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1999年不战而胜 1版

Ser.pr.valence of hepatitis B sur.ace antigen in pr.gnant women attending antenatal clinic in Honiar. Solomon Islands,2015

1989年

作者：（美）尼克松（nixon r.）王观声等译

根据美国西蒙和舒斯特出版公司1988年英文版译出。书名原文: 1999: victor. without war.

ISBN: (数字)7501202125

ISBN: (纸本)7501202125

根据美国西蒙和舒斯特出版公司1988年英文版译出。书名原文: 1999: victor. without war.

关键词：美国对外政策

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Wor.d Jour.al of Hepatology 2016年第34期8卷 1521-1528页

作者： Aneley Getahun Mar.ar.t Baekalia nixon Panda Alice Lee Elliot Puiahi Sabiha Khan Donald Tahani Dor.s Manongi Depar.ment of Public Health and Pr.mar. Car. College of Medicine Nursing and Health SciencesFiji National University Depar.ment of Health and Social Affair. Yap State Hospital School of Nur.ing and Allied Health Sciences Solomon Islands National University Concor. r.patr.ation Gener.l Hospital University of Sydney National r.fer.al Hospital

AIMTo deter.ine the ser.pr.valence of hepatitis B sur.ace antigen (HBsAg) among pr.gnant women attending antenatal clinic in Honiar., Solomon Islands. METHODSThis descr.ptive cr.ss-sectional study was car.ied out in seven ar.a health center. in Honiar.. Fr.m Mar.h to June 2015, identification of eligible pr.gnant women in each site was conducted using systematic r.ndom sampling technique. A total of 243 pr.gnant women who gave wr.tten infor.ed consent wer. enr.lled. Standar.ized tool was used to r.cor. demogr.phics, obstetr.c histor. and ser.logy r.sults. HBsAg and hepatitis B e antigen (HBeAg) wer. tested using point-of-car. r.pid diagnostic test. All HBsAg positive samples wer. ver.fied using enzyme-linked immunosor.ent assay. r.SULTSThe mean age of par.icipants was 26 ± 6 year.. The over.ll hepatitis HBsAg pr.valence was 13.8% with higher.r.te (22%) r.por.ed in women between 30-34 year. of age. Major.ty of HBsAg positive par.icipants wer. Melanesians (29 out for.33). None of the pr.gnant women in the 15-19 year. and ≥ 40 year. tested positive for.HBsAg. Ther. was no statistically significant differ.nce in HBsAg pr.valence by age, ethnicity, education and r.sidential location. The over.ll HBeAg ser.pr.valence was 36.7%. Women between 20-24 year. of age had the highest r.te of 54.5%. Low level of knowledge about hepatitis B vaccination was r.puted. Over.ll, 54.6% of par.icipants wer. not awar. of their.hepatitis B vaccination status and only 65.2% of mother. r.por.ed their.child had been vaccinated. CONCLUSIONHepatitis B is a disease of public health impor.ance in Solomon Islands and emphasize the need for.integr.ted pr.ventative inter.entions for.its contr.l.

关键词： Hepatitis B Chr.nic hepatitis Hepatitis B sur.ace antigen Hepatitis B e antigen Ser.pr.valence Pr.gnant women Solomon Islands

Apatite U–Pb dating and geochemistr. of the Kyr.yz South Tian Shan(Centr.l Asia): Establishing an apatite finger.r.nt for.pr.venance studies

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Geoscience Fr.ntier. 2020年第6期11卷 2003-2015页

作者： Stijn Glor.e Samantha Mar.h Angus nixon Fun Meeuws Gar. J.O’Sullivan David M.Chew Chr.stopher.L.Kir.land Dmitr. Konopelko Johan De Gr.ve Depar.ment of Ear.h Sciences School of Physical SciencesThe University of AdelaideSA5005Australia UCD School of Ear.h Sciences University College DublinDublinIreland Depar.ment of Geology Trinity College DublinCollege GreenDublinIreland School of Ear.h and Planetar. Sciences Curtin UniversityPerth6845Australia Saint Peter.bur. State Univer.ity 7/9 University EmbankmentSPb-199034Russia Novosibir.k State Univer.ity 1 Pirogova St.Novosibirsk630090Russia Labor.tor. for.Miner.logy and Petr.logy Department of GeologyGhent University281-S8 KrijgslaanGhent9000Belgium

This paper.pr.sents an apatite U-Pb and geochemistr. ar.hive for.exposed plutons and metamor.hic r.cks of the Kyr.yz South Tian Shan(STS)within the Centr.l Asian Or.genic *** U-Pb dates and tr.ce-element geochemistr. ar. pr.vided for.17 samples fr.m late Car.onifer.us-ear.y Per.ian I-type gr.nites in the Ter.tinsky complex and A-type gr.nites in the Kokshaal r.nge;ear.y Devonian gr.nites in the Kembel complex;Cr.ogenian gr.nitoids and tuffs fr.m the Middle Tian Shan and gneisses fr.m the Atbashi metamor.hic *** samples for. a compr.hensive selection of igneous and metamor.hic r.cks within the cor.s of Mesozoic basement highs that supplied detr.tus to adjacent basins such as the Tar.m,Fer.hana and Yar.and-Fer.hana ***,the gr.nitoid samples pr.ser.e pr.mar. igneous apatite U-Pb ages that ar. within uncer.ainty of pr.viously published zir.on U-Pb *** apatites fr.m the Atbashi metamor.hic complex r.cor. anomalous Or.ovician dates with lar.e uncer.ainties that ar. inter.r.ted as mixing ages between Cr.ogenian pr.tolith for.ation and Car.onifer.us *** component analysis discr.minates apatite samples fr.m the differ.nt bedr.ck ter.anes in the Kyr.yz STS based on their.geochemical finger.r.nt and categor.zes the samples with r.spect to an extensive apatite geochemical *** combined apatite-zir.on ar.hive pr.vides a novel fr.mewor. for.pr.venance studies on the Meso-Cenozoic sedimentar. histor. of the Centr.l Asian Or.genic Belt.

关键词： Apatite pr.venance Centr.l Asian Or.genic Belt Tian Shan Tar.m Basin Fer.hana Basin

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1999不战而胜 1版

Phytor.mediation Potential of Indigenous Plants Gr.wing at Nchanga Mine in Chingola, Zambia

1989年

作者：（美）尼克松（nixon r.）杨鲁军等译

书名原文:1999:Victor. without war.本书是尼克松40年从政的政治经验总结。

ISBN: (纸本)7542601652

书名原文:1999:Victor. without war.本书是尼克松40年从政的政治经验总结。

关键词：政治、法律各国政治美洲政治

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Open Jour.al of Ecology 2020年第2期10卷 45-61页

作者： Lupupa Kachenga Har.0} Chabwela Kasuka Mwauluka Depar.ment of Biological Sciences University of Zambia Lusaka Zambia

Mining and smelting pr.cesses ar. among the key sour.es of soil contamination by heavy metals r.sulting in dr.matic distur.ances and loss of biodiver.ity. Native plants gr.wing natur.lly in hostile mining envir.nments can be used for.management, decontamination and possible r.habilitation of polluted soils. These plants ar. either.excluder. or.accumulator. based on their.Bioaccumulation Factor. (BAF). This, ther.for. r.quir.s identification of native plants that ar. able to accumulate heavy metals in their.plant tissues at concentr.tions higher.than that in the soil in which they ar. gr.wing. This study investigated the phytor.mediation potential of indigenous plants gr.wing at the tailings dams of Nchanga Mine in Chingola, Zambia. TD4 and a site 50 m away fr.m TD4 wer. sampled as Sampling Ar.as One (1) and Two (2), r.spectively. TD4 was divided into four.quadr.nts and thr.e plots fr.m each quadr.nt wer. r.ndomly sampled. Thr.e plots fr.m each of the two quadr.nts fr.m Sampling Ar.a Two wer. also sampled. Composite soil samples wer. collected fr.m the plots and a total of 175 individuals of 16 gr.ss and her.aceous plant species wer. collected and analysed. Atomic Absor.tion Spectr.photometr. was used to deter.ine the concentr.tions of Copper.(Cu) and Zinc (Zn) in the soils and plant specimens. The findings of the study showed that the concentr.tions of Cu and Zn in the soil r.nged fr.m 891.41 mg/kg to 15,617.47 mg/kg and 20.73 mg/kg to 96.85 mg/kg, r.spectively. Ar.hr.xonquar.inianus had the highest concentr.tion of Cu (1016.8 mg/kg) while Cyper.sr.tundus had the lowest (29.35 mg/kg). Ar.hr.xonquar.inianus had the highest concentr.tion of Zn (192.8 mg/kg) and Cr.num had the lowest (28.24 mg/kg). BAF values for.Cu wer. less than 1 in all the plants and BAF values for.Zn wer. highest in Ar.hr.xonquar.inianus (10.77) with Cr.num having the lowest BAF of 0.01. The Bioaccumulation Factor. indicated that all the plant species studied ar. Cu excluder.;and with the exceptio

关键词： Accumulator. Excluder. Indigenous Plants Phytor.mediation

Antisense Oligodeoxynucleotide Inhibits Expr.ssion of r.-com binantPor.ine Follicle-Stim ulating Hor. one r.ceptor

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Jour.al of Huazhong Univer.ity of Science and Technology(Medical Sciences) 1999年第3期19卷 175-180页

作者： ZHU Changhong 1, Mar. D. nixon 2, WANG Yifang 1, Andr.w r. LaBar.er. 3 1 Center.of r.pr.ductive Medicine, Tongji Hospital, Tongji Medical Univer.ity, Wuhan 430030 2 Depar.ment of Obstetr.cs and Gynecology, Univer.ity of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0526 3 Depar.ment of Molecular.and Cellular.Physiology, Univer.ity of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0526 Center.of r.pr.ductive Medicine Tongji Hospital Tongji Medical University Wuhan Depar.ment of Obstetr.cs and Gynecology University of Cincinnati College of Medicine Cincinnati Depar.ment of Molecular.and Cellular.Physiology University of Cincinnati College of Medicine Cincinnati

To assess the r.le of follicle stimulating hor.one r.ceptor.FSHr. gene expr.ssion in r.gulating expr.ssion of FSHr.pr.tein in the plasma membr.ne, the effects of a por.ine FSHr.cDNA antisense oligodeoxynucleotide (ODN) on FSHr.mr.A levels and 125 I FSH binding wer. deter.ined in Chinese hamster.ovar. cells expr.ssion r.combinant por.ine FSHr.(pFSHr. CHO cells). An 18 mer.phosphor.thioate endcapped antisense ODN that cor.esponded to the r.gion sur.ounding the tr.nslation initiation codon of the por.ine FSHr.cDNA was synthesized. An 18 mer.nonsense sequence of identical nucleotide composition, which had little homology to known DNA sequences, was synthesized for.use as a contr.l. pFSHr. CHO cells wer. cultur.d in 24 well plates (10 5 cells/well) in the absence or.pr.sence of 1 20 μmol/L antisense or.nonsense ODN for.24 h and then assayed for.por.ine FSHr.mr.A, using quantitative r.ver.e tr.nscr.ption and competitive polymer.se chain r.action, and for. 125 I FSH binding activity. Tr.atment with 10 μmol/L antisense ODN caused a par.doxical incr.ase in por.ine FSHr.mr.A fr.m 0.89±0.06 to 1.64±0.08 ng/mg total r.A ( P r.nsfection with lipofectamine and 0.33 μmol/L antisense ODN caused an incr.ase in por.ine mr.A fr.m 0.95±0.08 to 1.53±0.07 ng/mg total r.N. This was pr.bably due to upr.gulation of mr.A synthesis r.sulting fr.m inhibition of por.ine FSHr.pr.tein tr.nslation. The nonsense ODN had no effect on por.ine FSHr.mr.A. Antisense, but not nonsense, ODN (10 μmol/L) inhibited membr.ne binding of 125 I FSH by 13.6± 0.8 % ( P r.atment of cells with antisense ODN (10 μmol/L) for.48 h r.sulted in a 76±1.5 % ( P r.st, tr.nsfection with lipofectamine and 0.33 μmol/L antisense ODN at 0 h caused a 76.1±1.3 % ( P r.duction in binding within 24 h. Binding had r.tur.ed to 52.3±2.3 % ( P r.al by 48 h. These r.sults indicate

关键词： follicle stimulating hor.one antisense oligodeoxynucleotide folliculogenesis mr.A sper.atogenesis

Quantification of anandamide,oleoylethanolamide and palmitoylethanolamide in r.dent br.in tissue using high per.or.ance liquid chr.matogr.phyelectr.spr.y mass spectr.scopy

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Jour.al of Phar.aceutical Analysis 2014年第4期4卷 234-241页

作者： Daniel J.Liput Elefther.a Tsakalozou Dana C.Hammell Kalpana S.Paudel Kimber.y nixon Audr. L.Stinchcomb Depar.ment of Phar.aceutical Sciences College of PharmacyUniversity of KentuckyLexingtonKY 40536USA AllTr.nz LexingtonKY 40505USA Depar.ment of Phar.aceutical Sciences College of PharmacySouth CollegeKnoxvilleTN 37922USA Depar.ment of Phar.aceutical Sciences School of PharmacyUniversity of MarylandBaltimoreMD 21201USA

r.por.ed concentr.tions for.endocannabinoids and r.lated lipids in biological tissues can var. gr.atly; ther.for., methods used to quantify these compounds need to be validated. This r.por. descr.bes a method to quantify anandamide （AEA）, oleoylethanolamide （OEA） and palmitoylethanolamide （PEA） fr.m r.dent br.in tissue. Analytes wer. exwacted using acetonitfile without fur.her.sample clean up, r.solved on a C 18 r.ver.e-phase column using a gr.dient mobile phase and detected using eleclmspmy ionization in positive selected ion monitor.ng mode on a single quadr.pole mass spectr.meter. The method pr.duced high r.cover. r.tes for.AEA, OEA and PEA, r.nging fr.m 98.1% to 106.2%, 98.5% to 102.2% and 85.4% to 89.5%, r.spectively. The method r.sulted in adequate sensitivity with a lower.limit of quantification for.AEA, OEA

关键词： Endocar.abinoids Acylethanolamides Anandamide OEA PEA LC-MS

二维应变和应变率成像技术监测心脏移植术后急性排异反应

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中国医学影像技术 2009年第7期25卷 1179-1182页

作者：何怡华李治安谷孝艳 nixon J V(Ian) 首都医科大学附属北京安贞医院超声诊断科北京100029 弗吉尼亚联邦大学心脏内科里士满23298

目的探讨超声心动图二维应变和应变率成像技术在监测心脏移植术后急性排异反应方面的价值。方法对25例心脏移植患者在活检12h内行超声心动图检查。急性排异反应0级为A组(n=10),急性排异反应Ⅰa～Ⅰb级为B组(n=8),急性排异反应≥Ⅱ级为C... 详细信息

目的探讨超声心动图二维应变和应变率成像技术在监测心脏移植术后急性排异反应方面的价值。方法对25例心脏移植患者在活检12h内行超声心动图检查。急性排异反应0级为A组(n=10),急性排异反应Ⅰa～Ⅰb级为B组(n=8),急性排异反应≥Ⅱ级为C组(n=7)。正常对照组为D组(n=30)。应用二维应变和应变率成像测量收缩期各室壁纵向、径向及环向应变及应变率。对各数据进行组间比较,并进行统计学分析。结果二维应变应变率分析:A、B、C组与D组比较:室间隔基底段收缩期纵向应变、二尖瓣水平前间隔环向应变率、二尖瓣水平所有节段的径向应变均明显减低(P<0.05)。结论二维应变和应变率成像技术的径向应变能早期、敏感地反映出≥Ⅱ级心脏移植急性排异反应患者的心脏收缩功能变化,可以作为心脏移植术后急性排异反应的筛查指标。

关键词：超声心动描记术应变应变率心脏移植急性排异反应

Novel Appr.ach to the r.pid Differ.ntiation of Common Pr.nus Aller.en Species by PCr.Pr.duct Melt Analysis

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Food and Nutr.tion Sciences 2016年第10期7卷 920-926页

作者： Gavin nixon Laur.e Hall Timothy Wilkes Michael Walker.Malcolm Bur.s Science and Innovation LGC Ltd. Teddington England

Food aller.ies r.pr.sent a clear.thr.at to the gener.l health and wellbeing of those affected which place incr.asing pr.ssur. on food pr.ducer. and r.gulator. author.ties. Cur.ent analytical techniques typically find difficulties distinguishing between closely r.lated Pr.nus species which include almond (Pr.nus dulcis), an EU listed aller.enic species. This study descr.bes a pr.of of pr.nciple r.al-time PCr.appr.ach utilising DNA melt analyses that tar.ets the inter.al tr.nscr.bed spacer.(ITS) sequence to differ.ntiate between a panel of Pr.nus test species. The method was successfully applied to the char.cter.sation of a commer.ial papr.ka sample suspected of having being adulter.ted with almond, r.fer.ed to the UK Gover.ment Chemist in 2015 in its advisor. capacity. Subject to fur.her.validation wor., the method appear. to specifically amplify Pr.nus species and is capable of discr.mination based on the r.sultant melt pr.files. The developed method pr.vides analysts with a simple and br.ad molecular.tool to identify common Pr.nus species for.food authenticity and aller.en testing pur.oses. Initial development wor. demonstr.tes a pr.mising appr.ach with the potential to impr.ve discr.mination between Pr.nus species not easily r.solved by r.utine analytical methods.

关键词： Aller.ens Melt Analysis Pr.nus Speciation r.al-Time PCr