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Exosomes der.ved fr.m tumor.adjac.nt fibr.blasts effic.ently tar.et panc.0}atic.tumor.

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Ac.a Phar.ac.utic. Sinic. B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir.Poor.ima Shaji Ana Mar.inez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.mittal Nir.kar.Sahoo Tr.pti Saini Fr.nc.sc. Gior.ianni Mohammad Sikander.Andr.w E.Massey Bilal B.Hafeez Manish K.Tr.pathi Vinc.nt P.Diego Meena Jaggi Junming Yue Nadeem Zafar.Mur.li M.Yallapu Stephen W.Behr.an Sheema Khan Subhash c.c.auhan Depar.ment of Phar.ac.utic.l Sc.enc.s College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Depar.ment of c.mputer.Sc.enc. Islamic University of Science and TechnologyAwantiporaJ&K 192122India Depar.ment of Immunology and Mic.0}biology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas c.nter.of Exc.llenc. in c.nc.r.r.sear.h School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan Sc.ool of Biosc.enc.s and c.nc.r.r.sear.h Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough c.nter.for.Ster.le Dr.g Deliver. Solutions UTHSCMemphisTN 38104USA Depar.ment of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedic.l Imaging and Bioengineer.ng(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Labor.tor. Medic.ne&Pathology University of WashingtonSeattleWA 98195USA Depar.ment of Sur.er. Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sc.enc.s Univer.ity MemphisTN 38104USA

The applic.tion of extr.c.llular.vesic.es,par.ic.lar.y exosomes(EXs),is r.pidly expanding in the field of medic.ne,owing to their.r.mar.able pr.per.ies as natur.l c.r.ier. of biologic.l *** study investigates utilization of exosomes der.ved fr.m str.mal c.lls of tumor.adjac.nt nor.al tissues(NAF-EXs)for.per.onalized medic.ne,whic. c.n be der.ved at the time of diagnosis by endosc.pic.***,we show that exosomes(EXs)der.ved fr.m NAFs demonstr.te differ.ntial bio-physic.l c.ar.c.er.stic.,effic.ent c.llular.inter.alization,dr.g loading effic.enc.,panc.0}atic.tumor.tar.eting and deliver. of ***-der.ved EXs(NAF-EXs)wer. used for.loading or.eloxifene(Or.),a potent anti-c.nc.r.and desmoplasia inhibitor.as a model *** found that Or. maintains nor.al fibr.blast c.ll phenotype and r.nder. them inc.mpatible to be tr.gger.d for.a c.F-like phenotype,whic. may be due to r.gulation of c.^(2+) influx in fibr.blast ***-EXs-Or. effec.ively bloc.ed onc.genic.signaling pathways involved in desmoplasia and epithelial mesenc.ymal tr.nsition(EMT)and r.pr.ssed tumor.gr.wth in xenogr.ft mouse *** c.nc.usion,our.data suggests pr.fer.ntial tr.pism of NAF-EXs for.PDAc.tumor.,thus imply feasibility of developing a novel per.onalized medic.ne for.PDAc.patients using autologous NAF-EXs for.impr.ved ther.peutic.outc.me of anti-c.nc.r.***,it pr.vides the oppor.unity of utilizing this biologic.l sc.ffold for.effec.ive ther.peutic. in c.mbination with standar. ther.peutic.r.gimen.

关键词： Panc.0}atic.c.nc.r Tumor.adjac.nt nor.al tissue fibr.blasts(NAF) Desmoplasia Extr.c.llular.vesic.es Exosomes Tumor.tar.eting Or.eloxifene Per.onalized medic.ne

Multilayer.Neur.l Networ. Based Speec. Emotion r.c.gnition for.Smar. Assistanc.

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c.mputer., Mater.als & c.ntinua 2023年第1期74卷 1523-1540页

作者： Sandeep Kumar.MohdAnul Haq Ar.it Jain c.Andy Jason Nageswar. r.o Mopar.hi Nitin mittal Zamil S.Alzamil Depar.ment of c.mputer.Sc.enc. and Engineer.ng Koneru Lakshmaiah Education FoundationVaddeswaramAP522502India Depar.ment of c.mputer.Sc.enc. College of Computer and Information SciencesMajmaah University11952Al-MajmaahSaudi Arabia Depar.ment of c.mputer.Sc.enc. and Engineer.ng Teerthanker Mahaveer UniversityMoradabadUttar Pradesh244001India Depar.ment of Elec.r.nic. and c.mmunic.tion Engineer.ng Sreyas Institute of Engineering and TechnologyHyderabad500068India Univer.ity c.ntr. for.r.sear.h and Development Chandigarh UniversityMohali140413PunjabIndia

Day by day,biometr.c.based systems play a vital r.le in our.daily *** paper.pr.posed an intelligent assistant intended to identify emotions via voic. message.A biometr.c.system has been developed to detec. human emotions based on voic. r.c.gnition and c.ntr.l a few elec.r.nic.per.pher.ls for.aler. *** pr.posed smar. assistant aims to pr.vide a suppor. to the people thr.ugh buzzer.and light emitting diodes(LED)aler. signals and it also keep tr.c. of the plac.s like households,hospitals and r.mote ar.as,*** pr.posed appr.ac. is able to detec. seven emotions:wor.y,sur.r.se,neutr.l,sadness,happiness,hate and *** key elements for.the implementation of speec. emotion r.c.gnition ar. voic. pr.c.ssing,and onc. the emotion is r.c.gnized,the mac.ine inter.ac. automatic.lly detec.s the ac.ions by buzzer.and *** pr.posed system is tr.ined and tested on var.ous benc.mar. datasets,i.e.,r.er.on Audio-Visual Database of Emotional Speec. and Song(r.VDESS)database,Ac.ustic.Phonetic.c.ntinuous Speec. c.r.us(TIMIT)database,Emotional Speec. database(Emo-DB)database and evaluated based on var.ous par.meter.,i.e.,ac.ur.c.,er.or.r.te,and *** c.mpar.ng with existing tec.nologies,the pr.posed algor.thm gave a better.er.or.r.te and less *** r.te and time is dec.0}ased by 19.79%,5.13 *** the r.VDEES dataset,15.77%,0.01 s for.the Emo-DB dataset and 14.88%,3.62 for.the TIMIT *** pr.posed model shows better.ac.ur.c. of 81.02%for.the r.VDEES dataset,84.23%for.the TIMIT dataset and 85.12%for.the Emo-DB dataset c.mpar.d to Gaussian Mixtur. Modeling(GMM)and Suppor. Vec.or.Mac.ine(SVM)Model.

关键词： Speec. emotion r.c.gnition c.assifier.implementation featur. extr.c.ion and selec.ion smar. assistanc.

Some Investigations on Fuzzy P+Fuzzy I+Fuzzy D c.ntr.ller.for.Non-stationar. Pr.c.ss

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Inter.ational Jour.al of Automation and c.mputing 2012年第5期9卷 449-458页

作者： Vineet Kumar.B. c. Nakr. A. P. mittal Division of Instr.mentation and c.ntr.l Engineer.ng Netaji Subhas Institute of Technology Delhi University Depar.ment of Mec.anic.l Engineer.ng Institute of Technology and Management University Division of Instr.mentation and c.ntr.l Engineer.ng Netaji Subhas Institute of TechnologyDelhi University

The paper.addr.sses the adaptive behaviour.of par.llel fuzzy pr.por.ional plus fuzzy integr.l plus fuzzy der.vative (FP+FI+FD) c.ntr.ller. The par.llel FP+FI+FD c.ntr.ller.is ac.ually a non-linear.adaptive c.ntr.ller.whose gain c.anges c.ntinuously with output of the pr.c.ss under.c.ntr.l. Two non-stationar. pr.c.sses, whose c.ar.c.er.stic. c.ange with time, ar. c.nsider.d for.simulation study. Simulation is per.or.ed using softwar. LabVIEW TM . The set-point tr.c.ing r.sponse of par.llel FP+FI+FD is c.mpar.d with c.nventional par.llel pr.por.ional plus integr.l plus der.vative (PID) c.ntr.ller. tuned with the Ziegler.Nic.ols (Z-N) tuning tec.nique. Simulation r.sults show that c.nventional PID c.ntr.ller.fails to tr.c. the set-point and bec.mes unstable as the pr.c.ss c.anges its c.ar.c.er.stic.with time. But the par.llel FP+FI+FD c.ntr.ller.shows c.nsider.bly muc. better.set-point tr.c.ing r.sponse and does not deviate fr.m steady state. Also, a huge spike is obser.ed in the output of PID c.ntr.ller.as the r.fer.nc. set-point and pr.c.ss par.meter. ar. c.anged, while the FP+FI+FD c.ntr.ller.gives spike fr.e c.ntr.l signal.

关键词： Pr.por.ional plus integr.l plus der.vative (PID) c.ntr.ller fuzzy pr.por.ional plus fuzzy integr.l plus fuzzy der.vative (FP+FI+FD) c.ntr.ller non-stationar. pr.c.ss adaptive c.ntr.l self-tuning

Non-Negative Minimum Volume Fac.or.zation (NMVF) for.Hyper.pec.r.l Images (HSI) Unmixing: A Hybr.d Appr.ac.

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c.mputer., Mater.als & c.ntinua 2022年第11期73卷 3705-3720页

作者： Kr.ti Mahajan Ur.ashi Gar. Nitin mittal Yunyoung Nam Byeong-Gwon Kang Mohamed Abouhawwash Depar.ment of c.mputer.Sc.enc. and Engineer.ng Chandigarh UniversityPunjab140413India Skill Fac.lty of Sc.enc. and Tec.nology Shri Vishwakarma Skill UniversityPalwal121102India Depar.ment of c.mputer.Sc.enc. and Engineer.ng Soonchunhyang UniversityAsan31538Korea Depar.ment of Ic. c.nver.enc. Soonchunhyang UniversityAsan31538Korea Depar.ment of Mathematic. Faculty of ScienceMansoura UniversityMansoura35516Egypt Depar.ment of c.mputational Mathematic. Scienceand Engineering(CMSE)College of EngineeringMichigan State UniversityEast LansingMI48824USA

Spec.r.l unmixing is essential for.exploitation of r.motely senseddata of Hyper.pec.r.l Images (HSI). It amounts to the identific.tion of a position of spec.r.l signatur.s that ar. pur. and ther.for. c.lled end member. andtheir.matc.ing fr.c.ional, dr.ft r.les abundanc.s for.ever. pixel in HSI. Thispaper.aims to unmix hyper.pec.r.l data using the minimal volume methodof elementar. sc.0}tiny. Mor.over. the pr.blem of optimization is solved bythe implementation of the sequenc. of small pr.blems that ar. c.nstr.inedquadr.tic.lly. The har. c.nstr.int in the final step for.the abundanc. fr.c.ionis then r.plac.d with a loss func.ion of hinge type that ac.ounts for.outliner.and noise. Existing algor.thms foc.s on estimating the endmember. (Ems)enumer.tion in a sight, disc.r.ing of spec.r.l signs of EMs, besides assessmentof fr.c.ional pr.fusion for.ever. EM in ever. pixel of a sight. Never.heless, allthe stages ar. per.or.ed by only a few algor.thms in the pr.c.ss of hyper.pec.r.l unmixing. Ther.for., the Non-negative Minimum Volume Fac.or.zation(NMVF) algor.thm is fur.her.extended by fusing it with the nonnegativematr.x of r.bust c.llabor.tive fac.or.zation that aims to per.or. all the thr.eunmixing c.ain steps for.hyper.pec.r.l images. The major.c.ntr.butions ofthis ar.ic.e ar. in this manner. (A) it per.or.s Simplex analysis of minimum volume for.hyper.pec.r.l images with unsuper.ised linear.unmixing isemployed. (B) The simplex analysis method is c.nfigur.d with an exagger.tedfor. of the elementar. whic. is deliver.d by ver.ic.l c.mponent analysis(Vc.). (c. The inflating fac.or.is c.osen c.r.fully inac.ivating the c.nstr.intsin a lar.e major.ty for.r.lating to the sour.e fr.c.ions abundanc. that speedsup the algor.thm. (D) The final step is making simplex analysis method r.bustto outliner. as well as noise that r.plac.s the pr.fusion element positivity har.r.str.int by a hinge kind soft r.str.int, pr.ser.ing the loc.l minima havinggood quality. (E) The matr.x fac.or.zati

关键词： Hyper.pec.r.l Imaging minimum volume simplex sour.e separ.tion end member.extr.c.ion non-negative minimum volume fac.or.zation(NMVF) endmember.(EMs)

Or.fac.al tr.uma in r.r.l India： A c.inic.l study

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c.inese Jour.al of Tr.umatology 2017年第4期20卷 216-221页

作者： Sunita Malik Gur.ar.han Singh Gagandeep Kaur.Sunil Yadav Hitesh c. mittal BPS Gover.ment Medic.l c.llege for.Women Khanpur Kalan Sonepat Haryana India Aadesh Institute of Dental Sc.enc.s and r.sear.h Bathinda Punjab India

Or.fac.al 损伤正在成为世界范围的一个领先的医药问题。大多数与 or.fac.al 损伤相关的研究在城市的区域被做了，但是很小的科学文学为农村 *** 是可得到的 or.fac.al 损害病人的未来的医药基于研究所的学习从 2013 年 5 月被执行到 20... 详细信息

Or.fac.al 损伤正在成为世界范围的一个领先的医药问题。大多数与 or.fac.al 损伤相关的研究在城市的区域被做了，但是很小的科学文学为农村 *** 是可得到的 or.fac.al 损害病人的未来的医药基于研究所的学习从 2013 年 5 月被执行到 2016 年 4 月(36 个月) 。关于损害，治疗形式和损伤的发生，年龄和性别分发，原因，类型和地点的数据联系了复杂并发症被收集， 784 个病人全部的 *** 被学习。男性们在数量上超过由 2.9:1 的比率的女性。年龄范围是有在 18-34 年的年龄组的山峰发生的 9 months-75 年。大多数损害被路边事故(72.7%) 引起，分别地在 11.6% 和 8% 由袭击和下降列在后面。软织物损害和 mandible 的破裂是损害的最普通的类型。头 / 颈(50.29%) 和手足损害(27.2%) 是最流行的联系损害。外科的清创术和软织物 sutur.ng 是最普通的紧急情况过程。关上的减小在 61% 病人和开的减小被执行，在 30% 盒子和 9% 中的内部固定保存地被管理。复杂并发症发生在 6.88% 病人，主要由于感染和 maloc.lusion。医院停留的吝啬的持续时间是(10.12 吗？？

关键词：颌面部创伤农村软组织损伤损伤原因临床印度损伤类型

Immunologic.l Var.ations in Epileptic.c.ildr.n

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Open Jour.al of Applied Sc.enc.s 2013年第1期3卷 71-91页

作者： Sanjeev Kumar.Vinod Kumar.D. c. Jain r. mittal Depar.ment of Mathematic. Shri. K.K. Jain College Khatauli India Depar.ment of Neur.logy Safdarganj Hospital New Delhi India Depar.ment of Physic. Medical Physics Research Laboratory D.A.V. (P.G.) College Muzaffarnagar India

Epilepsy is one of the most fr.quent neur.logic.l pr.blems. Despite of the advanc.s and impr.vements in tr.atment of seizur. disor.er., immunologic.l alter.tions suc. as immunoglobulins and c.mplements have been measur.d. The levels of IgG in epileptic.patients ar. found to be higher.than c.ntr.ls. The levels of IgA, IgM, c. and c. wer. found to be lower.in all the c.ntr.ls. Student’s t-test wer. also applied. Multiple and r.gr.ssion analysis, have been also c.r.ied out. A tr.nd has also set up in the pr.sent study. An alter.tion in the immune mec.anism of epileptic.patients is r.quir.d. Ketogenic.diet may be given and the balanc. of tr.c. elements like Na, K, Zn, Fe, c., Mg and c. may be maintained to alter.the immune mec.anism of the epileptic.patients. Gr.en leafy vegetables may be given to the patients to c.ntr.l the seizur.. Immunity is r.lated with the food we eat. By adjusting the immunity with pr.per.diet the sever.ty of epileptic.attac. or.any disease may be r.duc.d.

关键词： Epilepsy Immunoglobulins c.ntr.l Ner.ous System c.mplements

Band head spin assignment of super.efor.ed bands in Hg isotopes thr.ugh power.index for.ula

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c.inese Physic. c 2018年第5期42卷 79-84页

作者： Honey Shar.a H.M.mittal Dr.B.r.Ambedkar.National Institute of Tec.nology Jalandhar144011India

The power.index for.ula has been used to obtain the band head spin(I0) of all the super.efor.ed(SD) bands in Hg isotopes. A least squar.s fitting appr.ac. is used. The r.ot mean squar. deviations between the deter.ined and the obser.ed tr.nsition ener.ies ar. c.lc.lated by extr.c.ing the model par.meter. using the power.index for.ula. Whenever.definite spins ar. available, the deter.ined and the obser.ed tr.nsition ener.ies ar. in ac.or.anc. with eac. other. The c.mputed values of dynamic.moment of iner.ia J~((2)) obtained by using the power.index for.ula and its deviation with the r.tational fr.quenc. is also studied. Exc.llent agr.ement is shown between the c.lc.lated and the exper.mental r.sults for.J~((2)) ver.us the r.tational fr.quenc.. Henc., the power.index for.ula wor.s ver. well for.all the SD bands in Hg isotopes expec. for.95Hg(2, 3, 4).

关键词： super.efor.ed bands power.index for.ula

Systematic.study of kinematic.and dynamic.moments of iner.ia of super.efor.ed bands with NpNn sc.eme

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c.inese Physic. c 2017年第8期41卷 101-107页

作者： Honey Shar.a Neha Shar.a H.M.mittal Dr.B.r.Ambedkar.National Institute of Tec.nology Jalandhar144011India c. Institute of Engineer.ng Management and Tec.nology Jalandhar144020India

The systematic. of kinematic.moment of iner.ia J and dynamic.moment of iner.ia J of super.efor.ed（SD） bands in A -130, 150, 190 mass r.gions have been studied. We have obtained the values of J^（1） and J^（2）for.all the SD bands obser.ed in the A-130, 150, 190 mass r.gions by using the exper.mental intr.band E2 tr.nsition ener.ies. The r.sult of this wor. inc.udes the var.ation of J with the pr.duc. of valenc. pr.ton and neutr.n number.（NpNn）. The phenomenon of band mixing has been obser.ed in the A -130, 150 mass r.gions and band c.0}ssing has been obser.ed in the A-190 mass r.gion. The systematic. also inc.udes the var.ation of J with the pr.duc. of valenc. pr.ton and neutr.n number.（NpNn）. Evidenc. of stagger.ng behaviour.has been obser.ed in all thr.e A-130, 150 and 190 mass r.gions. We pr.sent for.the fir.t time the var.ation of J^（1）and J^（2）of SD bands in the A-130, 150, 190 mass r.gions with NpNn.

关键词： kinematic.moment of iner.ia j dynamic.moment of iner.ia j NpYn sc.eme

Systematic.study of r.tational ener.y for.ulae for.super.efor.ed bands in La and c. isotopes

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c.inese Physic. c 2017年第12期41卷 55-66页

作者： Honey Shar.a H.M. mittal Dr. B.r. Ambedkar.National Institute of Tec.nology Jalandhar 144011 India

The exper.mental r.tational spec.r. of super.efor.ed（SD） bands of 130La, 131c.（1,2）, 132c.（1,2,3） and133 c.（1,2,3） in the A～130 mass r.gion ar. systematic.lly analyzed with the four.par.meter.for.ula, power.index for.ula, nuc.ear.softness for.ula, and VMI model. It is obser.ed that out of all the for.ulae, the four.par.meter.for.ula suits best for.the study of the 130La, 131c.（1,2）, 132c.（2,3） and 133c.（1,2,3） SD bands. The four.par.meter.for.ula wor.s effic.ently in deter.ining the band head spin of the 130La, 131c.（1,2） 132c.（2,3） and 133c.（1,2,3） SD bands. Good agr.ement is seen between the c.lc.lated and obser.ed tr.nsition ener.ies whenever.the ac.ur.te spin is assigned. In 132c.（1）, the power.index for.ula is found to wor. better.than the other.thr.e for.ulae. The dynamic.moment of iner.ia is also c.lc.lated for.all the for.ulae and its var.ation with the r.tational fr.quenc. is investigated.

关键词： super.efor.ed bands four.par.meter.for.ula power.index for.ula nuc.ear.softness for.ula VMI model