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Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications

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research 2023年第2期2023卷 577-581页

作者： Sha Li Nan Li Jie He runxin Zhou Zhimin Lu Yizhi Jane Tao Yusong r.guo Yugang Wang Department of Biochemistry and Molecular Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Neurosurgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Zhejiang University School of Medicine HangzhouZhejiang 310029China Department of Bioscience Rice UniversityHoustonTX 77005USA Cell Architecture research Center Huazhong University of Science and TechnologyWuhanHubei 430030China

Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases(HATs)advance our understandings in the regulation of histone ***,the molecular basis of HATs selecting acyl coenzyme A(acyl-CoA)substrates for histone modification is less *** here report that lysine acetyltransferase 2A(KAT2A)as an illustrative instance of HATs can selectively utilize acetyl-CoA,propionyl-CoA,butyryl-CoA,and succinyl-CoA to directly deposit 18 histone acylation hallmarks in *** analyzing the co-crystal structures of the catalytic domain of KAT2A in complex with acetyl-CoA,propionyl-CoA,butyryl-CoA,malonyl-CoA,succinyl-CoA,and glutaryl-CoA,we conclude that the alternative substrate-binding pocket of KAT2A and the length and electrostatic features of the acyl chain cooperatively determine the selection of the acyl-CoA substrates by *** study reveals the molecular basis underlying the pluripotency of HATs that selectively install acylation hallmarks in nucleosomes,which might serve as instrumental mechanism to precisely regulate histone acylation profiles in cells.

关键词： utilize selecting electrostatic

Effect of environments and normal loads on tribological properties of nitrided Ni(45)(FeCoCr)(40)(AlTi)(15)high-entropy alloys

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Journal of Materials Science & Technology 2020年第7期42卷 85-96页

作者： L.W.Lan X.J.Wang r.P.guo H.J.Yang J.W.Qiao research Center for High-Entropy Alloys College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan030024China

The tribological properties of nitrided Ni(45)(FeCoCr)(40)(AlTi)(15)high-entropy alloys(HEAs)were investigated in air and simulated acid rain under different normal loads(5,7,10,and 12 N)at ambient *** results revealed that as-cast HEAs were only composed of FCC phase,while the volume fraction of FCC phase in the nitrided alloys was significantly ***,the hard phases of AIN,CrN,Fe4 N,and TiN phases were formed in the nitrided *** thickness of the nitriding layer was about 8.4μ*** hardness increased from 8.7 GPa in as-cast alloys to 14.5 GPa in the nitrided *** addition,under the same conditions,the friction coefficient of the nitrided alloys was higher than that of as-cast alloys,but the wear rate was generally lower than that of as-cast ***,the wear rate of the nitrided alloys was the lowest in acid rain due to the lubrication,cleaning,and cooling in the liquid *** air,dominating wear mechanisms in as-cast and nitrided alloys were abrasive,delamination,and adhesive ***,the wear mechanism of as-cast and nitrided alloys in acid rain was mainly abrasive and corrosion wears.

关键词： Abrasive wear Hardness Corrosive wear Microstructure Wear mechanism

Moisture Analysis of a Squall Line Case Based on Precipitable Water Vapor Data from a Ground-Based GPS Network in the Yangtze river Delta

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Advances in Atmospheric Sciences 2007年第3期24卷 409-420页

作者：丁金才杨引明叶其欣黄炎马晓星马雷鸣 Y. r. guo Shanghai Meteorological Center Shanghai 200030 Shanghai remote Sensing and Measurement Application Center Shanghai Typhoon Institute Shanghai 200030 National Center for Atmospheric research CO USA

A squall line swept eastward across the area of the Yangtze river Delta and produced gusty winds and heavy rain from the afternoon to the evening of 24 August 2002. In this papers the roles of moisture in the genesis and development of the squall line were studied. Based on the precipitable water vapor （PWV） data from a ground-based GPS network over the Yangtze river Delta in China, plus data from a Pennsylvania State University/National Atmospheric Center （PSU/NCAr） mesoscale model （MM5） simulation, initialized by three-dimensional variational （3D-VAr） assimilation of the PWV data, some interesting features are revealed. During the 12 hours prior to the squall line arriving in the Shanghai area, a significant increase in PWV indicates a favorable moist environment for a squall line to develop. The vertical profile of the moisture illustrates that it mainly increased in the middle levels of the troposphere, and not at the surface. Temporal variation in PWV is a better precursor for squall line development than other surface meteorological parameters. The characteristics of the horizontal distribution of PWV not only indicated a favorable moist environment, but also evolved a cyclonic wind field for a squall line genesis and development. The ＂＋2 mm＂ contours of the three-hourly PWV variation can be used successfully to predict the location of the squall line two hours later.

关键词： squall line global positioning system (GPS) precipitable water vapor (PWV)

EFFECT　OF　P，S　AND　Si　ON　THE　SOLIDIFICATION，SEGrEGATION，MICrOSTrUCTUrE　AND　MECHANICAL　PrOPErTIES　IN　Fe－Ni　BASE　SUPErALLOYS

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Acta Metallurgica Sinica(English Letters) 1996年第6期9卷 443-452页

作者： Z.Q. Hu W.r.Sun and S.r. guo(Institute of Metal research, Chinese Academy of Sciences, Shenyang 110015, China

The effects of the trace elements, P, S and Si,on the solidification, segregation,microstructure and mechanical properties of GH761 and In718 alloys were *** was found that the segregation of the P,S and Si can be greatly aggravated or relieved by the precipitation taking place during the solidification. In the heat treated state,P enhances the intergranular precipitation in the GH761 *** refinement of P in In718 alloy causes the appearance of a film-like δ*** increases the intergranular precipitation of the M_6C and the Laves Phase in the In718 alloy.P, S and Si play diverse roles in the tensile and the stress rupture properties of the GH761 and In718 alloys. The most striking effect is that P significantly prolongs the stress rupture lives of the GH761 and In718 alloys in a wide range of 0.00050.015 wt% .The mechanisms by which P,S and Si influence the superalloys are discussed in the text.

关键词： superalloy,segregation microstructure mechanical property

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PSKNN铁电单晶及其激光法生长

中国激光 2000年第9期27卷 842-846页

作者：蒋毅坚 r.guo A.S.Bhalla 北京工业大学国家产学研激光技术中心北京100022 宾夕法尼亚州立大学材料研究实验室

采用改进的激光加热基座法 (LHPG)生长出了位于准同形相界附近的含有 Pb元素的钨青铜结构的铁电晶体 (1- x) Pb2 KNb5O15- x Sr2 Na Nb5O15(PSKNN)。通过调节激光功率和陶瓷源棒中 Pb O的含量 ,有效地控制和补偿了晶体生长过程中 Pb O... 详细信息

采用改进的激光加热基座法 (LHPG)生长出了位于准同形相界附近的含有 Pb元素的钨青铜结构的铁电晶体 (1- x) Pb2 KNb5O15- x Sr2 Na Nb5O15(PSKNN)。通过调节激光功率和陶瓷源棒中 Pb O的含量 ,有效地控制和补偿了晶体生长过程中 Pb O的挥发。通过选择适当的籽晶 ,可以得到沿 [0 0 1],[10 0 ]和 [110 ]方向生长的 PSKNN晶体。研究了所生长晶体的铁电、介电和压电性质 ,并对其准同形相界进行了初步的讨论。

关键词： PSKNN 铁电单晶激光加热基座生长

(Mg_(0.95)Ca_(0.05))TiO_3晶体的激光加热基座法生长及其性质测定

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功能材料 2003年第2期34卷 158-159页

作者：蒋毅坚 r.guo A.S.Bhalla 北京工业大学国家产学研激光技术中心北京100022 宾夕法尼亚州立大学材料研究实验室

采用激光加热基座法(LHPG)生长出了共晶系(Mg0.95Ca0.05)TiO3晶体。通过粉末X射线衍射分析了所生长晶体的晶相,采用扫描电镜和显微拉曼光谱技术研究了所生长晶体的微观结构。(Mg0.95Ca0.05)TiO3晶体由CaTiO3和Mg-TiO3两种晶体复合而成... 详细信息

采用激光加热基座法(LHPG)生长出了共晶系(Mg0.95Ca0.05)TiO3晶体。通过粉末X射线衍射分析了所生长晶体的晶相,采用扫描电镜和显微拉曼光谱技术研究了所生长晶体的微观结构。(Mg0.95Ca0.05)TiO3晶体由CaTiO3和Mg-TiO3两种晶体复合而成。介电测量结果表明:(Mg0.95Ca0.05)TiO3晶体沿生长方向具有较大的介电常数和较小的共振频率温度系数。

关键词：激光加热基座法共晶介电性质晶体生长粉末X射线衍射微波介电材料

High-precision orbit prediction and error control techniques for COMPASS navigation satellite

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Chinese Science Bulletin 2014年第23期59卷 2841-2849页

作者： Xiaojie Li Jianhua Zhou rui guo Beijing Satellite Navigation Center

A new satellite orbit prediction method based on artificial neural network(ANN)model is proposed to improve the precision of orbit *** order to avoid the difficulty of amending the dynamical model,it is attempted to use ANN model to learn the variation of orbit prediction error,and then the prediction result of ANN model is used to compensate the predicted orbit based on dynamic model to form a final predicted *** experiment results showed that the orbit prediction error based on ANN model was less than that based on dynamical model,and the improvement effects for different satellites and different time were *** maximum rates of improvement of predicting 8,15,30 d were respectively 80%,77.77%,85%.The orbit prediction error control technique based on the method of back overlap arc compare was brought forward to avoid the risk that the precision of predicted orbit is even worse after it is compensated by ANN *** phenomena of failure were basically eliminated based on this technique,and the rate of failure was reduced from 30%to 5%.This technique could ensure that the engineering application of ANN model could come true.

关键词：北斗导航卫星差错控制技术轨道预报高精度人工神经网络模型动力学模型轨道预测神经网络学习

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reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： guo-Fu Xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

rational design of AgGaS/ZnS/ZnS quantum dots with a near-unity photoluminescence quantum yield via double shelling scheme

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Journal of Materials Science & Technology 2024年第2期169卷 235-242页

作者： H.X.Lu H.Liu Z.Z.Fu Y.Y.Chen H.Q.Dai Z.Hu W.L.Zhang r.Q.guo Institute for Electric Light Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China Yiwu research Institute of Fudan University YiwuZhejiang 322000China Zhongshan-Fudan Joint Innovation Center Zhongshan 528437China

In this study,a two-step method was used to synthesize highly luminescent AgGaS/ZnS/ZnS quantum dots(QDs).In the first step,an inner ZnS shell was formed via a one-pot method,which resulted in a smaller lattice mismatch between the AgGaS core and the outer ZnS shell,thereby facilitating the formation of a thick outer *** the two-step shelling process,the synthesized AgGaS/ZnS/ZnS QDs showed an excellent photoluminescence quantum yield(PLQY)of 96.4%with a peak wavelength of 508 nm,repre-senting the highest PLQY reported thus far for AgGaS ***,the effect of halogen ions in Zn precursors on the shelling process was *** was proposed that the capacity of halogen ions to coordinate with the QDs influenced the balance between Zn cation diffusion and ZnS shelling ***,the ZnS shelling reaction was dominant when ZnCl_(2)was employed,while Zn cation diffusion was the dominant process under the I^(−)-rich *** work provides insights into the interfacial restructuring during the ZnS shelling and offers a clear map for the tailored synthesis of core/shell QDs.

关键词： AgGaS Quantum dots Photoluminescence Core/shell Alloyed core/shell interface