.atment of tamoxifen or.matr.x pellets as a contr.l(placebo).We used von Fr.y monofilaments and the“up-down method”to evaluate mechanical *** tr.atment decr.ased allodynia only in female r.ts with spinal cor. injur. r.vealing a sexdependent *** expr.ssion pr.file of glutamater.ic tr.nspor.er.(excitator. amino acid tr.nspor.er.1/glutamate aspar.ate tr.nspor.er.and excitator. amino acid tr.nspor.er.2/glutamate tr.nspor.er.1)r.vealed a sexual dimor.hism in the r.str.l,epicenter.and caudal ar.as of the spinal cor. with a patter. of expr.ssion pr.mar.ly on *** r.dents showed a significantly higher.level of excitator. amino acid tr.nspor.er.1 expr.ssion while male r.dents showed incr.ased

关键词： allodynia centr.l neur.pathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate tr.nspor.er. selective estr.gen r.ceptor.modulator sexual dimor.hism spinal cor. injur. tr.uma

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e2F tr.nscr.ption factor. and digestive system malignancies: How much do we know?

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Wor.d Jour.al of Gastr.enter.logy 2013年第21期19卷 3189-3198页

作者： Athanasios Xanthoulis dina G Tiniakos Depar.ment of Sur.er. Section of Gastroenterological SurgeryLevanger HospitalNord-Tr ndelag Hospital Trust7600 LevangerNorway Labor.tor. of Histology-embr.ology Medical SchoolNational and Kapodistrian University of Athens11527 AthensGreece

e2F family of tr.nscr.ption factor. r.gulates var.ous cellular.functions r.lated to cell cycle and apoptosis. Its individual member. have tr.ditionally been classified into activator. and r.pr.ssor., based on in vitr. studies. However.their.contr.bution in human cancer.is mor. complicated and difficult to pr.dict. We r.view cur.ent knowledge on the expr.ssion of e2Fs in digestive system malignancies and its clinical implications for.patient pr.gnosis and tr.atment. e2F1, the most extensively studied member.and the only one with pr.gnostic value, exhibits a tumor.suppr.ssing activity in esophageal, gastr.c and color.ctal adenocar.inoma, and in hepatocellular.car.inoma (HCC), wher.as in pancr.atic ductal adenocar.inoma and esophageal squamous cell car.inoma may function as a tumor.r.moter. In the latter.malignancies, e2F1 immunohistochemical expr.ssion has been cor.elated with higher.tumor.gr.de and wor.e patient sur.ival, wher.as in esophageal, gastr.c and color.ctal adenocar.inomas is a mar.er.of incr.ased patient sur.ival. e2F2 has only been studied in color.ctal cancer. wher. its r.le is not consider.d significant. e2F4's r.le in color.ctal, gastr.c and hepatic car.inogenesis is tumor.pr.moting. e2F8 is str.ngly upr.gulated in human HCC, thus possibly contr.buting to hepatocar.inogenesis. Adenovir.l tr.nsfer.of e2F as gene ther.py to sensitize pancr.atic cancer.cells for.chemother.peutic agents has been used in exper.mental studies. Other.ther.peutic str.tegies ar. yet to be developed, but it appear. that tar.eted appr.aches using e2F-agonists or.antagonists should take into account the tissue-dependent function of each e2F member. Fur.her.under.tanding of e2Fs' contr.bution in cellular.functions in vivo would help clar.fy their.r.le in car.inogenesis.

关键词： e2F Color.ctal cancer Gastr.c cancer esophageal cancer Pancr.atic cancer Hepatocellular car.inoma Digestive system malignancies

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Advances and challenges in diagnosing and managing adult autoimmune enter.pathy

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Wor.d Jour.al of Gastr.enter.logy 2025年第2期31卷 128-131页

作者： Gr.gor.os Chr.stodoulidis Sar. e Agko Mar.na N Kouliou Konstantinos e Koumar.las Dimitr.s Zachar.ulis Depar.ment of Gener.l Sur.er. University Hospital of LarissaLarissa 41110Greece Depar.ment of Intensive car. Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany Depar.ment of emer.ency Medicine General Hospital of LarissaLarissa 41221Greece Depar.ment of Sur.er. University Hospital of LarissaLarissa 41334Greece

Autoimmune enter.pathy(AIe)is a r.r. immune mediated disor.er.pr.mar.ly affecting childr.n,char.cter.zed by chr.nic diar.hea,malabsor.tion,vomiting,weight loss and villous *** has also been obser.ed in adults pr.senting diagnostic and tr.atment challenges due to its over.ap with other.gastr.intestinal disor.er. such as celiac *** diagnostic cr.ter.a for.AIe include small bowel villous atr.phy,lack of r.sponse to dietar. r.str.ctions,pr.sence of anti-enter.cyte antibodies,and pr.disposition to autoimmunity without sever. *** cr.ter.a emphasize char.cter.stic histological findings and exclusion of other.causes of villous *** is associated with var.ous autoimmune disor.er. and can pr.sent with over.apping featur.s with Celiac disease,including villous atr.phy but without significant intr.epithelial *** pr.mar.ly involves immunosuppr.ssion using cor.icoster.ids,calcineur.n inhibitor.,and anti-tumor.necr.sis factor.ther.py,alongside nutr.-tional *** the challenges,under.tanding AIe’s diver.e manifest-ations and impr.ving diagnostic cr.ter.a ar. essential for.effective management and impr.ved patient *** r.sear.h is needed to elucidate the pathogenesis,disease pr.gr.ssion and long-ter. outcomes of AIe.

关键词： Autoimmune enter.pathy Diagnosis Pr.gnosis Adult autoimmune enter.opathy and challenges Autoimmune enter.pathy and tr.atment Autoimmune enter.pathy and diagnostic cr.ter.a Pathophysiology of autoimmune enter.pathy

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A Pr.me Submodule Pr.nciple

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Algebr. Colloquium 2014年第4期21卷 697-710页

作者： r. Nekooei e. r.stami Depar.ment of Mathematics Shahid Bahonar University of Kerman Kerman Iran

In this paper. we extend the concept of Ako and Ol~ families to submodules, study the behavior.of the extended pr.me submodule pr.nciple and use these concepts to give new pr.ofs of some familiar.theor.ms.

关键词： pr.me submodules multiplication modules Ako and Oka families str.nglyAko and str.ngly Oka

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Or.anor.enium(Ⅶ) oxides

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r.r. Metals 2006年第z1期25卷 411-421页

作者： KüHN Fr.tz e. JAIN Kavita r. Depar.ment für.Chemie der.Technischen Univer.itt München Lichtenbergstrasse 4 D-85747 Garching bei München Germany

Methyltr.oxor.enium (MTO) and its der.vatives wer. utilized as catalysts for.a br.ad var.ety of or.anic r.actions after.the discover. of an easy synthetic access way to this class of compounds. Among the numer.us char.cter.zation techniques, 17O-NMr.spectr.scopy and vibr.tional spectr.scopy wer. exemplar. discussed. The immobilization of MTO and its der.vatives is of significant cur.ent inter.st as is the synthesis of chir.l der.vatives.

关键词： catalysis epoxidation immobilization olefination r.enium

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Ver. ear.y family-based inter.ention for.anxiety:two case studies with toddler.

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Gener.l Psychiatr. 2019年第6期32卷 349-355页

作者： dina r.Hir.hfeld-Becker.Aude Henin Stephanie J r.popor. Timothy e Wilens Alice S car.er Child CBT Pr.gr.m Department of PsychiatryMassachusetts General HospitalBostonMassachusettsUSA Depar.ment of Psychiatr. Harvard Medical SchoolBostonMassachusettsUSA Division of Child and Adolescent Psychiatr. Department of PsychiatryMassachusetts General HospitalBostonMassachusettsUSA Depar.ment of Psychology University of Massachusetts BostonBostonMassachusettsUSA

Anxiety disor.er. r.pr.sent the most common categor.of psychiatr.c disor.er.in childr.n and adolescents and contr.bute to distr.ss,impair.ent and *** Anxiety disor.er. or.their.temper.mental pr.cur.or. ar. often evident in ear.y childhood,and anxiety can impair.functioning,even dur.ng pr.school age and in toddler. A gr.wing number.of investigator. have shown that anxiety in pr.schooler. can be tr.ated efficaciously using cognitive-behaviour.l ther.py(CBT)administer. either.by tr.ining the par.nts to apply CBT str.tegies with their.childr.n or.thr.ugh dir.ct inter.ention with par.nts and *** date,most investigator. have dr.wn the line at offer.ng dir.ct CBT to childr.n under.the age of ***,since toddler. can also pr.sent with impair.ng symptoms,and since behaviour.str.tegi can be applied in older.pr.schooler. with poor.languag ability successfully,it ought to be possible to apply CBT anxiety to younger.childr.n as *** ther.for. pr.se two cases of ver. young childr.n with impair.ng anxiet(ages 26 and 35 months)and illustr.te the combinatio par.nt-only and par.nt-child CBT sessions that compr. their.*** tr.atment was well toler.ted by par.nts and childr.n and showed pr.mise for.r.ducing anxiety symptoms and impr.ving coping skills.

关键词： distr.ss behaviour apply

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The evolution of phenotypic plasticity in fish swimming

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Cur.ent Zoology 2016年第5期62卷 475-488页

作者： Chr.stopher.e. OUFIer. Katr.na r. WHITLOW Depar.ment of Biological Sciences Towson University Towson MD 21252 USA

Fish have a r.mar.able amount of var.ation in their.swimming per.or.ance, fr.m within species dif- fer.nces to diver.ity among major.taxonomic gr.ups. Fish swimming is a complex, integr.tive phenotype and has the ability to plastically r.spond to a myr.ad of envir.nmental changes. The plasticity of fish swimming has been obser.ed on whole-or.anismal tr.its such as bur.t speed or.cr.tical swimming speed, as well as under.ying phenotypes such as muscle fiber.types, kinematics, car.iovascular.system, and neur.nal pr.cesses. Whether.the plastic r.sponses of fish swimming ar. beneficial seems to depend on the envir.nmental var.able that is changing. For.example, because of the effects of temper.tur. on biochemical pr.cesses, alter.tions of fish swimming in r.sponse to tem- per.tur. do not seem to be beneficial. In contr.st, changes in fish swimming in r.sponse to var.ation in flow may benefit the fish to maintain position in the water.column. In this paper. we examine how this plasticity in fish swimming might evolve, focusing on envir.nmental var.ables that have r.ceived the most attention： temper.tur., habitat, dissolved oxygen, and car.on dioxide var.ation. Using examples fr.m pr.vious r.sear.h, we highlight many of the ways fish swimming can plastic- ally r.spond to envir.nmental var.ation and discuss potential avenues of futur. r.sear.h aimed at under.tanding how plasticity of fish swimming might evolve. We consider.the dir.ct and indir.ct ef- fects of envir.nmental var.ation on swimming per.or.ance, including changes in swimming kine- matics and subor.anismal tr.its thought to pr.dict swimming per.or.ance. We also discuss the r.le of the evolution of plasticity in shaping macr.evolutionar. patter.s of diver.ity in fish swimming.

关键词： envir.nmental var.ation evolution fish phenotypic plasticity swimming kinematics swimming per.or.ance.

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effects of absolute fasting on r.pr.duction and sur.ival of the invasive apple snail Pomacea canaliculata in its native r.nge

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Cur.ent Zoology 2016年第4期62卷 369-375页

作者： Nicolas e. TAMBUr. Pablo r. MAr.IN INBIOSUr.(UNS-CONICeT) Universidad Nacional del Sur Departamento de Biologla Bioquimica y Farmacia San Juan 670 8000 Bahia Blanca Argentina

A South Amer.can fr.shwater.gastr.pod, the apple snail Pomacea canaliculata, has become a dr.ver.of ecosystemic changes in wetlands and an impor.ant r.ce pest after.its intr.duction to var.ous par.s of the wor.d, mainly Asia. The objective of this study was to study the effect of an abr.pt inter.uption in food availability in the shor. ter. （up to 4 weeks） and long ter. （up to 8 months） on sur.ival and r.- pr.ductive activity. The main r.sults indicate that shor.-ter. fasting mainly affects the sur.ival of males, but only when they ar. r.ised together.with females, pr.bably due to a gr.ater.mate-sear.hing activity that incr.ases mor.ality in the individuals with lower.r.ser.es. The number.of copulating snails or.egg-laying females shows an abr.pt dr.p when fasting and a r.pid r.cover. after.the food supply is r.stor.d. The str.tegy of discontinuing r.pr.ductive activity pr.or.tizes ener.y conser.ation for.the sur.ival of the females. Inter.opulation var.ation in r.sistance to star.ation was obser.ed in adults, which can be explained to some extent by the food availability that they exper.enced in their.natur.l envir.nment. No inter.opulational differ.nces in sur.ival wer. seen in hatchlings. The mean maximum values of sur.ival under.star.ation wer. 52.6 days in hatchlings and the 3.3% of adults sur.ive over.than 200 days, which may be a r.levant tr.it in disper.al and establishment in new habitats.

关键词： GASTr.PODA POMACeA canaliculata WeTLANDS STAr.ATION eNer.Y conser.ation

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Synthesis of a copper.Ⅱ) oxide–montmor.llonite composite for.lead r.moval

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Inter.ational Jour.al of Miner.ls,Metallur.y and Mater.als 2019年第7期26卷 803-810页

作者： Davidson e. egir.ni Nanfe r. Poyi Napoleon Wessey Faculty of Science Niger Delta University Wilberforce Island Nigeria Niger.an Institute of Mining and Geosciences Jos Nigeria

The synthesis of a copper.II) oxide–montmor.llonite composite and its application in the r.moval of lead(II) ions in solution wer. investigated. The Acr.s Or.anics (ACOr. montmor.llonite was activated using potassium hydr.xide solution. The activated ACOr.montmor.llonite was titr.ted with copper.II) nitr.te solution to pr.duce the copper.II) oxide–montmor.llonite composite. Adsor.tion exper.ments wer. conducted using batch-mode techniques under.r.ducing conditions at ambient temper.tur.. The r.action mechanism indicated a higher.pr.ton coefficient, gr.ater.intr.par.icle diffusion, and higher.mass tr.nsfer.r.tes compar.d with those achieved with bar. montmor.llonite. The intr.par.icle diffusion constant der.ved fr.m the slope was 2.93^-3 (mg·g^–1·min^–0.5), and the inter.ept C was 9.86,≠ 0. In the pr.sence of a CuO coating, the adsor.tion efficiency was 85.55% at pH 4 and 89.62% at pH 7. Ther.for., the copper.II) oxide-montmor.llonite composite, as a novel adsor.ent with a ver. high adsor.tion capacity, exhibited substantially enhanced adsor.tion of Pb^2+ ions compar.d with bar. montmor.llonite.

关键词： activation adsor.tion kinetics aging coatings copper oxide montmor.llonite

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Nuclear.mechanics dur.ng constr.cted migr.tion

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Acta Mechanica Sinica 2019年第2期35卷 299-308页

作者： Yuntao Xia Char.otte r. Pfeifer.Dennis e. Discher Physical Sciences Oncology Center.at Pennsylvania (PSOC@Penn) University of Pennsylvania PhiladelphiaPA 19104USA Molecular.and Cell Biophysics Lab University of PennsylvaniaPhiladelphiaPA 19104 USA Depar.ment of Physics and Astr.nomy University of Pennsylvania Philadelphia PA 19104USA

Cell migr.tion thr.ugh nar.ow inter.titial space in tissues is commonly seen in both physiological and pathological conditions. For.example, immune cells have to squeeze thr.ugh vasculatur. and extr.cellular.matr.x to r.ach the wound or.diseased sites, and similar.y cancer.cells need to cr.wl thr.ugh por.us space in tissues to invade sur.ounding tumor.fr.e r.gions. Ther.for., the bulky stiff nucleus in the cell becomes a bar.ier.dur.ng constr.cted migr.tion making such pr.cess por.-size dependent with smaller.por.s exponentially alleviate the passage capability. However. in some cases, cells can actively defor. their.nuclei to squeeze thr.ugh constr.ctions although some pr.ce needs to be paid. In this r.view, we focus on:(1) nuclear.str.ctur.s and mor.hological r.gulations,(2) pr.posed mechanisms that dr.ve constr.cted migr.tion,(3) shor.-ter. consequences such as nuclear.envelope (Ne) r.ptur. and DNA damage dur.ng such pr.cess,(4) biophysical factor. that facilitate Ne r.ptur., and (5) long ter. consequences such as genomic var.ation caused by r.petitive Ne r.ptur.. Both exper.mental r.sults and modeling ar. pr.vided with the intention to better.under.tand the constr.cted migr.tion.

关键词： Constr.cted migr.tion Nuclear envelope r.ptur. DNA damage

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