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Astrocytes in the cerebral cortex play a role in the spontaneous motor recovery following experimental striatal hemorrhage

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Neural regeneration research 2018年第1期13卷 67-68页

作者： Juliana Dalibor Neves régis gemerasca mestriner Carlos Alexandre Netto Graduate Program of Physiology Institute of Basic Health Sciences Universidade Federal do Rio Grande do Sul Department of Biochemistry Institute of Basic Health Science Universidade Federal do Rio Grande do Sul Neurorehabilitation and Neural repair research Group Pontifícia Universidade Católica do Rio Grande do Sul

Intracerebral hemorrhage （ICH） is a stroke subtype caused by spontaneous rupture of small vessels and bleeding into the brain paren- chyma, resulting in cell death and sensorimotor deficits. Despite the greater prevalence of the ischemic form of stroke （87%）, ICH has the highest mortality rate of all stroke subtypes. The striatum is the most affected structure in hemorrhagic stroke （35-70%）, followed by cere- bral cortex （15-30%）, brain stem and cerebellum （5-10%）; patients suffering striatal and/or cortical ICH bear persistent sensorimotor disabilities. Although chronic sensorimotor impairment is established, a considerable amount of patients experience some degree of spontaneous recovery during the first six months after stroke （Qureshi et al., 2009）, and the neurobiological basis of this process is not understood.

关键词： Astrocytes in the cerebral cortex play a role in the spontaneous motor recovery following experimental striatal hemorrhage ICH

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Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats

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Neural regeneration research 2018年第11期13卷 1945-1952页

作者： Mayara Ferraz de Menezes Fabricio Nicola Ivy reichert Vital da Silva Adriana Vizuete Viviane rostirola Eisner Leder Leal Xavier Carlos Alberto Saraiva Goncalves Carlos Alexandre Netto regis gemerasca mestriner Neurorehabilitation and Neural repair research Group Pontificia Universidade Catolica do Rio Grande do Sul Porto Alegre RS Brazil Graduate Program in Cellular and Molecular Biology Pontificia Universidade Catolica do Rio Grande do SUl Porto Alegre RS Brazil Department of Biochemistry Basic Science Institute Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil Graduate Program in Biosciences and rehabilitation. Centro Universitairio Metodista IPA Porto Alegre RS Brazil

Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity-a wellknown process that markedly influences the tissue remodeling after a central nervous system injury-is crucial for tissue remodeling after spinal cord injury（SCI）. However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood. We sought to investigate the relation between both glial fibrillary acidic protein（GFAP） and S100 calcium-binding protein B（S100B）（astrocytic reactivity classical markers） and global histone H4 acetylation levels. Sixty-one male Wistar rats（aged ~3 months） were divided into the following groups： sham; 6 hours post-SCI; 24 hours post-SCI; 48 hours post-SCI; 72 hours post-SCI; and 7 days post-SCI. The results suggested that GFAP, but not S100B was associated with global histone H4 acetylation levels. Moreover, global histone H4 acetylation levels exhibited a complex pattern after SCI, encompassing at least three clearly defined phases（first phase： no changes in the 6, 24 and 48 hours post-SCI groups; second phase： increased levels in the 72 hours post-SCI group; and a third phase： return to levels similar to control in the 7 days post-SCI group）. Overall, these findings suggest global H4 acetylation levels exhibit distinct patterns of expression during the first week post-SCI, which may be associated with GFAP levels in the perilesional tissue. Current data encourage studies using H4 acetylation as a possible biomarker for tissue remodeling after spinal cord injury.

关键词： histones spinal cord injury glial fibrillary acidic protein S100 calcium-binding protein B neuralplasticity astrocyte ELISA-immunoassay recovery neural repair rats

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