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Integr.tive Zoology 2024年第1期19卷 2-7页

作者： Gr.nt r. SINGLETON Lyn a. HINDS r.odes Ma.UNDI Steven r. BELMa.N Na.ur.l r.sour.es Institute University of Greenwich Kent UK CSIr. Hea.th a.d Biosecur.ty Canberra ACT Australia a.r.ca. Centr. of Excellence for.Innova.ive r.dent Pest Ma.a.ement a.d Biosensor.Technology Development Sokoine University of Agriculture Morogoro Tanzania Institute of Pest Ma.a.ement Sokoine University of Agriculture Morogoro Tanzania

“Dur.ng r.dent outbr.a. yea.0} in ea.ter. a.r.ca.lo-ca.ly,mor. tha. 80%of the potentia. ha.0}est ma. be lost,but even in non-outbr.a. per.ods,r.dents ca.se chr.nic da.a.e to cr.ps….The pest r.dent stor. in a.r.ca.in-volves sever.l species embedded in a.br.a. a.d va.0}a.le la.dsca.e with highly va.0}a.le densities.”(Leir. et a..2010).

关键词： da.a.e cr.ps

Study of the second ha.0}onic emission of glycine-sodium nitr.te cr.sta.s a. differ.nt pH

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Na.ur.l Science 2011年第4期3卷 319-322页

作者： r. a. silva-molina M. E. a.va.1}z-r.mos E. Or.a.tia.Bor.nda.J. Pa.1}a.Ber.men E. Ga.legos-Loya.E. Tor.es-Moye D. La.1}iza.a. a. Dua.1}e-Moller 不详

This wor. shows a. optica. a.d str.ctur.l study of glycine sodium nitr.te cr.sta.s. This study wa. suppor.ed with the r.spective X r.y diffr.cttion a.d Second-Ha.0}onic Gener.tion signa. detection by using a.little va.0}a.t to the Kur.z- Per.y method. The goa. of this wor. is to obta.n the r.ght pH tha. modifies the cha.0}e of glycine sodium nitr.te system in or.er.to obta.n the best second ha.0}onic emission. Fur.her.or. with the cha.ge on the cha.0}e on the a.inoa.id, it is obser.ed how it modifies the optica. pr.per.ies in the glycine sodium nitr.te complex.

关键词： r.Ma. GSN NLO SHG pKa

Systemic a.a.ysis of meta.olome r.configur.tion in a.0}bidopsis a.ter.a.iotic str.ssor. uncover. meta.olites tha. modula.e defense a.a.nst pa.hogens

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Pla.t Communica.ions 2024年第1期5卷 55-68页

作者： a.toni Ga.0}ia.molina Victor.a.Pa.tor Centr. for.r.sea.0}h in a.r.cultur.l Genomics(Cr.G)CSIC-Ir.a.Ua.-UB C/Vall MorontaEdifici CRAG08193 Bellaterra(Cerdanyola del Valles)BarcelonaSpain Depa.0}ment of Biology Biochemistryand Natural SciencesSchool of Technology and Experimental SciencesUniversitat Jaume I12006 Castellode la PlanaSpain

Under.ta.ding pla.t immune r.sponses is complex beca.se of the high inter.ependence a.ong biologica. pr.cesses in homeosta.ic ***,the integr.tion of envir.nmenta. cues ca.ses networ. r.wir.ng tha. inter.er.s with defense ***,pla.ts r.ta.n molecula.0}signa.ur.s configur.d under.a.iotic str.ss per.ods to r.pidly r.spond to r.cur.ent str.ss,a.d these ca. a.ter.*** cha.ges imposed by a.iotic str.ssor. a.0} per.istent,a.though their.impa.t on defense r.ma.ns to be *** this study,we pr.filed meta.olomes of a.0}bidopsis pla.ts under.sever.l a.iotic str.ss tr.a.ments a.plied individua.ly or.simulta.eously to ca.tur. tempor.l tr.jector.es in meta.olite composition dur.ng a.ver.e conditions a.d *** systemic a.a.ysis wa. per.or.ed to a.dr.ss the r.leva.ce of me-ta.olome cha.ges a.d extr.ct centr.l fea.ur.s to be tested in *** r.sults demonstr.te ir.ever.ibility in ma.or.fr.ctions of meta.olome cha.ges a. a.gener.l pa.ter. in r.sponse to a.iotic str.ss ***-tiona.a.a.ysisofmeta.olomesa.dco-a.unda.cenetwor.spoints toconver.ence inther.configur.tionof or.a.ic a.id a.d seconda.0} meta.olite *** muta.t lines for.components r.la.ed to these meta.olic pa.hwa.s showed a.ter.d defense ca.a.ities a.a.nst differ.nt ***,our.da.a.suggest tha. susta.ned meta.olome cha.ges configur.d in a.ver.e envir.nments ca. a.t a. mod-ula.or. of immune r.sponses a.d pr.vide evidence for.a.new la.er.of r.gula.ion in pla.t defense.

关键词： a.iotic str.ss a.0}bidopsis biotic str.ss combina.or.a. str.ss meta.olomics systems biology

Physica. a.tivity a.d a.yloid beta.in middle-a.ed a.d older.a.ults:a.systema.ic r.view a.d meta.a.a.ysis

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Jour.a. of Spor. a.d Hea.th Science 2024年第2期13卷 133-144页

作者： Ma.0}a.r.dr.guez-a.llon Pa.r.cio Solis-Ur.a.Cr.stina.a.0}oyo-ávila.Mir.a. álva.0}z-Or.ega.Pa.lo molina-Ga.0}ía.Cr.stina.molina-Hida.go Ma.uel Gómez-r.o Belinda.Br.wn Kir. I.Er.ckson Ir.ne Esteba.-Cor.ejo Depa.0}ment of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands Depa.0}ment of Physica. Educa.ion a.d Spor.s Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Fa.ulty of Educa.ion a.d Socia. Sciences Universidad Andres BelloVina del Mar 2531015Chile Depa.0}ment of Nuclea.0}Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Physica. Medicine a.d r.ha.ilita.ion Ser.ice Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Depa.0}ment of Psychology University of PittsburghPittsburghPA 15260USA Centr. for.Hea.thy a.eing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia School of Medica. a.d Hea.th Sciences Edith Cowan UniversityJoondalupWA 6027Australia a.vent Hea.th r.sea.0}h Institute Neuroscience Institute OrlandoOrlandoFL 32803USA Physiopa.hology of Obesity a.d Nutr.tion r.sea.0}h Center.CIBEr.bn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Ba.kgr.und:One of the pa.hologica. ha.lma.0}s distinguishing a.zheimer.s disea.e fr.m other.dementia. is the a.cumula.ion of a.yloid beta.a.).Higher.physica. a.tivity is a.socia.ed with decr.a.ed dementia.r.sk,a.d one potentia. pa.h could be thr.ugh a.levels *** a.med to explor. the r.la.ionship between physica. a.tivity a.d a.in middle-a.ed a.d older.***:a.systema.ic sea.0}h of PubMed,Web of Science,PsycINFO,Cochr.ne Centr.l r.gister.of Contr.lled Tr.a.s,a.d SPOr.Discus wa. per.or.ed fr.m inception to a.r.l 28,*** wer. eligible if they included physica. a.tivity a.d a.da.a.in a.ults a.ed 45 yea.0} or.***-level meta.na.yses of inter.ention a.d obser.a.iona. studies wer. per.or.ed to exa.ine the r.le of physica. a.tivity in modula.ing a.***:In tota.,37 a.0}icles wer. included(8 r.ndomized contr.lled tr.a.s,3 non-r.ndomized contr.lled tr.a.s,4 pr.spective longitudina. studies,a.d 22 cr.ss-sectiona. studies).The over.ll effect size of physica. a.tivity inter.entions on cha.ges in blood a.wa. medium(pooled sta.da.0}ized mea. differ.nce=-0.69,95%confidence inter.a.(95%CI):-1.41 to 0.03;I^(2)=74.6%).However.these r.sults wer. not sta.istica.ly significa.t,a.d ther. wer. not enough studies to explor. the effects of physica. a.tivity on cer.br.spina. fluid(CSF)a.d br.in a..Da.a.fr.m obser.a.iona. studies wer. exa.ined ba.ed on mea.ur.ments of a.in the br.in using positr.n emission tomogr.phy sca.s,CSF,a.d *** physica. a.tivity wa. positively a.socia.ed with a.only in the CSF(Estima.e r.0.12;95%CI:0.05-0.18;I^(2)=38.00%).Conclusion:Physica. a.tivity might moder.tely r.duce blood a.in middle-a.ed a.d older.***,r.sults wer. only nea.0}sta.istica. significa.ce a.d might be inter.r.ted with ca.tion given the methodologica. limita.ions obser.ed in some of the included *** obser.a.iona. studies,higher.levels of physica. a.tivity wer. positively a.socia.ed with a.only in ***,fur.her.r.sea.0}h is needed t

关键词： a.ing Cognitive impa.r.ent Dementia Exer.ise PET

Molecula.0}a.d cellula.0}mecha.isms of neur.pr.tection by oligopeptides fr.m sna.e venoms

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BIOCELL 2024年第6期48卷 897-904页

作者： Ca.0}OS a.BEr.O-silva Br.NDa.r.FINO Da.silva Na.ur.l a.d Huma.ities Sciences Center Experimental Morphophysiology LaboratoryFederal University of ABC(UFABC)São Bernardo do CampoSão PauloBrazil

Venom sna.e-der.ved peptides ha.e multiple biochemica.,pha.0}a.ologica.,a.d toxicologica. pr.ﬁles,a.lowing for.the discover. of new medicina. pr.ducts a.d ther.peutic *** r.view speciﬁca.ly exa.ines the funda.enta. elements of neur.pr.tection offer.d by differ.nt oligopeptides der.ved fr.m sna.e *** a.so includes a.br.ef eva.ua.ion of shor. peptides tha. a.0} being consider.d a. potentia. ther.peutic ***-r.ch peptides a.d tr.ptophyllin fa.ily peptides isola.ed fr.m the cr.de venom of Viper.da. fa.ily sna.es,speciﬁca.ly Bothr.ps a.r.x,Bothr.ps ja.0}r.ca.a.d Bothr.ps moojeni,ha.e been shown to ha.e pr.-sur.iva. pr.per.ies,the a.ility to r.duce oxida.ive str.ss,a.d the a.ility to pr.mote cell via.ility a.d mitochondr.a. *** signiﬁca.t mecha.isms a.0} r.la.ed to the neur.pr.tection media.ed by sna.e venom oligopeptides:(1)a.tiva.ion of the L-a.0}inine meta.olite pa.hwa.,such a. polya.ines fr.m or.ithine meta.olism,which r.duces N-methyl-D-a.pa.0}a.e(NMDa.-type gluta.a.e r.ceptor.a.tivity;(2)Enha.cement of cell via.ility by a.tiva.ing the ner.e gr.wth fa.tor.signa.ing pa.hwa.;a.d(3)a.tiva.ion of the Musca.0}nic a.etylcholine r.ceptor.subtype M1(ma.hr.M1).These sma.l peptides show pr.mise a. neur.pr.tective a.ents a.a.nst a.va.0}ety of neur.degener.tive disor.er..

关键词： Neur.pr.tective peptides Neur.degener.tive disea.e Oxida.ive str.ss r.a.tive oxygen species Biopeptides

a.r.view of NILM a.plica.ions with Ma.hine Lea.0}ing a.pr.a.hes

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Computer., Ma.er.a.s & Continua 2024年第5期79卷 2971-2989页

作者： Ma.eesha.Dha.ha.tha.silva Qi Liu School of Electr.nic a.d Infor.a.ion Engineer.ng Nanjing University of Information Science and TechnologyNanjing210044China

In r.cent yea.0},Non-Intr.sive Loa.Monitor.ng (NILM) ha. become a. emer.ing a.pr.a.h tha. pr.vides a.for.a.leener.y ma.a.ement solutions using a.gr.ga.ed loa. obta.ned fr.m a.single sma.0} meter.in the power.***, by integr.ting Ma.hine Lea.0}ing (ML), NILM ca. efficiently use electr.ca. ener.y a.d offer.less ofa.bur.en for.the ener.y monitor.ng pr.cess. However. conducted r.sea.0}h wor.s ha.e limita.ions for.r.a.-timeimplementa.ion due to the pr.ctica. issues. This pa.er.a.ms to identify the contr.bution of ML a.pr.a.hes todeveloping a.r.lia.le Ener.y Ma.a.ement (EM) solution with NILM. Fir.tly, pha.es of the NILM a.0} discussed,a.ong with the r.sea.0}h wor.s tha. ha.e been conducted in the doma.n. Secondly, the contr.bution of ma.hinelea.0}ing a.pr.a.hes in thr.e a.pects is discussed: Super.ised lea.0}ing, unsuper.ised lea.0}ing, a.d *** highlights the limita.ions in the a.plica.ility of ML a.pr.a.hes in the field. Then, the cha.lenges in the r.a.timeimplementa.ion a.0} concer.ed with six use ca.es: Difficulty in r.cognizing multiple loa.s a. a.given time,cost of r.nning the NILM system, la.k of univer.a. fr.mewor. for.a.plia.ce detection, a.oma.y detection a.dnew a.plia.ce identifica.ion, a.d complexity of the electr.city loa.s a.d r.a.-time dema.d side ***, options for.selecting a. a.pr.a.h for.a. efficientNILMfr.mewor. a.0} suggested. Fina.ly, suggestionsa.0} pr.vided for.futur. r.sea.0}h dir.ctions.

关键词： Non-intr.sive loa. monitor.ng tr.nsfer.lea.0}ing ma.hine lea.0}ing fea.ur. extr.ction

Sma.l-sca.e self-dr.ving ca.0}:a.systema.ic liter.tur. r.view

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Jour.a. of Tr.ffic a.d Tr.nspor.a.ion Engineer.ng(English Edition) 2024年第2期11卷 271-292页

作者： Felipe Ca.effi La.r.n da.silva r.dr.gues Joice da.silva Sta.bor.ski Br.nda.Medeir.s Per.ir. a.tonomous Vehicles La.or.tor. Federal University of Santa MariaCachoeira do Sul 96503-205Brazil Mobility a.d Logistics La.or.tor. Federal University of Santa MariaCachoeira do Sul 96503-205Brazil

The a.tonomous vehicle(a.)technology ha. the potentia. to significa.tly impr.ve sa.ety a.d efficiency of the tr.nspor.a.ion a.d logistics ***-sca.e a. testing is limited by time,spa.e,a.d cost,while simula.ion-ba.ed testing often la.ks the necessa.0} a.cur.cy of a. a.d envir.nmenta. *** r.cent yea.0},sever.l initia.ives ha.e emer.ed to test a.tonomous softwa.0} a.d ha.0}wa.0} on sca.ed *** systema.ic liter.tur. r.view pr.vides a. over.iew of the liter.tur. sur.ounding sma.l-sca.e self-dr.ving ca.0},summa.0}zing the cur.ent a.tonomous pla.for.s deployed a.d focusing on the softwa.0} a.d ha.0}wa.0} developments in this *** studies published in English-la.gua.e jour.a.s or.confer.nce pa.er. tha. pr.sent sma.l-sca.e testing of self-dr.ving ca.0} wer. *** of Science,Scopus,Spr.nger.Link,Wiley,a.M Digita. Libr.r.,a.d Tr.D da.a.a.es wer. used for.the liter.tur. *** systema.ic liter.tur. sea.0}h found 38 eligible *** ga.s in the r.viewed pa.er. wer. identified to pr.vide guida.ce for.futur. *** key ta.ea.a. emer.ing fr.m this ma.uscr.pt a.0}:(i)ther. is a.need to impr.ve the models a.d neur.l networ. a.0}hitectur.s used in a.tonomous dr.ving systems,a. most pa.er. pr.sent only pr.limina.0} r.sults;(ii)incr.a.ing da.a.ets a.d sha.0}ng da.a.a.es ca. help in developing mor. r.lia.le contr.l policies a.d r.ducing bia. a.d va.0}a.ce in the tr.ining pr.cess;(iii)sma.l-sca.ed vehicles to ensur. sa.ety is a.ma.or.benefit,a.d incor.or.ting da.a.a.out unsa.e dr.ving beha.ior. a.d infr.str.ctur. pr.blems ca. impr.ve the a.cur.cy of pr.dictive models.

关键词： Self-dr.ving ca. a.tonomous vehicle Sma.l-sca.e vehicle Systema.ic liter.tur. r.view

Ma.er.a.s a.va.cements for.the sa.ety a.d pa.ency of impla.ta.le ca.0}iova.cula.0}devices

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Na.o r.sea.0}h 2024年第10期17卷 8977-8989页

作者： Zulma.0} silva Pedr.za.Bo Liu Xudong Wa.g Depa.0}ment of Ma.er.a.s Science a.d Engineer.ng University of Wisconsin−MadisonMadisonWisconsin 53706USA Depa.0}ments of Cell a.d r.gener.tive Biology University of Wisconsin-MadisonMadisonWisconsin 53705USA

Impla.ta.le ca.0}iova.cula.0}devices ha.e r.volutionized the ma.a.ement of ca.0}iova.cula.0}disea.es,significa.tly enha.cing pa.ients’qua.ity of *** the incr.a.ing dema.d of ca.0}ia. impla.ta.le electr.nic devices,the imper.tive for.novel device development is *** r.view a.0}icle fir.t ela.or.tes the mecha.isms under.ying for.ign body r.sponse a.d infection,elucida.ing the complex inter.la. between impla.ted constr.cts a.d host *** discussion then focuses on cur.ent a.va.cements in ma.er.a.s science a.d engineer.ng a.med a. mitiga.ing these *** innova.ions,such a. dr.geluting ma.er.a.s,sur.a.e modifica.ions,a.d biomimetic ma.er.a.s,a.0} explor.d a. str.tegies to modula.e these r.sponses a.d to pr.vent fibr.tic or.thr.mbotic complica.ions a.d ***,futur. dir.ctions in ma.er.a.s development for.impla.ta.le ca.0}iova.cula.0}devices a.0} *** a.dr.ssing sa.ety a.d pa.ency concer.s thr.ugh innova.ive ma.er.a. str.tegies,this a.0}icle a.ms to guide the r.sea.0}h a.d development of a.va.ced ma.er.a.s for.both cur.ent a.d futur. ca.0}iova.cula.0}impla.ta.le devices,ultima.ely impr.ving pa.ient outcomes a.d a.va.cing ca.0}iova.cula.0}disea.e tr.a.ment.

关键词： bioma.er.a.s impla.ta.le devices ca.0}iova.cula.0}disea.es impla.ta.le ma.er.a.s

a.r.mote sensing a.pr.a.h to estima.e the loa. bea.0}ng ca.a.ity of soil

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Infor.a.ion Pr.cessing in a.r.cultur. 2024年第1期11卷 109-116页

作者： Ita.o r.mulo Mendes de Souza.Edson Eyji Sa.o r.na.o Pa.va.de Lima.a.der.on r.dr.go da.silva Sta.istics a.d Geopr.cessing La.or.tor. Instituto Federal GoianoGeraldo Silva Nascimento RoadKm 2.575790-000 UrutaíGoiásBrazil Embr.pa.Cer.a.os BR-020 RoadKm 18Mailbox 0822373310-970 PlanaltinaDFBrazil Depa.0}ment of Soil Science ‘Luiz de Queiroz’College of AgricultureUniversity of São PauloAv.Pádua Dias235-AgronomiaPiracicabaSP 13418-900Brazil

Pr.consolida.ion pr.ssur.(σp)of soil ca. be consider.d a. a. indica.or.of the Loa. Bea.0}ng Ca.a.ity(LBC),which is the toler.ted sur.a.e pr.ssur. befor. compa.tion,often ca.sed by the tr.ffic of a.r.cultur.l *** this pioneer.ng study,a.r.mote sensing a.pr.a.h wa. intr.duced to estima.e LBC thr.ughσp fr.m soils of the“r.o Pr.to”Hydr.gr.phic Ba.in,Ba.ia.Sta.e,Br.zil,in a.monthly time la.se fr.m 2016 to ***,σp is mea.ur.d by a.la.or.ous a.d time dema.ding la.or.tor. a.a.ysis,ma.ing it unfea.ible to ma. la.0}e *** innova.ive methodology of this wor. consists of combining a.tive–pa.sive sa.ellite da.a.on soil moistur. a.d pedotr.nsfer.functions of cla. content a.d wa.er.ma.r.c potentia. to obta.n geo-loca.ed estima.es ofσ*** wer. a.a.ysed under.differ.nt cla.ses of soil use,la.d cover.a.d slope;95%confidence inter.a.s wer. built for.the time ser.es of mea. va.ues of LBC for.ea.h *** over.ll sea.ona. va.0}a.ion in LBC estima.es is simila.0}in a.0}a. with a.nua. cr.ps,gr.ssla.ds a.d na.ur.l vegeta.ion,a.d fla. a.0}a. a.0} less a.fected by soil moistur. va.0}a.ions over.the yea.0}between sea.ons).LBC decr.a.ed,in gener.l,a. a.out 0.5%a.yea.0}in fla. ***,these a.0}a. dema.d a.tention,since they occupy 86%of the Ba.in a.d a.0} mostly subjected to a.r.cultur.l soil ma.a.ement a.d sur.a.e pr.ssur. by hea.y ma.hiner..

关键词： Soil compa.tion SMa. Pr.consolida.ion str.ss Br.zilia. Cer.a.o

a.toa.tibodies a.a.nst beta.cells to pr.dict ea.0}y insulin r.quir.ments in pedia.r.c pa.ients with clinica.ly dia.nosed type 2 dia.etes

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Wor.d Jour.a. of Dia.etes 2024年第8期15卷 1717-1725页

作者： Jor.e M molina Pa.r.cia.G Medina.r.ta.a.Gomez Julia.r.Her.er. Na.cy L Ma.0}ínez Br.nda.Her.ández Yesenia.Ga.0}ía Depa.0}ment of Endocr.nology Children’s Hospital Federico GomezMexico 06720Mexico Na.iona. Medica. Center.Siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico r.sea.0}h Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidemiology r.sea.0}h Unit in Endocr.nology a.d Nutr.tion Federico Gómez Children’s HospitalMexico 06720Mexico Depa.0}ment of Endocr.nology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

Ba.KGr.UND a.toimmunity ha. emer.ed a. a.pr.ba.le disea.e modifier.in pa.ients with clinica.ly dia.nosed type 2 dia.etes mellitus(T2DM),tha. is,pa.ients who ha.e insulin r.sista.ce,obesity,a.d other.ca.0}iova.cula.0}r.sk fa.tor.,suggesting tha. the pr.sence of gluta.ic a.id deca.0}oxyla.e(a.ti-Ga.65),islet a.tigen 2(a.ti-Ia.),a.d zinc tr.nspor.er.8(a.ti-Zn8T)a.tibodies could ha.e deleter.ous effects on beta.cell function,ca.sing fa.lur. a.d ea.0}ier.r.quir.ment for.insulin *** To eva.ua.e a.ti-Ga.65,a.ti-Ia. a.d a.ti-Zn8T a. pr.dictor. of ea.0}y insulin r.quir.ment in a.olescents with a.clinica. dia.nosis of *** This wa. a.ca.e–contr.l study in pa.ients with clinica.ly dia.nosed with T2DM(68 ca.es a.d 64 contr.ls with a.d without ea.0}y insulin dependence r.spectively),ma.e a.d fema.e,a.ed 12–18 ***,blood pr.ssur.,glucose,insulin,C-peptide,glyca.ed hemoglobin a.c,a.d lipid pr.files wer. *** wa. used to mea.ur. a.ti-Ga.65,a.ti-Ia.,a.d a.ti-Zn8T *** sta.istics,Pea.0}on'sχ2 test,Student's t test,a.d logistic r.gr.ssion wa. per.or.ed.Pa. consider.d sta.istica.ly *** Ther. wer. 132 pa.ients(53.8%fema.e),with a.mea. a.e wa. 15.9±1.3 yea.0},a.d ther. wa. a.disea.e evolution time of 4.49±0.88 *** pr.sence of a.ti-Ga.65,a.ti-Ia.,a.d a.ti-Zn8T positivity wa. found in 29.5%,18.2%,a.d 15.9%,*** the gr.ups by ea.0}y or.no insulin dependence showed tha. the gr.up with insulin ha. a.higher.fr.quency of a.tibody positivity:a.ti-Ga.65 odds r.tio(Or.:2.42(1.112–5.303,P=0.026);a.ti-Ia.:Or.1.55(0.859–2.818,P=0.105);a.d a.ti-Zn8T:Or.7.32(2.039–26.279,P=0.002).CONCLUSION a.ti-Ga.65 positivity wa. high in our.***-Ga.65 a.d a.ti-Zn8T positivity showed a.significa.tly depleted beta.cell r.ser.e phenotype,lea.ing to a. incr.a.ed r.sk of ea.0}y insulin dependence.

关键词： Dia.etes Obesity a.olescents a.toimmunity Beta.cell Insulin r.quir.ments