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Nonalcoholic fatty liver disease and mitochondrial dysfunction

World Journal of Gastroenterology 2008年第2期14卷 193-199页

作者： Yongzhong Wei r scott rector John P Thyfault Jamal A Ibdah Division of Gastroenterology and Hepatology Harry S. Truman VA MedicalCenter Columbia MO 65212 United States Division of Gastroenterology and Hepatology Department of Nutritional Sciences University of Missouri-Columbia Harry S. Truman VA Medical Center Columbia MO65212 United States

Nonalcoholic fatty liver disease (NAFLD) includes hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. NAFLD is the most common liver disorder in the United States and worldwide. Due to the rapid rise of the metabolic syndrome, the prevalence of NAFLD has recently dramatically increased and will continue to increase. NAFLD has also the potential to progress to hepatocellular carcinoma (HCC) or liver failure. NAFLD is strongly linked to caloric overconsumption, physical inactivity, insulin resistance and genetic factors. Although significant progress in understanding the pathogenesis of NAFLD has been achieved in years, the primary metabolic abnormalities leading to lipid accumulation within hepatocytes has remained poorly understood. Mitochondria are critical metabolic organelles serving as "cellular power plants". Accumulating evidence indicate that hepatic mitochondrial dysfunction is crucial to the pathogenesis of NAFLD. This review is focused on the significant role of mitochondria in the development of NAFLD.

关键词：非酒精性脂肪肝肝功能紊乱线粒体脂肪酸氧化

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Non-alcoholic fatty liver disease and the metabolic syndrome:An update

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World Journal of Gastroenterology 2008年第2期14卷 185-192页

作者： r scott rector John P Thyfault Yongzhong Wei Jamal A Ibdah Division of Gastroenterology and Hepatology University of Missouri Columbia MO 65212 United States Division of Gastroenterology and Hepatology Harry S. Truman Memorial Veterans Medical Center andDepartments of Nutritional Sciences University of MissouriColumbia MO 65212 United States Division of Gastroenterology and Hepatology Harry S. Truman Memorial Veterans Medical Center Universityof Missouri Columbia MO 65212 United States Division of Gastroenterology and Hepatology Harry S. Truman Memorial Veterans Medical Center andDepartments of Medical Pharmacology and PhysiologyUniversity of Missouri Columbia MO 65212 United States

Sedentary lifestyle and poor dietary choices are leading to a weight gain epidemic in westernized countries, subsequently increasing the risk for developing the metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). NAFLD is estimated to affect approximate 30% of the general US population and is considered the hepatic manifestation of the metabolic syndrome. recent findings linking the components of the metabolic syndrome with NAFLD and the progression to nonalcoholic steatohepatitis (NASH) will be reviewed; in particular, the role of visceral adipose tissue, insulin resistance, and adipocytokines in the exacerbation of these conditions. While no therapy has been proven effective for treating NAFLD/NASH, common recommendations will be discussed.

关键词：非酒精性脂肪肝代谢综合症胰岛素抵抗饮食习惯

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