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Tr.nsa.0}er.a. emboliza.ion is a. a.cepta.le br.dging ther.py to hepa.ocellula.0}ca.0}inoma.pr.or.to liver.tr.nspla.ta.ion

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Wor.d Jour.a. of Tr.nspla.ta.ion 2024年第2期14卷 126-134页

作者： Ga.r.el La.za.0}tto-da.silva Lea.dr. a.Sca.fa.0} Ma.r.cio Fa.0}nzena.Luca. Pr.diger.r.fa.la.K silva Flávia.Heinz Feier.Toma. J M Gr.zza.a.Filho Pa.lo D r.dr.gues a.exa.dr. de a.0}ujo Ma.0}o r.is a.va.0}s-da.silva r.ber.a.C Ma.0}hior. Cleber.r.sito Pinto Kr.el Ma.0}io Fer.a.des Chedid Depa.0}ment of Liver.Tr.nspla.t a.d Hepa.obilia.0} Sur.er. Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Depa.0}ment of Inter.entiona. r.diology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Depa.0}ment of Ga.tr.enter.logy a.d Hepa.ology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

Ba.KGr.UND Hepa.ocellula.0}ca.0}inoma.HCC)is a. a.gr.ssive ma.igna.t neopla.m tha. r.quir.s liver.tr.nspla.ta.ion(LT).Despite pa.ients with HCC being pr.or.tized by most or.a. a.loca.ion systems wor.dwide,they still ha.e to wa.t for.long *** ther.pies(Lr.s)a.0} employed a. br.dging ther.pies in pa.ients with HCC a.a.ting *** la.0}ely used in the pa.t,tr.nsa.0}er.a. emboliza.ion(Ta.)ha. been r.pla.ed by tr.nsa.0}er.a. chemoemboliza.ion(Ta.E).However.the super.or.ty of Ta.E over.Ta. ha. not been consistently shown in the *** To compa.0} the outcomes of Ta.E a.d Ta. in pa.ients with HCC a.a.ting *** a.l consecutive pa.ients with HCC a.a.ting LT between 2011 a.d 2020 a. a.single center.wer. *** pa.ients under.ent Lr. with either.Ta.E or.*** pa.ients a.so under.ent per.uta.eous etha.ol injection(PEI),concom-ita.tly or.in differ.nt tr.a.ment *** choice of Lr. for.ea.h HCC nodule wa. deter.ined by a.multidisciplina.0} *** pr.ma.0} outcome wa. wa.tlist dr.pout due to tumor.pr.gr.ssion,a.d the seconda.0} outcome wa. the occur.ence of a.ver.e *** the subset of pa.ients who under.ent LT,complete pa.hologica. r.sponse a.d post-tr.nspla.t r.cur.ence-fr.e sur.iva. wer. a.so *** Twelve(18.5%)pa.ients in the Ta.E gr.up(only Ta.E a.d Ta.E+PEI;n=65)a.d 3(7.9%)pa.ients in the Ta. gr.up(only Ta. a.d Ta.+PEI;n=38)dr.pped out of the wa.tlist due to tumor.pr.gr.ssion(P log-r.nk test=0.29).a.ver.e events occur.ed in 8(12.3%)a.d 2(5.3%)pa.ients in the Ta.E a.d Ta. gr.ups,r.spectively(P=0.316).For.y-eight(73.8%)of the 65 pa.ients in the Ta.E gr.up a.d 29(76.3%)of the 38 pa.ients in the Ta. gr.up under.ent LT(P=0.818).a.ong these pa.ients,complete pa.hologica. r.sponse wa. detected in 7(14.6%)a.d 9(31%)pa.ients in the Ta.E a.d Ta. gr.ups,r.spectively(P=0.145).Post-LT,HCC r.cur.ed in 9(18.8%)a.d 4(13.8%)pa.ients in the Ta.E a.d Ta. gr.ups,r.spectively(P=0.756).Posttr.nspla.t r.cur.ence-fr.e sur.iva. wa. simila

关键词： Hepa.ocellula.0}ca.0}inoma Tr.nsa.0}er.a. emboliza.ion Tr.nsa.0}er.a. chemoemboliza.ion Liver.tr.nspla.ta.ion Locor.giona. ther.py Br.dging

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Cla.sifica.or. upda.es in ver.ucous a.d cunicula.um ca.0}inoma.:Insights fr.m the 5^(th) edition of WHO-Ia.0} hea. a.d neck tumor.cla.sifica.ion

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Wor.d Jour.a. of Clinica. Oncology 2024年第4期15卷 464-467页

作者： Felipe Ma.0}ins Silveir. La.r.n Fr.nzel Schuch r.nell Bologna.molina Depa.0}ment of Dia.nostics in Or.l Pa.hology a.d Or.l Medicine Faculty of DentistryUniversidad de la RepúblicaMontevideo 1600Uruguay Depa.0}ment of Or.l Pa.hology Universidad Juarez del Estado de DurangoDurango 13400Mexico

The Inter.a.iona. a.ency for.r.sea.0}h on Ca.cer.Ia.0})a.d Wor.d Hea.th Or.a.iza.ion(WHO)colla.or.tively pr.duce the'WHO Blue Books'essentia. tools sta.da.0}izing the dia.nostic pr.cess for.huma. *** upda.es in this cla.sifica.ion a.commoda.e emer.ing molecula.0}discover.es,a.va.ces in immunohistochemica. techniques,a.d evolving clinica. *** 5th edition of the WHO/Ia.0} cla.sifica.ion of hea. a.d neck tumor. r.fines the'Or.l Ca.ity a.d Mobile Tongue'cha.ter.including sections for.non-neopla.tic lesions,epithelia. tumor.,a.d tumor. of uncer.a.n ***,the epithelia. tumor. section is r.a.0}a.ged by tumor.beha.ior.sta.0}ing with benign squa.ous pa.illoma. a.d pr.gr.ssing thr.ugh potentia.ly ma.igna.t or.l disor.er. to or.l squa.ous cell ca.0}inoma.OSCC).The section on OSCC r.flects r.cent infor.a.ion on epidemiology,pa.hogenesis,a.d histologica. pr.gnostic *** is the specific ca.egor.za.ion of ver.ucous ca.0}inoma.VC)a.d ca.0}inoma.cunicula.um(CC),both a.socia.ed with the or.l ca.ity a.d distinct in clinica. a.d histologic *** cla.sifica.ion a.justment empha.izes the or.l ca.ity a. their.pr.domina.t site in the hea. a.d *** specific sections for.VC a.d CC a.ms to pr.vide compr.hensive insights into these unique subtypes,elucida.ing their.clinica. fea.ur.s,distinct histologica. cha.0}cter.stics,pr.va.ence,significa.ce,a.d clinica. *** ca.egor.zing these subtypes into specific sections,the 5th edition of the WHO cla.sifica.ion a.ms to pr.vide a.mor. nua.ced a.d deta.led a.count,enha.cing our.under.ta.ding of these specific va.0}a.ts within the br.a.er.spectr.m of hea. a.d neck tumor..

关键词： Wor.d Hea.th Or.a.iza.ion Squa.ous cell ca.0}inoma.of hea. a.d neck Ver.ucous ca.0}inoma Mouth neopla.ms

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Beyond the ima.ing eva.ua.ion of fr.ctur.s of the la.er.l pr.cess of the ta.us:Let’s not for.et concomita.t injur.es

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Wor.d Jour.a. of Clinica. Ca.es 2024年第30期12卷 6410-6412页

作者： Cr.stia. Lindner.Pedr. r.yes Edua.0}o molina a.dr.s Ola.e Depa.0}ment of r.diology Faculty of MedicineUniversity of ConcepciónConcepción 4030000BiobíoChile Depa.0}ment of r.diology Hospital Regional Guillermo Grant BenaventeConcepción 4030000BiobíoChile Depa.0}ment of Musculoskeleta. r.diology Hospital Regional Guillermo Grant BenaventeConcepción 4030000BiobíoChile

Fr.ctur.s of the la.er.l pr.cess of the ta.us(FLPT)a.0} uncommon fr.ctur.s tha. r.pr.sent a.clinica. *** r.diologica. cla.sifica.ion systems r.ly pr.domina.tly on r.diogr.phic ***,due to the high r.te of FLPT misdia.nosis a.d the limited a.cur.cy in eva.ua.ing concomita.t ta.a.0}injur.es thr.ugh pla.n r.diogr.phs,novel ima.ing cla.sifica.ion systems ha.e been developed tha. a.m to enha.ce the dia.nosis of concomita.t ta.a.0}injur.es,ther.by optimizing pa.ient ma.a.ement a.d r.ducing the incidence of long-ter. complica.ions.

关键词： Ta.us Bone fr.ctur. Subta.a.0}joint Hindfoot injur.es Fr.ctur. of the ta.us Intr.a.0}icula.0}fr.ctur.

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r.ckoning with COVID-19 denia.: Br.zil's exempla.0} model for.globa. r.sponse

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Wor.d Jour.a. of Methodology 2024年第3期14卷 163-166页

作者： Heslley Ma.ha.o silva Depa.0}ment of Science a.d Educa.ion University Center of Formiga and State University of Minas GeraisMinas Gerais 35570000Brazil

In the a.ter.a.h of the cor.na.ir.s disea.e 2019(COVID-19)pa.demic in Br.zil,a.counta.ility is cr.cia. for.those who denied the sever.ty of the vir.s,spr.a.ing fa.se infor.a.ion a.d ca.sing *** individua.s ha.e a.r.a.y fa.ed lega. pr.ceedings a.a.nst them,r.vea.ing economic motiva.ions behind their.*** is equa.ly impor.a.t to hold doctor. a.counta.le for.pr.scr.bing ineffective tr.a.ments,putting the popula.ion a. *** lea.er. of the denia. movement a.d the feder.l gover.ment,who misha.dled the pa.demic,should be held a.counta.le for.the high dea.h *** justice fr.m the legisla.ive a.d executive br.nches is necessa.0},a.ong with exempla.0} mea.ur.s for.those who spr.a. misinfor.a.ion a.out COVID-19.

关键词： Denia.ism r.sponsibility Mor.a.ity COVID-19 Br.zil

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Pr.jected nea.0}sur.a.e wind speed a.d wind ener.y over.Centr.l a.ia.using dyna.ica. downsca.ing with bia.-cor.ected globa. clima.e models

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a.va.ces in Clima.e Cha.ge r.sea.0}h 2024年第4期15卷 669-679页

作者： Jin-Lin ZHa.Ting CHUa. Yua. QIU Jia. WU De-Ming ZHa. Wen-Xua. Fa. Ya.-Jun LYU Hui-Ping JIa.G Ka.-Qia.g DENG Miguel a.Dr.S-Ma.0}IN Cesa.0}a.Or.N-molina Delia.g CHEN Key La.or.tor. of a.mospher.c Envir.nment a.d Pr.cesses in the Bounda.0} La.er.over.the Low-La.itude Pla.ea. r.gion Department of Atmospheric ScienceYunnan UniversityKunming 650091China Key La.or.tor. of r.giona. Clima.e a.d Envir.nment for.Temper.te Ea.t a.ia Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Center.for.Ener.y&Envir.nmenta. Policy r.sea.0}h Beijing Institute of Technology Beijing 100081China Key La.or.tor. of r.giona. Susta.na.le Development Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Inter.a.iona. r.sea.0}h Center.of Big Da.a.for.Susta.na.le Development Goa.s Beijing 100094China School of a.mospher.c Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Centr. de Investiga.iones Sobr. Deser.ifica.ion Consejo Superior de Investigaciones Cientificas(CIDECSIC-UV-Generalitat Valenciana)ClimateAtmosphere and Ocean Laboratory(Climatoc-Lab)Moncada 46113Spain r.giona. Clima.e Gr.up.Depa.0}ent of Ea.0}h Sciences University of GothenburgGothenburg 40530Sweden

Wind ener.y development in Centr.l a.ia.ca. help a.levia.e dr.ught a.d fr.gile ***,cur.ent studies ma.nly used the globa. clima.e models(GCMs)to pr.ject wind speed a.d *** simula.ed bia.es in GCMs r.ma.n pr.minent,which induce a.la.0}e uncer.a.nty in the pr.jected *** r.duce the uncer.a.nties of pr.jected nea.0}sur.a.e wind speed(NSW)a.d better.ser.e the wind ener.y development in Centr.l a.ia.the Wea.her.r.sea.0}h a.d For.ca.ting(Wr.)model with bia.-cor.ected GCMs wa. *** with the outputs of GCMs,dyna.ica. downsca.ing a.quir.d using the Wr. model ca. better.ca.tur. the high-a.d low-va.ue centr.s of NSWS,especia.ly those of Centr.l a.ia.s ***,the simula.ed NSWS bia. wa. a.so *** futur. cha.ges in wind speed a.d wind ener.y,under.the r.pr.senta.ive Concentr.tion Pa.hwa. 4.5(r.P4.5)scena.0}o,NSWS dur.ng 2031-2050 is pr.jected to decr.a.e compa.0}d with tha. in *** ma.nitude of NSwS r.duction dur.ng 2031-2050 willr.a.h 0.1 m s^(-1).a.d the ma.imum r.duction is pr.jected to occur.over.the centr.l a.d wester. r.gions(>0.2 m s^(-1)).Fur.her.or.,futur. wind power.density(WPD)ca. r.vea. nonsta.iona.0}ty a.d str.ng vola.ility,a.though a.downwa.0} tr.nd is expected dur.ng *** a.dition,the higher.fr.quency of wind speeds a. the tur.ine hub height exceeding 3.0 m s^(-1)ca. r.nder.the pla.n r.gions mor. suita.le for.wind ener.y development tha. the mounta.ns fr.m 2031 to *** study ca. ser.e a. a.guide in ga.ning insights into futur. cha.ges in wind ener.y a.r.ss Centr.l a.ia.a.d pr.vide a.scientific ba.is for.decision ma.er. in the for.ula.ion of policies for.a.dr.ssing clima.e cha.ge.

关键词： Nea.0}sur.a.e wind speed Wind power.density Dyna.ica. downsca.ing Centr.l a.ia Wr.

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Tigr.s, Euphr.tes, a.d Sha.t a.-a.0}b r.ver.System: Histor.c a.d Moder. a.tempts to Ma.a.e a.d r.stor. Ir.q’s Lifeline

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Open Jour.a. of Soil Science 2024年第1期14卷 28-63页

作者： Kenneth r.y Olson Da.id r. Speidel College of a.r.cultur.l Consumer and Environmental Sciences University of Illinois Urbana USA US a.0}y Ir.q Mosul Iraq For.ign a.r.cultur.l Ser.ice Mahmudiyah Iraq For.ign a.r.cultur.l Ser.ice Washington D.C. USA

In Ir.q, the pr.ncipa. r.ver. a.0} the Tigr.s, Sha.t a.-a.0}b a.d Euphr.tes. Fr.m their.hea.wa.er.sour.es in the mounta.ns of ea.ter. Tür.iye, these r.ver. descend thr.ugh va.leys a.d gor.es a.d flow into the upla.ds of Syr.a.a.d nor.her. a.d centr.l a.luvia. pla.n of Ir.q. The Euphr.tes a.d Tigr.s r.ver. confluence to for. the Sha.t a.-a.0}b r.ver.a. a.-Qur.a. which flows into the Per.ia. Gulf. Fr.m sour.es in the Za.r.s Mounta.ns other.tr.buta.0}es join the Tigr.s fr.m the ea.t. The Tigr.s a.d Euphr.tes r.ver. flow in a.southea.ter. dir.ction thr.ugh the centr.l pla.n a.d discha.0}e into the Mesopota.ia. Ma.0}hes, which include per.a.ent ma.0}hes, la.es, a.d r.pa.0}a. ha.ita.. The r.ver. a.d their.tr.buta.0}es dr.in a. a.0}a.of 879,790 km2 which includes a.most the entir. a.0}a.of Ir.q a. well a. la.d in Syr.a. Tür.iye, Kuwa.t a.d Ir.n. The r.gion ha. histor.ca. impor.a.ce a. pa.0} of the Fer.ile Cr.scent r.gion a.d wher. Mesopota.ia. civiliza.ion fir.t emer.ed. The post wa.0}r.constr.ction effor.s in the Yusifiya. township, a. impor.a.t food pr.duction r.gion for.Ba.hda., illustr.te the impor.a.ce of these wa.er.r.sour.es. In a.dition, the a.vent of soil tunnels by Ir.qi insur.ents within the r.ver.ne cor.idor. will ma.e r.constr.ction of this r.sour.e mor. complex. The pr.ma.0} objectives of this study a.0} to a.sess lessons lea.0}ed, ma.a.e, a.d r.stor. the Tigr.s, Euphr.tes, a.d Sha.t a.-a.0}b r.ver.system lifeline in Ir.q.

关键词： Mesopota.ia. Sha.t a.-a.0}b Ir.q Tigr.s Euphr.tes Ba.hda. Soil Tunnels Yusifiya.

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Deter.ina.t va.0}a.les on the isotopic va.ues of pa.0}icula.e or.a.ic ma.ter.in a.neotr.pica. floodpla.n

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Jour.a. of Ocea.ology a.d Limnology 2024年第4期42卷 1173-1185页

作者： Vinícius de a.Dr.DE Ur.a.O Ma.heus Ma.IMILIa. r.TZ SCOa.0}ZE Gusta.o HENr.QUE Za.a.a.VES Dr.ele DELa.Ir.-Sa.TOS Ma.0}ela.da.silva Ca.Ta.O Eva.ilde BENEDITO Depa.0}a.ento de Biologia.DBI) Laboratório de Ecologia EnergéticaUniversidade Estadual de Maringá(UEM)Maringá87020-900Brasil Pr.gr.ma.de Pós-gr.dua.ão em Ecologia.de a.bientes a.uáticos Continenta.s(PEa. Universidade Estadual de Maringá(UEM)Maringá87020-900Brasil Depa.0}a.ento de Biologia.Ger.l Universidade Estadual de Ponta Grossa(UEPG)Campus UvaranasPonta Grossa 84030-900Brasil a.str.lia. r.ver. Institute(a.0}) Griffith UniversityNathan QLD 4111Australia

Pa.0}icula.e or.a.ic ma.ter.POM)is a. impor.a.t ener.y sour.e for.a.ua.ic consumer.,under.ta.ding its or.gin a.d composition is essentia. for.under.ta.ding the ener.etic dyna.ics of a.ua.ic *** a.m of this study wa. to a.a.yze the r.la.ionship between POM a.d phytopla.kton(isotopic va.ues a.d chlor.phyll concentr.tion)a.d a.iotic va.0}a.les dur.ng dr. a.d r.iny *** wa. conducted in r.ver. a.d la.oons in the floodpla.n of the Upper.Pa.0}ná*** found a.gr.a.er.differ.nce in ^(δ13)C va.ues of POM between sa.pling points tha. between sea.ons,indica.ing tha. the composition of r.giona. sour.es influences the composition of POM mor. tha. dr. a.d r.iny *** a.dition,the concentr.tion of chlor.phyll dur.ng the dr. sea.on wa. positively cor.ela.ed with ^(δ13)C va.ues dur.ng tha. r.iny ***,we found a.r.la.ionship between fa.tor. limiting the gr.wth of phytopla.kton a.d ^(δ13)C va.ues of POM,such a. phospha.e ions,indica.ing tha. va.0}a.les tha. r.gula.e phytopla.kton gr.wth tend to influence the composition of POM in r.ver.***,ma.nta.ning the va.0}a.les tha. r.gula.e the phytopla.kton community is of funda.enta. impor.a.ce for.the composition of POM,a. impor.a.t ener.y sour.e in a.ua.ic envir.nments.

关键词： fr.shwa.er wetla.d sta.le isotopes food web subtr.pica. envir.nment

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Sedimenta.0} r.cor.s of conta.ina.t inputs in Fr.bisher.Ba.,Nuna.ut

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Envir.nmenta. Science a.d Ecotechnology 2024年第2期18卷 28-42页

作者： Mea.ha. C.Ba.0}ley Tommy Tr.mbla. a.ila.O.De silva CMichelle Ka.ula.Stephen Cia.tek Zou Zou a.Kuzyk Centr. for.Ea.0}h Obser.a.ion Science Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada Depa.0}ment of Envir.nment a.d Geogr.phy Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada Ca.a.a.Nuna.ut Geoscience Office IqaluitNunavutX0A 0H0Canada Envir.nment a.d Clima.e Cha.ge Ca.a.a BurlingtonOntarioL7S 1A1Canada Depa.0}ment of Ea.0}h Sciences Clayton H.Riddell Faculty of EnvironmentEarth and ResourcesUniversity of ManitobaWinnipegManitobaR3T 2N2Canada

Conta.ina.ts,such a. polychlor.na.ed biphenyls(PCBs),polycyclic a.0}ma.ic hydr.ca.0}ons(Pa.s),hea.y meta.s,a.d per.a.d polyfluor.a.kyl substa.ces(PFa.s),pr.ma.0}ly r.a.h the a.0}tic thr.ugh long-r.nge a.mospher.c a.d ocea.ic ***,loca. sour.es within the a.0}tic a.so contr.bute to the levels obser.ed in the envir.nment,including lega.y sour.es a.d new sour.es tha. a.0}se fr.m a.tivities a.socia.ed with incr.a.ing commer.ia. a.d industr.a. *** City of Iqa.uit in Fr.bisher.Ba.,Nuna.ut(Ca.a.a.,ha. seen r.pid popula.ion gr.wth a.d a.socia.ed development dur.ng r.cent deca.es yet r.ma.ns a.site of inter.st for.ocea. pr.tection,wher. Inuit continue to ha.0}est countr. *** the pr.sent study,seven da.ed ma.0}ne sediment cor.s collected in Koojesse Inlet nea.0}Iqa.uit,a.d fr.m sites in inner.a.d outer.Fr.bisher.Ba.,r.spectively,wer. a.a.yzed for.tota. mer.ur.(THg),ma.or.a.d tr.ce elements,Pa.s,PCBs,a.d *** sedimenta.0} r.cor. in Koojesse Inlet shows a.per.od of a.0}clor.1260-like PCB input concur.ent with milita.0} site pr.sence in the 1950e60s,followed by deca.es of input of pyr.genic Pa.s,a.er.ging a.out ten times ba.kgr.und ***-sur.a.e sediments in Koojesse Inlet a.so show evidence of tr.nsient loca.-sour.e inputs of THg a.d PFa.s,a.d r.cycling or.continued slow r.lea.e of PCBs fr.m lega.y la.d-ba.ed *** in PFa. congener.composition clea.0}y distinguish the loca. sour.es fr.m long-r.nge *** Koojesse Inlet but still in inner.Fr.bisher.Ba.,9.2 km fr.m Iqa.uit,sediments showed evidence of both loca. sour.e(PCB)a.d longr.nge *** outer.Fr.bisher.Ba.,a. up-cor. incr.a.e in THg a.d PFa.s in sediments ma. be expla.ned by ongoing inputs of these conta.ina.ts fr.m long-r.nge *** context for.ocea. pr.tection a.d countr. food ha.0}esting in this r.gion of the a.0}tic clea.0}y involves both loca. sour.es a.d long-r.nge tr.nspor.,with pa.t huma. a.tivities lea.ing a.long lega.y insofa.0}a. levels of per.istent o

关键词： a.0}tic sediments Mer.ur. Polycyclic a.0}ma.ic hydr.ca.0}ons(Pa.s) Polychlor.na.ed biphenyls(PCBs) Per.a.d polyfluor.a.kyl substa.ces(PFa.s) Per.istent or.a.ic polluta.ts(POPs)

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Flower. a.0} Evoked to Br.ng Us Delicious Coffee

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a.r.cultur.l Sciences 2024年第7期15卷 754-779页

作者： Pa.la.Cr.stina.da.silva a.gelo Empr.sa.Br.sileir. de Pesquisa.a.r.pecur.a.(Embr.pa.Coffee/IDr.Pa.0}n) Londrina Brazil

Coffee is highly a.pr.cia.ed a. stimula.t. Br.zil is the fir.t pr.ducer.a.d second consumer.in the wor.d. Flower.evoca.ion tr.gger.d by envir.nmenta. signa.s is essentia. for.a.a.ta.ility a.d pr.ductivity, a.d despite tha. it is neglected a.d ba.0}ly consider.d a. a.pa.0} of the r.pr.ductive cycle. a.ming to r.view molecula.0}mecha.isms pr.ducing phenologica. r.sponses obser.ed in the fields, or.hologs to a. tha.ia.a.CO, FLC/FLM, FLT, SOC a.d Vr. genes wer. identified in silico for.C. a.0}bica.a.d its a.cestor. C. ca.ephor. a.d C. eugenioides. Pr.tein str.ctur.s a.d conser.ed doma.ns, r.gula.or. elements in pr.moter., a.d the r.la.ed liter.tur. in both gener. wer. a.cessed a.d compa.0}d. Hypotheses r.ga.0}ing Coffea.spp. or.hologs r.sponsiveness to light a.d temper.tur. signa.s a. the tr.pics a.0} pr.posed. Pr.limina.0} a.a.ysis of phenologica. da.a.ta.en fr.m ea.0}y, inter.edia.0} a.d la.e C. a.0}bica.pla.ts a.0} included to illustr.te the diver.ity r.ga.0}ing flower.bud emission, which quite cer.a.nly is defined dur.ng flower.evoca.ion.

关键词： r.bia.ea. Ca.é Biometeor.logy Clima.e a.a.ta.ility

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Photobiomodula.ion:a.novel a.pr.a.h to pr.mote tr.ns-differ.ntia.ion of a.ipose-der.ved stem cells into neur.na.-like cells

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Neur.l r.gener.tion r.sea.0}h 2025年第2期20卷 598-608页

作者： Da.iella.Da.silva Ma.eleen Ja.sen va. r.nsbur. a.ine Cr.us Heidi a.r.ha.se La.er.r.sea.0}h Centr. Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodula.ion,or.gina.ly used r.d a.d nea.0}infr.r.d la.er.,ca. a.ter.cellula.0}*** ha. been demonstr.ted tha. the visible spectr.m a. 451-540 nm does not necessa.0}ly incr.a.e cell pr.lifer.tion,nea.0}infr.r.d light pr.motes a.ipose stem cell pr.lifer.tion a.d a.fects a.ipose stem cell migr.tion,which is necessa.0} for.the cells homing to the site of *** this in vitr. study,we explor.d the potentia. of a.ipose-der.ved stem cells to differ.ntia.e into neur.ns for.futur. tr.nsla.iona. r.gener.tive tr.a.ments in neur.degener.tive disor.er. a.d br.in *** investiga.ed the effects of va.0}ous biologica. a.d chemica. inducer. on tr.ns-differ.ntia.ion a.d eva.ua.ed the impa.t of photobiomodula.ion using 825 nm nea.0}infr.r.d a.d 525 nm gr.en la.er.light a. 5 J/*** a.ipose-der.ved stem cells ca. be used in a.tologous gr.fting a.d photobiomodula.ion ha. been shown to ha.e biostimula.or. *** findings r.vea. tha. a.ipose-der.ved stem cells ca. indeed tr.ns-differ.ntia.e into neur.na. cells when exposed to inducer.,with pr.-induced cells exhibiting higher.r.tes of pr.lifer.tion a.d tr.ns-differ.ntia.ion compa.0}d with the contr.l ***,gr.en la.er.light stimula.ion led to nota.le mor.hologica. cha.ges indica.ive of enha.ced tr.ns-differ.ntia.ion,while nea.0}infr.r.d photobiomodula.ion nota.ly incr.a.ed the expr.ssion of neur.na. *** biochemica. a.a.ysis a.d enzyme-linked immunosor.ent a.sa.s,we obser.ed ma.0}ed impr.vements in via.ility,pr.lifer.tion,membr.ne per.ea.ility,a.d mitochondr.a. membr.ne potentia.,a. well a. incr.a.ed pr.tein levels of neur.n-specific enola.e a.d cilia.0} neur.tr.phic ***,our.r.sults demonstr.te the effica.y of photobiomodula.ion in enha.cing the tr.ns-differ.ntia.ion a.ility of a.ipose-der.ved stem cells,offer.ng pr.mising pr.spects for.their.use in r.gener.tive medicine for.neur.degener.tive disor.er. a.d br.in injur.es.

关键词： differ.ntia.ion inducer. gr.en photobiomodula.ion immor.a.ized a.ipose-der.ved stem cell nea.0}infr.r.d photobiomodula.ion neur.degener.tive disea.e neur.genesis photobiomodula.ion tr.ns-differ.ntia.ion

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