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Neurogenic potential of NG2 in neurotrauma:a systematic review

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Neur.l regeneration research 2024年第12期19卷 2673-2683页

作者： Yuri r.rigo radharani Benvenutti luis V.Portela Nathan r.Strogulski Departamento de Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublinIreland School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of *** is reflected in a large disparity between the number of studies investigating primary and secondary injury as therapeutic to rgets in spinal co rd and traumatic brain *** advances in biotechnology may have the potential to reshape the current state-of-the-art and bring focus to primary injury neurotrauma *** studies using neur.l-glial factor/antigen 2(NG2)cells indicate that they may differentiate into neurons even in the developed *** these cells show great potential to play a regenerative r.le,studies have been conducted to test various manipulations in neurotrauma models aimed at eliciting a neurogenic response from *** the present study,we systematically reviewed the experimental protocols and findings described in the scientific literature,which were peer-reviewed original research articles(1)describing preclinical experimental studies,(2)investigating NG2 cells,(3)associated with neurogenesis and neurotrauma,and(4)in vitro and/or in vivo,available in PubMed/MEDlINE,Web of Science or SCOPUS,from 1998 to ***,we have reviewed a total of 1504 papers,and summarized findings that ultimately suggest that NG2 cells possess an inducible neurogenic potential in animal models and in *** also discriminate findings of NG2 neurogenesis promoted by different pharmacological and genetic approaches over functional and biochemical outcomes of traumatic brain injury and spinal co rd injury models,and provide mounting evidence for the potential benefits of manipulated NG2 cell ex vivo transplantation in primary injury *** findings indicate the feasibility of NG2 cell neurogenesis strategies and add new players in the development of therapeutic alternatives for neurotrauma.

关键词： neur.l-glial antigen 2 neur.l-glial factor 2 neuron differentiation NG2 cell regeneration spinal cord injury(SCI) traumatic brain injury(TBI)

Science and reflections: With some thoughts to young applied scientists and engineers

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Earthquake Science 2024年第5期37卷 459-493页

作者： robert l Nowack Department of Earth Atmospheric and Planetary SciencesPurdue UniversityWest LafayetteIN47906USA

I provide some science and reflections from my experiences working in geophysics,along with connections to computational and data sciences,including recent developments in machine learning.I highlight sever.l individuals and groups who have influenced me,both through direct collaborations as well as from ideas and insights that I have learned *** my reflections are rooted in geophysics,they should also be r.levant to other computational scientific and engineering fields.I also provide some thoughts for young,applied scientists and engineers.

关键词： geophysics computational and data science applied science and engineering

Impact of Paenibacillus elgii supernatant on screening bacterial strains with potential for biotechnological applications

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Engineering Microbiology 2024年第3期4卷 1-15页

作者： I.C.Cunha-Ferreira C.S.Vizzotto T.D.Frederico J.Peixoto l.S Carvalho M.r.Tótola r.H.Krüger laboratory of Enzymology Department of Cellular BiologyUniversity of Brasília(UNB)Brasília70910-900Brazil laboratory of Environmental Sanitation Department of Civil and Environmental EngineeringUniversity of Brasília(UNB)Brasília70910-900Brazil laboratório de Biotecnologia e Biodiversidade para o Meio Ambiente Universidade Federal de Viçosa(UFV)Viçosa36570-900Brazil

The biotechnological industry faces a crucial demand for novel bioactive compounds,particularly antimicrobial agents,to address the rising challenge of bacterial resistance to current available *** strate-gies for cultivating natur.lly occurring microorganisms often limit the discovery of novel antimicrobial *** study presents a protocol for targeted selection of bacterial strains using the supernatant of Paenibacillus el-gii,which produces abundant signal molecules and antimicrobial *** samples were inoculated in these enriched culture media to selectively cultivate bacteria resistant to the supernatant,indicating their potential to produce similar *** bacterial strains isolated through this method were assessed for their antibac-terial *** addition,the functional annotation of the genome of one of these strains revealed sever.l gene clusters of biotechnological *** study highlights the effectiveness of using this approach for selective cultivation of microorganisms with potential for biotechnological applications.

关键词： Prospecting Supernatant Antibacterial activity

Water quality, habitat, and fish assemblage r.lationships in middle-order agriculture and forest streams of the Mississippi Alluvial Plain

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Ecological Processes 2024年第1期13卷 217-236页

作者： Matthew l.Skoog Michael A.Eggleton Yushun Chen Department of Aquaculture and Fisheries University of Arkansas at Pine Bluff Minnesota Department of Natur.l resources State Key laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences University of Chinese Academy of Sciences

Background Agriculture has greatly influenced water quality, habitats, and fish assemblages in streams of the Mississippi Alluvial Plain(MAP) ecoregion. However, MAP streams have historically been understudied compared to streams in other agricultur.l regions of the USA. In this study, water quality, habitat, and fish assemblage composition were assessed seasonally(spring, summer, and fall) in eight representative MAP streams located across three U.S. states. The study design included four streams containing highly agricultur.l watersheds(herein termed “agriculture” streams) and four streams containing mostly forested watersheds(herein termed “forest” streams), which were intended to represent reference conditions for MAP *** In gener.l, forest streams contained significantly better instream and riparian habitats than agriculture streams(P = 0.010–0.040) whereas agriculture streams contained significantly greater.levels of primary nutrients(P rences between agriculture and forest streams with respect to other physical and chemical variables were intermittent and season dependent. Fish assemblages in agriculture and forest streams were structured primar.ly along an environmental gradient reflecting instream habitat conditions, water nutrient concentrations, and benthic chlorophyll-a production. Structur.lly, fish assemblages in both stream types contained many regionally common species, though some species appeared to exhibit affinities for a particular stream type. Functionally, fish assemblages in agriculture streams contained more tolerant species, more omnivores, and fewer insectivores compared to forest stream assemblages, which were nearly all insectivores. Over.ll, one-third of the fish specimens collected in forest streams classified as intolerant *** Our results suggested that stream water quality, habitat, and fish assemblages differed between agriculture and forest streams in the MAP, with fish assemblages e

关键词： Agriculture Stream land use Water quality Habitat Fish Multivariate statistics Mississippi Alluvial Plain

Parametric investigation on the novel and cost-effective nano fly ash impregnated geopolymer system for sustainable construction

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Frontiers of Structur.l and Civil Engineering 2024年第2期18卷 170-183页

作者： r.MOHANA S.M.leela BHArATHI Department of Civil Engineering Mepco Schlenk Engineering CollegeSivakasi 626123India

The hazardous environmental effects of greenhouse gas emissions and climate change demand alternative sources for cementitious materials in the construction *** development of geopolymer structures provides a way of producing 100%cement-free *** this research work,a novel and simple way of deriving nano particles from waste fly ash particles is *** effect of adding the synthesized nano fly ash particles as a filler medium in geopolymer mortars was investigated by considering strength and durability *** optimization was done by using regression analysis on the geopolymer mortar and the impact of adding nano fly ash particles was studied by varying different percentages of addition ranging from 0 to 7.5%by weight of binder *** the results,it was observed that 1%nano fly ash acted not only as a filler but also as nano-sized precursors of the polymerization process,resulting in denser geopolymer *** can explain the extraordinary gain in strength of 72.11 MPa as well as the denser core with negligible level of chloride ion penetration,making the material suitable for the development of structures susceptible to marine environment.

关键词： geopolymer nano fly ash chloride ion penetration durability polymerization fillers

Determination of the standardized ileal digestible calcium requirement of ross broilers from hatch to day 14 post-hatch

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Animal Nutrition 2024年第1期16卷 122-129页

作者： Carrie l.Walk raffaella Aur.li Pauline Jenn DSM Nutritional Products Delves RoadHeanorDerbyshireDE757SGUnited Kingdom research Center for Animal Nutrition and Health DSM Nutritional ProductsVillage-Neuf68128France

An experiment was conducted to determine the standardized ileal digestible(SID)calcium requirement of fast-growing broilers from hatch to d 14 *** 308(n=360)male broilers were obtained on day of hatch and allocated to 1 of 5 treatments in battery *** were 6 birds per cage and 12 pens per *** treatments were formulated to contain 0.60%,0.46%,0.32%or 0.18%SID *** final treatment was formulated using total Ca to meet or exceed all nutrient requirements,including 0.90%total Ca and 0.49%non-phytate P(nPP),using the same *** treatment was the reference diet for comparison and validation of the SID Ca *** and feed were weighed at placement and on d *** and ileal contents were obtained on d 14 and excreta was collected per pen and pooled on d *** were analyzed using JMP Pro and requirements were estimated using 3different non-linear regression *** the SID Ca content in the diet from 0.18%to 0.60%improved(quadratic,Prtality corrected feed conversion ratio(mFCr).The estimated SID Ca requirement to optimize gain or m FCr was between 0.39%and 0.52%.Tibia ash percent and weight increased(quadratic,Preased and the estimated SID Ca requirement was between 0.32%and 0.58%.Phosphorus utilization was improved in birds fed diets formulated using SID Ca compared with birds fed the reference *** conclusion,the SID Ca requirement of fast-growing broilers from hatch to d 14 was estimated between 0.534%and 0.398%when quadratic,straight-broken line,or quadratic-broken line regressions were *** results agree with previously published data evaluating the SID Ca requirement of fast-growth broilers from hatch to d 10.

关键词： Apparent ileal digestibility Digestible calcium requirements retention Tibia ash

Beyond network centr.lity: individual-level behavior.l traits for predicting information superspreaders in social media

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National Science review 2024年第7期11卷 148-157页

作者： Fang Zhou linyuan lü Jianguo liu Manuel Sebastian Mariani Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Yangtze Delta region Institute(Huzhou) University of Electronic Science and Technology of China School of Cyber Science and Technology University of Science and Technology of China Department of Digital Economics Shanghai University of Finance and Economics UrPP Social Networks Universit?t Zürich

Understanding the heterogeneous r.le of individuals in large-scale information spreading is essential to manage online behavior as well as its potential offline consequences. To this end, most existing studies from diverse research domains focus on the disproportionate r.le played by highly connected ‘hub’ ***, we demonstrate here that information superspreaders in online social media are best understood and predicted by simultaneously considering two individual-level behavior.l traits: influence and susceptibility. Specifically, we derive a nonlinear network-based algorithm to quantify individuals' influence and susceptibility from multiple spreading event data. By applying the algorithm to large-scale data from Twitter and Weibo, we demonstrate that individuals' estimated influence and susceptibility scores enable predictions of future superspreaders above and beyond network centr.lity, and reveal new insights into the network positions of the superspreaders.

关键词： complex networks social networks social media information spreading superspreaders

Nonlinear dynamic modeling of planar moving Timoshenko beam considering non-rigid non-elastic axial effects

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 479-496页

作者： M.ABBASI GAVArI M.r.HOMAEINEZHAD Faculty of Mechanical Engineering K.N.Toosi University of TechnologyTehran 19991-43344Iran

Due to the importance of vibration effects on the functional accuracy of mechanical systems,this research aims to develop a precise model of a nonlinearly vibrating single-link mobile flexible *** manipulator consists of an elastic arm,a rotary motor,and a rigid carrier,and undergoes gener.l in-plane rigid body motion along with elastic transverse *** accurately model the elastic behavior,Timoshenko’s beam theory is used to describe the flexible arm,which accounts for rotary inertia and shear deformation *** applying Newton’s second law,the nonlinear governing equations of motion for the manipulator are derived as a coupled system of ordinary differential equations(ODEs)and partial differential equations(PDEs).Then,the assumed mode method(AMM)is used to solve this nonlinear system of governing equations with appropriate shape *** assumed modes can be obtained after solving the characteristic equation of a Timoshenko beam with clamped boundary conditions at one end and an attached mass/inertia at the *** addition,the effect of the transverse vibration of the inextensible arm on its axial behavior is *** the axial rigidity,the effect makes the rigid body dynamics invalid for the axial behavior of the ***,numerical simulations are conducted to evaluate the performance of the developed model,and the results are compared with those obtained by the finite element *** comparison confirms the validity of the proposed dynamic model for the *** to the mentioned features,this model can be r.liable for investigating the system’s vibrational behavior and implementing vibration contr.l algorithms.

关键词： planar moving Timoshenko beam non-rigid non-elastic axial effect as-sumed mode method(AMM) nonlinear motion analysis

Nonlinear-Optical Analogies in Nuclear.like Soliton reactions:Selection r.les,Nonlinear Tunneling and Sub-Barrier Fusion–Fission

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Chinese Physics letters 2024年第8期41卷 1-7页

作者： T.l.Belyaeva V.N.Serkin Universidad Autonoma del Estado de Mexico Av.Instituto Literario 100C.P.50000TolucaMexico Benemerita Universidad Autonoma de Puebla Av.4 Sur 104C.P.72001PueblaMexico

The main goal of our study is to reveal unexpected but intriguing analogies arising between optical solitons and nuclear physics,which still remain hidden from *** consider the main cornerstones of the concept of nonlinear optics of nuclear reactions and the well-dressed repulsive-core *** the base of this model,we reveal the most intriguing properties of the nonlinear tunneling of nucleus-like solitons and the soliton selfinduced sub-barrier transparency *** describe novel interesting and stimulating analogies between the interaction of nucleus-like solitons on the repulsive barrier and nuclear sub-barrier *** main finding of this study concerns the conservation of total number of nucleons(or the baryon number)in nuclear.like soliton *** show that inelastic interactions among well-dressed repulsive-core solitons arise only when a“cloud”of“dressing”spectr.l side-bands appears in the frequency spectra of the *** property of nucleus-like solitons is directly r.lated to the nuclear density distribution described by the dimensionless small shape-squareness *** the Fourier spectra of nucleus-like solitons are similar to the nuclear form *** show that the nuclear.like reactions between well-dressed solitons are realized by“exchange”between“particle-like”side bands in their spectra.

关键词： solitons soliton Nonlinear