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Perfluorinated iodine alkanes promote the differentiation of mouse embryonic stem cells by regulating estrogen receptor signaling

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Journal of Environmental Sciences 2024年第3期137卷 443-454页

作者： Zhihua Ren Xiaoxi Yang Tingting Ku Qian S.Liu Jiefeng Liang qunfang zhou Francesco Faiola Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China College of Sino-Danish University of Chinese Academy of SciencesBeijing 100049China

Investigating the development toxicity of perfuorinated iodine alkanes(PFIs)is critical,given their estrogenic effects through binding with estrogen receptors(ERs).In the present study,two PFIs,including dodecafuoro-1,6-diiodohexane(PFHx DI)and tridecafuorohexyl iodide(PFHx I),with binding preference to ERαand ERβ,respectively,were selected to evaluate their effects on proliferation and differentiation of the mouse embryonic stem cells(m ESCs).The results revealed that,similar to E_(2),50μmol/L PFHx DI accelerated the cell proliferation of the m *** PFI stimulation at the exposure concentrations of 2–50μmol/L promoted the differentiation of the m ESCs as characterized by the upregulation of differentiation-related biomarkers(i.e.,Otx2 and Dnmt3β)and downregulation of pluripotency genes(i.e.,Oct4,Nanog,Sox2,Prdm14 and Rex1).Comparatively,PFHx DI exhibited higher induction effect on the differentiation of the m ESCs than did PFHx *** tests on ER signaling indicated that both PFI compounds induced exposure concentration-dependent expressions of ER signaling-related biomarkers(i.e.,ERα,ERβand Caveolin-1)in the m ESCs,and the downstream ER responsive genes(i.e.,c-fos,c-myc and c-jun)well responded to PFHx I *** role of ER in PFI-induced effects on the m ESCs was further validated by the antagonistic experiments using an ER inhibitor(ICI).The findings demonstrated that PFIs triggered ER signaling,and perturbed the differentiation program of the m ESCs,causing the potential health risk during early stage of development.

关键词： Perfuorinated iodine alkanes(PFIs) Embryonic stem cells(ESCs) Developmental toxicity Cell differentiation Estrogen receptor-related signaling

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Environmental Obesogens and Their Perturbations in Lipid Metabolism

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Environment & Health 2024年第5期2卷 253-268页

作者： Xiaoyun Wang Zhendong Sun Qian S.Liu qunfang zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China

Epidemiological data show that obesity is now a *** homeostasis requires the coordination of multiple tissues and organs,including the liver,kidney,cardiovascular system,and adipose tissues,to maintain bodily *** increasing amounts of chemicals are being synthesized,applied,and released into the environment,their obesogenic effects have triggered serious ***,more than 50 types of chemicals with high human exposure levels have been identified as environmental obesogens that can interfere with lipid metabolism and induce *** studies have shown that the lipid metabolism interference effects of obesogens have multiple targets,including nuclear receptors,transcription factors,cytokines,and *** interfering factors of environmental obesogeninduced obesity include transgenerational effects,susceptibility windows,gender differences,structure−effect relationships,and diet *** research approaches have been established to conduct obesogenic effect *** comprehensive review summarizes the mechanisms underlying obesogen actions and the research progress on obesogen-disrupted lipid metabolism,along with the influencing factors and research approaches,aiming to provide a framework for understanding the effects of environmental obesogens on lipid metabolism.

关键词： environmental obesogens lipid metabolism risk assessment influencing factors research approaches

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Enhanced Research Needed on the Structural Analogues of Chlorinated Paraffins as Emerging Contaminants of Concern

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Environment & Health 2024年第10期2卷 681-683页

作者： Weifang Chen Dazhou Ren Qian Liu qunfang zhou Jiyan Liu Guibin Jiang School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China the Research Center for Eco-Environmental Sciences Chinese Academy of Sciences(RCEESCAS).

INTRODUCTION Structural analogues of chlorinated paraffins(CPs)are compounds that contain the chlorinated n-alkanes skeleton of CPs and other functional ***,some structural analogues of CPs at high levels were detected in the environment and general population.1−5 The atmospheric concentrations of unsaturated short,medium,and long chain chlorinated olefins(COs)were 0.01−0.27,0.02−0.56,and 0.01−0.55 ng/m3 in China.1 Over 700 brominated-chlorinated paraffin and brominated-chlorinated olefin congeners(BCPs and BCOs)were found in different matrices in *** concentrations of BCPs and BCOs in dust samples(median concentrations of 5.4 and 0.18μg/g,respectively)are comparable to CPs,and 1−2 orders of magnitude higher than those in the atmosphere and sediments at some sites.

关键词： analogues chlorinated alkanes

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合成酚类化合物的脂代谢干扰效应与致肥胖作用

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色谱 2024年第2期42卷 131-141页

作者：刘惠楠孙振东刘倩周群芳江桂斌中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室北京100085 中国科学院大学资源与环境学院北京100049 国科大杭州高等研究院环境学院浙江杭州310024

随着社会经济的不断发展,肥胖已经成为一种不可忽视的全球性流行疾病。除了受到遗传和饮食因素的影响外,肥胖的形成与发展也与环境中的化学物质暴露有关。研究发现一些具有内分泌干扰活性的化学物质可以影响机体脂代谢,如促进脂肪细胞... 详细信息

随着社会经济的不断发展,肥胖已经成为一种不可忽视的全球性流行疾病。除了受到遗传和饮食因素的影响外,肥胖的形成与发展也与环境中的化学物质暴露有关。研究发现一些具有内分泌干扰活性的化学物质可以影响机体脂代谢,如促进脂肪细胞形成、引起体内脂质累积增加等,这类物质被称为“环境致肥胖物质”。合成酚类化合物广泛用于工业生产和日常生活用品中,如塑料制品、消毒剂、杀虫剂和食品添加剂等,它们可通过饮食、饮水或皮肤接触等方式进入人体,是影响人体健康的潜在威胁。研究显示,合成酚类化合物具有内分泌干扰效应,可以影响脂肪生成过程、干扰脂代谢,具有致肥胖作用。由于这类物质都具有类似的苯酚结构,因此系统梳理这类化合物脂代谢干扰效应与致肥胖作用,有助于理解其构效关系与潜在健康风险。本文阐述了筛选环境致肥胖物质的3种常用研究模型,即体外分子互作研究模型、细胞成脂分化模型和动物脂代谢实验模型,并比较了各种模型的适用场景和优缺点。在此基础上,针对3种合成酚类化合物,即双酚A及其类似物、烷基酚和酚类抗氧化剂,结合其体外细胞与动物实验数据,对这些化合物的暴露现状和脂代谢干扰效应进行了分类描述,从它们对脂肪生成和代谢、肝组织脂代谢的影响等方面展开讨论。基于近年来脂代谢和致肥胖效应的相关研究,本文归纳总结了环境内分泌干扰物干扰脂代谢的内在毒理机制,主要包括核受体调控作用、炎症和氧化应激、肠道微环境、表观遗传和其他信号通路。最后本文指出了当前针对环境污染物,特别是新污染物,影响机体脂代谢引起肥胖效应研究中的不足,并对该领域研究进行了展望。

关键词：合成酚类化合物肥胖环境致肥胖物质脂代谢综述

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Analysis of human urine metabolites using SPE and NMR spectroscopy

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Science China Chemistry 2008年第3期51卷 218-225页

作者： YANG WeiJin WANG YaWei zhou qunfang TANG HuiRu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Centre for Magnetic ResonanceWuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China

Nuclear magnetic resonance (NMR) spectroscopic analysis of metabonome/metabolome has widespread applications in biomedical science researches. However, most of NMR resonances for urinary metabolites remain to be fully assigned. In the present study, human urine samples from two healthy volunteers were pre-treated with C18 solid-phase extraction and the resultant 5 sub-fractions were subjected to one- and two-dimensional NMR studies, including 1H J-Resolved, 1H-1H COSY, 1H-1H TOCSY, 1H-13C HSQC, and HMBC 2D NMR. More than 70 low molecular weight metabolites were identified, and complete assignments of 1H and 13C resonances including many complex coupled spin systems were obtained.

关键词： urine metabolites NMR spectroscopy solid phase extraction metabonomics/metabolomics

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Butyltin compounds in vinegar collected in Beijing:Species distribution and source investigation

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Science China Chemistry 2012年第2期55卷 323-328页

作者： CUI ZongYan ZHANG KeGang zhou qunfang LIU JiYan JIANG GuiBin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China

Forty-eight vinegar samples including white vinegar, rice vinegar and mature vinegar were collected from several markets in Beijing. Butyltin compounds were determined by headspace solid-phase microextraction coupled with gas chromatography and flame photometric detector after in situ ethylation with sodium tetraethylborate. Butyltin species were detected in sixteen vinegar samples and ranged from 0.012 to 14.10 lag Sn L 1. The detection rate of white vinegar is higher than that of rice vinegar and mature vinegar. Vinegar samples with relatively high butyltin concentration (〉1.5 μg Sn L-1) were those stored in plastic bags, indicating that the plastic bag was one of the possible sources of butyltin contamination. This was further confirmed by the leaching experiments of three selected plastic bags, and monobutyltin was detected in the leaching solvents. According to the estimation, the average daily intake of total butyltin compounds through vinegar consumption is about 0.04 ng Sn/kg b.w., much lower than the Tolerable Daily Intake (TDI) of 100 ng Sn/kg b.w. set by the European Food Safety Authority (EFSA).

关键词： butyltin compounds vinegar headspace solid-phase microextraction gas chromatography-flame photometric detection

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Effects of cadmium,17 β-estradiol and their interaction in the male Chinese loach (Misgurnus anguillicaudatus)

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Chinese Science Bulletin 2012年第8期57卷 858-863页

作者： LÜ XueFei LIU FeiYuan zhou XiaoPing zhou qunfang DENG YuLin School of Life Science Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy ofSciencesBeijing 100085China Beijing Centre for Physical and Chemical Analysis Beijing 100094China

To assess the interaction effect between cadmium (Cd) and 17-estradiol (E2),male Chinese loaches (Misgurnus anguillicaudatus) were exposed to E2 (1 g/L) and Cd (50 or 500 g/L) alone and in combination using a semi-static waterborne exposure *** effects of E2 on the accumulation and distribution of Cd,as well as the effects of Cd on vitellogenin (Vtg) synthesis induced by E2,were *** mainly accumulated in the kidneys,liver,intestines,and gills,with little amounts in muscles,bones,and ***-exposure with E2 did not change the main targets for Cd.E2 could induce Vtg synthesis in male Chinese loaches,and co-exposure with 50 or 500 g/L Cd could inhibit the Vtg induced by 1 g/L *** with the results reported in the literature,it can be concluded that factors such as fish species,Cd dosage,and manner of exposure might make contributions to the interaction between Cd and *** results also suggested that male Chinese loaches are susceptible to Cd,and can be recommended as a potential sentinel species to study the ecotoxicology of heavy metals.

关键词：镉(Cd) 泥鳅中国雌二醇卵黄蛋白原生态毒理学互动效应曝光系统

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Intranasal administration of tetrabromobisphenol A bis(2-hydroxyethyl ether) induces neurobehavioral changes in neonatal Sprague Dawley rats

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Journal of Environmental Sciences 2018年第1期30卷 76-86页

作者： Qian S.Liu Na Liu Zhendong Sun qunfang zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences School of Life Science Shanxi University

Tetrabromobisphenol A（TBBPA） and its derivatives are now being highly concerned due to their emerging environmental occurrence and deleterious effects on non-target *** the potential neurotoxicity of TBBPA derivatives which has been demonstrated in vitro, what could happen in vivo is worthy of being studied. Tetrabromobisphenol A bis（2-hydroxyethyl ether）（TBBPA-BHEE）, a representative TBBPA derivative, was selected for a21-day exposure experiment on neonatal Sprague Dawley（SD） rats through intranasal administration. The neurobehavioral, histopathological changes, and differentially expressed genes based on RNA microarray were investigated to evaluate the neurological effects of this chemical. The results indicated that TBBPA-BHEE exposure significantly compromised the motor co-ordination performance and the locomotor activities（p 〈 0.05）. The neurobehavioral phenotype could be attributed to the obvious histopathological changes in both cerebrum and cerebellum, such as neural cell swelling, microglial activation and proliferation. A total of 911 genes were up-regulated, whereas 433 genes were down-regulated. Gene set enrichment analysis showed multiple signaling pathways, including ubiquitin-mediated proteolysis and wingless-int（Wnt） signaling pathway etc. were involved due to TBBPA-BHEE exposure. The gene ontology enrichment analysis showed the basic cellular function and the neurological processes like synaptic transmission were influenced. The toxicological effects of TBBPA-BHEE observed in this study suggested the potential neuronal threaten from unintended exposure,which would be of great value in the biosafety evaluation of TBBPA derivatives.

关键词： TBBPA derivatives Intranasal administration Neurobehavorial test Histopathological observation Microarray analysis

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Vitellogenic responses of male Chinese loach (Misgurnus anguillicaudatus) exposed to the individual or binary mixtures of 17β-estradiol and nonylphenol

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Chinese Science Bulletin 2007年第24期52卷 3333-3338页

作者： LU XueFei zhou qunfang SONG MaoYong JIANG GuiBin SHAO Jing State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Beijing100085 China

Male Chinese loaches were exposed to 17β-estradiol (E2) and nonylphenol (NP) both singly and in combination for 42 days using semi-static waterborne exposure system. Plasma vitellogenin (Vtg) was chosen as determining endpoint. The results demonstrated that 0.5 μg/L E2 could induce the enhancement of Vtg contents in male Chinese loaches after exposure for 21 days, which showed a time-related increasing manner; NP was also estrogenic to male Chinese loach, and the vitellogenic responses showed in a time-and dose-related manner, which was less potent than that of E2. The bi- nary mixtures of E2 and NP can significantly elicit the production of Vtg in male Chinese loaches, which was more potent than that of individual compounds, and Vtg induced in the binary mixture groups was higher than the summation of Vtg induced in the corresponding single-compound groups at the same concentration.

关键词：化学相互作用内分泌 17β-雌二醇卵黄蛋白原

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Alterations of endogenous metabolites in urine of rats exposed to decabromodiphenyl ether using metabonomic approaches

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Journal of Environmental Sciences 2014年第4期26卷 900-908页

作者： Weijin Yang Jianjie Fu Thanh Wang Hanxia Liu Yawei Wang qunfang zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

There is large usage of polybrominated diphenyl ethers （PBDEs） especially for decabromodiphenyl ether （BDE-209, Deca-BDE） in controlling the risks of fire. The toxicological effects of PBDEs are worth being concerned about. Female SD rats were daily gavaged with BDE-209 ether at the dose of 100 mg/kg for 20 days. Histological observation was performed for the screening of the target organs for BDE-209 exposure. The distribution and metabolism of PBDEs in the exposed main organs were evidenced by HRGC-HRMS. Alterations of the endogenous metabolite concentrations in urine were investigated using metabonomic approaches based on IH NMR spectrum. Histopathological changes including serious edema in kidney, hepatocellular spotty necrosis and perivasculitis in liver indicated that BDE-209 caused potential influences on endogenous metabolism in the exposed liver and the kidney. BDE-209 was found to be highly accumulated in lipid, ovary, kidney and liver after 20 days＇ exposure. Occurrence of other lower brominated PBDEs in the rats demonstrated that reductive debromination process happened in vivo. Hydroxylated and methoxylated-BDEs, as metabolism products, were also detected in the rat tissues. A total of 12 different endogenous metabolites showed obvious alterations in urine from the exposed rats, indicating the disturbance of the corresponding internal biochemical processes induced by BDE-209 exposure. These findings in vivo suggested the potential health risk might be of concern due to the toxicological effects of BDE-209 as a ubiquitous compound in the environment.

关键词： decabromodiphenyl ether metabonomic approaches endogenous metabolites

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