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流程工业 2022年第3期 36-37页

作者： MA Alexander stark 德文版杂志

位于德累斯顿市的初创公司Neuron-D正在开发一种高通量系统——用以筛选出治疗神经退行性疾病的候选药物。该系统采用了由德国神经退行性疾病研究中心(DZNE)和国际专利家族(IPF)共同开发的3D细胞培养技术。

关键词：神经退行性疾病初创公司 Neuron 德累斯顿专利家族候选药物高通量共同开发

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德国药企预计2021年推出30多种新药

流程工业 2021年第2期 26-27页

作者： MA Alexander stark 本刊德文版杂志

面对各种疾病的困扰——德国制药企业凸显研发力量,新的治疗方案已经进入临床试验阶段。据德国研究型制药企业协会(Vfa)预测,2021年会面市针对Covid-19和各种类型癌症的新型药物,以及几种新型HIV药物和抗生素。Vfa会长Han Steutel表示,... 详细信息

面对各种疾病的困扰——德国制药企业凸显研发力量,新的治疗方案已经进入临床试验阶段。据德国研究型制药企业协会(Vfa)预测,2021年会面市针对Covid-19和各种类型癌症的新型药物,以及几种新型HIV药物和抗生素。Vfa会长Han Steutel表示,多发性硬化症、先天性代谢异常和许多其他疾病的患者也将获得新的治疗选择。

关键词：制药企业多发性硬化症先天性代谢异常药企临床试验阶段新型药物研究型研发力量

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借助超级计算机寻找有效的分子

流程工业 2022年第3期 60-61页

作者： MA Alexander stark 《流程工业》德文版杂志

虽然不断批准的疫苗给新型冠状病毒的预防带来了希望,但是仍缺少一种强有力的治疗药物——德国于利希市的科学家正在欧洲的一个联合项目中寻找能够阻断新型冠状病毒蛋白分子合成的方法。为此,研究人员征用了欧洲最大的超级计算中心,期... 详细信息

虽然不断批准的疫苗给新型冠状病毒的预防带来了希望,但是仍缺少一种强有力的治疗药物——德国于利希市的科学家正在欧洲的一个联合项目中寻找能够阻断新型冠状病毒蛋白分子合成的方法。为此,研究人员征用了欧洲最大的超级计算中心,期望借助其超强的计算能力推进药物的研发。

关键词：超级计算中心超级计算机蛋白分子计算能力疫苗治疗药物

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设计数学基础

设计数学基础

Effects of Electrical Stimulation in People with Post-Concussion Syndromes: A Pilot Study

作者： r.M.·斯塔克(r.M. stark) r.L.·尼科尔斯(r.L. Nicholls)

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Health 2018年第4期10卷 381-395页

作者： Yi-Ning Wu Jessica Gravel Naseem Chatiwala Terrie Enis Caroline stark robert C. Cantu Department of Physical Therapy University of Massachusetts Lowell Lowell MA USA Dr. robert C. Cantu Concussion Center Emerson Hospital Concord MA USA Center for rehabilitative and Sports Therapies Emerson Hospital Concord MA USA Department of Neurosurgery and Neurology Boston University School of Medicine Boston MA USA

Post-concussion syndrome (PCS) is a complex disorder with various symptoms. There is limited evidence to support that any intervention enhances recovery after a concussion. This pilot study aimed to examine the efficacy of neck paraspinal muscles electrical stimulation (ES) in conjunction with physical therapy (PT) on reducing the severity of post concussive symptoms. Twenty-four individuals with PCS were randomly assigned to the ES group (PT + ES) or the control group (PT only). Both groups received the intervention twice a week for eight weeks. Clinical measures including the Concussion Signs/Symptoms Checklist, balance error scoring system, King-Devick test, ImPACT, and the Standardized Assessment of Concussion were used to evaluate the symptoms. We investigated the recovery rate by calculating slopes of changes over time for each participant. A changing slope was derived by linearly fitting the symptoms severity over time with the initial severity score as the intercept. Significant overall improvement was observed in both groups after the interventions. There was no significant difference seen in total symptom recovery rate between two groups (-1.49 ± 1.59 versus -1.2 ± 1.56, p = 0.32). The cognitive symptoms recovery rate of the ES group was faster than the control group (-0.5 ± 0.49 and -0.13 ± 0.46 respectively, p = 0.04). Physical therapy targeting the cervical region is beneficial for persons with PCS. Moreover, peripheral electrical stimulation on the paraspinal muscles surrounding the neck region could potentially advance the cognitive function recovery of persons with PCS.

关键词： Post-Concussion Syndrome Cognitive Function Physical Therapy Electrical Stimulation

Validation of reference Genes for mrNA Quantification in Adjuvant Arthritis

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Open Journal of rheumatology and Autoimmune Diseases 2012年第3期2卷 64-72页

作者： Muhammad Ayaz Alam Qureshi Aisha Siddiqah Ahmed Jian Li André stark Per Eriksson Mahmood Ahmed Department of Clinical Neurosciences Karolinska Institutet Stockholm Sweden Department of Clinical Sciences Danderyd Hospital Karolinska Institutet Stockholm Sweden Department of Medicine Karolinska University Hospital Karolinska Institutet Stockholm Sweden Department of Molecular Medicine and Surgery Karolinska University Hospital Karolinska Institutet Stockholm Sweden Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden

real time quantitative PCr (rT-qPCr) requires a method to normalize the expression of target genes against an en- dogenous reference gene. It is known that commonly used housekeeping genes (HKGs) vary tremendously in inflam- matory conditions;however information about the stability and expression of HKGs in chronic inflammatory joint dis- ease such as rheumatoid arthritis (rA) is scarce. The expressional stability of 10 commonly used HKGs was analyzed in the neuronal (spinal cord, dorsal root ganglia) and in the musculoskeletal tissues (tendon, muscle, epiphysis, capsule, periosteum and ankle joint) using rT-qPCr in the rat model of rA. In individual tissues, suitable HKGs were selected by | △Ct| (│Ct control-Ct arthritis│) and further analyzed by using software programs;geNorm and normfinder. We found hypoxanthine-guanine phosphoribosyl tranferase (HPrT) as the most stable gene except ankle joint while glyce-raldehyde-3-phosphate dehydrogenase (GAPDH) was found as the least stable gene in musculoskeletal tissues. In in-flamed ankle joint where no reference gene was found to be stably expressed, an inflammatory cell marker CD3 was used to normalize peptidylprolyl isomerase B (PPIB), the most homogenous HKG identified among the 10 HKGs. The normalized PPIB was then used to analyze the gene expression of neurokinin 1 (NK1), receptor of substance P, a potent pro-inflammatory mediator. We observed a 3.5 fold increase (p = 0.009) in NK1 expression in inflamed ankle joint compared to control. Our results indicate that reference genes stability should be evaluated before using them as refer- ence during inflammatory conditions. In tissues with intense inflammatory cell infiltration, an inflammatory cell marker should be used to normalize the selected reference gene to avoid erroneous results.

关键词： Quantitative PCr Adjuvant Arthritis Housekeeping Gene

Cascaded Fractional Kalman Filtering for State and Current Estimation of Large-Scale Lithium-Ion Battery Packs

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Cascaded Fractional Kalman Filtering for State and Current E...

Super-receiver Design for Superchannel Coherent Optical Systems

第30届中国控制与决策会议

作者： Martin Kupper Jochen Brenneisen Oliver stark Stefan Krebs S?ren Hohmann Institute of Control Systems Karlsruhe Institute of Technology

In this paper, a cascaded fractional Kalman filter for state of charge and branch current estimation of largescale battery systems is proposed. As a centralized approach for the estimation of a large-scale system is costly in terms of effort and time, a partition into smaller and, therefore, simpler subsystems is applied. Since the overall system is divided into smaller units, a local computation is allowed and complexity reduced. In these distributed systems, usually,the subsystems communicate with each other to exchange relevant data. Using a model based on mesh currents, we receive a cascaded system structure which results in a hierarchical arrangement of all subsystems. This concludes in a one-directional information flow and, therefore, reduces the overall communication effort. Using this proposed approach,it is not only possible to estimate the states of each branch locally but also to calculate the branch currents when the total current is known. Finally, a practical test with real measurement data is presented.

关键词： State of Charge estimation Current estimation Kalman filter Cascaded systems Fractional order Battery pack Large-scale Lithium-ion

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ZTE Communications 2012年第1期10卷 30-33页

作者： Thomas Detwiler Andrew stark Yu-Ting Hsueh Gee-Kung Chang Stephen E. ralph School of Electrical and Computer Engineering Georgia Institute of Technology

In this paper, we propose a novel superreceiver architecture for Nyquistwavelengthdivision multiplexing （WDM） superchannel optical coherent systems. As opposed to a conventional coherent receiver, where each subchannel is demodulated independently, the proposed superreceiver jointly detects and demodulates multiple subchannels simultaneously. By taking advantage of information from side channels that use joint DSP to cancel interchannel interference （ICI）, the proposed super receiver performs much better than a conventional receiver. This architecture also has the potential to compensate for crosschannel impairments caused by linear and nonlinear effects. We examine the proposed architecture through experiment and simulation. OSNr is improved by more than 5 dB after 1280 km fiber transmission with narrow channel spacing.

关键词： superchannel joint DSP ICI coherent receiver

在高压工况下通过应用齿轮传动压缩机节省功率和成本

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工程设计学报 1999年第3期6卷 48-52页

作者： M.stark M.Schⅹlch 毛谦德柏林GHHBOrSIG透平机械有限公司北京理工大学机械工程系 100081

ＧＨＨＢＯＲＳＩＧ透平机械公司建造了世界上首台１０级齿轮传动压缩机，并且成功地进行了试验。该机器在一个俄罗斯的尿素合成装置中用于压缩二氧化碳至２００ｂａｒ。与在这种情况下通常使用的多室式单轴压缩机相比，新的... 详细信息

ＧＨＨＢＯＲＳＩＧ透平机械公司建造了世界上首台１０级齿轮传动压缩机，并且成功地进行了试验。该机器在一个俄罗斯的尿素合成装置中用于压缩二氧化碳至２００ｂａｒ。与在这种情况下通常使用的多室式单轴压缩机相比，新的解法明显地降低了成本和功率。本文介绍了新式压缩机的技术特点，特别着重于齿轮传动和控制方面。此外还叙述了压缩机各级的热动力设计特色。

关键词：压缩机齿轮传动高压工况设计功率成本

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环境微塑料中的空中短绒飞尘

国际纺织导报 2022年第7期50卷 36-39页

作者： M.stark 徐宸(译) 孟粉叶(校) 德国弗莱堡不详

短绒飞尘无处不在,甚至在公海上空和偏远地区的尘埃沉积中也能找到。特别是较短和较细的纤维,它们可以进行长距离传输,并像沙漠中的灰尘一样在全球传播。近期,关于农村地区环境空气和沉积物中短绒飞尘的研究表明:粗略估计,合成纤维的沉... 详细信息

短绒飞尘无处不在,甚至在公海上空和偏远地区的尘埃沉积中也能找到。特别是较短和较细的纤维,它们可以进行长距离传输,并像沙漠中的灰尘一样在全球传播。近期,关于农村地区环境空气和沉积物中短绒飞尘的研究表明:粗略估计,合成纤维的沉积率为1~5 kg/(km2·a)。这些结果证实了一个假设,即与污水处理厂的排放相比,海洋环境中的短绒数量与空气路径更相关,这种短绒的长距离飞行输送导致了它们在北极冰等极度偏远地区也会大量存在。

关键词：短绒飞尘长距离传输环境空气沉积物