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An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne Lugtu-Pe Xuning Zhang Sako Mirzaie Hao Han r.chang Nour AL-Mousawi Kuan Chen Yongqiang Li Anil Kane Daniel Bar-Shalom Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution ***,most new chemical entities exhibit poor water solubility,and hence are exempt from such *** combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage ***,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CrASD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)*** to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CrASD bead surface,and greater extent of celecoxib ***-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to *** work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CrASD.

关键词： Controlled release amorphous solid dispersion Poorly soluble drug Internal recrystallization Membrane-reservoir coated beads Molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions

Facile Fabrication of Conductive Paper-based Materials from Tunicate Cellulose Nanocrystals and Polydopamine-decorated Graphene Oxide

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Paper And Biomaterials 2018年第4期3卷 19-25页

作者： XiaoZhou Ma YaoYao Chen Peter r. chang Jin Huang School of Chemistry and Chemical Engineering Joint International Research Laboratory of Bio-mass-Based Macromolecular Chemistry and Materials Southwest University Chongqing 400715 China School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology Wuhan Hubei Province 430070 China Bioproducts and Bioprocesses National Science Program Agriculture and Agri-Food Canada 107 Science Place Saskatoon SK S7N 0X2 Canada

Conductive papers made from graphene and its derivatives are important for the development of electronic devices; however, elastomer-based matrices usually make it difficult for the conductive sheets to form continuous conductive networks. In this work, we used tunicate-derived cellulose nanocrystals （TCNC） instead of traditional elastomers as the matrix for polydopamine （PDA）-coated and reduced graphene oxide （GO） to prepare conductive paper, which, at a low concentration, were better for the formation of conductive networks from conductive sheets. It was found that the Young’s modulus of the conductive paper produced via this strategy reached as high as 7 GPa. Meanwhile, owing to the partial reduction of GO during the polymerization of dopamine, the conductivity of the conductive paper reached as high as 1.3×10-5 S/cm when the PDA-coated GO content was 1 wt%, which was much higher than the conductivity of pure GO （-4.60×10-8 S/cm）. This work provides a new strategy for preparing environmentally friendly conductive papers with good mechanical properties and low conductive fller content, which may be used to produce high-performance, low-cost electronic devices.

关键词： conductive paper tunicate cellulose nanocrystal graphene oxide polydopamine coating casting paper

Using Microgripper in Development of Automatic Adhesive Glue Transferring and Binding Microassembly System

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Engineering（科研） 2010年第1期2卷 1-11页

作者： r. J. chang C. C. CHEN 不详

A system using microgripper for gluing and adhesive bonding in automatic microassembly was designed, implemented, and tested. The development of system is guided by axiomatic design principle. With a compliant PU microgripper, regional-edge-statistics (rES) algorithm, and PD controller, a visual-servoing system was implemented for gripping micro object, gluing adhesive, and operating adhesive bonding. The rES algorithm estimated and tracked a gripper’s centroid to implement a visual-servoing control in the microassembly operation. The main specifications of the system are: gripping range of 60~80μm, working space of 7mm×5.74mm×15mm, system bandwidth of 15Hz. In the performance test, a copper rod with diameter 60μm was automatically gripped and transported for transferring glue and bonding. The 60μm copper rod was dipped into a glue container and moved, pressed and bonding to a copper rod of 380μm. The amount of binding glue was estimated about 5.7nl.

关键词： Micro Gripper Adhesive Bonding Microassembly Visual Servo

review of Cellulose Nanocrystal-based Fluorophore Materials and Their Application in Metal Ion Detection

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Paper And Biomaterials 2018年第4期3卷 45-61页

作者： Ya Wang Alain Dufresne Peter r. chang XiaoZhou Ma Jin Huang School of Chemistry and Chemical Engineering Joint International Research Laboratory of Biomass-Based Macromolecular Chemistry and Materials Southwest University Chongqing 400715 China Université Grenoble Alpes CNRS Grenoble INP LGP2 F-38000 Grenoble France Bioproducts and Bioprocesses National Science Program Agriculture and Agri-Food Canada 107 Science Place Saskatoon SK S7N0X2 Canada

Cellulose nanocrystals （CNCs）, a unique and promising natural material extracted from native cellulose, have attracted considerable attention owing to their physical properties and special surface chemistry. This review focuses on chemical conjugation strategies that can be used for preparation of ？uorescent-molecule labeled CNCs and the development of biomaterials. Furthermore, their application in the detection of metal ions and future development prospects are discussed. We hope to provide a clear view of the strategies for surface fluorescent modifcation of CNCs and their application in detection of metal ions.

关键词： fluorescent cellulose nanocrystals detection of metal ions sensors optical imaging biomaterial

Establishment of Core Collection and Analysis of Genetic Diversity for Both Hunan and Hubei Soybean Germplasm resources

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Establishment of Core Collection and Analysis of Genetic Div...

Mobius Isoparametric Hypersurfaces in S^(n+1) with Two Distinct Principal Curvatures

2003年全国作物遗传育种学术研讨会

作者： Y.Guan r.X.Guan L.J.Qiu r.Z.chang Key lab of crop germplasm and Biotechnology

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Acta Mathematica Sinica,English Series 2002年第3期18卷 437-446页

作者： Hai Zhong LI Department of Mathematics, Tsinghua University. Beijing 100084. P. r. China Hui Li LIU Department of Mathematics, Northeastern University. Shenyang 110000. P. r. China chang Ping WANG Key Laboratory of Pure and Applied Mathematics, School of Mathematical Sciences. Peking University, Beijing 100871, P. r. China Guo Song ZHAO Department of Mathematics, Sichuan University, Chengdu 610064. P. r. China Department of Mathematics Tsinghua University Beijing P. R. China Department of Mathematics Northeastern University Shenyang P. R. China Key Laboratory of Pure and Applied Mathematics School of Mathematical Sciences Peking University Beijing P. R. China Department of Mathematics Sichuan University Chengdu P. R. China

A hypersurface x: M→S^(n+1) without umbilic point is called a Mbius isoparametric hypersurface if its Mbius form Φ=-ρ^(-2)∑_i(ei(H)+∑_j(h_(ij)-Hδ_(ij))e_j(logρ))θ_i vanishes and its Mbius shape operator S=ρ^(-1)(S-Hid) has constant eigenvalues. Here {e_i} is a local orthonormal basis for I=dx·dx with dual basis {θ_i}, II=∑_(ij)h_(ij)θ_iθ_J is the second fundamental form, H=1/n∑_i h_(ij), ρ~2=n/(n-1)(‖II‖~2-nH^2) and S is the shape operator of x. It is clear that any conformal image of a (Euclidean) isoparametric hypersurface in S^(n+1) is a Mbius isoparametric hypersurface, but the converse is not true. In this paper we classify all Mbius isoparametric hypersurfaces in S^(n+1) with two distinct principal curvatures up to Mbius transformations. By using a theorem of Thorbergsson [1] we also show that the number of distinct principal curvatures of a compact Mbius isoparametric hypersurface embedded in S^(n+1) can take only the values 2, 3, 4, 6.

关键词： Mobius geometry Isoparametric hypersurface Principal curvature

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退火对ZnO薄膜结构及发光特性的影响

光学学报 2002年第2期22卷 178-180页

作者：王金忠杜国同王新强闫玮马燕姜秀英杨树人高鼎三 chang r P H 吉林大学电子工程系光电子联合重点实验室长春130023 Material research Center

生长在蓝宝石C面上的ZnO薄膜是通过等离子体金属有机物化学汽相淀积方法获得的 ,由其X光衍射得知 ,生长过程中分段退火和最后退火在薄膜中分别引入了张应力和压应力。通过对样品光致发光光谱研究表明 :分段退火样品在 380nm附近出现了... 详细信息

生长在蓝宝石C面上的ZnO薄膜是通过等离子体金属有机物化学汽相淀积方法获得的 ,由其X光衍射得知 ,生长过程中分段退火和最后退火在薄膜中分别引入了张应力和压应力。通过对样品光致发光光谱研究表明 :分段退火样品在 380nm附近出现了单一激子发射峰 ,而最后退火样品却出现了与应变有关的Γ5和Γ6两激子发射峰 ,同时在两者的光致发光光谱中与深能级有关的荧光峰都未出现。

关键词：等离子体金属有机物化学汽相淀积光致发光光谱 ZnO 氧化锌薄膜结构发光特性退火

用移动加热器方法生长Hg 基(HgCdTe)合金

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激光与红外 1988年第3期 33-34页

作者： r.r.chang 乃文

已用多种块状和薄膜技术生长碲镉汞。目前红外探测器对材料有严格的要求。然而由于在生长三元化合物,特别是含汞化合物中所遇到的困难,单晶生长尚未能满足所有器件的要求。本工作研究了用于生长大面积(Hg Cd)Te和(Hg,Mn)Te单晶的移动加... 详细信息

已用多种块状和薄膜技术生长碲镉汞。目前红外探测器对材料有严格的要求。然而由于在生长三元化合物,特别是含汞化合物中所遇到的困难,单晶生长尚未能满足所有器件的要求。本工作研究了用于生长大面积(Hg Cd)Te和(Hg,Mn)Te单晶的移动加热器方法(THM法)。移动加热器方法作为一种生长高质量晶体的优良方法早已有报导。***和***阐述了THM方法的突出的优点。本文目的是提供电学性质、MIS

关键词：加热器 THM 均匀性晶体生长 HgCdTe 热传导分析界面形状组份载流子浓度载流子密度

A New Synthesis reaction of Nano-TiC Powder from Titanium and Graphite Fluorinate Powder Mixture

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A New Synthesis Reaction of Nano-TiC Powder from Titanium an...