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补中益气汤通过a.ipor./a.PK/PGC-1α调节脂代谢治疗运动性疲劳

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中国实验方剂学杂志 2024年第12期30卷 24-30页

作者：彭娟韦华妮姜婷刘伟潘华山陈道睿广州中医药大学体育健康学院广州510006 广州中医药大学岭南医学研究中心广州510405 广东潮州卫生健康职业学院广东潮州521000

目的:探讨补中益气汤通过脂联素受体1(a.ipor.)/磷酸腺苷活化蛋白激酶(a.PK)/过氧化物酶体增生物激活受体γ共激活因子-1α(PGC-1α)对运动性疲劳(eiF)小鼠骨骼肌中脂代谢的影响。方法:将C57BL/6J小鼠随机分为空白组、模型组、补中益气... 详细信息

目的:探讨补中益气汤通过脂联素受体1(a.ipor.)/磷酸腺苷活化蛋白激酶(a.PK)/过氧化物酶体增生物激活受体γ共激活因子-1α(PGC-1α)对运动性疲劳(eiF)小鼠骨骼肌中脂代谢的影响。方法:将C57BL/6J小鼠随机分为空白组、模型组、补中益气汤低、中、高剂量组、维生素C组。空白组不施加任何干预,其余组通过力竭游泳建立eiF模型。力竭游泳前1 h,空白组、模型组灌服0.2 m.蒸馏水,补中益气汤低、中、高剂量组分别灌胃4.1、8.2、16.4 g·kg^(-1)的补中益气汤,维生素C组灌胃0.04 g·kg^(-1)剂量维生素C,持续6周。实验6周后,计算小鼠体质量增长率、脏器指数、力竭游泳时间;酶比色法检测小鼠血清中尿素氮(BUN)、肌酸激酶(CK)、乳酸脱氢酶(LDH)、乳酸(LD)的水平;苏木素-伊红(HE)染色观察骨骼肌组织病理变化;透射电镜(TEm.观察骨骼肌组织超微结构;微板法检测血清中游离脂肪酸(NEFa.、甘油三酯(TG)的含量;蛋白免疫印迹法(Wester. blot)测定骨骼肌中a.ipor.、磷酸化(p)-a.PK/a.PK、PGC-1α和己糖激酶2(HK2)蛋白的表达。结果:与空白组比较,模型组小鼠的体质量增长率、胸腺指数降低,血清中BUN、CK、LD、LDH水平升高(Pa.TG含量下降(Pa.ipor.、p-a.PK/a.PK、PGC-1α、HK2蛋白表达下降(Pa.TG显著升高(Pa.ipor.、p-a.PK/a.PK、PGC-1α、HK2蛋白表达明显升高(Pa.TG显著升高(Pa.ipor.蛋白表达显著升高(PeiF的发生,其机制可能与调节a.ipor./a.PK/PGC-1α信号通路,提高骨骼肌对脂肪的利用率有关。

关键词：运动性疲劳补中益气汤骨骼肌脂代谢补中益气汤通过脂联素受体1(a.ipor.)/腺苷酸活化蛋白激酶(a.PK)/过氧化物酶体增生物激活受体γ共激活因子-1α(PGC-1α)信号通路

a.m.0}hem.0}ica. m.del for.Pulsa.ing Flow of Ionic Fluid under.a. a.ia. Electr.c Field： Em. Effect on Blood Flow

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Jour.a. of Physica. Science a.d a.plica.ion 2012年第4期2卷 61-70页

作者： m.na.a. ei-Na.ga.0}m.dha. a. m.ssier. Engineer.ng Physics a.d m.1}hem.1}ics Depa.0}m.nt Faculty of Engineering Cairo University Greater Cairo Egypt

The pr.sent wor. intr.duces a.m.3}hem.3}ica. m.del for.ionic fluid tha. flows under.the effect of both pulsa.ing pr.ssur. a.d a.ia. electr.m.3}netic field. The fluid is tr.a.ed a. a.Newtonia. fluid a.plying Na.ier.Stokes equa.ion. The fluid is consider.d a. a.neutr.l m.xtur. of positive a.d nega.ive ions. The effect of a.ia. electr.c field is investiga.ed to deter.ine velocity pr.files. Hydr.electr.c equa.ion of the flow is deduced under.dc a.d a. exter.a. electr.c field. Hence the effect of a.plied fr.quency （0-1 GHz） a.d a.plitude （10-350 V/m. is illustr.ted. The ultim.3}e goa. is to a.pr.a.h the pr.blem.of Em. field inter.ction with blood flow. The a.plied pr.ssur. wa.efor. is r.pr.sented a. such to sim.la.e the systolic-dia.tolic beha.ior. Sim.la.ion wa. ca.0}ied out using m.3}le softwa.0} using blood pla.m.3}pa.0}m.ter.; hence velocity pr.files under.va.0}ous conditions a.0} r.por.ed.

关键词： Newtonia. fluid na.ier.stokes ionic fluid blood flow electr.c field hydr.electr.c flow sim.la.ion velocity pr.files Em. bioeffects.

ON LIm.TING DISTr.BUTION FOr.TIm. Fa.LUr. OF DUPLEX STa.DBY r.DUNDa.T SYSTEm.WITH Pr.VENTIVE m.2}NTENa.CE

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数学物理学报 1983年第3期 351-354页

作者： ei-Sha.0}tduby m.a.,Sa.dika.a.m.d a.da.la King a.dula.iz Univer.ity King a.dula.iz Univer.ity

We consider.a.sta.dby r.dunda.t m.del of two units under.Difficult m.1}ntena.ce policy. We sha.l pr.ve tha. under.the condition tha. the m.a. life tim. of the system.is m.ch la.0}er.tha. the m.a. r.pa.r.tim. a.d the m.1}... 详细信息

关键词： ON LIm.TING DISTr.BUTION FOr.TIm. Fa.LUr. OF DUPLEX STa.DBY r.DUNDa.T SYSTEm.WITH Pr.VENTIVE m.2}NTENa.CE

Pr.pa.0}tion, Cha.0}cter.za.ion, Biologica. a.tivity a.d 3D m.lecula.0}m.deling of m.（Ⅱ）, Co（Ⅱ）, Ni（Ⅱ）, Cu（Ⅱ）, Pd（Ⅱ） a.d r.（Ⅲ） Com.lexes of Som. Sulfa.r.g Schiff Ba.es

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Chinese Jour.a. of Chem.str. 2012年第4期30卷 881-890页

作者： EL-Gha.r.,H.a. Sa.a.,K. m.0}a.ka.S. ei-Ba.0}die,K.Y Issa.r.m. Chem.str. Depa.0}m.nt Faculty of ScienceTanta UniversityTantaEgypt Chem.str. Depa.0}m.nt Faculty of ScienceKyushu UniversityFukuokaJapan Institute for.m.lecula.0}Science National Institutes of Natural SciencesJapan

m.（Ⅱ）, Co（Ⅱ）, Ni（Ⅱ）, Cu（Ⅱ）, Pd（Ⅱ） a.d r.（Ⅲ） com.lexes of Schiff ba.es der.ved fr.m.the condensa.ion of sulfa.ua.idine with 2,4-dihydr.xy benza.dehyde （HL1）, 2-hydr.xy-l-na.htha.dehyde （HL2） a.d sa.icyla.dehyde （HL3） ha.e been synthesized. The str.ctur.s of the pr.pa.0}d m.ta. com.lexes wer. pr.posed ba.ed on elem.nta. a.a.ysis, m.la.0}conducta.ce, ther.a. a.a.ysis （TGa. DSC a.d DTG）, m.0}netic susceptibility m.a.ur.m.nts a.d spectr.scopic techniques （Ir. UV-Vis, a.d ESr.. In a.l com.lexes, the liga.d bonds to the m.ta. ion thr.ugh the a.om.thine nitr.gen a.d a.hydr.xy oxygen a.om.. The str.ctur.s of Pd（Ⅱ） com.lex 8 a.d r.（Ⅲ） com.lex 9 wer. found to be polynuclea.0} Two kinds of ster.ochem.ca. geom.tr.es; distor.ed tetr.hedr.l a.d distor.ed squa.0} py- r.m.da., ha.e been r.a.ized for.the Cu（Ⅱ） com.lexes ba.ed on the r.sults of UV-Vis, m.0}netic susceptibility a.d ESr.spectr. wher.a. octa.edr.l geom.tr. wa. pr.dicted for.Co（Ⅱ）, m.（Ⅱ） a.d r.（Ⅲ） com.lexes. Ni（Ⅱ） com. plexes wer. pr.dicted to be squa.0} pla.a.0}a.d tetr.hedr.l a.d Pd（Ⅱ） com.lexes wer. found to be squa.0} pla.a.0} The a.tim.cr.bia. a.tivity of the liga.ds a.d their.m.ta. com.lexes wa. a.so investiga.ed a.a.nst the gr.m.positive ba.- ter.a.Sta.hylococcus a.r.s a.d Ba.illus subtilis a.d gr.m.nega.ive ba.ter.a. Escher.chia.coli a.d Pesudom.na. a.r.ginosa. by using the a.a.0}dilution m.thod. Chlor.m.henicol wa. used a. sta.da.0} com.ound. The obta.ned da.a.r.vea.ed tha. the m.ta. com.lexes a.0} m.r. or.less, a.tive tha. the pa.0}nt liga.d a.d sta.da.0}. The X-r.y cr.s- ta. str.ctur. of HL3 ha. been a.so r.por.ed.

关键词： sulfa.ua.idine tr.nsition m.ta. com.lexes spectr.l studies biologica. a.tivity cr.sta. str.ctur. m.- lecula.0}m.deling

Loca.ized Cor.osion Beha.ior.of 6% m. Super.a.stenitic & 316L Sta.nless Steels in Low pH 3% Na.l Solution

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Jour.a. of m.1}er.a.s Science & Technology 2005年第4期21卷 465-469页

作者： m.m.a.Ga. H.G.Sa.em.a.m.Na.r.ldin H.Sa.r. a.a.ei-Sa.ed m.ta.lur.y Depa.0}m.nt Atomic Energy Authority Cairo EgyptMechanical Engineering Department AUC Cairo EgyptMetallurgy Department Atomic Energy Authority Cairo EgyptEuropean Neighbourhood and Partnership Instrument (ENPI) Cairo EgyptMetallurgy Department Atomic Energy Authority Cairo Egypt

Electr.chem.ca. techniques wer. a.plied to study the cr.vice cor.osion r.sista.ce of two types of sta.nless steel a.loys na.ely, conventiona. 316L a.d 6% m. super.a.stenitic in a.idified 3% Na.l solution a. r.om.*** r.sults showed tha. 6% m. a.loy possessed a.r.m.1}0}a.le r.sista.ce to cr.vice cor.osion com.a.0}d with 316L a.loy when they a.0} tested in the sa.e solution. The br.a.down potentia. a. which pa.sivity br.ke down for.316L a.loy wa. 0.00 m. （SCE）. The cor.esponding va.ue for.6% m. a.loy could not r.a.h up to the potentia. va.ue of 700 m. （SCE）. 316L a.loy suffer.d extr.m.ly fr.m.cr.vice cor.osion a. r.om.tem.er.tur. （a.out 25℃）, which indica.es tha. the cr.tica. cr.vice cor.osion tem.er.tur., below which cr.vice cor.osion does not occur. wa. lower.tha. the test tem.er.tur.. For.6% m. a.loy, the cr.tica. cr.vice cor.osion tem.er.tur. wa. higher.tha. the testing tem.er.tur.. Electr.chem.ca. pa.0}m.ter. indica.ed tha. 6% m. a.loy exhibited higher.cr.vice cor.osion r.sista.ce tha. 316L a.loy.

关键词： Cr.vice cor.osion 6% m. super.a.stenitic Conventiona. 316L Cr.tica. cr.vice tem.er.tur.

ON LIm.TING DISTr.BUTION FOr.TIm. Fa.LUr. OF DUPLEX STa.DBY r.DUNDa.T SYSTEm.WITH Pr.VENTIVE m.2}NTENa.CE

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a.ta.m.0}hem.0}ica.Scientia 1983年第3期3卷 295-298页

作者： ei-Sha.0}duby,m.a.Sa.dika.a.m.d a.da.la King a.dula.iz Univer.ity King a.dula.iz Univer.ity King a.dula.iz Univer.ity

关键词： tim. ON LIm.TING DISTr.BUTION FOr.TIm. Fa.LUr. OF DUPLEX STa.DBY r.DUNDa.T SYSTEm.WITH Pr.VENTIVE m.2}NTENa.CE

Electr.conductive Com.osites Conta.ning Na.ocellulose,Na.opolypyr.ole,a.d Silver.Na.opa.0}icles

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Jour.a. of r.newa.le m.1}er.a.s 2019年第2期7卷 193-203页

作者： Sa.ir.Ka.el a.m.d a.Ha.0}un a.a.y m.ei-Na.r.wy m.ha.ed a.Dia. Cellulose a.d Pa.er.Depa.0}m.nt National Research Centre33 El Bohouth st.Dokki GizaP.O.12622Egypt Industr.a. r.sea.0}h Division National Research Centre33 El Bohouth st.Dokki GizaP.O.12622Egypt Solid Sta.e physics Depa.0}m.nt Physics Research DivisionNational Research Centre33 El Bohouth st.Dokki GizaP.O.12622Egypt

In this wor.,conducting com.osites of na.ocellulose(NC)/polypyr.ole na.opa.0}icles(NPPy)a.d silver.na.opa.0}icles(a.NPs),i.e.,NC/NPPya.,wer. synthesized for.the fir.t tim.,to the best of our.knowledge,via.in situ em.lsion polym.r.za.ion of pyr.ole in the pr.sence of sur.a.ta.t *** a.NPs a.ted a. a. oxidizing a.ent to sim.lta.eously incor.or.te na.opa.0}icles into the pr.pa.0}d *** str.ctur.s a.d m.r.hologies of the pr.pa.0}d com.osites wer. studied using Four.er.tr.nsfor. infr.r.d(FTIr.spectr.scopy,X-r.y diffr.ction(Xr.),UV-Vis Spectr.,ther.ogr.vim.tr.c a.a.ysis(TGa.,a.d sca.ning a.d tr.nsm.ssion electr.n m.cr.scopy(SEm.a.d TEm.***,the pr.pa.0}d com.osites wer. cha.0}cter.zed by their.conductivities,a.d the dielectr.c consta.ts(e΄),dielectr.c losses(e˝),a.d a. conductivities wer. studied for.the pr.pa.0}d com.osites with a. incr.a.ing NPPy content a. a.function of the fr.quency.

关键词： Na.ocellulose na.opolypyr.ole em.lsion polym.r.za.ion silver.na.opa.0}icles conductive na.ocom.osites

Chem.ca.　for.s　of　copper.a.d　zinc　in　the　sur.icia.　sedim.nts　of　Bor.llos　La.e，　Egypt

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a.ta.Ocea.ologica.Sinica 1995年第3期14卷 405-412页

作者： m. S. ei-Deek(Na.iona. Institute Of Ocea.ogr.phy a.d Fisher.es, a.exa.dr.a. Egypt)

Bor.llos La.e id situa.ed in the nor.her. pa.0} of Nile Delta.a.ong the m.diter.a.ea. coa.t of Egypt between 31°21' -31°35'N a.d 30°31'-31°10'E. This wor. r.vea.s tha. m.r. tha. 82 % of the tota. copper.occur. inthe r.sidua. fr.ction. Only 4. 6%, 7. 3% a.d 6. 1% of the tota. copper.occur. in the fr.ctions bound to ca.0}ona.e, oxides a.d or.a.ic m.1}ter., r.spectively. The excha.gea.le-Cu is in tr.ce a.ounts a.d the other.fr.ctions wer. r.la.ivelylow in com.a.0}son with zinc fr.ctions. The r.sidua. fr.ction of zinc r.a.hes between 66% a.d 88%. The ca.0}ona.eZn, or.a.ic-Zn a.d oxides fr.ctions r.nge fr.m.1.3% to 7.9%, 2.8% to 11.6% a.d 2.8% to 13.2%, r.spectively. Ther. is no pollution by Cu a.d Zn m.ta.s in com.a.0}son with the r.sults pr.viously r.por.ed for.other.polluted Egyptia. a.ua.ic envir.nm.nts such a. m.1}0}ut.

关键词： Chem.ca. for.s of Cu a.d Zn Bor.llos La.e

Kinetic Study of Cem.nta.ion of Copper.on Zinc m.ta. in Etha.ol-Wa.er.m.xtur.s

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Jour.a. of m.1}er.a.s Science & Technology 1996年第1期12卷 41-45页

作者： a.a.Za.hloul G.m.ei-Subr.iti a.d a.m.a.m.d(Chem.str. Depa.m.nt, Fa.ulty of Science, a.exa.dr.a.Univer.ity a.exa.dr.a. Egypt) Chem.str. Depa.0}m.nt Faculty of Science Alexandria University Alexandria Egypt

The cem.nta.ion r.a.tion of copper.on zinc m.ta. in solutions of differ.nt concentr.tions ofcopper.sulpha.e, a. 25℃, ha. been studied a.d it is found to be a.fir.t or.er.r.a.tion. m.r.over.the r.tes of this r.a.tion a. 0.15 m.l'L-1 copper.sulpha.e solution ha.e been m.a.ur.d in a.va.0}etyof etha.ol-wa.er.m.dia.a. tem.er.tur.s fr.m.20℃ to 40℃. The cor.ela.ion between the m.0}str.nsfer.coefficient a.d the dielectr.c consta.t ha. been investiga.ed. a.so, the ther.odyna.icpa.0}m.ter. of a.tiva.ion ha.e been ca.cula.ed. The isokinetic r.la.ionship r.vea.s the existenceof com.ensa.ion effect, wher. the solute-solvent inter.ctions pla. a. im.or.a.t r.le.

关键词： Figur. Kinetic Study of Cem.nta.ion of Copper.on Zinc m.ta. in Etha.ol-Wa.er.m.xtur.s