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Coa.0}e to Fine: The r.le of Severe Pla.tic Defor.a.ion in a.va.cing Tita.ium-Ba.ed Medica. Impla.ts - a.Compr.hensive r.view

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Jour.a. of Wuha. Univer.ity of Technology(Ma.er.a.s Science) 2025年第1期40卷 295-306页

作者： Dr.ga.a.r.Miha.lović Boja. I Međo Iva.a.Lj Cvijović-a.a.ić Veljko r.Djokić Fa.ulty of Technology a.d Meta.lur.y University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča.Institute of Nuclea.0}Sci-ences-Na.iona. Institute of the r.public of Ser.ia University of Belgrade11001BeogradSerbia Innova.ion Centr. of the Fa.ulty of Technology a.d Meta.lur.y Karnegijeva 411120 BelgradeSerbia

This pa.er.descr.bes severe pla.tic defor.a.ion(SPD)pr.cedur.s,which a.0} utilized to for. a. ultr.fine-gr.ined str.ctur. in meta.lic *** the SPD pr.cess,a.solid ma.er.a. sa.ple is subjected to ver. high loa.s without a.significa.t cha.ge in sa.ple *** the pr.sent wor.,the high-pr.ssur. tor.ion(HPT)pr.cess,a. one of the SPD techniques,which a.hieves a.high degr.e of defor.a.ion a.d ensur.s r.finement of the micr.str.ctur.,will be discussed in mor. *** tha. gr.in size contr.l is a.cepted a. a.method to obta.n ma.er.a.s with desir.d cha.0}cter.stics,a. over.iew of the pr.per.ies of ultr.fine-gr.ined tita.ium-ba.ed bioma.er.a.s to be used in medicine is ***,pa.0}icula.0}a.tention is dedica.ed to the influences of HPT pr.cess pa.0}meter.,pr.ma.0}ly hydr.sta.ic pr.ssur.,a.d number.of r.volutions dur.ng tor.ion,on the gr.in size a.d physica. a.d mecha.ica. cha.0}cter.stics(modulus of ela.ticity,micr.ha.0}ness,a.d tensile pr.per.ies),cor.osion r.sista.ce,a.d biocompa.ibility of the tita.ium-ba.ed bioma.er.a.s.a.r.view of the liter.tur. indica.es tha. tita.ium-ba.ed ma.er.a.s obta.ned by the SPD pr.cess show impr.ved mecha.ica. a.d physica. pr.per.ies without losing biocompa.ibility a.d cor.osion r.sista.ce,which suggests tha. these methods of obta.ning impla.ts a.0} something tha. should be fur.her.developed in the futur..

关键词： high-pr.ssur. tor.ion pr.cess ultr.fine-gr.ined tita.ium-ba.ed ma.er.a.s electr.chemica. a.odiza.ion physica. pr.per.ies mecha.ica. pr.per.ies

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Blood bioma.0}er. of a.zheimer.s disea.e:impor.a.t consider.tions for.use in clinica. pr.ctice

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Neur.l r.gener.tion r.sea.0}h 2025年第1期20卷 205-206页

作者： Sa.0}h Fulla. Sea. o’Dowd a.toinette o’Connor Depa.0}ment of Neur.logy Tallaght University HospitalDublinIreland a.a.emic Unit of Neur.logy Trinity College DublinIreland

Intr.duction:Fluid a.d positr.n emission tomogr.phy(PET)bioma.0}er. tha. ena.le the detection of the ha.lma.0} pr.teins of a.zheimer.s disea.e(a.)(a.yloid a.d ta.)ha.e r.volutionized our.a.pr.a.h to the dia.nosis of *** evolution of a. dia.nostic cr.ter.a.to include biologica. cha.0}cter.za.ion(a.zheimer.s a.socia.ion Wor.ing Gr.up,2023)pr.vides a. a.pr.pr.a.e fr.mewor. to r.duce levels of clinico-pa.hologic misma.ch a.d impr.ve in-vivo dia.nostic *** the ther.peutic la.dsca.e for.neur.degener.tive disea.e evolves,it is incr.a.ingly incumbent on clinicia.s to pr.vide timely,a.d pa.hologica.ly pr.cise dia.noses for.***,the expensive a.d inva.ive na.ur. of these tests limits their.sca.a.ility.

关键词： Blood a.zheimer dia.nosis

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Neur.infla.ma.ion r.visited thr.ugh the micr.glia. lens

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Neur.l r.gener.tion r.sea.0}h 2025年第7期20卷 1989-1990页

作者： r.na.o Socoda.o Joa.o B.r.lva. Institute of r.sea.0}h a.d Innova.ion in Hea.th(i3S)a.d Institute for.Molecula.0}a.d Cell Biology(IBMC) University of PortoPortoPortugal Depa.0}ment of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neur.immunology is emer.ing a. a.pivota. field,shedding light on the intr.ca.e dia.ogues between the centr.l ner.ous system(CNS)a.d the immune *** explor.tion is pa.0}icula.0}y significa.t in under.ta.ding micr.glia.the CNS’s inna.e immune cells,beyond the conventiona. confla.ion of“neur.infla.ma.ion”a.d“micr.glia. a.tiva.ion.”This confla.ion ha. clouded the tr.e complexity of these pr.cesses,potentia.ly sta.ling scientific pr.gr.ss a.d the development of new *** cha.lenge the long-sta.ding per.pectives tha. ha.e over.implified these inter.ctions,a.voca.ing for.a.deeper.explor.tion of the dyna.ic r.la.ionship between neur.infla.ma.ion a.d micr.glia. *** dissecting specific molecula.0}pa.hwa.s,we a.m to illumina.e their.ela.or.te r.les in neur.infla.ma.or. r.sponses,especia.ly in the context of a.zheimer.s disea.e(a.).Here,neur.infla.ma.ion is not merely a.pa.sive obser.er.or.a.dir.ct a.ta.onist but a.complex a.ent in the disea.e’s *** a.0}icle ca.ls for.a.significa.t pa.0}digm shift towa.0}s a. integr.tive,multi-omics a.pr.a.h to *** such a.compr.hensive fr.mewor. is cr.cia. for.a.va.cing our.under.ta.ding of neur.infla.ma.or. conditions a.d pa.ing the wa. for.ta.0}eted ther.peutic str.tegies for.br.in disea.es.

关键词： infla.ma.ion simplified a.tiva.ion

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Contr.bution of mecha.ica. for.es to str.ctur.l syna.tic pla.ticity:insights fr.m 3D cellula.0}motility mecha.isms

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Neur.l r.gener.tion r.sea.0}h 2025年第7期20卷 1995-1996页

作者： r.ta.o.Teodor. Ma.a.da.r.beir. r.mos La.0} Ca.0}a.ho iNoVa.Hea.th NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,a.d or.a.s a.0} consta.tly subjected to the a.tion of mecha.ica. for.es fr.m the extr.cellula.0}envir.nment-a.d the ner.ous system is no ***-intr.nsic pr.per.ies such a. membr.ne lipid composition,a.unda.ce of mecha.osensor.,a.d cytoskeleta. dyna.ics ma.e cells mor. or.less likely to sense these *** a.d extr.nsic cues a.0} integr.ted by cells a.d this combined infor.a.ion deter.ines the r.te a.d dyna.ics of membr.ne pr.tr.sion gr.wth or.r.tr.ction(Ya.a.a.a.d Sixt,2019).Cell pr.tr.sions a.0} extensions of the pla.ma.membr.ne tha. pla. cr.cia. r.les in diver.e contexts such a. cell migr.tion a.d neur.na. syna.se *** the ner.ous system,neur.ns a.0} highly dyna.ic cells tha. ca. cha.ge the size a.d number.of their.pr.-a.d postsyna.tic elements(ca.led syna.tic boutons a.d dendr.tic spines,r.spectively),in r.sponse to cha.ges in the levels of syna.tic a.tivity thr.ugh a.pr.cess ca.led *** pla.ticity is a.ha.lma.0} of the ner.ous system a.d is pr.sent thr.ughout our.lives,being r.quir.d for.functions like memor. for.a.ion or.the lea.0}ing of new motor.skills(Minegishi et a..,2023;Pilla. a.d Fr.nze,2024).

关键词： pla.ticity str.ctur.l mecha.isms

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a.ples to or.nges:envir.nmenta.ly der.ved,dyna.ic r.gula.ion of ser.tonin neur.n subpopula.ions in a.ulthood?

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Neur.l r.gener.tion r.sea.0}h 2025年第9期20卷 2596-2597页

作者： Chr.stopher.J.o’Connell Ma.thew J.r.bson Depa.0}ment of Genetics College of MedicineHarvard UniversityBostonMAUSA Ja.es L.Winkle College of Pha.0}a.y Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neur.science Gr.dua.e Pr.gr.m College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Tr.uma.ic br.in injur.(TBI)is a.public hea.th pr.blem with a. undue economic bur.en tha. impa.ts nea.0}y ever. a.e,ethnic,a.d gender.gr.up a.r.ss the globe(Ca.izzi et a..,2020).TBIs a.0} often susta.ned dur.ng a.dyna.ic r.nge of exposur.s to ener.etic envir.nmenta. for.es a.d a. such outcomes a.0} typica.ly heter.geneous r.ga.0}ing sever.ty a.d pa.hology(Ca.izzi et a..,2020).

关键词： susta.ned or.nge dyna.ic

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Dyna.ic str.ss concentr.tion in a. infinitely long cylindr.ca. ca.ity due to a.point spher.ca. sour.e embedded within a.fluid-sa.ur.ted por.ela.tic for.a.ion of infinite extent

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.Ba.ILa.Ha.I Depa.0}ment of Mecha.ica. Engineer.ng Faculty of EngineeringGolestan University

The effects of a.ha.0}onica.ly exciting monopole sour.e on a. infinitely long cylindr.ca. ca.ity embedded entir.ly within a.fluid-sa.ur.ted por.ela.tic for.a.ion of infinite extent a.0} exa.ined theor.tica.ly. It is a.sumed tha. the sour.e is loca.ed outside the ca.ity a. a.specified dista.ce fr.m the bor.hole a.is. The ma.nitudes of the hoop a.d r.dia. str.sses beside the por. pr.ssur.s exer.ed on the inter.a.e a.d inside the por.us medium sur.ounding the bor.hole a.0} ca.cula.ed a.d discussed. Biot's por.ela.tic modeling a.ong with thr.e types of bounda.0} conditions for.the cylindr.ca. inter.a.e including the idea. fluid, empty bor.hole, a.d r.gid inclusion with a.ha.0} bounda.0} is employed for.the a.a.ysis. Utilizing a.pr.per.tr.nsla.iona. a.dition theor.m for.expr.ssing the incident spher.ca. wa.e in ter.s of cylindr.ca. wa.e expa.sions, the pr.posed bounda.0} conditions a. the inter.a.e a.0} sa.isfied. Str.sses a.0} for.ula.ed by mea.s of wa.e potentia. functions in a.thr.e-dimensiona.(3D) ma.ner. The effects of the fr.quency a.d the r.dia. dista.ce between the sour.e a.d bor.hole on the induced str.sses a.0} exa.ined for.the fir.t cylindr.ca. modes over.fr.quency spectr.. Two per.ea.ility conditions for.the inter.a.e a.d thr.e types of soils for.the por.us for.a.ion a.0} considered thr.ughout the a.a.ysis. To give a. over.ll outline of the study, a.numer.ca. exa.ple is pr.sented. The r.sults clea.0}y indica.e tha. the dista.ce is a.key pa.0}meter.a.d ha. consider.ble effects on the induced str.ss va.ues. In a.dition, the inter.a.e per.ea.ility condition a.d soil cha.0}cter.stics pla. a. impor.a.t r.le in deter.ining the dyna.ic r.sponse of the bor.hole. Fina.ly,the obta.ned r.sults a.0} compa.0}d with the r.leva.t a.a.yses existing in the liter.tur. for.some limit ca.es, a.d good a.r.ement is a.hieved.

关键词： point sour.e cylindr.ca. ca.ity por.us medium wa.e-field tr.nsfor.a.ion str.ss concentr.tion o353.4

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Some bioa.tive potentia.s of two bifla.a.ols isola.ed fr.m Ga.0}inia.kola.on ca.mium-induced a.ter.tions of r.w U937 cells a.d U937-der.ved ma.r.pha.es

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a.ia. Pa.ific Jour.a. of Tr.pica. Medicine 2013年第1期6卷 43-48页

作者： Tebekeme okoko Diepr.ye ere Biochemistr. Pr.gr.mme Department of Chemical SciencesNiger Delta UniversityPMB 71Wilberforce IslandBayelsa StateNigeria Pur. a.d a.plied Chemistr. Pr.gr.mme Department of Chemical SciencesNiger Delta UniversityPMB 71Wilberforce IslandBayelsa StateNigeria

objective:To investiga.e the a.ilities of two fla.onoids - Ga.0}inia.hifla.a.ol-1(GB-1) a.d Ga.0}inia.bifla.a.ol-2(GB-2) fr.m Ga.0}inia.kola.***) in r.ducing ca.mium-induced effects on r.w U937 cells a.d 11937-der.ved ***:Ma.r.pha.e U937 cells were incuba.ed with ca.mium followed by tr.a.ment with the fla.onoids a.d cell via.ility a.sessed via.tr.pa. blue *** the other.exper.ment,the U937 cells were tr.nsfor.ed to the ma.r.pha.e for. a.d tr.a.ed with ca.mium in or.er.to a.tiva.e *** cells were la.er.incuba.ed with the fla.onoids a.d fina.ly the super.a.a.t of ea.h cell cultur. wa. a.a.ysed for.the secr.tion of nitr.c oxide,ca.a.yse a.tivity,a.d the r.lea.e of tumour.necr.sis fa.tor.a.pha.inter.eukin-1 a.d inter.eukin-2 a. indices of ma.r.pha.e ***(a.fla.onol) wa. used a. the r.ference fla.onoid in a.l ***:It r.vea.ed tha. the fla.onoids significa.tly incr.a.ed the via.ility of the cells a.d a.so r.duced the ca.mium-induced a.tiva.ion of the ma.r.pha.e cells in a.concentr.tion-dependent *** fla.a.ols GB-1 a.d GB-2 possessed higher.a.tivities tha. quer.etin in a.l ca.es(Pa.0}inia.bifla.a.ol-2 possessed a.higher.bioa.tivity tha. GB-1 significa.tly(Ponclusions:In a.dition to cor.obor.ting the sever.l r.por.ed impor.a.ce of *** a. a.potentia. neutr.ceutica. a.d pha.0}a.ologica. condiment,the study a.so clea.0}y indica.es the r.le hydr.xyla.ion especia.ly a. the 3’- position of polyphenols could pla. in enha.cing bioa.tivities of fla.onoids.

关键词： Ca.mium Fla.onoids Quer.etin Ma.r.pha.e Via.ility

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Hibiscus sa.da.0}ffa.extr.ctivities on ca.mium-media.ed a.ter.tions of huma. U937 cell via.ility a.d a.tiva.ion

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a.ia. Pa.ific Jour.a. of Tr.pica. Medicine 2012年第1期5卷 33-36页

objectiveTo investiga.e the effect of the a.thocya.in-r.ch extr.ct of Hibiscus sa.da.0}ffa.(H. sa.da.0}ffa. ca.yx on the via.ility of ca.mium-tr.a.ed U937 cells a.d ca.mium-media.ed a.tiva.ion of U937-der.ved ma.r.pha.es.MethodsThe ma.r.pha.e cell line U937 wa. tr.a.ed with ca.mium (0.1 μ mol/L) a.d la.er.incuba.ed with the a.thocya.in-r.ch extr.ct a.d cell via.ility wa. a.sessed via.tr.pa. blue sta.ning. In the other.exper.ment, the U937 cells were tr.nsfor.ed to the ma.r.pha.e for. by tr.a.ment with phor.ol 12, myr.sta.e 13, a.d a.eta.e a.d incuba.ed with ca.mium (10 μ mol/L). The a.thocya.in-r.ch extr.ct wa. a.ded to the cells la.er.a.d subsequently, the super.a.a.t of ea.h cell cultur. wa. a.a.ysed for.the pr.duction of tumour.necr.sis fa.tor.a.pha.(TNF-α), inter.eukin 1 (IL-1), inter.eukin 6 (IL-6), nitr.c oxide, a.d ca.a.a.e a.tivity a. indices for.the a.tiva.ion of ma.r.pha.es.r.sultsIt r.vea.ed tha. the a.thocyna.in-r.ch extr.ct significa.tly (P r.a.ed the via.ility of the cells which wa. suppr.ssed by ca.mium when compa.0}d to quer.etin dihydr.te. The extr.ct a.so r.duced the ca.mium-media.ed pr.duction of the ma.0}er. of ma.r.pha.e-a.tiva.ion when compa.0}d to quer.etin dihydr.te. In both exper.ments, the a.tivity of the extr.ct wa. concentr.tion-dependent (P onclusionsThe findings show tha. H. sa.da.0}ffa.possesses significa.t immunopr.tective effect. These cor.obor.te the immense r.por.ed a.tioxida.t a.d medicina. potentia. of the ca.yces of the pla.t which could be exploited for.pha.0}a.ologica. a.d neutr.ceutica. a.va.ta.es.

关键词： Hibiscus sa.da.0}ffa Ca.mium Ma.r.pha.e Quer.etin dehydr.te Immunopr.tective

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STUDY oF THr.E-DIMENSIoNa. SEPa.0}TIoN oF BoUNDa.0} La.Er.oVEr.BLUNT BoDIES

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Jour.a. of Hydr.dyna.ics 2009年第1期21卷 100-107页

作者： a.Ma.I r. Br.Ma.a. a.KoVIC r. La.or.toir. de méca.ique des fluides Université de ValenciennesAulnoy lez Valenciennes 59326 France Dépa.0}ement de Méca.ique Université de BiskraBiskra 07000 Algérie

In the ca.e of thr.e-dimensiona. flows, the sepa.0}tion ca. be defined in mor. tha. one wa.. Discussions a.out thr.e-dimensiona. bounda.0} la.er.sepa.0}tion in the liter.tur. ha.e found a.r.tiona. extension of the zer. skin fr.ction. a.tempts ha.e been ma.e to esta.lish the identity of “sepa.0}tion lines”. a.ong definitions, these ma. be found：（1） envelopes of limiting str.a.lines, （2） lines dividing flow which ha. come fr.m different r.gions, （3） lines of singula.0}ties （pr.blems of topology）, （4） lines on which some component of the skin fr.ction va.ishes. Ea.h of these is va.id under.cer.a.n conditions, but none is univer.a.ly va.id. In the pr.sent wor., we use the definition （4）, i.e. a. low incidence of a.blunt body the sepa.0}tion line is identified a. the zer. of the mer.dia. skin fr.ction component （Wa.g 1975）. So the sepa.0}tion line on a.fla.tened spher.id （6：3：1） a. 6° of incidence is ca.cula.ed, a. well a. exper.menta.ly deter.ined by using the electr.chemica. method, which a.lows to follow the evolution of the pa.0}eta. velocity gr.dient.

关键词： thr.e-dimensiona. flows sepa.0}tion bounda.0} la.er. blunt bodies

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Emer.ing potentia. of pr.gr.nulin-dependent Sor.S2 signa.ing in hea.thy a.d disea.ed ner.ous systems

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Neur.l r.gener.tion r.sea.0}h 2025年第9期20卷 2591-2593页

作者： a.ena.Sa.a.ova.a.der. Nykjær Da.ish r.sea.0}h Institute of Tr.nsla.iona. Neur.science Da.Dr.TE-Nor.ic EMBL Pa.0}ner.hip for.Molecula.0}Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The for.a.ion of the ma.ma.ia. ner.ous system a.d its ma.ur.tion into sensor.,motor.cognitive,a.d beha.ior.l cir.uits is a.complex pr.cess tha. begins dur.ng ea.0}y embr.ogenesis a.d la.ts until young *** neur.developm... 详细信息

关键词： pr.gr jointly CS2

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