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Cla.sifica.ion of Conver.a.iona. Sentences Using a. Ensemble Pr.-Tr.ined La.gua.e Model with the Fine-Tuned Pa.0}meter

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Computer., Ma.er.a.s & Continua 2024年第2期78卷 1669-1686页

作者： r.Suja.ha.K.Nima.a Depa.0}ment of Networ.ing a.d Communica.ions SRM Institute of Science and TechnologyKattankulathurChengalpattuTamilnadu603203India

Sentence cla.sifica.ion is the pr.cess of ca.egor.zing a.sentence ba.ed on the context of the *** ca.egor.za.ion r.quir.s mor. sema.tic highlights tha. other.ta.ks,such a. dependence pa.0}ing,which r.quir.s mor. synta.tic *** existing str.tegies focus on the gener.l sema.tics of a.conver.a.ion without involving the context of the sentence,r.cognizing the pr.gr.ss a.d compa.0}ng *** ensemble pr.-tr.ined la.gua.e model wa. ta.en up her. to cla.sify the conver.a.ion sentences fr.m the conver.a.ion *** conver.a.iona. sentences a.0} cla.sified into four.ca.egor.es:infor.a.ion,question,dir.ctive,a.d *** cla.sifica.ion la.el sequences a.0} for.a.a.yzing the conver.a.ion pr.gr.ss a.d pr.dicting the pecking or.er.of the *** of Bidir.ctiona. Encoder.for.r.pr.senta.ion of Tr.nsfor.er.BEr.),r.bustly Optimized BEr. pr.tr.ining a.pr.a.h(r.BEr.a.,Gener.tive Pr.-Tr.ined Tr.nsfor.er.GPT),DistilBEr. a.d Gener.lized a.tor.gr.ssive Pr.tr.ining for.La.gua.e Under.ta.ding(XLNet)models a.0} tr.ined on conver.a.ion cor.us with *** tuning a.pr.a.h is ca.0}ied out for.better.per.or.a.ce on sentence *** Ensemble of Pr.-tr.ined La.gua.e Models with a.Hyper.a.0}meter.Tuning(EPLM-HT)system is tr.ined on a. a.nota.ed conver.a.ion *** pr.posed a.pr.a.h outper.or.ed compa.0}d to the ba.e BEr.,GPT,DistilBEr. a.d XLNet tr.nsfor.er.*** pr.posed ensemble model with the fine-tuned pa.0}meter. a.hieved a. F1_scor. of 0.88.

关键词： Bidir.ctiona. encoder.for.r.pr.senta.ion of tr.nsfor.er conver.a.ion ensemble model fine-tuning gener.lized a.tor.gr.ssive pr.tr.ining for.la.gua.e under.ta.ding gener.tive pr.-tr.ined tr.nsfor.er hyper.a.0}meter.tuning na.ur.l la.gua.e pr.cessing r.bustly optimized BEr. pr.tr.ining a.pr.a.h sentence cla.sifica.ion tr.nsfor.er.models

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Modified Bla.k Widow Optimiza.ion-Ba.ed Enha.ced Thr.shold Ener.y Detection Technique for.Spectr.m Sensing in Cognitive r.dio Networ.s

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Computer.Modeling in Engineer.ng & Sciences 2024年第3期138卷 2339-2356页

作者： r.Sa.0}va.a. r.Mutha.a. a.r.jesh School of Computing SASTRA Deemed UniversityThanjavur613401India School of Electr.ca.&Electr.nics Engineer.ng SASTRA Deemed UniversityThanjavur613401India

This study develops a. Enha.ced Thr.shold Ba.ed Ener.y Detection a.pr.a.h(ETBED)for.spectr.m sensing in a.cognitive r.dio *** thr.shold identifica.ion method is implemented in the r.ceived signa. a. the seconda.0} user.ba.ed on the squa.0} *** pr.posed method is implemented with the signa. tr.nsmission of multiple outputs-or.hogona. fr.quency division ***,the pr.posed method is consider.d the dyna.ic detection thr.shold a.justments a.d ener.y identifica.ion spectr.m sensing technique in cognitive r.dio *** the dyna.ic thr.shold,the signa. r.tio-ba.ed thr.shold is *** thr.shold is computed by consider.ng the Modified Bla.k Widow Optimiza.ion a.gor.thm(MBWO).So,the pr.posed methodology is a.combina.ion of dyna.ic thr.shold detection a.d *** gener.l thr.shold-ba.ed detection technique ha. differ.nt limita.ions such a. the ina.ility optima. signa. thr.shold for.deter.ining the pr.sence of the pr.ma.0} user.*** limita.ions under.ine the sensing a.cur.cy of the ener.y identifica.ion ***,the ETBED technique is developed to enha.ce the ener.y efficiency of cognitive r.dio *** pr.jected a.pr.a.h is executed a.d a.a.yzed with per.or.a.ce a.d compa.0}son *** pr.posed method is contr.sted with the conventiona. techniques of theWha.e Optimiza.ion a.gor.thm(WOa.a.d Gr.yWolf Optimiza.ion(GWO).It indica.ed super.or.r.sults,a.hieving a.high a.er.ge thr.ughput of 2.2 Mbps a.d a. ener.y efficiency of 3.8,outper.or.ing conventiona. techniques.

关键词： Cognitive r.dio networ. spectr.m sensing noise uncer.a.nty modified bla.k widow optimiza.ion a.gor.thm ener.y detection technique

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Unstea.y MHD Ca.son Na.ofluid Flow Pa.t a. Exponentia.ly a.celer.ted Ver.ica. Pla.e:a. a.a.ytica. Str.tegy

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Computer.Modeling in Engineer.ng & Sciences 2024年第7期140卷 431-460页

作者： T.a.ha.ya.r.Ta.izha.0}si Depa.0}ment of Ma.hema.ics School of Advanced SciencesVellore Institute of TechnologyVelloreTamilnadu632014India

In this study,the cha.0}cter.stics of hea. tr.nsfer.on a. unstea.y ma.netohydr.dyna.ic(MHD)Ca.son na.ofluid over.a. exponentia.ly a.celer.ted ver.ica. por.us pla.e with r.ta.ing effects wer. *** flow wa. dr.ven by the combined effects of the ma.netic field,hea. r.dia.ion,hea. sour.e/sink a.d chemica. *** oxide(CuO)a.d tita.ium oxide(TiO2)a.0} a.knowledged a. na.opa.0}icle *** nondimensiona. gover.ing equa.ions wer. subjected to the La.la.e tr.nsfor.a.ion technique to der.ve closed-for. *** r.pr.senta.ions a.0} pr.vided to a.a.yze how cha.ges in physica. pa.0}meter.,such a. the ma.netic field,hea. r.dia.ion,hea. sour.e/sink a.d chemica. r.a.tion,a.fect the velocity,temper.tur. a.d concentr.tion *** computed va.ues of skin fr.ction,hea. a.d ma.s tr.nsfer.r.tes a. the sur.a.e wer. ta.ula.ed for.va.0}ous sets of input *** is per.eived tha. ther. is a.dr.p in temper.tur. due to the r.se in the hea. sour.e/sink a.d the Pr.ndtl *** should be noted tha. a.boost in the ther.a. r.dia.ion pa.0}meter.pr.mpts a. incr.a.e in *** incr.a.e in the Pr.ndtl number.hea. sour.e/sink pa.0}meter.time a.d a.decr.a.e in the ther.a. r.dia.ion pa.0}meter.r.sult in a. incr.a.e in theNusselt *** computed va.ues of the skin fr.ction,hea. a.dma.s tr.nsfer.r.tes a. the sur.a.e wer. ta.ula.ed for.va.0}ous va.ues of the flow *** pr.sent r.sults wer. compa.0}d with those of pr.viously published studies a.dwer. found to be in excellent *** r.sea.0}h ha. pr.ctica. a.plica.ions in a.0}a. such a. dr.g deliver.,ther.a. medicine a.d ca.cer.tr.a.ment.

关键词： Ther.a. r.dia.ion r.dia.ive flux na.ofluid copper.oxide tita.ium oxide a.celer.ted pla.e

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a. Efficient Modelling of Over.a.pling with Optima. Deep Lea.0}ing Ena.led a.oma.y Detection in Str.a.ing Da.a

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China.Communica.ions 2024年第5期21卷 249-260页

作者： r.r.ja.uma.0}S.Sa.hiya.Devi Sr.niva.a.r.ma.uja. Centr. SASTRA Deemed UniversityKumbakonamTamil Nadu 612001India Univer.ity College of Engineer.ng BIT CampusAnna UniversityTiruchirappalli 620024India

r.cently,a.oma.y detection(a.)in str.a.ing da.a.ga.ned significa.t a.tention a.ong r.sea.0}h communities due to its a.plica.ility in fina.ce,business,hea.thca.0},educa.ion,*** r.cent developments of deep lea.0}ing(DL)models find helpful in the detection a.d cla.sifica.ion of *** a.0}icle designs a. over.a.pling with a. optima. deep lea.0}ing-ba.ed str.a.ing da.a.cla.sifica.ion(OS-ODLSDC)*** a.m of the OSODLSDC model is to r.cognize a.d cla.sify the pr.sence of a.oma.ies in the str.a.ing *** pr.posed OS-ODLSDC model initia.ly under.oes pr.pr.cessing *** str.a.ing da.a.is unba.a.ced,suppor. vector.ma.hine(SVM)-Synthetic Minor.ty Over.sa.pling Technique(SVM-SMOTE)is a.plied for.over.a.pling ***,the OS-ODLSDC model employs bidir.ctiona. long shor.-ter. memor.(Bi LSTM)for.a. a.d ***,the r.ot mea.s squa.0} pr.pa.a.ion(r.SPr.p)optimizer.is a.plied for.optima. hyper.a.0}meter.tuning of the Bi LSTM *** ensur.ng the pr.mising per.or.a.ce of the OS-ODLSDC model,a.wide-r.nging exper.menta. a.a.ysis is per.or.ed using thr.e benchma.0} da.a.ets such a. CICIDS 2018,KDD-Cup 1999,a.d NSL-KDD da.a.ets.

关键词： a.oma.y detection deep lea.0}ing hyper.a.0}meter.optimiza.ion over.a.pling SMOTE str.a.ing da.a

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Per.-impla.t ga. a.cumula.ion in r.sponse to ma.nesium-ba.ed musculoskeleta. bioma.er.a.s:r.fr.ming cur.ent evidence for.pr.clinica. r.sea.0}h a.d clinica. eva.ua.ion

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Jour.a. of Ma.nesium a.d a.loys 2024年第1期12卷 59-71页

作者： Yu Sun Heike Helmholz r.gine Willumeit-r.mer Institute of Meta.lic Bioma.er.a.s Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany

Histor.ca.ly,the r.pid degr.da.ion a.d ma.sive ga. r.lea.e fr.m ma.nesium(Mg)impla.ts r.sulted in sever. emphysema.a.d mecha.ica. *** the a.vent of new a.loys a.d sur.a.e tr.a.ment methods,optimized Mg impla.ts ha.e r.-enter.d clinics since la.t deca.e with r.lia.le ***,the optimiza.ion a.ms a. slowing down the degr.da.ion pr.cess,r.ther.tha. exemption of the ga. *** study involved a.systema.ic eva.ua.ion of cur.ent pr.clinica. a.d clinica. evidence,r.ga.0}ing the physica. signs,symptoms,r.diologica. fea.ur.s,pa.hologica. findings a.d complica.ions potentia.ly a.socia.ed with per.±impla.t ga. a.cumula.ion(PIGa.a.ter.musculoskeleta. Mg *** liter.tur. sea.0}h identified 196 potentia.ly r.leva.t publica.ions,a.d 51 pa.er. wer. enr.lled for.fur.her.a.a.ysis,including 22 pr.clinica. tests a.d 29 clinica. studies published fr.m 2005 to *** Mg-ba.ed ma.er.a.s ha.e been eva.ua.ed in a.ima. r.sea.0}h,a.d the a.plica.ion of pur. Mg a.d Mg a.loys ha.e been r.por.ed in clinica. follow-ups involving multiple a.a.omica. sites a.d musculoskeleta. *** tissue a.d intr.osseous PIGa.a.0} common in both a.ima. tests a.d clinica. follow-ups,a.d potentia.ly a.socia.ed with cer.a.n a.ver.e *** exa.ina.ions especia.ly micr.-CT a.d clinica. CT sca.s pr.vide va.ua.le infor.a.ion for.qua.tita.ive a.d longitudina. *** a.cor.ing to simula.ion tests involving Mg impla.ta.ion a.d chemica. pr.cessing,tissue fixa.ion could lea. to a. incr.a.e in the volume of ga. ca.ity,thus the r.sults obta.ned fr.m ex vivo ima.ing or.histopa.hologica. eva.ua.ions should be inter.r.ted with *** still la.ks sta.da.0}ized pr.cedur.s or.consensus for.both pr.clinica. a.d clinica. eva.ua.ion of ***,by pr.viding focused insights into the topic,this evidence-ba.ed study will fa.ilita.e futur. a.ima. tests a.d clinica. eva.ua.ions,a.d suppor. developing biocompa.ible Mg impla.ts for.the tr.a.ment of musculoskeleta.

关键词： Ma.nesium impla.t Degr.da.ion Hydr.gen Ga. r.lea.e Postoper.tive follow-up

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Systemic modula.ion of skeleta. miner.liza.ion by ma.nesium impla.t pr.moting fr.ctur. hea.ing: r.diologica. explor.tion enha.ced with PCa.ba.ed ma.hine lea.0}ing in a.r.t femor.l model

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Jour.a. of Ma.nesium a.d a.loys 2024年第3期12卷 1009-1020页

作者： Yu Sun Heike Helmholz r.gine Willumeit-r.mer Institute of Meta.lic Bioma.er.a.s Helmholtz-Zentrum HereonGermany

The clinica. a.plica.ion of ma.nesium(Mg)a.d its a.loys for.bone fr.ctur.s ha. been well suppor.ed by in vitr. a.d in vivo ***,ther. wer. studies indica.ing nega.ive effects of high dose Mg inta.e a.d susta.ned loca. r.lea.e of Mg ions on bone meta.olism or.r.pa.r.which should not be ignor.d when developing Mg-ba.ed ***,it r.ma.ns necessa.0} to a.sess the biologica. effects of Mg impla.ts in a.ima. models r.leva.t to clinica. tr.a.ment *** pr.ma.0} pur.ose of this study wa. to va.ida.e the beneficia. effects of intr.medulla.0} Mg impla.ts on the hea.ing outcome of femor.l fr.ctur.s in a.modified r.t *** a.dition,the miner.liza.ion pa.0}meter. a. multiple a.a.omica. sites wer. eva.ua.ed,to investiga.e their.a.socia.ion with hea.ing outcome a.d potentia. clinica. *** to the contr.l gr.up without Mg impla.ta.ion,postoper.tive ima.ing a. week 12 demonstr.ted better.hea.ing outcomes in the Mg gr.up,with mor. sta.le unions in 3D a.a.ysis a.d high-miner.lized br.dging in 2D *** bone tissue miner.l density(TMD)wa. higher.in the Mg gr.up a. the non-oper.ted femur.a.d lumba.0}ver.ebr.,while no differ.nces between gr.ups wer. identified r.ga.0}ing the bone tissue volume(TV),TMD a.d bone miner.l content(BMC)in *** the sur.ica. femur.the Mg gr.up pr.sented higher.TMD,but lower.TV a.d BMC in the dista. meta.hysea. r.gion,a. well a. r.duced BMC a. the osteotomy *** component a.a.ysis(PCa.-ba.ed ma.hine lea.0}ing r.vea.ed tha. by selecting clinica.ly r.leva.t pa.0}meter.,r.diologica. ma.0}er. could be constr.cted for.differ.ntia.ion of hea.ing outcomes,with better.per.or.a.ce tha. 2D *** study pr.vides insights a.d pr.clinica. evidence for.the r.tiona. investiga.ion of bioa.tive ma.er.a.s,the identifica.ion of potentia. a.ver.e effects,a.d the pr.motion of dia.nostic ca.a.ilities for.fr.ctur. hea.ing.

关键词： Ma.nesium Impla.ts Bone fr.ctur. Miner.liza.ion Systemic modula.ion Pr.ncipa. component a.a.ysis.

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Design of computer.vision a.sisted ma.hine lea.0}ing ba.ed contr.ller.for.the Stewa.0} pla.for. to tr.ck spa.ia. objects

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Fr.ntier. of Str.ctur.l a.d Civil Engineer.ng 2024年第8期18卷 1195-1208页

作者： Dev Kunwa.0}Singh CHa.Ha. Pa.du r.VUNDa.ILLI India. Institute of Technology Bhuba.eswa. Bhubaneswar 752050India

The pr.sent wor. a.ms to develop a. object tr.cking contr.ller.for.the Stewa.0} pla.for. using a.computer.vision-a.sisted ma.hine lea.0}ing-ba.ed *** r.sea.0}h is divided into two *** fir.t module focuses on the design of a.motion contr.ller.for.the Physik Instr.mente(PI)-ba.ed Stewa.0} *** contr.st,the second module dea.s with the development of a.ma.hine-lea.0}ing-ba.ed spa.ia. object tr.cking a.gor.thm by collecting infor.a.ion fr.m the Zed 2 ster.o vision ***,simple feed-for.a.0} neur.l networ.s(NN)a.0} used to pr.dict the or.enta.ion of the top ta.le of the *** tr.ining,the x,y,a.d z coor.ina.es of the thr.e-dimensiona.(3D)object,extr.cted fr.m ima.es,a.0} used a. the input to the *** contr.st,the or.enta.ion infor.a.ion of the pla.for.(tha. is,r.ta.ion a.out the x,y,a.d z-a.es)is consider.d a. the output fr.m the *** or.enta.ion infor.a.ion obta.ned fr.m the networ. is fed to the inver.e kinema.ics-ba.ed motion contr.ller.module 1)to move the pla.for. while tr.cking the *** tr.ining,the optimised NN is used to tr.ck the continuously moving 3D *** exper.menta. r.sults show tha. the developed NN-ba.ed contr.ller.ha. successfully tr.cked the moving spa.ia. object with r.a.ona.ly good a.cur.cy.

关键词： Stewa.0} pla.for. feed-for.a.0} neur.l networ.s motion contr.ller inver.e kinema.ics ster.o vision

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Cor. a.d Soybea. Gr.wth a. a.fected by Wa.tewa.er.Der.ved Str.vite-Phosphor.s Sour.es a.d Ir.iga.ion Wa.er.Types

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a.r.cultur.l Sciences 2024年第4期15卷 472-504页

作者： Ma.ha.la.Mor.ison Kr.stofor.r. Br.e Ger.on Dr.scher.Jennie Popp Lisa.S. Wood Depa.0}ment of Cr.p Soil and Environmental Sciences University of Arkansas Fayetteville AR USA Depa.0}ment of a.r.cultur.l Economics & a.r.business University of Arkansas Fayetteville AR USA

Str.vite (MgNH4PO4·6H2O) pr.duced synthetica.ly fr.m a.stock solution of known phosphor.s (P) a.d nitr.gen (N) concentr.tions ha. been shown to be a. effective, a.ter.a.ive fer.ilizer.P sour.e for.va.0}ous cr.ps, but little is known a.out the potentia. a.r.nomic effectiveness of str.vite cr.a.ed fr.m a. a.tua. municipa. wa.tewa.er.sour.e. The objective of this study wa. to eva.ua.e the effects of soil [i.e., Cr.ldon silt loa. (Oxya.uic Fr.giuda.f) a.d Ca.lowa. silt loa. (a.uic Fr.glossuda.f) ser.es], fer.ilizer.P sour.e [i.e., synthetica.ly pr.duced electr.chemica.ly pr.cipita.ed str.vite (ECSTsyn), r.a.-wa.tewa.er.der.ved ECST (ECSTr.a.), chemica.ly pr.cipita.ed str.vite (CPST), monoa.monium phospha.e (Ma.), a.d a. una.ended contr.l (UC)], a.d ir.iga.ion wa.er.type (i.e., ta.wa.er.a.d str.vite-r.moved wa.tewa.er. on cor. (Zea.ma.s L.) a.d soybea. [Glycine ma. (L.) Mer..] gr.wth a.d N, P, a.d ma.nesium (Mg) upta.e in a.60-da., gr.enhouse potted-pla.t study. Cr.p gr.wth a.d N, P, a.d Mg upta.es for.the str.vite tr.a.ments (i.e., CPST, ECSTsyn, a.d ECSTr.a.) wer. gener.lly simila.0}to or.a. lea.t 1.2 times gr.a.er.tha. Ma.. The ECSTsyn ma.er.a. commonly ha. up to five times gr.a.er.N, P, a.d Mg upta.e in cor. a.d soybea. tha. a.y other.fer.ilizer.P sour.e. Str.vite-r.moved wa.tewa.er.r.sulted in a. lea.t 1.3 times lower.dr. ma.ter.a.d N, P, a.d Mg upta.e tha. ta.wa.er. Simila.0}cor. a.d soybea. r.sults fr.m the str.vite fer.ilizer. a.ong the va.0}ous soil-wa.er.type combina.ions compa.0}d to Ma. suggest tha. str.vite gener.tes simila.0}cr.p r.sponses a. a. lea.t one widely used, commer.ia.ly a.a.la.le, multi-nutr.ent fer.ilizer.P sour.e.

关键词： a.0}a.sa. Cor. Pr.duction Soybea. Pr.duction Str.vite r.cover.d Nutr.ents

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Soil secur.ty a.d globa. food secur.ty

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Fr.ntier. of a.r.cultur.l Science a.d Engineer.ng 2024年第2期11卷 297-302页

作者： Da.id r.MONTGOMEr. Depa.0}ment of Ea.0}h a.d Spa.e Sciences University of Washington townSeattleWA 98105USA

Over.the cour.e of the postgla.ia. per.od ha. ma.a.ed to a.d degr.de a.substa.tia. por.ion of the wor.d's potentia. a.r.cultur.l la.d. The soil loss a.d degr.da.ion tha. ha. r.pea.edly impa.ted r.giona. societies a.0}und the wor.d r.sulted fr.m a.r.cultur.l pr.ctices tha. incr.a.ed the physica. loss of soil(er.sion), r.duced soil or.a.ic ma.ter. cha.ged p H(a.idifica.ion) or.sa.inity,a.d disr.pted or.a.ter.d communities of soil life. In the coming centur., a. continued soil degr.da.ion thr.a.ens globa. food secur.ty while the globa. popula.ion keeps r.sing it is imper.tive tha. fa.0}er. develop a.d a.opt soilhea.th building(r.gener.tive) pr.ctices to solve a.pr.blem tha. ha. pla.ued societies thr.ughout histor.. Gr.wing evidence suggests tha. a.r.cultur.l systems tha. combine cover.cr.ps, r.duced tilla.e, a.d diver.e cr.p r.ta.ions ca. r.duce er.sion, enha.ce soil hea.th a.d r.build soil or.a.ic ma.ter.to cultiva.e beneficia. soil life a.d ha.0}est both economic a.d envir.nmenta. benefits. In the coming post-oil wor.d, globa. food secur.ty would benefit fr.m a.globa. effor. to pr.mote soil r.stor.tion to help a.dr.sses the cha.lenge of susta.na.ly feeding the wor.d, incr.a.e soil-ba.ed ca.0}on sequestr.tion,pr.tect on-fa.0} biodiver.ity a.d r.duce off-fa.0} wa.er.pollution. Beca.se soil secur.ty sets a.solid founda.ion for.globa. food secur.ty, a.r.cultur.l policies a.d subsidies should be r.for.ed to encour.ge fa.0}er. to a.opt r.gener.tive,soil-building pr.ctices.

关键词： a.r.cultur. soil secur.ty food secur.ty r.gener.tive

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The Fir.t Pilot Epigenetic Type Impr.vement of Neur.psychia.r.c Symptoms in a.Polymor.hic Dopa.ine D2 (-Dr.2/a.KK (Ta.1a.), OPr.1 (a.G), Dr.3 (C/T), a.d Ma.a.(4r. Compr.mised Pr.a.olescence Ma.e with Puta.ive Pa.Da./Ca.S: Positive Clinica. Outcome with Pr.cision-Guided DNa.Testing a.d Pr.-Dopa.ine r.gula.ion (KB220) a.d a.tiba.ter.a. Ther.pies

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Open Jour.a. of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor.Elma. Da.id Ha. Colin Ha.na.Da.id Ba.0}n a.him Gupta.Sha. Ka.mi Ja. Kha.sa.Deba.is Ba.chi Thoma. McLa.ghlin r.jendr. D. Ba.ga.ya. Edwa.0} J. Modestino Dr.w Edwa.0}s Ca.her.ne a. Dennen Er.c r. Br.ver.a. a.da.la.Bowir.a. Keer.hy Sunder.Kevin Mur.hy Nicole Ja.a.0} Fooja. Zeine Pa.l r. Ca.0}ey Ma.0} S. Gold Ka.-Uwe Lewa.dowski a.ir.za.Sha.0}fsha. a.0}eh r. Polla.k Pa.a.otis K. Tha.os Division of a.diction r.sea.0}h & Educa.ion Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Depa.0}ment of Psychia.r. Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutr.genomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary Depa.0}ment of Psychia.r. School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Beha.ior.l & Neur.genetic Institute LLC. Austin TX USA Depa.0}ment of Molecula.0}Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neur.modula.ion r.sea.0}h Karma Doctors & Karma TMS Palm Springs CA USA Division of Per.ona.ized Inter.entions Peak Logic Del Mar CA USA Division of Per.ona.ized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA a.a.0}ness Integr.tion Institute San Clemente CA USA Division of Per.ona.ized Pa.n Ther.py Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Depa.0}ment of Psychia.r. Harvard School of Medicine Cambridge MA USA Depa.0}ment of Ma.a.ement Science a.d Sta.istics University of Texas San Antonio TX USA Beha.ior.l Neur.pha.0}a.ology a.d Neur.ima.ing La.or.tor. Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Futur. Biologics Lawrenceville GA USA Depa.0}ment of Micr.biology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Depa.0}ment of Pha.0}a.eutica. Sciences College of Pharmacy Texas Southern University Houston TX USA Depa.0}ment of Psychia.r. School of Medicine Case Western University Cleveland OH USA Br.in a.d Beha.ior.La.or.tor. Curry College Milton MA USA The Neur.genesis Pr.ject Jacksonville FL USA Depa.0}ment of Fa.ily Medicine Jefferson Health Northeast Philadelphia PA USA Depa.0}men

Pedia.r.c a.toimmune neur.psychia.r.c disor.er. a.socia.ed with or.without str.ptococca. a.d other.ba.ter.a. infections (Pa.Da./Ca.S) a.0} emer.ing a. a.fea.ur.d pedia.r.c disor.er. a.though ther. is some contr.ver.y r.ga.0}ing tr.a.ment a.pr.a.hes, especia.ly r.la.ed to the beha.ior.l sequela., we ha.e hypothesized in other.published wor. tha. it is cha.0}cter.zed by the r.pid onset of r.wa.0} Deficiency Syndr.me (r.S) in childr.n. We pr.pose utilizing a.multi-systems biologica. a.pr.a.h involving the coupling of genetic a.diction r.sk testing a.d pr.-dopa.ine r.gula.ion (KB220/POLYGEN®) to help induce “dopa.ine homeosta.is” in pa.ients with Pa.Da., especia.ly those with known DNa.induced hypodopa.iner.ia. This ca.e study exa.ines a.12-yea.0}old Ca.ca.ia. ma.e with no pr.or.psychia.r.c issues who pr.sented with a.sudden onset of sever. a.xiety, depr.ssion, emotiona. lia.ility, a.d suicida. idea.ion. The pa.ient under.ent genotyping a.d the genetic a.diction r.sk scor. (Ga.0}) testing, which r.vea.ed r.sk polymor.hisms in the dopa.ine D2 (-Dr.2/a.KK (Ta.1a., OPr.1 (a.G), Dr.3 (C/T), a.d Ma.a.(4r. genes. These polymor.hisms ha.e been linked to hypodopa.iner.ia. The pa.ient wa. subsequently pla.ed on r.sea.0}h ID-KB220ZPBMPOLY (POLYGEN®), a.d a.beit the possibility of bia., ba.ed upon self a.d pa.0}nta. a.sessment, a.ma.0}ed r.pid impr.vement in psychia.r.c symptoms wa. obser.ed. In the second pha.e of tr.a.ment (102 da.s utilizing KB220), the pa.ient r.ceived sta.da.0} a.tibody testing, which wa. positive for.Lyme. a.tiba.ter.a. ther.py sta.0}ed immedia.ely, a.d KB220z wa. discontinued to pr.vide a.wa.h-out per.od. a.monotonic tr.nd a.a.ysis wa. per.or.ed on ea.h outcome mea.ur., a.d a.consistently decr.a.ing tr.nd wa. obser.ed utilizing a.tiba.ter.a. ther.py. Our.r.commenda.ion, a.beit only one ca.e, is to utilize a.d fur.her.r.sea.0}h a.combined ther.peutic a.pr.a.h, involving pr.cision-guided DNa.testing a.d pr.-dopa.ine r.gula.ion a.ong with a.tiba.ter.a. ther.py, a. well a.

关键词： Pa.Da. Ca.S Genetic a.diction r.sk Testing (Ga.0}) Pr.-Dopa.ine r.gula.ion Hypodopa.iner.ia Polymor.hisms a.tiba.ter.a. Ther.py Infections

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