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Bioactive Materials 2018年第1期3卷 64-73页

作者： Taylor B.Dorsey Alexander grath Annling Wang Cancan Xu Yi Hong Guohao Dai Department of Biomedical Engineering Rensselaer Polytechnic InstituteTroyNY 12180USA Center for Biotechnology and Interdisciplinary Studies Rensselaer Polytechnic InstituteTroyNY 12180USA Department of Bioengineering Northeastern UniversityBostonMA 02115USA Department of Bioengineering University of Texas at ArlingtonArlingtonTX 76019USA

Bioactive signals play many important roles on cell function and *** most biological studies,soluble biochemical cues such as growth factors or cytokines are added directly into the media to maintain and/or manipulate cell activities in ***,these methods cannot accurately mimic certain in vivo biological signaling motifs,which are often immobilized to extracellular matrix and also display spatial gradients that are critical for tissue *** biochemical cues,biophysical properties such as substrate stiffness can influence cell behavior but is not easy to manipulate under conventional cell culturing *** development in photocrosslinkable hydrogels provides new tools that allow precise control of spatial biochemical and biophysical cues for biological applications,but doing so requires a comprehensive study on various hydrogel photochemistry kinetics to allow thorough photocrosslink reaction while maintain protein bioactivities at the same *** this paper,we studied several photochemistry reactions and evaluate key photochemical parameters,such as photoinitiators and ultra-violet(UV)exposure times,to understand their unique contributions to undesired protein damage and cell *** data illustrates the retention of protein function and minimize of cell health during photoreactions requires careful selection of photoinitiator type and concentration,and UV exposure *** also developed a robust method based on thiol-norbornene chemistry for independent control of hydrogel stiffness and spatial bioactive ***,we highlight a class of bioactive hydrogels to stiffness control and site specific immobilized bioactive proteins/peptides for the study of cellular behavior such as cellular attraction,repulsion and stem cell fate.

关键词： Photo-patterning Bioactive signals PEG hydrogels Click-chemistry

A multi-isotope approach (Pb, S, N, O and Sr) to estimate the impact of long distance air pollution

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Chinese Journal Of Geochemistry 2006年第B8期25卷 154-155页

作者： Martin Kralik Franko Humer Johannes grath Johanna Nurmi-Legat Andrea Hanus-Illnar Stan Halas Monika Jelenc Umweltbundesamt Austria （Federal Environment Agency Austria） Spittelauer Laende 5 A-1090 Vienna Austria Mass Spectrometry Laboratory Marie-Curie-Sklodowska Univ. PL-20-031 Lublin Poland Geochronology Lab. Inst. of Geological Sci. Univ. of Vienna Althanstr. 14 A-1090 Vienna Austria

污染含水介质中有机污染物（PAHs）的解吸

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国外地质与勘测 1996年第1期 38-42页

作者： grath.,P 郑西来

硬化性苔癣细胞外基质蛋白-1自身抗体IgG的特征

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 33-34页

作者： Oyama N. Neill S.M J.A. Mc-grath 马慧群 Genetic Skin Disease Group St. John's Institute of Dermatology St. Thomas'Hospital Lambeth Palace Road London SE1 7EH United Kingdom

Although the precise aetiology of lichen sclerosus is unknown, evidence for an autoimmune basis to the disorder is emerging. Indeed, circulating IgG autoantibodies to the glycoprotein extracellular matrix protein 1 (ECM1) have been demonstrated in the sera of about 75%of affected individuals. To assess this humoral immune response further, immunoblotting was performed using bacterial recombinant proteins spanning different domains of the ECM1 protein. The aim was to identify autoantibody-reactive sites recognized by 90 lichen sclerosus sera. The subclass distribution of anti-ECM1 IgG autoantibodieswas also determined in 54 lichen sclerosus sera. Immunoblotting showed that the IgG autoantibodies from lichen sclerosus patients recognize multiple antigenic reactive sites on the ECM1 protein within both the amino terminus (50/90, 55.6%) and the protein loop cysteine-rich repeat domains (54/90, 60%), although few sera (7/90, 7.8%) had antibodies to the carboxyl terminus of ECM1. IgG subclass analysis revealed that the anti-ECM1 autoantibodies belong predominantly to the IgG2 subclass (48/54, 88.9%), either IgG2 alone (28/54, 51.9%) or in combination with one or more other IgG subclasses. No correlation was found between the site(s) of the ECM1 epitopes or the anti-ECM1 IgG profile and any specific clinical parameters. Nevertheless, characterization of anti-ECM1 antibodies does provide further insight into humoral immune responses and understanding disease mechanisms in lichen sclerosus.

关键词： IgG 细胞外基质蛋白自身抗体硬化性临床参数体液免疫反应自身免疫异常免疫印迹检测细菌蛋白抗原识别位

哥伦比亚大学市场重弹,拓展市场份额的有力武器

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董事会 2005年第8期 97-97页

作者： r.G.Mc grath 哥伦比亚大学

位于华盛顿州贝尔维尤市的币星(Coinstar)公司专门为杂货店和折扣商店提供统计零钱处理的设备。币星公司瞄准了一个让银行和消费者都很头疼的问题——统计和处理零钱——并且把它变成一个能够盈利的业务。我们认为，这家公司找到了一个... 详细信息

位于华盛顿州贝尔维尤市的币星(Coinstar)公司专门为杂货店和折扣商店提供统计零钱处理的设备。币星公司瞄准了一个让银行和消费者都很头疼的问题——统计和处理零钱——并且把它变成一个能够盈利的业务。我们认为，这家公司找到了一个“市场重弹”(Marketbusting)战略。币星具备了一个一流的战略行动的所有特点，它找到一个普遍的但是没有获得满足的需求，推出一个集中解决的方案。虽然只做了一件事，但是币星把这件事做得非常出色。

关键词：大学市场哥伦比亚市场份额武器折扣商店华盛顿州杂货店公司消费者零钱统计业务盈利银行所有

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实时监测全球树木覆盖面积变化

东方企业家 2014年第4期 106-106页

作者： Matt Mc grath BBC

全球森林观察（简称为GFW）获得谷歌以及40多家企业和活动组织的支持，综合数百万卫星图以及来自地面的信息。这个新的数据库受到了很多企业的欢迎。企业们认为，这个数据库能够帮助他们证明他们产品是不破坏生态平衡的。

关键词：覆盖面积实时监测树木活动组织生态平衡数据库企业谷歌

表皮松解性大疱病表皮真皮连接处发生鳞癌的危险增大

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 48-48页

作者： Mallipeddi r. Keane F.M. Mc grath J.A. r.A.J. Eady 张宪旗 Guy's King's/St Thomas'Sch. of Med. St John's Institute of Dermatology St Thomas'Hospital London SE1 7EH United Kingdom

Non-Herlitz junctional epidermolysis bullosa (JEB) is an autosomal recessive genodermatosis characterized by skin fragility and blistering. It is usually caused by mutations in the genes encoding the basement membrane proteins laminin 5 or type XVII collagen. Clinically, impairedwound healing and chronic erosions cause major morbidity in affected patients. Previously it was thought that these individuals, unlike patients with dystrophic EB, did not have an increased risk of developing skin cancer. However, we describe three patients with non-Herlitz JEB (aged 42, 56 and 75 years) who developed cutaneous squamous cell carcinomas (SCCs). The tumours were well-differentiated in two cases, but one patient had multiple primary SCCs that were either well-or moderately differentiated. Most cases of SCC in non-Herlitz JEB described have occurred in those with laminin 5 defects and on the lower limbs. These clinicopathological observations have important implications for the management of patients with this mechanobullous disorder as well as providing further insight into the biology of skin cancer associated with chronic inflammation and scarring.

关键词：表皮松解大疱鳞癌 Laminin 多发型临床病理学营养不良性基因突变于非