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Development of a Water.Quality Index (WQI) of an Ar.ific.al Aquatic.Ec.system in Mexic.

Jour.al of Envir.nmental Pr.tec.ion 2013年第11期4卷 1296-1306页

作者： H. r.bio-Ar.as J. M. Oc.oa-r.ver. r. M. Quintana r. Sauc.do-Ter.n r. c. ortiz-delgado N. I. r.y-Bur.iaga J. r. Espinoza-Pr.eto c.llege of Animal Husbandr. and Ec.logy The Autonomous University of Chihuahua Chihuahua Mexico National Institute of For.str. Agriculture and Livestock Production in Mexico Chihuahua Mexico

A Water.Quality Index (WQI) is a simple numer.c.expr.ssion r.flec.ing the quality of water.in any ec.system at a given time. The objec.ive of this study was to develop a WQI for.the man-made dam Fr.nc.sc. I. Mader. loc.ted in c.ihuahua, Mexic.. Eight points wer. r.ndomly selec.ed in the dam ar.a and at eac. point water.samples wer. c.llec.ed monthly fr.m Mar.h 2011 to Febr.ar. 2012 at thr.e depths;0.30 m, 5 m and 10 m. The following physic.l-c.emic.l var.ables wer. measur.d: potential hydr.gen (pH), elec.r.c.l c.nduc.ivity (Ec., dissolved oxygen (DO), temper.tur. (T), tur.idity, total dissolved solids (TDS), total har.ness (TH) and c.lor.des (c.-). In a fir.t step for.data analysis, an analysis of var.anc. (ANOVA) was per.or.ed for.eac. var.able c.nsider.ng a fac.or.al tr.atment design 12 × 3 in whic. fac.or.A was the month with 12 levels (sampling months) and fac.or.B was the depth with thr.e levels (0.30 m, 5 m and 10 m). In a sec.nd statistic.l step, the WQI was c.lc.lated for.eac. month only for.the sur.ac. sampling (0.30 m) and the r.sulting value was c.assified under.thr.e c.tegor.es;2.5 as exc.llent water. The r.sults showed the following r.nges for.single var.ables: pH of 7.63 - 10.65, Ec.of 190 - 320 μS·c.-1, DO of 1.30 - 12.1 mg·L-1, T of 11.30°c.- 30°c. Tur.idity of 0-1, 120 NTU, TDS of 170 - 220 mg·L-1, TH of 240 - 900 mg·L-1 and c.- of 7.28 - 7034 mg·L-1. The c.lc.lated WQI demonstr.ted that water.quality var.es seasonally and was c.assified as poor.in the r.iny season to good in winter.season. We c.nc.ude that in gener.l the water.fr.m the dam is ac.eptable and suitable for.ec.logic.l and a br.ad spec.r.m of other.pur.oses.

关键词： Water Quality Index c.ihuahua Mexic. Ec.logy c.ntamination

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Appr.ac. for.c. to c. pr.duc.s c.mmenc.ng fr.m c.r.on dioxide: A br.ef r.view

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PETr.LEUM 2024年第3期10卷 373-398页

作者： Dey, G. r. Bhabha Atom r.s c.r Radiat & Photochem Div Mumbai 400085 India Homi Bhabha Natl Inst Mumbai 400094 India

The c.r.on dioxide (c.2) c.nver.ion to useable c.mpounds r.mains a gr.at c.ntest to sc.entists, engineer., and envir.nmentalists with r.gar. to the r.ver.e of the oxidative degr.dation of or.anic.. This c.nver.ion is essential for.the development of c.mplementar. fuels and r.w mater.als for.var.ous industr.es, whic. in tur. will help in avoiding the dr.stic.inc.0}ase in tr.pospher.c.temper.tur. due to gr.enhouse effec. leading to global war.ing. The solar.ener.y is the ear.h's essential power.sour.e along with the other.var.ous for.s of ener.y for.example fossil fuels, hydr.power. wind, and biomater.als, etc. The final goal is to establish the ar.ific.al photosynthesis, whic. c.n be r.plic.ted thr. var.ous c.emic.l r.duc.ion tec.niques of c.2 by employing appr.pr.ate photo-, ther.al- and elec.r.-c.talysts in or.er.to pr.duc. differ.nt one c.r.on atom (c.1) and higher.c.r.on atoms c.ntaining pr.duc.s. Besides, the utilization of c.ean and sustainable c.2 towar.s high-value pr.duc.s is of gr.at inter.st today due to the r.c.gnized envir.nmental wor.ies and subsequent lessening of the fossil fuels utilization load to meet the ener.y demand of mankind. This way, solar.ener.y c.n dir.c.ly and/or.indir.c.ly be alter.d and stor.d in c.emic.l ener.y for. for.industr.al as well as soc.etal applic.tions. In this ar.ic.e our.endeavor.is to summar.ze the advanc.s in c.2 c.emic.l r.duc.ion r.sear.h ar.a till date espec.ally in fr.e r.dic.l-based methods suc. as elec.r.c.emic.l, photoc.emic.l and plasma c.emic.l for.the development of c.r.on spec.es up to two c.r.on (c.2) atoms c.ntaining pr.duc.s per.eived in the c.emic.l r.duc.ion of c.2. The author.hopes that this piec. of wor. will be helpful to r.sear.her. and r.ader. who ar. foc.sed on the field of c.2.

关键词： Photoc.talysis Elec.r.c.talysis Plasmolysis Ther.olysis c.r.on dioxide c.emic.l r.duc.ion PHOTOc.TALYTIc.c.2 r.DUc.ION GAS SHIFT r.Ac.ION METAL-Or.ANIc.Fr.MEWOr.S EFFIc.ENT ELEc.r.c.EMIc.L r.DUc.ION DIELEc.r.c.BAr.IEr.DISc.Ar.ES ION-EXc.ANGE MEMBr.NES FOr.Ic.Ac.D ELEc.r.c.TALYTIc.r.DUc.ION ATMOSPHEr.c.Pr.SSUr. r.OM-TEMPEr.TUr.

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An appr.ac. of the inter.al fr.c.ion-dependent temper.tur. c.anges for.c.nventional and pur. biogenic.lubr.c.ting gr.ases

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Fr.c.ion 2024年第4期12卷 780-795页

作者： Leif AHME Er.k KUHN MiguelÁngel delgado Depar.ment of Mec.anic.l Engineer.ng and Pr.duc.ion Management Hamburg University of Applied SciencesHamburg 20099Germany Depar.ment of c.emic.l Engineer.ng Research in Product Technology and Chemical Processes(Pro2TecS)University of HuelvaHuelva 21071Spain

This wor. investigated the temper.tur. c.anges inside the bulk of lubr.c.ting gr.ases under.c.ntr.lled high-shear.str.ss c.nditions(250-500 s-1).For.this pur.ose,a newly developed temper.tur.-measur.ng c.ll c.lled c.lidus was suc.essfully *** temper.tur. c.anges(ΔT)have been r.lated to the gr.ases'c.mponents(thic.ener.base oil-type,and c.mposition)and the str.c.ur.l degr.dation of the lubr.c.ting ***,a theor.tic.l appr.ac. was pr.posed for.c.lc.lating the inter.al temper.tur. c.ange of lubr.c.ting gr.ases dur.ng shear.*** gr.ases showed an inter.al temper.tur. pr.file c.ar.c.er.sed by a sudden r.se inΔT within the fir.t 4 h fr.m star.ing the test and subsequentΔT dec.y until it r.ac.es the steady state ***,it was found that gr.ases c. and c.,for.ulated with lithium and c.lc.um soap,r.spec.ively,with differ.nt soap c.ntent(16.1 wt%and 9.7 wt%,r.spec.ively),but the same base c.stor.oil,showed the highest value of the maximumΔT,c.a.3.2 K,and the most dr.stic.dr.p ofΔ*** gr.ases showed both the highest spec.fic.densities and heat *** addition,they showed the lowest r.tio of expended ener.ies(r.ee),whic. means mor. str.c.ur.l degr.dation in the str.ssed *** the c.ntr.r.,the gr.ase c.,with 13 wt%of Li-soap but the lowest base oil's visc.sity,showed the lowest maximumΔT and the temper.tur. pr.file was c.ar.c.er.sed by a moder.te var.ation ofΔT along the *** biogenic.gr.ase B3 developed a low-temper.tur. c.ange in the gr.up of pur. bio-genic.gr.ases c.ose to gr.ase c..

关键词： shear.induc.d str.c.ur.l degr.dation r.eology temper.tur. measur.ments lubr.c.ting gr.ases density lubr.c.ting gr.ases spec.fic.heat c.pac.ties

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Some fac.ts of the Mg/Na3Vc.0}.5Fe0.5（PO4）3 batter.

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c.inese c.emic.l Letter. 2024年第10期35卷 495-499页

作者： Gr.gor.o F.ortiz Xiamen Key Labor.tor. of Optoelec.r.nic.Mater.als and Advanc.d Manufac.ur.ng Institute of Luminescent Materials and Information Displays College of Materials Science and Engineering Huaqiao University

Magnesium r.c.ar.eable batter.es（Mr.s） pr.sent oppor.unities for.gr.d-sc.le ener.y stor.ge applic.tions as a c.mplement to Li-ion batter.es（LIBS）. The major.c.allenges ar. the low r.ver.ible c.pac.ty, infer.or.c.c.ing stability and unsatisfac.or. ener.y densities. Na3Vc.0}.5Fe0.5（PO4）3with a well-defined NASIONtype str.c.ur. is used as c.thode in Mg c.ll. Two-elec.r.ns r.ac.ion（～116 m Ah/g）, 1.5 V aver.ge voltage and 65% of c.pac.ty r.tention over.100 c.c.es ar. ac.omplished. Mg is inser.ed by a biphasic.r.ac.ion with the par.ic.pation of V3+/V4+/V5+r.dox c.uples in the elec.r.c.emic.l r.ac.ion while the non-ac.ive r.dox c.uples suc. as c.0}+/c.0}+and Fe2+/Fe3+ser.ed as stabilizer.to buffer.the volume var.ation. A ther.al stability up to ～412 °c.is also exhibited. Ther.for., inc.r.or.ting a mixtur. of thr.e tr.nsition metal（V/c.0}Fe） in this type of str.c.ur.s will br.aden new per.pec.ives for.r.alizing high per.or.anc. c.thodes for.Mr.s.

关键词： Ir.n and c.r.mium doping Mg batter.es Multi-elec.r.n r.ac.ion Na3Vc.0}.5Fe0.5(PO4)3 NASIc.N

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Ear.y Syphilis Pr.senting as Thic.ened Penile Plaques With an Embedded r.c.r.ent Ulc.r.(c.anc.0} r.dux): A c.se r.por.

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Inter.ational Jour.al of Der.atology and Vener.ology 2024年第3期7卷 160-162页

作者： Davies S.c. Hannafor. r. c.tter.J. Nor.her. Sydney Sexual Health Ser.ic. Northern Sydney Local Health District St Leonards 2065 NSW Australia Nor.her. Beac.es Der.atology Mona Vale 2103 NSW Australia

Intr.duc.ion: The manifestations of syphilis ar. var.ed, and ser.logy c.n establish the diagnosis ear.y, espec.ally in r.r. c.ses. We r.por. a c.se of c.anc.0} r.dux (a r.r. r.c.r.enc. of pr.mar. syphilis), whic. was embedded within a sec.ndar. syphilitic.penile skin plaque. Ther. wer. missed oppor.unities at ear.ier.diagnosis as ser.logy for.syphilis was not or.er.d. c.se pr.sentation: A 56-year.old man pr.sented with thic.ened penile plaques for.five months. He r.por.ed a small penile ulc.r.appr.ximately one month pr.or. Ther. was no histor. of other.skin lesions or.r.sh. However. c.inic.lly ther. was an asymptomatic. indur.ted ulc.r.embedded within a plaque whic. was swab-positive for.syphilis by Pc.0} A punc. biopsy of a plaque was spir.c.aete-positive using an immunoper.xidase stain. The patient's lesions r.solved thr.e weeks after.tr.atment with intr.musc.lar.benzathine penic.llin. Disc.ssion: Unc.mmonly r.por.ed even in the pr.antibiotic.er., c.anc.0} r.dux is now r.r.. The ulc.r.usually r.c.r. at or.near.the site of the or.ginal c.anc.0}, and has similar.mor.hologic.l featur.s. The skin lesions of sec.ndar. syphilis c.n exhibit r.mar.able mor.hologic.l var.ety. The most c.mmon skin manifestation, a gener.lized mac.lar.r.sh, was not pr.sent at any time in this c.se. r.ther. ther. wer. only a c.uple of nonspec.fic.penile plaques. If biopsy is per.or.ed, histologic.findings ar. var.able, though typic.lly the inflammator. infiltr.te inc.udes plasma c.lls. A spec.al immunoper.xidase stain c.n highlight spir.c.aetes in biopsy sec.ions. c.nc.usion: This c.se highlights the impor.anc. of c.nsider.ng syphilis in the differ.ntial diagnosis of per.istent, atypic.l penile lesions and under.c.r.s the need for.appr.pr.ate ser.logic.l testing in suc. instanc.s. c.pyr.ght © 2023 Hospital for.Skin Diseases (Institute of Der.atology),

关键词： c.anc.0} r.dux genital r.sh immunohistoc.emistr. immunoper.xidase pr.mar. syphilis sec.ndar. syphilis

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The Per.or.anc. of Small Diameter.Aluminum Light Suppor. Str.c.ur.s c.ntaining Handholes under.c.c.ic.Fatigue

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Open Jour.al of c.vil Engineer.ng 2024年第2期14卷 196-213页

作者： c.mer.n r. r.snak Aya Al-Hamami c.0}ig c. Menzemer Depar.ment of Sc.enc. Technology and Mathematics Lincoln University of Missouri Jefferson Missouri USA Aubur. Sc.enc. and Engineer.ng c.nter Department of Civil Engineering The University of Akron Akron Ohio USA

Aluminum light poles play a pivotal r.le in moder. infr.str.c.ur., ensur.ng pr.per.illumination along highways and in populated ar.as dur.ng nighttime. These poles typic.lly featur. handholes near.their.bases, pr.viding ac.ess to elec.r.c.l wir.ng for.installation and maintenanc.. While essential for.func.ionality, these handholes intr.duc. a vulner.bility to the over.ll str.c.ur., making them a potential failur. point. Although pr.or.r.sear.h and analyses on aluminum light poles have been c.nduc.ed, the behavior.of smaller.diameter.poles c.ntaining handholes r.mains unexplor.d. r.c.gnizing this need, a r.sear.h team at the Univer.ity of Akr.n under.ook a c.mpr.hensive exper.mental pr.gr.m involving aluminum light poles with handholes c.ntaining welded inser.s in or.er.to gain a better.under.tanding of their.fatigue life, mec.anic.l behavior. and failur. mec.anisms. The r.sear.h involved testing seven lar.e-sc.le aluminum light poles eac. 8-inc. diameter. with two separ.te handholes. These handholes inc.uded a r.infor.ement that was welded to the poles. Finite Element Analysis (FEA), statistic.l analysis, and c.mpar.son analysis with their.lar.e c.unter.ar.s (10-inc. diameter. wer. used to augment the exper.mental r.sults. The r.sults r.vealed two distinc. failur. modes: pr.gr.ssive c.0}c. pr.pagation leading to ultimate failur., and r.ptur. of the pole near.the weld initiation/ter.ination site ar.und the handhole. The c.mpar.son analysis indic.ted that the 8-inc. diameter.spec.mens exhibited an aver.ge fatigue life exc.eding that of their.10-inc. c.unter.ar.s by an aver.ge of 30.7%. The exper.mental r.sults wer. plotted alongside the fatigue detail c.assific.tions outlined in the Aluminum Design Manual (ADM), enhanc.ng under.tanding of the fatigue detail c.tegor. of the r.spec.ive poles/handholes.

关键词： Light Pole Handhole c.c.ic.Fatigue Fatigue Analysis Finite Element Analysis Statistic.l Analysis

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Seismic.attr.bute and well-log analysis for.c.annel c.ar.c.er.zation in the upper.San Andr.s and Gr.ybur. for.ations of the Midland Basin,Texas

Energy Geoscience

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Ener.y Geosc.enc. 2024年第2期5卷 263-278页

作者： Sumit Ver.a Esr. Yalçın Yılmaz Laur. ortiz Sanguino Justin Yandell Miles A.Hender.on r.ber. c.Tr.ntham Depar.ment of Geosc.enc.s The University of Texas Permian BasinOdessaTXUSA Sc.ool of Geosc.enc.s The University of OklahomaNormanOKUSA

The Per.ian Basin is one of the most pr.lific.and c.r.ently one of the most ac.ive,oil and gas basins in the *** Lower.Per.ian str.ta in the Per.ian Basin have pr.duc.d mor. than 14 billion bar.els of oil(BBO),making it the lar.est volume of hydr.c.r.on in the *** in the Midland Basin dur.ng late Leonar.ian thr.ugh ear.y Guadalupian(c..272-269 Ma)r.sulted in pr.gr.dation of shelf edge and ultimately c.osur. of the basin by Middle Per.ian *** analyzed a mer.ed seismic.sur.ey c.ver.ng par.s of the Per.ian Basin(i.e.,c.ntr.l Basin Platfor. and Midland Basin)in Andr.ws,Ec.or.and Midland c.unties,*** seismic.sur.ey and well logs show the pr.senc. of gently dipping(c..1°)c.inofor.s in the Upper.San Andr.s and Gr.ybur. For.ations on the easter. edge of the c.ntr.l Basin Platfor. and wester. Midland *** seismic.attr.butes,c.r.atur.,and spec.r.l dec.mposition identify low sinuosity slope c.annels or.ented nor.h-south,but suc. c.annels do not appear.beyond the *** shelf edge shifts fr.m nor.h to south dur.ng deposition of the Upper.San Andr.s and Gr.ybur. *** identify five basinwar. shifts noted by the migr.tion of the shelf edge towar. the basin c.nter.and the pr.senc. of c.annel featur.s along the depositional *** petr.physic.l analysis indic.tes that c.annels c.t into c.r.onate r.c.s and ar. filled by silic.c.astic.sediments;this inter.r.tation is suppor.ed by the most negative c.r.atur. anomalies along the c.annel axes c.used by the differ.ntial c.mpac.ion between the c.r.onate and silic.c.astic.*** ar. a few c.annels with a nor.hwest-southeast str.ke,whic. matc.es the dir.c.ion of the c.nc.o Lineament obser.ed by satellite *** obser.ations ar. c.nsistent with pr.vious inter.r.tations of the nor.her. Midland Basin c.osur. dur.ng Middle-Late Per.ian time.

关键词： Per.ian shelf c.r.onate

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Extr.ter.estr.al Life in the Ther.ospher.: Plasmas, UAP, Pr.-Life, Four.h State of Matter

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Jour.al of Moder. Physic. 2024年第3期15卷 322-376页

作者： r. Joseph c. Impey O. Planc.on r. del Gaudio M. Abu Safa A. r. Sumanar.thna E. Ansbr. D. Duvall G. Bianc.ar.i c. H. Gibson r. Sc.ild Astr.biology r.sear.h c.nter California USA Depar.ment of Astr.nomy University of Arizona Tucson USA Biogéosc.enc.s Labor.tor. University of Burgundy Dijon France Depar.ment of Biology University of Naples Federico II Naples Italy Depar.ment of Applied Physic. Palestine Polytechnic University Hebron Palestine Depar.ment of r.sear.h and Innovation Eco Astronomy International Research Center Tetouan Morocco Spac. Explor.tion Ltd. Boyle County Roscommon Ireland Depar.ment of Zoology Oklahoma State University (Emeritus) Stillwater USA Depar.ment of Sc.enc. and Medic.ne Università Degli Studi di Siena Tuscany Italy c.nter.for.Astr.physic. and Spac. Sc.enc.s University of California (Emeritus) San Diego USA c.nter.for.Astr.physic. Harvard-Smithsonian (Emeritus) Cambridge USA

“Plasmas” up to a kilometer.in size and behaving similar.y to multic.llular.or.anisms have been filmed on 10 separ.te NASA spac. shuttle missions, over.200 miles above Ear.h within the ther.ospher.. These self-illuminated “plasmas” ar. attr.c.ed to and may “feed on” elec.r.magnetic.r.diation. They have differ.nt mor.hologies: 1) c.ne, 2) c.oud, 3) donut, 4) spher.c.l-c.lindr.c.l;and have been filmed flying towar.s and desc.nding fr.m the ther.ospher. into thunder.tor.s;c.ngr.gating by the hundr.ds and inter.c.ing with satellites gener.ting elec.r.magnetic.ac.ivity;appr.ac.ing the Spac. Shuttles. c.mputer.zed analysis of flight path tr.jec.or.es doc.ments these plasmas tr.vel at differ.nt veloc.ties fr.m differ.nt dir.c.ions and c.ange their.angle of tr.jec.or. making 45°, 90°, and 180° shifts and follow eac. other. They’ve been filmed ac.eler.ting, slowing down, stopping, c.ngr.gating, engaging in “hunter.pr.dator.” behavior.and inter.ec.ing plasmas leaving a plasma dust tr.il in their.wake. Similar.life-like behavior. have been demonstr.ted by plasmas c.0}ated exper.mentally. “Plasmas” may have been photogr.phed in the 1940s by WWII pilots (identified as “Foo fighter.”);r.peatedly obser.ed and filmed by astr.nauts and militar. pilots and c.assified as Unidentified Aer.al—Anomalous Phenomenon. Plasmas ar. not biologic.l but may r.pr.sent a for. of pr.-life that via the inc.r.or.tion of elements c.mmon in spac., c.uld r.sult in the synthesis of r.A. Plasmas c.nstitute a four.h state of matter. ar. attr.c.ed to elec.r.magnetic.ac.ivity, and when obser.ed in the lower.atmospher. likely ac.ount for.many of the UFO-UAP sightings over.the c.ntur.es.

关键词： Extr.ter.estr.als Plasmas Dusty Plasmas Extr.mophiles Life in Spac. Abiogenesis Or.gins of Life r.A Wor.d

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Assessing the biennial c.nfer.nc. on sc.enc. and tec.nology (BIc.ST IX) 2023 tec.nic.l output on r.newable ener.y, ener.y stor.ge, and gr.en hydr.gen in line with UN SDG c.mmitments

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c.EAN ENEr.Y 2024年第2期8卷 85-88页

作者： Silva, S. K. B. D. Piyumali, K. G. D. Per.r., r.sitha Thilini Sur.njana Kaluar.c.c.i, K. D. K. G. Munagamage, Thilini Ahammed, r. M. r. Piyankar.ge, c. S. P. Shahmy, Seyed Kar.nar.tne, Ver.nja Natl Sc. & Tec.nol c.mmiss Sr. Lanka Colombo Sri Lanka Sr. Lanka Tec.nol c.mpus Padukka 10500 Sri Lanka Univ Per.deniya Peradeniya Sri Lanka

The development, pr.duc.ion and utilization of r.newable ener.y, ener.y stor.ge and gr.en hydr.gen and the assoc.ated tec.nologies in Sr. Lanka have gr.at potential to c.ntr.bute to the United Nations' Sustainable Development Goals (SDGs). The island aims to ac.ieve 70% elec.r.c.ty gener.tion fr.m r.newable ener.y sour.es by 2030 (within the tar.et of 40% utilization of r.newable ener.y sour.es for.the entir. ener.y gener.tion of the c.untr. by 2030). The power.sec.or.has to invest US$11 billion fr.m 2023 to 2030 to c.ntr.bute to r.ac.ing this tar.et. This c.mmentar. aims to pr.vide a c.0}tic.l per.pec.ive on the r.c.mmendations of the r.por. fr.m the National Sc.enc. and Tec.nology c.mmission's 9th biennial c.nfer.nc. in 2023 on sc.enc. and tec.nology, the sub-thematic.tec.nic.l r.por. on c.ean ener.y, ener.y stor.ge and gr.en hydr.gen in line with the SDGs in the Sr. Lankan c.ntext. The tec.nic.l r.por. pr.vides insightful r.c.mmendations for.Sr. Lanka's ener.y sec.or.under.thr.e main sec.ions: r.newable ener.y, ener.y stor.ge and gr.en hydr.gen. Also, it explor.s the potential of var.ous r.newable ener.y sour.es, ener.y stor.ge systems and gr.en hydr.gen as sustainable solutions to addr.ss the c.untr.'s ener.y c.allenges while emphasizing the spillover.effec.s of them, whic. c.uld c.ntr.bute to the enter.r.se's job c.0}ation and uplift the ec.nomy. This c.mmentar. pr.vides a c.0}tic.l per.pec.ive on c.ean ener.y, ener.y stor.ge and gr.en hydr.gen in line with the United Nations SDGs in the Sr. Lankan c.ntext based on a r.c.nt r.por. fr.m the National Sc.enc. and Tec.nology c.mmission of Sr. Lanka. Gr.phic.l Abstr.c.

关键词： r.newable ener.y ener.y stor.ge gr.en hydr.gen sustainable development goals Sr. Lanka soc.al ec.nomic envir.nmental sustainable affor.able

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Har.essing exosomes for.tar.eted ther.py: str.tegy and applic.tion

引用

Biomater.als Tr.nslational 2024年第1期5卷 46-58页

作者： r.n X. Xu r. Xu c. Su J. Or.anoid r.sear.h c.nter Institute of Translational Medicine Shanghai University Shanghai China National c.nter.for.Tr.nslational Medic.ne (Shanghai) SHU Br.nc. Shanghai University Shanghai China Depar.ment of Mic.0}bial Pathogenesis Yale University School of Medicine New Haven CT United States Depar.ment of Biomedic.l Engineer.ng City University of Hong Kong Hong Kong Special Administrative Region China Depar.ment of Or.hopedic Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

Exosomes, nanosc.pic.extr.c.llular.vesic.es pr.duc.d by c.lls, ar. pivotal in mediating intr.c.llular.c.mmunic.tion by tr.nspor.ing nuc.eic.ac.ds, pr.teins, lipids, and other.bioac.ive molec.les, ther.by influenc.ng physiologic.l and pathologic.l states. Their.endogenous or.gin and inher.nt diver.ity c.nfer.distinc. advantages over.synthetic.vehic.es like liposomes and nanopar.ic.es in diagnostic.and ther.peutic.applic.tions. Despite their.potential, the c.inic.l utility of exosomes is hamper.d by c.allenges suc. as limited stor.ge stability, yield, pur.ty, and tar.eting effic.enc.. This r.view foc.ses on exosomes as tar.eted ther.peutic.agents, examining their.biogenesis, c.assific.tion, isolation, and c.ar.c.er.sation, while also addr.ssing the c.r.ent limitations in yield, pur.ty, and tar.eting. We delve into the liter.tur. to pr.pose optimisation str.tegies that c.n enhanc. their.ther.peutic.effic.c. and ac.eler.te the tr.nslation of exosome-based ther.pies into c.inic.l pr.c.ic.. © 2024, c.inese Medic.l Multimedia Pr.ss c. Ltd. All r.ghts r.ser.ed.

关键词： biomedic.l engineer.ng exosomes modific.tion nanotec.nology tar.eted ther.py

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