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地方病译丛 1994年第1期15卷 60-62页

作者： turk,JL 郭其杰

r.liability and Validity of the Audit on Diabetes-Dependent Quality of Life (ADDQoL) and EQ-5D in Elder.y Slovenian Diabetes Mellitus Type 2 Patients

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Health 2014年第8期6卷 699-711页

作者： Eva turk Valentina Pr.volnik r.pel Alojz Tapajner.Ar.a Isola DNV GL Str.tegic r.sear.h and Innovation Healthcare Programme H&oslash vik Norway Faculty of Medicine Institute of Health Sciences University of Oulu Oulu Finland Faculty of Medicine University of Maribor Maribor Slovenia Institute for.Economic r.sear.h Ljubljana Slovenia

Pur.ose: This study r.por.s the r.liability and validity analyses of the Audit on diabetes-dependent quality of life (ADDQoL) and EQ-5D in elder.y Slovenian diabetic patients. Methods: A cr.ss-sectional study of elder.y (age ≥ 65 year.) non-insulin dependent diabetes mellitus type 2 (DMT2) patients was car.ied out. The ADDQoL and EQ-5D sur.eys wer. conducted between Januar. and May, 2012. Statistical analysis was per.or.ed using IBM SPSS Statistics softwar., ver.ion 20.0. r.sults: After.exclusion of non-eligible r.spondents, the final sample for.the analysis was 261 cases (51% male), r.sulting in 52.2%of r.sponse r.te. The mean age of the patients was 70.3 year. (SD ± 4.1). The Cr.nbach’s alpha was 0.93 for.ADDQoL and 0.73 for.*** was no impr.vement in the alpha value if any item was deleted in all instr.ments. Missing value items r.nged fr.m 0.8% to 1.5% for.EQ-5D, and fr.m 0.8% to 59.1% (wor.ing life) in ADDQoL. Spear.an’s cor.elation between the EQ-5D VAS scor. and ADDQoL weighted over.ll scor. r.sulted in weak cor.elations coefficient (r.= 0.294;p r.ved r.liable and valid for.assessing Health r.lated Quality of Life (Hr.oL) among elder.y Slovenian DMT2 patients. EQ-5D seemed to be too gener.c to descr.be limitations of DMT2 patients in detail. Using disease specific QoL instr.ments to lear. about patient limitations was r.commended. Compar.son of ADDQoL r.sults between var.ous studies pr.vided significant differ.nces in the impact of diabetes.

关键词： DMT2 Elder.y Patient r.por.ed Outcomes ADDQoL EQ-5D Health r.lated Quality of Life

Effect of taxifolin on cold-shock damages in sper.atozoa in r.bbits

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亚太生殖杂志:英文版 2023年第5期12卷 239-248页

作者： Ir.an Yılmaz Gaffar. turk Aslıhan Cakir.Cihangir.glu Tutku Can Acisu Ibr.him Halil Gungor.GozdeAr.ali Edanur.Guler.Ekmen Fir.t Univer.ity Faculty of Veterinary MedicineDepartment of Reproduction and Artificial InseminationElazigTur kiye Fir.t Univer.ity Faculty of Veterinary MedicineDepartment of PhysiologyElazıgTurkiye

Objective:To investigate the effect of taxifolin added to r.bbit semen on fr.ezing-induced cold-shock damages in ***:Semen was collected fr.m six adult New Zealand r.bbits once a week by ar.ificial *** collected semen was pooled at 38℃ and divided into four.equal *** wer. diluted with 0,50,100 and 200μM taxifolin-containing Tr.s+egg yolk extender.at 38℃ and their.temper.tur.s wer. lower.d to 4℃.Following equilibr.tion,semen dr.wn into 0.25 mL str.ws wer. fr.zen in an automatic semen fr.ezing device and stor.d in liquid nitr.gen container.at-196℃.Samples wer. thawed in 38℃ water.for.25 s and the analyses of motility,kinematic par.meter.,mor.hological defor.ities,changes in membr.ne integr.ty,mitochondr.al membr.ne potential,dead-live r.tio,acr.somal damages and as well as oxidative str.ss analyses wer. per.or.ed in ***:Addition of 50μM taxifolin significantly impr.ved motility(total,pr.gr.ssive,r.pid and static),high mitochondr.al membr.ne potential and the r.tios of sper.atozoa with acr.somal damage compar.d to the contr.l *** to the contr.l gr.up,malondialdehyde(MDA)levels in the 50 and 100μM taxifolin gr.ups wer. significantly lower.while the MDA level was high and viable sper.atozoa r.tio was low in the 200μM taxifolin *** wer. no significant differ.nces between the gr.ups in ter.s of kinematic par.meter.,mor.hological defor.ities,membr.ne integr.ty and antioxidant ***:The low dose of taxifolin(50μM)has a positive effect and the high dose(200μM)has a negative ***,it is concluded that the addition of low-dose(50μM)taxifolin to the extender. would be a useful additive in r.ducing cold-shock damage that occur. dur.ng fr.ezing of r.bbit semen.

关键词： Taxifolin Semen fr.ezing Cold-shock Oxidative str.ss r.bbit

Management of a patient on dual antiplatelet ther.py pr.sented for.living donor.liver.tr.nsplant

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Case r.por.s in Clinical Medicine 2013年第2期2卷 115-118页

作者： Mar.na Moguilevitch Ellise Delphin James Widyn David turk Depar.ment of Anesthesiology Montefiore Medical Center Bronx USA

We r.por. a case of a patient who under.ent Living Donor.Liver.Tr.nsplantation (LDLT) while being continued on his dual antiplatelet r.gimen of clopidigr.l and aspir.n per.oper.tively. The patient had two dr.g eluting stents for.cor.nar. ar.er. disease placed eight months pr.or.to sur.er.. Pr.oper.tive thr.mboelastogr.phy and platelet mapping showed nor.al clot for.ation. Based on these tests it was deter.ined that pr.oper.tive platelet tr.nsfusion was not necessar.. The sur.er. pr.ceeded r.latively uneventfully. The patient r.ceived 1 unit of packed r.d blood cells intr.oper.tively and continued on aspir.n dur.ng the postoper.tive per.od with no evidence of bleeding or.car.iac ischemia.

关键词： Liver Tr.nsplantation Antiplatelet Dr.gs Blood Tr.nsfusion Cor.nar. Ar.er. Disease

Var.ability of anti-human tr.nsglutaminase testing in celiac disease acr.ss Mediter.anean countr.es

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Wor.d Jour.al of Gastr.enter.logy 2017年第24期23卷 4437-4443页

作者： Andr.a Smar.azzo Giuseppe Magazzù Mongi Ben-Har.z Mar.a Legar.a Tamar. Vir.ut Velmishi Elefhter.a r.ma Aydan Kansu Dusanka Micetic-turk Enzo Br.vi Pio Stellato Car.ela Ar.idiaco Luigi Gr.co Depar.ment of Tr.nslational Medical Sciences School of MedicineSection of PediatricsUniversity of Naples“Federico II” Eur.pean Labor.tor. for.Food Induced Diseases Celiac r.gional Centr. Pediatric Gastroenterology and Cystic Fibrosis UnitUniversity of Messina Pediatr.c Unit Mongi SLIM’s Hospital of Tunis Paediatr.c Gastr.enter.logy Unit Cruces University Hospital Ser.ice of Pediatr.c Gastr.enter.logy"Mother.Ter.sa"Hospital Fir.t Depar.ment of Pediatr.cs University of Athens Depar.ment of Pediatr.c Gastr.enter.logy School of MedicineAnkara University Univer.ity Medical Centr. Paediatric Department Eur.spital SpA

To ver.fy the pr.cision and accur.cy of tr.nsglutaminase antibodies (TGA) assays acr.ss Mediter.anean countr.es. METHODSThis study involved 8 r.fer.al centr.s for.celiac disease (CD) in 7 Mediter.anean countr.es. A centr.l labor.tor. pr.par.d 8 kits of 7 blinded and r.ndomized ser.m samples, with a titr.ted amount of Human TGA IgA. Each sample was analysed thr.e times on thr.e differ.nt days, with each centr. r.nning a total of 21 tests. The r.sults wer. included in a blindly coded r.por. for., which was sent to the coor.inator.centr.. The coor.inator.estimated the mean coefficient of Var.ation (CoVar.= σ/μ), the mean accur.cy (Accur.= Vobser.ed - Vr.al) and the mean per.ent var.ation (Var. = [(Vobser.ed - Vr.al)/Vr.al] × 100). r.SULTSThe analysis showed that 79.17% of the mean var.ation fell between -25% and +25% of the expected value, with the accur.cy and pr.cision pr.gr.ssively incr.asing with higher.titr.s of TGA. Fr.m values 1.25 times gr.ater.than the nor.al cut-off, the measur.ments wer. highly r.liable. CONCLUSIONTGA estimation is a cr.cial step for.the diagnosis of CD; given its accur.cy and pr.cision, clinicians could be confident in establishing a diagnosis.

关键词： Coeliac disease Gluten Tr.nsglutaminase Non-invasive testing Accur.cy Pr.cision

Solving Two-Dimensional Moving-Boundar. Pr.blems with Meshless and Level Set Method

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Jour.al of Ener.y and Power.Engineer.ng 2010年第1期4卷 51-55页

作者： L. Vr.nkar.G. turk F. r.novc Faculty of Natur.l Sciences and Engineer.ng University of LjubljanaSlovenian SI-1001 Ljubljana Slovenia Faculty of Civil and Geodetic Engineer.ng University of Ljubljana Jamova cesta 2 1000 Ljubljana Slovenia Faculty of Natur.l Sciences and Engineer.ng University of Ljubljana Askerceva cesta 12 1000 Ljubljana Slovenia

Dur.ng the past decade, incr.asing attention has been given to the development of meshless methods using r.dial basis functions for.the numer.cal solution of Par.ial Differ.ntial Equations （PDEs）. A level set method is a pr.mising design tool for.tr.cking, modelling and simulating the motion of fr.e boundar.es in fluid mechanics, combustion, computer.animation and image pr.cessing. In the conventional level set methods, the level set equation is solved to evolve the inter.ace using a captur.ng Euler.an appr.ach. The solving pr.cedur. r.quir.s an appr.pr.ate choice of the upwind schemes, r.initialization, etc. Our.goal is to include Multiquadr.c r.dial Basis Functions （MQ r.Fs） into the level set method to constr.ct a mor. efficient appr.ach and stabilize the solution pr.cess with the adaptive gr.edy algor.thm. This paper.pr.sents an alter.ative appr.ach to the conventional level set methods for.solving moving-boundar. pr.blems. The solution was compar.d to the solution calculated by the exact explicit lime integr.tion scheme. The examples show that MQ r.Fs and adaptive gr.edy algor.thm is a ver. pr.mising calculation scheme.

关键词： Moving boundar. pr.blems level set method multiquadr.c gr.edy algor.thm exact time integr.tion scheme

Br.gg-mir.or.like cir.ular.dichr.ism in bio-inspir.d quadr.ple-gyr.id 4sr. nanostr.ctur.s

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Light(Science & Applications) 2016年第1期5卷 328-335页

作者： Benjamin P Cumming Ger. E Schr.̈der.turk Sukanta Debbar.a Min Gu Labor.tor. of Ar.ificial-Intelligence Nanophotonics and CUDOS School of ScienceRMIT UniversityMelbourneVictoria 3001Australia Centr. for.Micr.-Photonics Faculty of ScienceEngineering and TechnologySwinburne University of TechnologyHawthornVictoria 3122Australia School of Engineer.ng and Infor.ation Technology Mathematics and StatisticsMurdoch UniversityMurdochWestern Australia 6150Australia Laser.Physics Centr. and CUDOS Research School of Physical Sciences and EngineeringAustralian National UniversityCanberraAustralian Capital Territory 2601Australia

The smooth and tailor.ble spectr.l r.sponse of Br.gg mir.or. has dr.ven their.per.asive use in optical systems r.quir.ng customizable spectr.l contr.l of beam ***,the simple natur. of Br.gg mir.or.r.flection pr.vents their.application to the contr.l of impor.ant polar.zation states such as cir.ular.*** helical and gyr.id-based nanostr.ctur.s exhibiting cir.ular.dichr.ism have been developed extensively to addr.ss this limitation,they ar. often r.str.cted by the spectr.l inconsistency of their.optical *** we pr.sent the fabr.cation and char.cter.zation of quadr.ple-gyr.id 4sr. nanostr.ctur.s exhibiting bio-inspir.d Br.gg-mir.or.like cir.ular.dichr.ism:a smooth and unifor. band of cir.ular.dichr.ism r.miniscent of the spectr.m of a simple multilayer.***,we demonstr.te that the cir.ular.dichr.ism pr.duced by 4sr. nanostr.ctur.s ar. r.bust to changes in incident angle and beam collimation,pr.viding a new platfor. to cr.ate and engineer.cir.ular.dichr.ism for.functional cir.ular.polar.zation manipulation.

关键词： Bio-inspir.d Br.gg-mir.or Chir.lity Cir.ular.dichr.ism Gyr.id

Stathmin as a sur.ogate mar.er.of phosphatidylinositol-3-kinase pathway activity:Towar.s pr.cision medicine in HPV-negative head&neck squamous cell car.inoma

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Genes & Diseases 2022年第3期9卷 820-825页

作者： Andr.w T.turk Dar.o Gar.ia-Car.acedok David T.Kent Elizabeth Philipone Juana Mar.a Gar.ia-Pedr.r. Salvator. M.Car.ana Lanny G.Close Glor.a H.Su Depar.ment of Pathology and Cell Biology and Columbia UniversityNew YorkNY 10032USA Depar.ment of Otolar.ngology Columbia UniversityNew YorkNY 10032USA Depar.ment of Otolar.ngology Vanderbilt UniversityNashvilleTN 37232USA Depar.ment of Otolar.ngology Hospital Universitario Central de Asturias and Instituto Universitario de Oncologia Del Principado de AsturiasOviedo 33006Spain

In or.er.to assess Stathmin as an immunohistochemical(IHC)indicator.of phosphatidylinositol 3-kinase(PI3K)pathway activity in HPV-negative head&neck squamous cell car.inoma(HNSCC),we compar.d Stathmin IHC to expr.ssion of other.pathway *** also evaluated the r.lationship between Stathmin IHC and the mutational status of four.key pathway ***,we ascer.ained whether.Stathmin IHC cor.elates with tumor.gr.de or.pr.mar. *** exists between high Stathmin expr.ssion and high pAKT1 expr.ssion,indicating a r.le for.Stathmin IHC as a mar.er.of pathway *** analysis did not show cor.elation between Stathmin IHC and mutation of the four.genes *** also obser.ed an association between high Stathmin expr.ssion and or.phar.ngeal pr.mar. *** r.sults suggest utility of Stathmin IHC as an indicator.of PI3K pathway activity,and ther.by demonstr.te potential r.levance of Stathmin IHC in the context,of HNSCC.

关键词： Cancer Head&neck squamous cell car.inoma Pathology Stathmin

CD4+ T cells and natur.l killer.cells: Biomar.er. for.hepatic fibr.sis in human immunodeficiency vir.s/hepatitis C vir.s-coinfected patients

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Wor.d Jour.al of Hepatology 2017年第25期9卷 1073-1080页

作者： Natalia Laufer.Diego Ojeda Mar.a Laur. Polo Ana Mar.inez Héctor.Pér.z Gabr.ela turk Pedr. Cahn Nor.er.o Walter.Zwir.er.Jor.e Quar.er. Investigador.Asistente-CONICET Instituto Investigaciones Biomédicas en Retrovirus y SIDA INBIRS Universidad de Buenos Aires Instituto INBIr. UBA-CONICET Hospital Juan A Fer.ández Fundación Huésped Labor.tor.o de Fisiopatología de la Inmunidad Innata Instituto de Biología y Medicina Experimental Depar.amento de Química Biológica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires

AIM To char.cter.ze per.pher.l blood natur.l killer.NK) cells phenotypes by flow cytometr. as potential biomar.er.of liver.fibr.sis in human immunodeficiency vir.s(HIV)/hepatitis C vir.s(HCV) coinfected *** Per.pher.l mononuclear.cells fr.m 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV ser.negative individuals wer. evaluated. HIV/HCV coinfected patients wer. divided in to gr.ups: G1, patients with METAVIr.F0-F2 and G2, patients with METAVIr.F3-F4. NK sur.ace cell staining was per.or.ed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCr.(PE), anti-Tr.IL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometr. data acquisition was per.or.ed on BD FACSCanto, analyzed using Flow Jo softwar.. Fr.quency of fluor.scence was analyzed for.all single mar.er.. Clinical r.cor.s wer. r.viewed, and epidemiological and clinical data wer. *** Samples fr.m 11 patients wer. included in G1 and fr.m 13 in G2. All patients wer. on Ar., with undetectable HIV vir.l load. Liver.fibr.sis was evaluated by tr.nsient elastogr.phy in 90% of the patients and with biopsy in 10% of the patients. Mean HCV vir.l load was(6.18 ± 0.7 log10). Even though, no major.significant differ.nces wer. obser.ed between G1 and G2 r.gar.ing NK sur.ace mar.er., it was found that patients with higher.liver.fibr.sis pr.sented statistically lower.per.entage of NK cells than individual with low to mild fibr.sis and healthy contr.ls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy contr.ls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher.liver.fibr.sis pr.sented lower.CD4 LT count than those fr.m G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher.levels of liver.fibr.sis wer. associated with lower.per.entage of NK cells and LTCD4+ count; and they may ser.e as noninvasive biomar.er. of liver.damag

关键词： CD4^+ T cell Human immunodeficiency vir.s/hepatitis C vir.s-coinfection Fibr.sis Biomar.er Natur.l killer.cells

Postoper.tive intestinal obstr.ction caused by Meckel’s diver.iculitis after.appendectomy

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Open Jour.al of Pediatr.cs 2013年第4期3卷 346-349页

作者： Er.al turk Ayca Tan Fahr. Kar.ca Yesim Edir.e Ir.an Kar.ca Depar.ment of Pediatr.c Sur.er. Faculty of MedicineIzmir UniversityIzmirTurkey Clinic of Pathology Denizli State HospitalDenizliTurkey Clinic of Pediatr.c Sur.er. Denizli State HospitalDenizliTurkey

Sur.ical tr.atment of the complications associated with Meckel’s diver.iculum is widely accepted, but sur.ical management of an asymptomatic diver.iculum found incidentally dur.ng lapar.tomy for.other.r.asons is contr.ver.ial. Appendectomy is the most common r.ason for.lapar.tomy in many pediatr.c sur.er. clinics. The most common causes of an intestinal obstr.ction in the ear.y per.od after.appendectomy ar. an intr.-abdominal abscess, adhesive small bowel obstr.ction and invagination. Obstr.ction due to Meckel’s diver.iculum is r.por.ed r.r.ly. In this study, we pr.sent 2 cases, five and eleven year. old, with an asymptomatic Meckel’s diver.iculum wher. appendectomy was per.or.ed due to acute and per.or.ted appendicitis and obstr.ction developed due to Meckel’s diver.iculitis in the postoper.tive ear.y stage. Meckel’s diver.iculitis must be consider.d in intestinal obstr.ction cases developing in the ear.y stages after.appendectomy although quite r.r..

关键词： Appendicitis Meckel’s Diver.iculum Intestinal Obstr.ction