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Effect of trabeculated myocardial mass on left ventricle global and regional functions in noncompaction cardiomyopathy

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World Journal of Cardiology 2021年第7期13卷 211-222页

作者： Gulsah Yildirim Memduh Dursun rıfat arslan Department of radiology University of Health SciencesIstanbul Fatih Sultan Mehmet Training and Research Hospitalİstanbul 34752Turkey Department of radiology İstanbul University School of Medicineİstanbul 34752Turkey Department of radiology Istanbul UniversityIstanbul Faculty of Medicineİstanbul 34752Turkey

BACKGrOUND Left ventricular(LV)noncompaction cardiomyopathy is a rare cardiomyopathic subtype that has been recognized in recent years and is being diagnosed at an increased *** is no consensus regarding the diagnosis of the disease,and increased trabeculation rates that meet the existing diagnostic criteria may even be present in healthy asymptomatic *** indicates that differentiating criteria for diagnosis are *** To examine the increase in myocardial trabeculation and the change in left ventricular global and regional *** This retrospective study included 65 patients(28 females,37 males)diagnosed with LV noncompaction cardiomyopathy who underwent cardiac magnetic resonance imaging between January 2011 and August 2016 and had a noncompacted/compacted myocardial thickness ratio of over 2.3 in more than one segment in the left *** distribution and ratios of trabeculations in apical,midventricular,and basal regions were examined in short-axis images obtained from cardiac magnetic *** addition,by using short-axis cine images,regional ejection fraction(EF)and global EF were calculated using the Simpson method in the left ventricle at apical,basal,and midventricular *** While the number of trabeculated segments were similar at the apical(3.2±1.0)and midventricular levels,a statistically significant level of involvement was not observed at the basal level(0.4±0.9)(P>0.05).The highest noncompacted/compacted(trabeculation)ratio was observed at the apical level(3.9±1.4),while this ratio was higher at the anterior(59%-89.4%)and lateral(62%-84.8%)segments(P>0.05).Global EF was positively correlated with apical,midventricular,and basal regional EF(Pr,there was no significant correlation between regional EF and the number of trabeculated segments or trabeculation ratio in all three regions;nor was there a significant correlation between regional EF and the number of trabeculated segments or trabecula

关键词： Isolated noncompaction of the ventricular myocardium Cardiomyopathies Magnetic resonance imaging Stroke volume Magnetic resonance imaging Ventricular function

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Exploring the dynamics of creative tourism:A tourist-centric perspective to achieve economic sustainable development

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Journal of Mountain Science 2025年第1期22卷 278-295页

作者： ZOU Fuxia Atefeh AHMADI DEHrASHID Mehmet AKIF CIFCI Emrah arslan Nina KHALIGHI College of Tourism and Aviation Management Hunan Women's UniversityChangsha 410004China Faculty of Natural resources Department of ClimatologyUniversity of KurdistanSanandaj ***Iran Member of Department of Zrebar Lake Economic-social research Kurdistan Studies InstituteUniversity of KurdistanSanandaj ***Iran Department of Computer Engineering Bandirma Onyedi Eylul UniversityBalikesir 10200Türkiye Engineering and Informatics Department Klaipėdos ValstybinėKolegija/Higher Education InstitutionKlaipeda 92294Lithuania Engineering and Informatics Department KTO KaratayKonya 42020Türkiye Department of Urban Planning and Design Faculty of Art and ArchitectureUniversity of KurdistanSanandaj ***Iran

Creative tourism is a dynamic and innovative approach to tourism,which points out the importance of people's active participation and their immersion in such *** a vernacular context,it should attract people(local and tourists)attention to accomplish its main *** its rich cultural and natural assets,Kurdistan province faces several challenges that impact its tourism *** achieve that,the study uses quantitative approach to thoroughly analyze and evaluate the components of creative tourism in this *** research focuses on tourists who visited the province's ten towns during the spring and summer of *** collection utilized a Likert-scale questionnaire ranging from"very good"to"very poor".The study employed a semistructured questionnaire developed through qualitative interviews alongside a researcher-made questionnaire validated by experts from the University of *** qualitative questionnaire achieved a high-reliability score of 93%using Cronbach's alpha ***-depth interviews and literary research were conducted to identify creative tourism components and indicators,informing the development of a quantitative *** analysis was performed using SPSS 20 and AMOS software to scrutinize the survey findings,providing insights into enhancing creative tourism strategies in Kurdistan *** results reveal the varying significance of these dimensions,with the cultural dimension identified as the most crucial(factor loading:0.95),followed by the social(0.92),economic(0.88),and managerial/political dimensions(0.83).The study highlights the importance of cultural planning,community engagement,and infrastructural support in fostering creative ***,it explores the impact of creative industries,such as music and arts rooted in Kurdish culture,on tourism *** diversification and spatialphysical considerations are critical factors in enhancing Kurdistan's appeal as a creative

关键词： Creative tourism Tourism development Local and regional development Structural equation Iran

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Mediating role of self-esteem in the relationship between parental disapproval of the child and alexithymic personality

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World Journal of Psychiatry 2025年第2期15卷 140-151页

作者： Elif Yöyen Ali rıfat Kılıç Department of Psychology Faculty of Humanities and Social SciencesSakarya UniversitySakarya 54050Türkiye Department of Clinical Psychology Institute of Social SciencesFaculty of Humanities and Social SciencesGöztepeMarmara Universityİstanbul 34722Türkiye

BACKGrOUND Alexithymia is defined as difficulties in identifying,expressing,and understanding *** unapproving environment during childhood is defined as the child not receiving emotional approval from their parents,being punished,or having their emotions *** formation of self-esteem is shaped by the influence of parental behavior during *** commu-nication that the child establishes with their parents contributes to their increased self-esteem and sense of *** absence of this may play a role in developmental *** To examine the mediating role of self-esteem in the relationship between a disapproving environment in childhood and *** The research in the relational screening model was conducted with 404 *** Information Form,Disapproving Environment Scale in Childhood,Toronto Alexithymia Scale,and rosenberg Self-Esteem Scale were used as data collection ***’bootstrapping technique was used in the analysis of the data obtained from the *** As a result of the analyses,parental disapproval positively predicted the level of alexithymia(rmother=0.51,rfather=0.52,Predicted selfesteem(rmother=-0.75,rfather=-0.67,Predicted alexithymia(r=-0.58,Prved that self-esteem had a partial mediating effect on the relationship between parental disapproval and *** types were analyzed separately as chaotic,approving,perfect,and *** these,the chaotic family type positively predicted alexithymia(r=0.33,Predicted self-esteem(r=-0.60,Proving family type negatively predicted alexithymia(r=-0.43,Predicted self-esteem(r=0.61,Prfect family type negatively predicted alexithymia(r=-0.27,Predicted self-esteem(r=-0.45,Prows up in and parental d

关键词： Psychopathology Childhood trauma Disapproving environment in childhood Family type Alexithymia

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Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

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A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUrABH r.KIrAN D.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： bio-inspired composite plate finite element method (FEM) Green-Lagrange helicoidal inverse hyperbolic shear deformation theory (IHSDT) nonlinear O322

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Association of the glycemic background patterns and the diabetes management efficacy in poorly controlled type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 74-90页

作者： Ayşe N Erbakan Müzeyyen arslan Bahadır fatoşN Kaya Büşra Güleç MiraçVural Keskinler Ümmügülsüm AktemurÇelik Özge Faydalıel Banu Mesçi Aytekin Oğuz Department of Internal Medicine Prof Dr Suleyman Yalcin City HospitalIstanbul Medeniyet UniversityIstanbul 34722Türkiye Department of Family Medicine Istanbul Medeniyet UniversityIstanbul 34722Türkiye

BACKGrOUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic *** To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic *** This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 *** were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as *** analysis focused on the success rates of good glycemic control and the associated factors within each *** The study showed significant improvements in HbA1c levels in all *** most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,*** one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and *** In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored ***

关键词： Type 2 diabetes mellitus Glycated hemoglobin Glycemic control Patient-centered care Diabetes management glycemic background

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Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

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Security Strategy of Digital Medical Contents Based on Blockchain in Generative AI Model

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Computers, Materials & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Marek r.Ogiela Division of Computer Science and Engineering Sunmoon UniversityAsan31460Republic of Korea AGH University of Krakow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative AI environment through the integration of blockchain *** combining the strengths of blockchain and generative AI,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical AI services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative AI-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative AI models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative AI,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAI blockchain vulnerability pattern recognition

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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

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Pelvic floor dysfunction in patients with gestational diabetes mellitus

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World Journal of Diabetes 2025年第2期16卷 1-4页

作者： Mustafa arslan ramazan Kozan Department of Anestesiology and reanimation Gazi University Faculty of MedicineAnkara 06560YenimahalleTürkiye Department of General Surgery Gazi University Faculty of MedicineAnkara 06500YenimahalleTürkiye

In this editorial,we comment on an article by Wang et *** literature shows an increase in research on pelvic organ prolapse(POP).Although the true incidence of POP remains uncertain,its impact on quality of life is *** studies report high incidence rates,surpassing those observed in symptom-based *** of the endopelvic fascia is a primary anatomical risk factor for ***,gestational diabetes mellitus(GDM)has emerged as a growing concern,as poor glycemic control increases complications for both mother and *** and POP are interconnected,with factors like maternal obesity,macrosomia,and hormonal changes exacerbating pelvic floor *** risk factors,such as obesity and chronic hyperglycemia,along with multiparity,instrumental deliveries,and obstetric trauma,further increase *** patients with GDM,gynecological exams,Pelvic Organ Prolapse Quantification staging,and pelvic floor ultrasonography are valuable diagnostics,with proctological exams and magnetic resonance defecography aiding in multi-compartment prolapse ***,though uncomfortable during pregnancy,is safe in the early postpartum *** editorial emphasizes the need for further research on the pathophysiology of GDM-related POP and offers recommendations for improving diagnosis and clinical management of patients with GDM.

关键词： Defecography Chronic hyperglycemia Gestational diabetes mellitus Multiparity Pelvic floor ultrasonography Pelvic organ prolapse Obesity

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