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Severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

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World journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael levy Anais r.Briant Etienne javouhey Sophie Breinig julia Dina Marion Caseris Francois Angoulvant Stephane Leteurtre Morgan recher David W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive Care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-Cite ParisFrance Biostatistics and Clinical research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andPediatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU Sainte justine research Center MontréalCanada

Background Severe acute respiratory syndrome coronavirus-2(SArS-CoV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of SArS-CoV-2 on the mortality rate associated with SArS-CoV-2-related illnesses in the pediatric intensive care unit(PICU).Secondary objectives were to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old with positive SArS-CoV-2 polymerase chain reactions(PCrs)[acute corona virus disease 2019(COVID-19)or incidental SArS-CoV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMS)recorded in the French PICU registry(PICUre)between September 1,2021,and August 31,*** patients were classified and compared according to their living status at the end of their PICU *** patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of SArS-CoV-2 as the cause of death was classified into four categories:certain,very probable,possible,or unlikely,and was defined by any of the first three *** There were 948 patients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to SArS-CoV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to SArS-CoV-2 was considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients were admitted for pediatric inflam-matory multisystem syndrome(PIMS).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** SArS-CoV-2 mortality in the French pediatric population was *** though the imputability of SArS-Cov-2 on mortality was considered in almost two-thirds of cases,this imputability was considered certain in only one case.

关键词： Death Pediatric intensive care unit SArS-CoV-2

Machine learning approach to assess the association between anthropometric,metabolic,and nutritional status and semen parameters

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Asian journal of Andrology 2024年第4期26卷 349-355页

作者： Guillaume Bachelot Antonin Lamaziere Sebastien Czernichow Celine Faure Chrystelle racine rachel levy Charlotte Dupont Nutrition and Fertility(ALIFErT)Group Author Information Sorbonne University School of Medicine Saint-Antoine Research CenterINSERM UMR 93827 rue ChalignyParis 75012France reproductive Biology Department-CECOS Tenon HospitalAP-HP.Sorbonne UniversityParis 75020France Clinical Metabolomics Department Saint-Antoine HospitalAP-HP27 rue ChalignyParis 75012France Nutrition Department Obesity Specialist CentreGeorges Pompidou European HospitalAP-HPParis 75015France 不详

Many lifestyle factors,such as nutritional imbalance leading to obesity,metabolic disorders,and nutritional deficiency,have been identified as potential risk factors for male *** aim of this study was to evaluate the relationship between semen parameters and anthropometric,metabolic and nutritional *** was first assessed individually,then after the application of a previously constructed and validated machine learning score that allows their ***,metabolic,antioxidant,micronutrient,and sperm parameters from 75 men suffering from idiopathic infertility from four infertility centers in France(jean-Verdier ArT Center Hospital,Bondy;North Hospital ArT Center,Saint-Étienne;Navarre Polyclinic ArT Center,Pau;and Cochin Hospital ArT Center,Paris)between September 2009 and December 2013 were *** assessing standard correlation analysis,a previously built machine learning model,providing a score ranging from 0(the poorest)to 1(the most favorable),was calculated for each man in the study *** machine learning model,which separates infertile/fertile men with unexplained infertility on the basis of their bioclinical signature,provides a more holistic evaluation of the influence of the considered markers(anthropometric,metabolic,and oxidative status).We observed a significant correlation of some anthropometric,metabolic,and nutritional disorders with some sperm ***,an unfavorable machine learning score was associated with a high level of sperm DNA *** anthropometric,metabolic,and oxidative patterns,which may reflect an appropriate lifestyle,appear to positively impact overall health,in particular reproductive *** study,consistent with previous publications,suggests that beyond semen quality parameters,in an essential assessment of male fertility,other key factors should be taken into *** this regard,the application of emerging artificial intelligence t

关键词： lifestyle machine learning metabolism nutrition sperm DNA fragmentation

The Combined Effect of Lumenato and Ceramide in the Protection of Collagen Damage Induced by Neutrophils in Normal Human Dermal Fibroblasts

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Advances in Bioscience and Biotechnology 2024年第2期15卷 140-159页

作者： Yulia Solomonov rachel levy Immunology and Infectious Diseases Laboratory Department of Clinical Biochemistry and Pharmacology Faculty of Health Sciences Ben-Gurion University of The Negev Beer-Sheva Israel

Introduction: Collagen is the primary structural protein fibroblasts produce in the skin’s extracellular matrix. Infiltration of neutrophils into the epidermis and dermis by exposure to UV causes collagen damage and contributes to photoaging. Methods: To study the combined effect of Lumenato and ceramide in preventing collagen-1 damage induced by phagocytes, we used co-cultures of normal human dermal fibroblasts (fibroblasts) and activated human neutrophils. The present study aimed to determine the protective effect of the combination of Lumenato and ceramide on fibroblast collagen-1 damage induced by neutrophils. results: Lumenato (in the range of 6.5 - 208 μg/ml) or ceramide (in the range of 0.1 - 50 μM) inhibited the production of superoxides and MPO by TNFα-stimulated neutrophils, as well as the production of NO by LPS-stimulated macrophages in a dose-dependent manner. The combinations of Lumenato and ceramide, in low concentrations, caused synergistic prevention of fibroblasts’ collagen-1 damage induced by TNFα-activated neutrophils, detected by fluorescence immunostaining and WB analysis. MPO activity in the supernatants of the co-cultures was also synergistically inhibited. Adding Lumenato or ceramide singly or in combinations in these low concentrations to the fibroblast cultures did not affect the expression of collagen-1. The combinations of Lumenato or ceramide in these concentrations also caused a synergistic inhibition of NO production by activated macrophages. Conclusions: The results suggest that combining low concentrations of Lumenato and ceramide results in synergistic protection against fibroblasts’ collagen-1 damage induced by neutrophils, thus indicating their possible potential for enhanced skin health.

关键词： Dermal Fibroblasts Neutrophils Collagen-1 Lumenato Ceramide

冠状动脉支架携带基因作为血管内基因局部定位载运体系的研究

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冠状动脉支架携带基因作为血管内基因局部定位载运体系的研究

levy Constrained Search in Fock Space：An Alternative Approach to Noninteger Electron Number

中国化学会第12届反应性高分子（离子交换与吸附）学术研...

作者：宋存先金旭杨菁王满燕刘天军孙洪范 r.j.levy 中国医学科学院中国协和医科大学生物医学工程研究所中国医学科学院中国协和医科大学生物医学工程研究所中国医学科学院中国协和医科大学生物医学工程研究所中国医学科学院中国协和医科大学生物医学工程研究所中国医学科学院中国协和医科大学生物医学工程研究所中国医学科学院中国协和医科大学生物医学工程研究所 The Division of Cardiology Children’s Hospital of Philadelphia PA 19104 USA

＜正＞ 1 前言经皮冠状动脉腔内成形术（PTCA）及安放冠状动脉支架已挽救了大量的生命,但再狭窄是术后主要的并发症之一,至今仍无有效的预防及治疗措施。基因治疗是最有前途的方法之一,传统的基因转运方法是通过导管把载体悬浮液注入治... 详细信息

＜正＞ 1 前言经皮冠状动脉腔内成形术（PTCA）及安放冠状动脉支架已挽救了大量的生命,但再狭窄是术后主要的并发症之一,至今仍无有效的预防及治疗措施。基因治疗是最有前途的方法之一,传统的基因转运方法是通过导管把载体悬浮液注入治疗局部,但这不利于所载基因的局部定位,且载体易全身播散。以支架为基础的基因转运体系可以有效地解决这一问

关键词：基因治疗载体抗原抗体再狭窄

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物理化学学报 2018年第6期34卷 625-630页

作者： AYErS Paul W. levy Mel Department of Chemistry and Chemical Biology McMaster University Hamilton Ontario L8S 4M1 Canada. Department of Physics North Carolina A&T State University Greensboro NC 27411 USA. Department of Chemistry Duke University Durham NC 2770

By extending the levy wavefunction constrained search to Fock Space,one can define a wavefunction constrained search for electron densities in systems having noninteger number of *** pure-state v-representable densities,the results are equivalent to what one would obtain with the zero-temperature grand canonical *** other cases,the wavefunction constrained search in Fock space presents an upper bound to the grand canonical ensemble *** advantage of the Fock-space wavefunction constrained search functional over the zero-temperature grand-canonical ensemble constrained search functional is that certain specific excited states(i.e.,those that are not ground-statev-representable) are the stationary points of the Fock-space ***,a potential disadvantage of the Fock-space constrained search functional is that it is not convex.

关键词： Density functional theory levy constrained search functional Fock space Fractional electron number Excited-state density functional theory Universal density functional Zero temperature grand canonicalensemble Convexity

NUCLEAr NON-PrOLIFErATION AND INTErNATIONAL SECUrITY:A DrAMA THEOrETIC APPrOACH

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journal of Systems Science and Systems Engineering 2009年第4期18卷 437-460页

作者： jason K. levy Wilder School of Government and Public Affairs Virginia Commonwealth University

While game theoretic tools have been widely applied to nuclear proliferation and disarmament issues, traditional decision analysis assumes that decision makers, options, and preferences are fixed. A drama theoretic approach is used to overcome these limiting assumptions： Drama Theory （DT） II allows global leaders and national security policy makers to engage in a rational-emotional process of re-defining international security negotiations （and their ＂positions＂ in them） Until agreement on a satisfactory nuclear non-proliferation resolution is reached. The 2009 nuclear energy negotiations between Iran and world powers are modeled with DT II and the Confrontation ManagerTM Decision Support System. By adjusting strategy and deriving transformative security policy, it is shown how international security can be achieved by promoting nuclear non-proliferation and resolving strategic conflict.

关键词： Nuclear non-proliferation strategic conflict drama theory international security

A CASE FOr SUSTAINABLE SECUrITY SYSTEMS ENGINEErING:INTEGrATING NATIONAL,HUMAN,ENErGY AND ENVIrONMENTAL SECUrITY

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journal of Systems Science and Systems Engineering 2009年第4期18卷 385-402页

作者： jason K. levy L. Douglas Wilder School of Government and Public Affairs Virginia Commonwealth University

In the wake of the September 11,2001 terrorist attacks, there is a growing sense of insecurity felt by many citizens around the world. Sustainable security, with roots in the sustainable development and human security literature, seeks positive transformations for the co-evolving and mutually dependent human-environmental condition by integrating （and subsuming） national, human, environmental, and energy security concems and capitalizing on opportunities provided by human creativity, diplomatic openings, modernization and environmental change. The field of Sustainable Security Systems Engineering is proposed for protecting, restoring, designing, and implementing a set of integrated natural and man-made processes that equitably and responsibly meet the biophysical needs of human communities, while maintaining long-term security, respecting financial constraints, meeting ecological limits, and improving institutional arrangements for transparent and effective governance. Scenario planning is shown to help promote sustainable security by identifying the preconditions of instability and helping to proactively address them in an increasingly complex and uncertain world. The six papers published in this featured collection cross policy domains, geographic, political, and sectoral boundaries and were discussed at forums sponsored by the Systems Engineering and Global Policy group. Collectively, they demonstrate the quality, breadth and depth of systems engineering methodologies that are used to promote sustainable security.

关键词： Sustainable security systems engineering national security human security environment and energy scenario planning

MoSe_(2)/WS_(2) heterojunction photodiode integrated with a silicon nitride waveguide for near infrared light detection with high responsivity

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Light(Science & Applications) 2023年第3期12卷 456-464页

作者： rivka Gherabli S.r.K.C.Indukuri roy Zektzer Christian Frydendahl Uriel levy Department of Applied Physics The Faculty of ScienceThe Center for Nanoscience and NanotechnologyThe Hebrew University of JerusalemJerusalem91904Israel

We demonstrate experimentally the realization and the characterization of a chip-scale integrated photodetector for the near-infrared spectral regime based on the integration of a MoSe_(2)/WS_(2) heterojunction on top of a silicon nitride *** configuration achieves high responsivity of~1 A W−1 at the wavelength of 780 nm(indicating an internal gain mechanism)while suppressing the dark current to the level of~50 pA,much lower as compared to a reference sample of just MoSe_(2) without WS_(2).We have measured the power spectral density of the dark current to be as low as~1×10^(−12) A Hz−0.5,from which we extract the noise equivalent power(NEP)to be~1×10^(−12) W Hz^(−0.5).To demonstrate the usefulness of the device,we use it for the characterization of the transfer function of a microring resonator that is integrated on the same chip as the *** ability to integrate local photodetectors on a chip and to operate such devices with high performance at the near-infrared regime is expected to play a critical role in future integrated devices in the field of optical communications,quantum photonics,biochemical sensing,and more.

关键词： heterojunction waveguide resonator

Postnatal therapeutic approaches in genetic neurodevelopmental disorders

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Neural regeneration research 2021年第3期16卷 414-422页

作者： Gilad levy Boaz Barak The Sagol School of Neuroscience Tel Aviv UniversityTel AvivIsrael The School of Psychological Sciences Faculty of Social SciencesTel Aviv UniversityTel AvivIsrael

Genetic neurodevelopmental disorders are characterized by abnormal neurophysiological and behavioral phenotypes,affecting individuals *** the subject has been heavily researched,current treatment options relate mostly to alleviating symptoms,rather than targeting the altered genome *** this review,we address the neurogenetic basis of neurodevelopmental disorders,genetic tools that are enabling precision research of these disorders in animal models,and postnatal gene-therapy approaches for neurodevelopmental disorders derived from preclinical studies in the laboratory.

关键词： adeno-associated virus CrISPr-Cas9 developmental window genetic therapy mouse models neurodevelopmental disorders non-human primates preclinical studies