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Vasospasm as a Complication after Aneurysmal rupture and Its relation with Surgical Clipping and Endovascular Coiling among a georgian Sample

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World Journal of Neuroscience 2022年第3期12卷 153-162页

作者： Maha Kassem Lama Alchaar Ahmed Abdelkader Mohammad Eghbalbakhtiary Koka gogichashvili Mirza Khinikadze Shriniwas Chandrasekhar Yadav Astha Zambani sonali Mankar Mahalakshmi Jayasankar Mohamed Abdelsattar Atta Ismail Ali Sarah Ibrahim Natia Iashvili New-Vision University Tbilisi Georgia Medical Corporation Evex Caucasus Medical Center Tbilisi Georgia New-Vision University Hospital Tbilisi Georgia

Background: Potentially lethal, aneurysmal subarachnoid hemorrhage has a bad prognosis for many individuals. Over the past few decades, endovascular and surgical interventions have been developed, including surgical clipping, and endovascular coiling. Patients who have aSAH are also susceptible to delayed cerebral ischemia and cerebral vasospasm. The aim of this study is to compare the outcome of endovascular coiling with surgical clipping in patients with SAH, specifically in relation to prevalence of vasospasm, in the country of georgia. Method: In this study, we present a retrospective review of the outcomes of 217 patients with acute subarachnoid hemorrhage who underwent endovascular coiling or surgical clipping. The data were gathered from patients who are admitted to New Vision University Hospital and Caucasus Medical Center in Tbilisi, georgia, between 2017 and 2022. results: Vasospasm was prevalent in 217 of the patients who had aneurysmal rupture when they first appeared. Endovascular coiling or surgical clipping was used to treat aneurysmal rupture. In our sample, 24.81 percent of patients who underwent coiling experienced vasospasm after 14 days, compared to 31.25 percent of patients who underwent clipping. After endovascular coiling and surgical clipping, the severity of vasospasm was only slightly different, according to Lindegaard ratios. Finally, 32 patients (23.35 percent) died after coiling whereas 55 patients (68.75 percent) died within three decades of clipping. Conclusion: After 5 years of data collection, this study has demonstrated the most favorable option for treatment is endovascular coiling. However, the treatment choice takes multiple factors into account, and clipping is not ideal for some ruptured aneurysms. Despite the fact that endovascular coiling is usually successful and minimally invasive, complications can occur and additional monitoring and potential surgical intervention are indicated.

关键词： Aneurysms Subarachnoid Hemorrhage Surgical Clipping Endovascular Coiling Vasospasm

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Mnk kinase pathway: Cellular functions and biological outcomes

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World Journal of Biological Chemistry 2014年第3期5卷 321-333页

作者： sonali Joshi Leonidas C Platanias Department of Molecular and Cellular Oncology University of Texas MD Anderson Cancer Center robert H Lurie Comprehensive Cancer Center and Division of Hematology-Oncology Northwestern University Medical School Jesse Brown VA Medical Center

The mitogen-activated protein kinase(MAPK) interacting protein kinases 1 and 2(Mnk1 and Mnk2) play important roles in controlling signals involved in mrNA translation. In addition to the MAPKs(p38 or Erk), multiple studies suggest that the Mnk kinases can be regulated by other known kinases such as Pak2 and/or other unidentified kinases by phosphorylation of residues distinct from the sites phosphorylated by the MAPKs. Several studies have established multiple Mnk protein targets, including PSF, heterogenous nuclear ribonucleoprotein A1, Sprouty 2 and have lead to the identification of distinct biological functions and substrate specificity for the Mnk kinases. In this review we discuss the pathways regulating the Mnk kinases, their known substrates as well as the functional consequences of engagement of pathways controlled by Mnk kinases. These kinases play an important role in mrNA translation via their regulation of eukaryotic initiation factor 4E(eIF4E) and their functions have important implications in tumor biology as well as the regulation of drug resistance to anti-oncogenic therapies. Other studies have identified a role for the Mnk kinases in cap-independent mrNA translation, suggesting that the Mnk kinases can exert important functional effects independently of the phosphorylation of eIF4 E. The role of Mnk kinases in inflammation and inflammationinduced malignancies is also discussed.

关键词： Mnk kinases mrNA translation Mitogenactivated protein kinase signaling eIF4E phosphorylation Drug resistance Cytokine production Cytokine signaling

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Conceptualization and treatment of negative symptoms in schizophrenia

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World Journal of Psychiatry 2015年第4期5卷 352-361页

作者： sonali Sarkar Kiley Hillner Dawn I Velligan Department of Psychiatry University of Texas Health Science Center

Negative symptoms of schizophrenia including social withdrawal, diminished affective response, lack of interest, poor social drive, and decreased sense of purpose or goal directed activity predict poor functional outcomes for patients with schizophrenia. They may develop and be maintained as a result of structural and functional brain abnormalities, particularly associated with dopamine reward pathways and by environmental and psychosocial factors such as self-defeating cognitions and the relief from overstimulation that accompanies withdrawal from social and role functioning. Negative symptoms are more difficult to treat than the positive symptoms of schizophrenia and represent an unmet therapeutic need for large numbers of patients with schizophrenia. While antipsychotic medications to treat the symptoms of schizophrenia have been around for decades, they have done little to address the significant functional impairments in the disorder that are associated with negative symptoms. Negative symptoms and the resulting loss in productivity are responsible for much of the world-wide personal and economic burden of schizophrenia. Pharmacologic treatments may be somewhat successful in treating secondary causes of negative symptoms, such as antipsychotic side effects and depression. However, in the United States there are no currently approved treatments for severe and persistent negative symptoms(PNS) that are not responsive to treatments for secondary causes. Pharmacotherapy and psychosocial treatments are currently being developed and tested with severe and PNS as their primary targets. Academia, clinicians, the pharmaceutical industry, research funders, payers and regulators will need to work together to pursue novel treatments to address this major public health issue.

关键词： Motivation Functional outcomes Negative symptoms Schizophrenia Treatment

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Jaipur珀尔时装设计学院

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建筑技艺 2010年第6期16卷 66-73页

作者： Morphogenesis Andre J Fanthome Edmund Sumner 李昭君 sonali rastogi rudrajit Sabhaney Anna Kristiana Bergbom Shruti Dimri John Alok Decruz Oracles

经济的快速发展带来对普遍现代主义和新奇事物的盲目追寻，这成为了困扰当代印度建筑界的一个重要问题。如何将建筑传统与场地精神融入新的建筑形式之中成为建筑界最具挑战性的任务。Jaipur是拉奇普特、莫沃尔和其他多种文化的汇集地，... 详细信息

经济的快速发展带来对普遍现代主义和新奇事物的盲目追寻，这成为了困扰当代印度建筑界的一个重要问题。如何将建筑传统与场地精神融入新的建筑形式之中成为建筑界最具挑战性的任务。Jaipur是拉奇普特、莫沃尔和其他多种文化的汇集地，也是白话印度语的重要基地。在这样一个具有悠久历史的地区建造一所现代的先锋设计学院，既要强调新的时代特征，又要突出当代社会背景，并与传统有机结合，启发现代社会条件下的设计学学生们体会到“当代”的情感。

关键词：设计学院时装建筑传统社会背景现代主义建筑形式建筑界挑战性

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Standardization and Quality control parameters of Kayam Churna

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TMr Modern Herbal Medicine 2022年第3期5卷 39-47页

作者： Prajwal gupta Ashwini Kendle Diksha Bhagat Mahera Khan Prabuddha Wakode Shruti Shah sonali Patil Department of Bioanalytical Sciences B.K.Birla College(Autonomous)KalyanMaharashtraIndia

Kayam Churna is proprietary ayurvedic formulation which is blend of seven ingredients which are Senna leaves(Cassia angustifolia),Black Salt,Mulethi(glycyrrhiza glabra),Nishoth(Operculina turpethum),Ajwain(Trachyspermum ammi),Haritaki(Terminalia chebula)and Svarjikshara(Sodium bicarbonate)with Senna as a major *** and stability studies play a vital role for each herbal formulation,so the research was carried out to prepare the formulation in the laboratory and to standardize the Churna,by means of its physicochemical properties,phytochemical analysis and microbiology *** organoleptic and powdered characteristics were studied and compared with *** physicochemical analysis was carried out like bulk density,tapped density,percent compressibility,loss on drying,ash value and heavy metal *** analysis was carried out to find the presence of tannins,alkaloids,glycosides,flavonoids and *** analysis was evaluated using the Total Viable Count *** Chromatographic technique was used for *** analysis of Formulation showed the presence of Vessels,Fibre,Calcium oxalate crystals,***,Alkaloids,flavonoids were found to be present in the *** count and all physicochemical parameters were found to be within the limits as per the WHO *** studies can be carried out for finding out its efficacy and potency.

关键词： Herbal formulation Standardization Evaluation Quality control tests Fingerprinting

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曾经一切尽绿时

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疯狂英语（初中天地） 2010年第4期 32-32页

作者： sonali Krishan Kumar 小狐

曾经一切尽绿时黑暗杳然不曾见；夏炎热来冬凉爽自然不为人摆布。人类亦非悭吝辈——曾经一切尽绿时。

关键词：中学英语课外阅读阅读材料

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“Diabegon”, a safe and effective polyherbal therapy for type 2 diabetes mellitus

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World Journal of Translational Medicine 2013年第3期2卷 75-82页

作者： Sunil Mahajan Nita Singh Senthil K Subramanian Pratibha Chauhan sonali Saxena HM goswamy gBKS Prasad Prakash S Bisen School of Studies in Biochemistry Jiwaji University School of Studies in Biotechnology Jiwaji University

AIM: To investigate the antihyperglycemic, antihyperlipidemic and antioxidant functions of a polyherbal formulation, "Diabegon", in human subjects with type 2 diabetes ***: A total of 33 human subjects with type 2 diabetes mellitus were recruited for the study and all anthropological and biochemical parameters were recorded at the time of registration. The subjects were given hot water extract obtained from 10 gm of "Diabegon" powder, "Diabegon kwath", on an empty stomach everyday in the morning under personal supervision for 6 mo. The therapeutic functions of the "Diabegon kwath" was assessed by monitoring the blood glucoselevels at monthly intervals and glycosylated hemoglobin, lipid profile and biomarkers of oxidative stress, liver and kidney function markers at three monthly intervals in the study subjects. rESULTS: Daily administration of hot water extract of "Diabegon" regularly for 6 mo resulted in significant reductions of blood glucose and glycosylated hemoglobin levels. There was also a significant increase in high density lipoprotein cholesterol levels with concomitant decreases in total cholesterol, triglycerides, low density lipoprotein cholesterol and very low density lipoprotein. A significant improvement in glycosuria and proteinuria was also observed. Also, the subjects exhibited a significant improvement in enzymatic and nonenzymatic biochemical markers of oxidative stress. The kidney and liver functions remained normal and in fact improved in many ***: The study which is first of its kind, advocates "Diabegon kwath" as a safe and effective Ayurvedic therapy for the treatment of human type 2 diabetes mellitus and further placebo controlled trial may substantiate the therapeutic efficacy of the formulation.

关键词： Type 2 diabetes mellitus Diabegon kwath Polyherbal formulation Oxidative stress Blood glucose Lipids Antiglycemic Antihyperlipidemic Antioxidant antidiabetic therapies

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“万金油”银行家之年

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商业周刊（中文版） 2020年第14期 23-23页

作者： sonali Basak Crystal Tse 徐安琪(译) 不详

过去五年,华尔街的银行家们尽情享受着并购的盛宴,为一项简单的工作一合并两家公司,组成一家规模更大的企业,收取了数百亿美元的佣金。现在他们的工作变得复杂多了。尽管并购交易和股票发行开始恢复,但新冠疫情和市场动荡加大了执行交... 详细信息

过去五年,华尔街的银行家们尽情享受着并购的盛宴,为一项简单的工作一合并两家公司,组成一家规模更大的企业,收取了数百亿美元的佣金。现在他们的工作变得复杂多了。尽管并购交易和股票发行开始恢复,但新冠疫情和市场动荡加大了执行交易的难度。在缺乏持续的大规模并购交易的情况下,投资银行家们发现自己在为客户和潜在客户提供更多非正式的建议,内容包括从供应链中断到如何应对贸易战,或者如何对公司进行最佳定位,以应对美国大选结果。

关键词：股票发行投资银行家贸易战最佳定位大选结果并购万金油潜在客户

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