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a.a.ysis a.d Optimiza.ion of Opera.iona. a.d Polluta.t a.tributes of Diesel Engine with CNT-Infused Ora.ge Peel Biodiesel-Diesel Blend Fuel

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Journa. of Therma. Science 2024年第2期33卷 761-778页

作者： ra.jeet ra. r.r.Sa.OO Mecha.ica. Engineering Depa.tment GLA UniversityMathura281406India Mecha.ica. Engineering Depa.tment IIT(BHU)Varanasi221005India

The current study is performed to find susta.na.le solutions for the future of tra.sporta.ion a.d environmenta. *** conventiona. methods a.d experimenta. design ta.le(L16 Orthogona. a.ra.)techniques ha.e been employed to exa.ine a.d optimize a.diesel-powered engine's opera.iona. a.d polluta.t *** L16 Orthogona. a.ra. is obta.ned through Ta.uchi's experimenta. design a.proa.h using Minita. 16 *** experimenta. design incorpora.ed three control va.ia.les,na.ely engine speed,fuel type,a.d engine loa.,ea.h with four *** opera.iona. pa.a.eters,na.ely bra.e therma. efficiency(BTE)a.d bra.e specific fuel consumption(BSFC),a. well a. the emission cha.a.teristics,including hydroca.bon(HC),ca.bon monoxide(CO),nitrogen oxide(NO),a.d smoke emissions,were a.quired using the L16 orthogona. a.ra.(Oa. a.d subsequently *** utiliza.ion of methodologies such a. signa.-to-noise(S/N) ra.io a.d grey a.a.ysis wa. employed to determine the optima. opera.iona. sta.e of the engine to a.hieve ma.imum performa.ce while minimizing *** engine's idea. sta.e of opera.ion,in terms of BTE a.d BSFC,wa. determined to be a. 75% engine loa.,1000 r/min engine speed,a.d using 10^(-4)(in vol) ca.bon na.otube incorpora.ed 20% ora.ge peel biodiesel(OPB20CNT100) blended fuel(a.-B1-C4).The study indica.ed tha. engine loa. significa.tly influenced BTE a.d BSFC,with 84.05% a.d 87.79% contribution fa.tors,*** 25% engine loa.,1000 r/min,a.d OPB20CNT100 fuel(a.-B1-C4) CO,smoke,NO,a.d HC emissions were the *** loa. a.fects emissions the *** BSFC increa.ed 3.10% a.d NO emissions 1.77%.BTE,CO,smoke,a.d HC emissions decrea.ed by 1.9%,12.29%,47.05%,a.d 47.22%,respectively,a. optima. opera.ing conditions concerning diesel *** study shows tha. Ta.uchi-Grey's experimenta. design optimizes diesel engine opera.iona. a.d polluta.t *** outcomes revea.ed tha. ora.ge peel biodiesel infused with CNT ca. repla.e diesel fuel in a

关键词： Ta.uchi-Grey method OPB20CNT100 tra.sesterifica.ion S/N ra.io GrG HC CO a.d NO

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Multidimensiona. ima.es a.d a.erra.ions in STEM

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Chinese Physics B 2024年第9期33卷 68-74页

作者： Eric r.Hoglund a.drew r.Lupini Center for Na.opha.e Ma.eria.s Sciences Oak Ridge National LaboratoryOak RidgeTN 37831United States

recent a.va.ces in sca.ning tra.smission electron microscopy(STEM)ha.e led to increa.ed development of multidimensiona. STEM ima.ing moda.ities a.d novel ima.e reconstruction *** interest a.ises beca.se the ma.n electron lens in a.modern tra.smission electron microscope usua.ly ha. a.diffra.tion-spa.e informa.ion limit tha. is significa.tly better tha. the rea.-spa.e resolution of the sa.e *** sta.e-of-a.fa.rs is sometimes sha.ed by other sca.tering methods in modern physics a.d contributes to a.broa.er excitement surrounding multidimensiona. techniques tha. sca. a.probe while recording diffra.tion-spa.e ima.es,such a. ptychogra.hy a.d sca.ning na.o-bea. ***,the contra.ting resolution in the two spa.es ra.ses the question a. to wha. is limiting their effective ***,we exa.ine this pa.a.ox by considering the effects of a.erra.ions in both ima.e a.d diffra.tion pla.es,a.d likewise sepa.a.e the contributions of pre-a.d post-sa.ple *** considera.ion provides insight into a.erra.ion-mea.urement techniques a.d might a.so indica.e improvements for super-resolution techniques.

关键词： sca.ning tra.smission electron microscopy (STEM) a.erra.ions

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Multi-Compa.tment SCFa.Qua.tifica.ion in Huma.

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a.erica. Journa. of a.a.ytica. Chemistry 2024年第6期15卷 177-200页

作者： Jérémy Monteiro a.toine Lefèvre Dia.e Dufour-ra.nfra. a.eline Oury Ga.rielle Chicheri La.rent Ga.inea. Hélène Bla.co Lydie Na.a.-Desba.a.s Pa.rick Emond Ima.ing Bra.n & Neuropsychia.ry iBra.N U1253 Universit de Tours INSERM MetaboHub Tours Tours France CHrU de Tours Service de Mdecine Nuclaire in Vitro Tours France Service de Biochimie et Biologie Molcula.re CHRU Tours France

Short-cha.n fa.ty a.ids (SCFa. pla. a. importa.t role in huma. biochemistry. They origina.e prima.ily from the digestive system through ca.bohydra.es microbia. fermenta.ion. Most SCFa.produced in the colon a.e a.sorbed by the intestina. wa.l a.d enter the bloodstrea. to be distributed throughout the body for multiple purposes. a. the intestina. level, SCFa.pla. a.role in controlling fa. stora.e a.d fa.ty a.id meta.olism. The effects of these beneficia. compounds therefore concern overa.l hea.th. They fa.ilita.e energy expenditure a.d a.e va.ua.le a.lies in the fight a.a.nst obesity a.d dia.etes. SCFa.a.e a.so involved in the regula.ion of the levels of severa. neurotra.smitters such a. Ga.a.(γ-a.inobutyric a.id), gluta.a.e, serotonin, dopa.ine, a.d norepinephrine. Their role is a.so highlighted in ma.y infla.ma.ory a.d neurodegenera.ive disea.es such a. a.zheimer’s disea.e (a.) or Pa.kinson’s disea.e (PD). To ha.e a.rea.istic picture of the distribution of SCFa.in different biologica. compa.tments of the huma. body, we propose to study SCFa.simulta.eously in five huma. biologica. sa.ples: feces, sa.iva. serum, cerebrospina. fluid (CSF), a.d urine, a. well a. in Dried Blood Spot (DBS). To eva.ua.e their concentra.ion a.d repea.a.ility, we used 10 a.iquots from pooled sa.ples, a.a.yzed by 3-nitrophenylhydra.ine (3-NPH) deriva.ion a.d liquid chroma.ogra.hy coupled with high sensitivity ma.s spectrometry (LC-QqQ-MS). We a.so eva.ua.ed the SCFa.a.sa. on Dried Blood Spot (DBS). In this work, we a.a.ted the pre-a.a.ytica. pa.ts for ea.h sa.ple to be a.le to use a.common ca.ibra.ion curve, thus fa.ilita.ing multi-a.sa. qua.tifica.ion studies a.d so being less time-consuming. Moreover, we proposed new da.ghter ions from the sa.e neutra. loss (43 Da. to qua.tify SCFa., thus improving the sensitivity. In conclusion, our methodology, ba.ed on a.unique ca.ibra.ion curve for a.l sa.ples for ea.h SCFa. is well-suited to qua.tified them in a.clinica. context.

关键词： LC-MS 3-Nitrophenylhydra.ine Short-Cha.n Fa.ty a.ids Huma. Biologica. Sa.ples Qua.tifica.ion

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New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-a.ine: Synthesis, Cytotoxic Effects on Tumora. Cell Lines a.d in Silico a.MET Properties

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Interna.iona. Journa. of Orga.ic Chemistry 2024年第3期14卷 107-122页

作者： Ma.wa.Dhia.i Sirine Ka.oui Mehdi Fa.hfa.h Souhir a.id Emma.uelle Lima.ton rémy Le Guével Thierry Cha.lier Ludovic Pa.uin Jea.-Pierre Ba.urea. Houcine a.ma. La.ora.oire de Chimie a.plique: Htrocycles Corps et Polymres Facult des Sciences de Sfax Universit de Sfax Sfax Tunisie Institut des Sciences Chimiques de rennes Universit de Rennes Campus de Beaulieu Rennes Cedex France Depa.tment of Chemistry (Science a.d a.ts): a. Qura.a. Al-Jouf University Al Jawf Saudi Arabia S2Wa.e Pla.form ScanMAT UAR CNRS Universit de Rennes Campus de Beaulieu Rennes Cedex France ImPa.cell Pla.form Biosit SFR UMS CNRS Inserm Campus de Villejean Rennes France Institut de recherche en Sa.t Environnement et Travail IRSET Inserm UMR_S Rennes France

The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-a.ine in four steps including one step under microwa.e dielectric hea.ing is reported. The structura. identity of the synthesized compounds wa. esta.lished a.cording to their spectroscopic a.a.ysis, such a. FT-Ir, NMr a.d ma.s spectroscopy. These new compounds were tested for their a.tiprolifera.ive a.tivities on seven representa.ive huma. tumora. cell lines (Huh7 D12, Ca.o2, MDa.MB231, MDa.MB468, HCT116, PC3 a.d MCF7) a.d a.so on fibrobla.ts. a.ong them, only the compounds 6c showed micromola. cytotoxic a.tivity on tumor cell lines (1.8 50 50 > 25 μM). Fina.ly, in silico a.MET studies wa.e performed to investiga.e the possibility of using of the identified compound 6c a. potentia. a.ti-tumor compound.

关键词： 2-a.ino-4H-Chromene 4H-Chromeno[2 3-d]Pyrimidin-3(5H)-a.ine Microwa.e Irra.ia.ion Tumora. Cell Line in Silico a.MET

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Development of Extra.tion a.d Detection Method for a.Chemothera.eutic Drug with Phenytoin in Biologica. Sa.ples

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a.va.ces in Biologica. Chemistry 2024年第4期14卷 103-110页

作者： Micha.l a.not Nicola. Brice a.a. Ga.cia.Victor Lomeli my Phuong Vu Ka.no Ng Depa.tment of Chemistry & Biochemistry California State University San Marcos San Marcos CA U.S.A.

Dexa.etha.one is cla.sified a. a.corticosteroid a.d is commonly used a.ong ca.cer pa.ients to decrea.e the a.ount of swelling a.ound the tumor. a.ong pa.ients with ca.cer, in pa.ticula. bra.n tumors, seizures ca. become a.da.ly routine in their everyda. lives. To countera.t the seizures, a. a.tiepileptic drug such a. phenytoin is a.ministered to a.t a. a. a.ticonvulsa.t. Phenytoin a.d dexa.etha.one a.e frequently a.ministra.ed concurrently to bra.n ca.cer pa.ients. a.previous study ha. shown tha. phenytoin serum concentra.ion decrea.es when a.ministra.ed concurrently with dexa.etha.one. Thus, it is importa.t to monitor the concentra.ion of these two drugs in biologica. sa.ples to ensure tha. the proper dosa.es a.e a.ministra.ed to the pa.ients. This study a.ms to develop a. effective extra.tion a.d detection method for dexa.etha.one a.d phenytoin. a.reverse-pha.e high-performa.ce liquid chroma.ogra.hy (HPLC) method with UV/Vis detection ha. been developed to sepa.a.e phenytoin a.d dexa.etha.one a. 219 nm a.d 241 nm respectively from urine sa.ples. The mobile pha.e consists of a.mixture of 0.01 M KH2PO4, a.etonitrile, a.d metha.ol a.justed to pH 5.6 (48:32:20) a.d is pumped a. a.flow ra.e of 1.0 mL/min. Ca.ibra.ion curves were prepa.ed for phenytoin a.d dexa.etha.one (r2 > 0.99). a. efficient solid-pha.e extra.tion (SPE) method for the extra.tion of dexa.etha.one a.d phenytoin from urine sa.ples wa. developed with the use of C-18 ca.tridges. The percent recovery for phenytoin a.d dexa.etha.one is 95.4% (rSD = 1.15%) a.d 81.1% (rSD = 3.56%) respectively.

关键词： Dexa.etha.one Phenytoin Ca.cer Drug Intera.tion Solid Pha.e Extra.tion

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Kinema.ic a.a.ysis of flexible bipeda. robotic systems

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2024年第5期45卷 795-818页

作者： r.Fa.EL a.M.SHa.EI S.r.NEKOO Depa.tment of Mecha.ica. Engineering Shahid Bahonar University of KermanKerman ***Iran Depa.ta.ento de Ingenieria.de Sistema. y a.toma.ica Escuela Técnica Superior de IngenieriaUniversidad de SevillaSeville 41092Spain

In spite of its intrinsic complexities,the pa.sive ga.t of bipeda. robots on a.sloping ra.p is a.subject of interest for numerous *** distinguishes the present resea.ch from simila. works is the considera.ion of flexibility in the constituent links of this type of robotic *** is not a.fa.-fetched a.sumption beca.se in the tra.sient(impa.t)pha.e,due to the impulsive forces which a.e a.plied to the system,the likelihood of exciting the vibra.ion modes increa.es ***,the huma. leg bones tha. a.e involved in wa.king a.e supported by viscoela.tic muscles a.d ***,for a.hieving more exa.t results,it is essentia. to model the robot links with viscoela.tic *** this end,the Gibbs-a.pell formula.ion a.d Newton's kinema.ic impa.t la. a.e used to derive the most genera. form of the system's dyna.ic equa.ions in the swing a.d tra.sient pha.es of *** most importa.t issue in the pa.sive wa.king motion of bipeda. robots is the determina.ion of the initia. robot configura.ion with which the system could a.complish a.periodic a.d sta.le ga.t solely under the effect of gra.ita.iona. *** extremely unsta.le na.ure of the system studied in this pa.er a.d the vibra.ions ca.sed by the impulsive forces induced by the impa.t of robot feet with the inclined surfa.e a.e some of the very serious cha.lenges encountered for a.hieving the a.ove-mentioned *** overcome such cha.lenges,a. innova.ive method tha. uses a.combina.ion of the linea.ized equa.ions of motion in the swing pha.e a.d the a.gebra.c motion equa.ions in the tra.sition pha.e is presented in this pa.er to obta.n a. eigenva.ue *** solving this problem,the suita.le initia. conditions tha. a.e necessa.y for the pa.sive ga.t of this bipeda. robot on a.sloping surfa.e a.e *** effects of the cha.a.teristic pa.a.eters of ela.tic links including the modulus of ela.ticity a.d the Kelvin-Voigt coefficient on the wa.king sta.ility of this type of

关键词： bipeda. robot flexible link swing pha.e tra.sient pha.e eigenva.ue problem Kelvin-Voigt coefficient

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Hologra.hic da.k energy in non-conserved gra.ity theory

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Communica.ions in Theoretica. Physics 2024年第4期76卷 126-133页

作者： H r Fa.lolla.i Institute of Gra.ita.ion a.d Cosmology Peoples Friendship University of Russia(RUDN University)6 Miklukho-Maklaya StMoscow117198Russia

recently, reconsidering the ra.ta.l idea.T_(μ;νν)^(v)=α_(,μ) through rela.ivistic thermodyna.ics gives a.new form for the sca.a. field α which led us to construct modern modified theory of gra.ity debugged ‘non-conserved gra.ity theory’ Fa.lolla.i 2023 Euro. Phys. J. C 83 923. This theory unlike other modified theories of gra.ity ca.not directly expla.n the current a.celera.ion expa.sion in the a.sence of the cosmologica. consta.t a.d or existence of other forms of da.k energy. Hence, in this study we ha.e reinvestiga.ed hologra.hic da.k energy Ρ_(X)~H^(2) in the non-conserved theory of gra.ity. In this context, the density a.d pressure of da.k energy depend on the non-conserved term a.d density of the dust ma.ter field. a. shown, due to non-conserva.ion effects on la.ge-sca.e structures, unlike the origina. hologra.hic model, our model onsets a. a.celera.ion epoch for the current Universe sa.isfies observa.ions. Moreover, the intera.tion a.d viscous scena.ios a.e studied for this model.

关键词： non-conserved gra.ity cova.ia.t form of thermodyna.ics hologra.hic da.k energy

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Improvement of a.tivities of Da.ly Living (a.L) for Pa.ients Trea.ed in Skilled Nursing Fa.ilities (SNFs)

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Open Journa. of Thera.y a.d reha.ilita.ion 2024年第1期12卷 61-69页

作者： Ja.en a. Silver Sea. r. Silver Sa.ueli School of Engineering University of California Los Angeles USA

Ba.kground: Self-ca.e ta.ks or a.tivities of da.ly living (a.L)’s performa.ce a.e often disrupted a.ter a. older a.ult susta.ns a. injury or illness, which ca. be a.determining fa.tor for discha.ge pla.ement a.ter hospita.iza.ion, or it ca. determine the level of a.sista.ce required a.ter discha.ge from a.skilled nursing fa.ility (SNF). We believe tha. comprehensive reha.ilita.ion ca. improve a.pa.ient’s overa.l functioning during their short term sta. in SNFs. The purpose of this study is to determine if a. individua.’s level of independence improved a.ter a.mission to a.skilled nursing fa.ility a.d procurement of reha.ilita.ion services. Methods: This study retrospectively reviewed 4612 nursing home pa.ients in Ca.ifornia.who underwent reha.ilita.ive services a. skilled nursing fa.ilities to determine how the pa.ients responded to their environments, thera.y interventions, a.d a.y other a.ditiona. supportive mea.ures. The records of pa.ients who were a.mitted for short-term reha.ilita.ion were reviewed in a.blinded fa.hion, looking specifica.ly a. Section GG of the Minimum Da.a.Set (MDS). Self-Ca.e Section GG scores recorded by reha.ilita.ive sta.f provide objective da.a.a.d mea.ure pa.ients’ levels of a.sista.ce tha. were required. Ea.h a.tivity is scored from 1, being completely dependent, to 6, being entirely independent, with va.ying levels of a.sista.ce with scores in between. The a.mission scores versus the discha.ge scores ca. be compa.ed to determine if a.pa.ient improved their level of functioning upon discha.ge. results: Utilizing the Pea.son’s correla.ion coefficient, a.strong correla.ion of improvement in a.L performa.ce on Section GG between the a.mission a.d discha.ge scores wa. identified, implying significa.t improvement in functiona. independence upon discha.ge. The a.era.e percent improvement for Ma.a.ed Ca.e pa.ients wa. ~35.4% a.d ~39.4% for Medica.e pa.ients. Conclusions: The results support the benefits of reha.ilita.ion services in skilled n

关键词： a.tivities of Da.ly Living Skilled Nursing Fa.ilities reha.ilita.ion Independent Living

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Improvement in Pa.ient Mobility Following Short-Term reha.ilita.ion in Skilled Nursing Fa.ilities

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Open Journa. of Thera.y a.d reha.ilita.ion 2024年第1期12卷 52-60页

作者： Sea. r. Silver Ja.en a. Silver Sa.ueli School of Engineering University of California Los Angeles USA

Ba.kground: Mobility in older a.ults ca. be impa.red a.ter a.ute illness or hospita.iza.ion, a.d the level of severity ca. be used a. a.predictor of one’s a.ility to return to independent living. Pa.ients a.e often referred to skilled nursing fa.ilities in hopes of improving their mobility. We wa.ted to prove tha. reha.ilita.ive services a. Skilled Nursing Fa.ilities improve overa.l outcomes. Methods: We conducted a.retrospective a.a.ysis of da.a.from 4612 pa.ients a.mitted for short-term reha.ilita.ion in a.la.ge nursing home cha.n in Ca.ifornia. Our a.m wa. to determine whether pa.ients’ mobility scores, a. mea.ured by reha.ilita.ive sta.f, significa.tly improved by time of discha.ge compa.ed to their scores a. a.mission. Mobility scores were ra.ed from 1 to 6, with 1 being the most dependent on a.d a.d 6 being the most independent, over a.va.iety of ta.ks a. a.mission a.d compa.ed to scores a. discha.ge. Pea.son’s correla.ions were performed to determine if there were significa.t rela.ionships in the da.a. the Pea.son’s correla.ion coefficient wa. used to describe the rela.ionships between pa.ient a.mission to a.skilled nursing fa.ility a.d medica. improvement upon discha.ge. results: The study demonstra.ed a.sta.istica.ly significa.t improvement in pa.ients’ mobility scores upon discha.ge, with Medica.e insured pa.ients showing on a.era.e 57% improvement a.d Ma.a.ed Ca.e insured pa.ients showing on a.era.e 59% improvement. a.ditiona.ly, a.mission scores a.pea.ed to be predictive of the pa.ient’s outcome a. discha.ge. Conclusions: The va.ues a.d consistency of improvement support the use of a.ute reha.ilita.ive services in skilled nursing fa.ilities. a. equa.ion ca. be formula.ed tha. eva.ua.es pa.ients’ estima.ed mobility sta.uses upon discha.ge from fa.ilities ba.ed on their conditions on their a.riva.s. With this, new interventions ca. be studied a.d compa.ed to the current sta.da.d of ca.e by using these mea.urements. They ca. determine if further improvement

关键词： Mobility Skilled Nursing Fa.ility reha.ilita.ive Services Independent Living Hea.thca.e

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Investiga.ing the impa.t of the universa. function of the nuclea. proximity potentia. in hea.y-ion fusion cross sections

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Communica.ions in Theoretica. Physics 2024年第5期76卷 86-93页

作者： r Gha.a.i E Sa.va.i Depa.tment of Physics Sciences FacultyHakim Sabzevari UniversityPO Box 397SabzevarIran Depa.tment of Physics Faculty of ScienceFerdowsi University of MashhadPO Box 91775-1436MashhadIran Science Fa.ulty Department of PhysicsTarbiat Modares UniversityTehranIran

The fusion ba.riers a.d cross sections of 15 colliding systems with 320≤Z_(1)Z_(2)≤1512 a.e investiga.ed in deta.l to understa.d the influence of the universa. function of proximity potentia. forma.ism in the hea.y-ion fusion *** rea.ize this goa.,we select three versions of the phenomenologica. proximity potentia.s,including Prox.77,Zha.g 2013,a.d Guo 2013,to ca.cula.e the nucleus-nucleus *** experimenta. fusion cross sections for the selected rea.tions a.e a.a.yzed using the sta.da.d coupled-cha.nel ca.cula.ions,including couplings to the low-lying 2^(+)a.d 3^(-)sta.es in the ta.get a.d *** ca.cula.ed results show tha. the universa. functions of the Guo 2013 a.d Prox.77 models provide the lowest a.d highest fusion ba.riers,*** a.dition,it is found tha. the height of the fusion ba.riers is enha.ced by increa.ing the ma.s number of the projectile from light to hea.y *** highest sensitivity to the ma.s number of the projectile belongs to the results of Prox.77.a.discussion is a.so presented on the influence of the universa. function on the ra.ia. beha.ior of the intera.tion potentia. in the a.lowed region for overla.ping *** results revea. tha. the best fit to the experimenta. da.a.of the fusion cross sections for the rea.tions involving light a.d medium nuclei is obta.ned using the universa. function of the Zha.g 2013 *** the hea.ier systems,the results of the Guo 2013 model a. sub-ba.rier energies provide a.good description of the a.a.la.le da.a.

关键词： fusion rea.tions proximity-type potentia.s universa. function coupled-cha.nel ca.cula.ions

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