检索结果-南通市图书馆

Perfluorinated iodine alkanes promote the differentiation of mouse embryonic stem cells by regulating estrogen receptor signaling

引用

Journal of Environmental Sciences 2024年第3期137卷 443-454页

作者： Zhihua Ren Xiaoxi Yang Tingting Ku Qian S.Liu Jiefeng Liang qunfang zhou Francesco Faiola Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China College of Sino-Danish University of Chinese Academy of SciencesBeijing 100049China

Investigating the development toxicity of perfuorinated iodine alkanes(PFIs)is critical,given their estrogenic effects through binding with estrogen receptors(ERs).In the present study,two PFIs,including dodecafuoro-1,6-diiodohexane(PFHx DI)and tridecafuorohexyl iodide(PFHx I),with binding preference to ERαand ERβ,respectively,were selected to evaluate their effects on proliferation and differentiation of the mouse embryonic stem cells(m ESCs).The results revealed that,similar to E_(2),50μmol/L PFHx DI accelerated the cell proliferation of the m ESCs.The PFI stimulation at the exposure concentrations of 2–50μmol/L promoted the differentiation of the m ESCs as characterized by the upregulation of differentiation-related biomarkers(i.e.,Otx2 and Dnmt3β)and downregulation of pluripotency genes(i.e.,Oct4,Nanog,Sox2,Prdm14 and Rex1).Comparatively,PFHx DI exhibited higher induction effect on the differentiation of the m ESCs than did PFHx I.The tests on ER signaling indicated that both PFI compounds induced exposure concentration-dependent expressions of ER signaling-related biomarkers(i.e.,ERα,ERβand Caveolin-1)in the m ESCs,and the downstream ER responsive genes(i.e.,c-fos,c-myc and c-jun)well responded to PFHx I stimulation.The role of ER in PFI-induced effects on the m ESCs was further validated by the antagonistic experiments using an ER inhibitor(ICI).The findings demonstrated that PFIs triggered ER signaling,and perturbed the differentiation program of the m ESCs,causing the potential health risk during early stage of development.

关键词： Perfuorinated iodine alkanes(PFIs) Embryonic stem cells(ESCs) Developmental toxicity Cell differentiation Estrogen receptor-related signaling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Environmental pollution,a hidden culprit for health issues

引用

Eco-Environment & Health 2022年第1期1卷 31-45页

作者： Hanqing Xu Yang Jia Zhendong Sun Jiahui Su Qian S.Liu qunfang zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution and Zhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources ProtectionWenzhou UniversityWenzhou325035China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310000China College of Resources and Environment University of Chinese Academy of SciencesBeijing100049China Institute of Environment and Health Jianghan UniversityWuhan430056China

The environmental and health impacts from the massive discharge of chemicals and subsequent pollution have been gaining increasing public concern.The unintended exposure to different pollutants,such as heavy metals,air pollutants and organic chemicals,may cause diverse deleterious effects on human bodies,resulting in the incidence and progression of different diseases.The article reviewed the outbreak of environmental pollution-related public health emergencies,the epidemiological evidence on certain pollution-correlated health effects,and the pathological studies on specific pollutant exposure.By recalling the notable historical life-threatening disasters incurred by local chemical pollution,the damning evidence was presented to criminate certain pollutants as the main culprit for the given health issues.The epidemiological data on the prevalence of some common diseases revealed a variety of environmental pollutants to blame,such as endocrine-disrupting chemicals(EDCs),fine particulate matters(PMs)and heavy metals.The retrospection of toxicological studies provided illustrative clues for evaluating ambient pollutant-induced health risks.Overall,environmental pollution,as the hidden culprit,should answer for the increasing public health burden,and more efforts are highly encouraged to strive to explore the cause-and-effect relationships through extensive epidemiological and pathological studies.

关键词： Environmental pollution Public health emergency Epidemiological evidence Pathological study Cause-and-effect relationship

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intranasal administration of tetrabromobisphenol A bis(2-hydroxyethyl ether) induces neurobehavioral changes in neonatal Sprague Dawley rats

引用

Journal of Environmental Sciences 2018年第1期30卷 76-86页

作者： Qian S.Liu Na Liu Zhendong Sun qunfang zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences School of Life Science Shanxi University

Tetrabromobisphenol A（TBBPA） and its derivatives are now being highly concerned due to their emerging environmental occurrence and deleterious effects on non-target organisms.Considering the potential neurotoxicity of TBBPA derivatives which has been demonstrated in vitro, what could happen in vivo is worthy of being studied. Tetrabromobisphenol A bis（2-hydroxyethyl ether）（TBBPA-BHEE）, a representative TBBPA derivative, was selected for a21-day exposure experiment on neonatal Sprague Dawley（SD） rats through intranasal administration. The neurobehavioral, histopathological changes, and differentially expressed genes based on RNA microarray were investigated to evaluate the neurological effects of this chemical. The results indicated that TBBPA-BHEE exposure significantly compromised the motor co-ordination performance and the locomotor activities（p 〈 0.05）. The neurobehavioral phenotype could be attributed to the obvious histopathological changes in both cerebrum and cerebellum, such as neural cell swelling, microglial activation and proliferation. A total of 911 genes were up-regulated, whereas 433 genes were down-regulated. Gene set enrichment analysis showed multiple signaling pathways, including ubiquitin-mediated proteolysis and wingless-int（Wnt） signaling pathway etc. were involved due to TBBPA-BHEE exposure. The gene ontology enrichment analysis showed the basic cellular function and the neurological processes like synaptic transmission were influenced. The toxicological effects of TBBPA-BHEE observed in this study suggested the potential neuronal threaten from unintended exposure,which would be of great value in the biosafety evaluation of TBBPA derivatives.

关键词： TBBPA derivatives Intranasal administration Neurobehavorial test Histopathological observation Microarray analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Alterations of endogenous metabolites in urine of rats exposed to decabromodiphenyl ether using metabonomic approaches

引用

Journal of Environmental Sciences 2014年第4期26卷 900-908页

作者： Weijin Yang Jianjie Fu Thanh Wang Hanxia Liu Yawei Wang qunfang zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

There is large usage of polybrominated diphenyl ethers （PBDEs） especially for decabromodiphenyl ether （BDE-209, Deca-BDE） in controlling the risks of fire. The toxicological effects of PBDEs are worth being concerned about. Female SD rats were daily gavaged with BDE-209 ether at the dose of 100 mg/kg for 20 days. Histological observation was performed for the screening of the target organs for BDE-209 exposure. The distribution and metabolism of PBDEs in the exposed main organs were evidenced by HRGC-HRMS. Alterations of the endogenous metabolite concentrations in urine were investigated using metabonomic approaches based on IH NMR spectrum. Histopathological changes including serious edema in kidney, hepatocellular spotty necrosis and perivasculitis in liver indicated that BDE-209 caused potential influences on endogenous metabolism in the exposed liver and the kidney. BDE-209 was found to be highly accumulated in lipid, ovary, kidney and liver after 20 days＇ exposure. Occurrence of other lower brominated PBDEs in the rats demonstrated that reductive debromination process happened in vivo. Hydroxylated and methoxylated-BDEs, as metabolism products, were also detected in the rat tissues. A total of 12 different endogenous metabolites showed obvious alterations in urine from the exposed rats, indicating the disturbance of the corresponding internal biochemical processes induced by BDE-209 exposure. These findings in vivo suggested the potential health risk might be of concern due to the toxicological effects of BDE-209 as a ubiquitous compound in the environment.

关键词： decabromodiphenyl ether metabonomic approaches endogenous metabolites

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

合成酚类化合物的脂代谢干扰效应与致肥胖作用

引用

色谱 2024年第2期42卷 131-141页

作者：刘惠楠孙振东刘倩周群芳江桂斌中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室北京100085 中国科学院大学资源与环境学院北京100049 国科大杭州高等研究院环境学院浙江杭州310024

随着社会经济的不断发展,肥胖已经成为一种不可忽视的全球性流行疾病。除了受到遗传和饮食因素的影响外,肥胖的形成与发展也与环境中的化学物质暴露有关。研究发现一些具有内分泌干扰活性的化学物质可以影响机体脂代谢,如促进脂肪细胞... 详细信息

随着社会经济的不断发展,肥胖已经成为一种不可忽视的全球性流行疾病。除了受到遗传和饮食因素的影响外,肥胖的形成与发展也与环境中的化学物质暴露有关。研究发现一些具有内分泌干扰活性的化学物质可以影响机体脂代谢,如促进脂肪细胞形成、引起体内脂质累积增加等,这类物质被称为“环境致肥胖物质”。合成酚类化合物广泛用于工业生产和日常生活用品中,如塑料制品、消毒剂、杀虫剂和食品添加剂等,它们可通过饮食、饮水或皮肤接触等方式进入人体,是影响人体健康的潜在威胁。研究显示,合成酚类化合物具有内分泌干扰效应,可以影响脂肪生成过程、干扰脂代谢,具有致肥胖作用。由于这类物质都具有类似的苯酚结构,因此系统梳理这类化合物脂代谢干扰效应与致肥胖作用,有助于理解其构效关系与潜在健康风险。本文阐述了筛选环境致肥胖物质的3种常用研究模型,即体外分子互作研究模型、细胞成脂分化模型和动物脂代谢实验模型,并比较了各种模型的适用场景和优缺点。在此基础上,针对3种合成酚类化合物,即双酚A及其类似物、烷基酚和酚类抗氧化剂,结合其体外细胞与动物实验数据,对这些化合物的暴露现状和脂代谢干扰效应进行了分类描述,从它们对脂肪生成和代谢、肝组织脂代谢的影响等方面展开讨论。基于近年来脂代谢和致肥胖效应的相关研究,本文归纳总结了环境内分泌干扰物干扰脂代谢的内在毒理机制,主要包括核受体调控作用、炎症和氧化应激、肠道微环境、表观遗传和其他信号通路。最后本文指出了当前针对环境污染物,特别是新污染物,影响机体脂代谢引起肥胖效应研究中的不足,并对该领域研究进行了展望。

关键词：合成酚类化合物肥胖环境致肥胖物质脂代谢综述

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Possible role of extracellular vesicles in exogenous chemical exposure-associated health concern

引用

Journal of Environmental Sciences 2019年第6期31卷 1-4页

作者： Guangbo Qu Xingchen Zhao Yanna Liu Fang Hao Jie Gao Lili Yang qunfang zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Environment and Health Jianghan University

Extracellular vesicles(EVs) are mediators of intercellular message communication by transferring lipids, proteins, genetic materials, and are therefore involved in a wide spectrum of physiological or pathological processes. Exogenous chemicals exposure may affect the function of EVs at the biogenesis, secretion, transport or reception stage, which could further result in abnormal information communication between cells, and thus induce toxicity and diseases. This review briefly explores the role of EVs in chemical exposure-associated health concern and progressive diseases.

关键词： EV Possible role of extracellular vesicles in exogenous chemical exposure-associated health concern

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of nanoscale quantum dots in male Chinese loaches (Misgurnus anguillicaudatus):Estrogenic interference action,toxicokinetics and oxidative stress

引用

Science China Chemistry 2009年第10期52卷 1683-1690页

作者： HongCheng Li WenRu Luo Yong Tao Yuan Wu XueFei Lv qunfang zhou GuiBin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Quantum dots (QDs) have received more and more attention as a novel example of nanocrystals due to their unique fluorescent characteristics. Recently, the toxicity and the potential environmental effects of QDs have become a research hotspot. In this work, in vivo endocrine disrupting effect, toxicokinetics and oxidative stress of QDs were characterized following the intraperitoneal dosing in Chinese loaches. Vitellogenin (Vtg) levels induced by E2 decreased significantly when administrated with the mixture of QDs and E2, which was consistent with the observations of histopathology in testes. The release of free Cd2+ from QDs and the non-specific adsorption of E2 by QDs might be the joint factors contributing to the inhibition of Vtg expression induced by E2 in the male Chinese loaches. In the muscle, bone, intestines, blood and testis, CdSe QDs reached the maximal concentration (Cmax) in approximately 1-h postinjection and subsequently presented downtrend with the prolonged time. Whereas, there were even increasing tendencies of CdSe QDs' concentrations in the liver and kidney. It is educible that CdSe QDs can be persistent at least for 7 days, indicating the overall half-life of CdSe QDs in the fish body is very long. The measurement of hepatic superoxide dismutase (SOD) activity and reduced glutathione (GSH) content indicate that QDs have smaller effects on the antioxidative system of the organisms compared with free Cd2+ due to the effective prevention of the release of Cd by PEG coating of QDs. The comprehensive evaluation of QDs' toxicity in the present study provides an essential and general framework towards more focused research on the elucidation of the biological effects of QDs in vivo.

关键词： quantum dot estrogenic effect toxicokinetics oxidative stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Corrigendum to “Environmental pollution, a hidden culprit for health issues” [Eco-Environ. Health (2022) 31–45]

引用

Eco-Environment & Health 2022年第3期1卷 198-199页

作者： Hanqing Xu Yang Jia Zhendong Sun Jiahui Su Qian S. Liu qunfang zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution and Zhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources Protection Wenzhou University Wenzhou 325035 China School of Environment Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Hangzhou 310000 China College of Resources and Environment University of Chinese Academy of Sciences Beijing 100049 China Institute of Environment and Health Jianghan University Wuhan 430056 China

The authors regret having incorrectly described some symptoms of public health emergencies in Fig.1.The original manuscript describes the symptoms of the Bangladesh event in 1990 as“Kidney stones in infants,acute renal failure”.This should have been“Skin lesions(keratosis,melanoderma)and death”.The original description of“Behavioral abnormalities,developmental malformations,neurological”in Niigata event should have been“Behavioral abnormalities,developmental malformations,neurological diseases”.

关键词： Kidney acute Cor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Growing Knowledge of Stem Cells as a Novel Experimental Model in Developmental Toxicological Studies

引用

Chemical Research in Chinese Universities 2023年第3期39卷 342-360页

作者： REN Zhihua KU Tingting REN Mengyao LIANG Jiefeng NING Xia XU Hanqing REN Danqin zhou qunfang SANG Nan College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuan030006P.R.China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085P.R.China Shandong Key Laboratory of Environmental Processes and Health School of Environmental Science and EngineeringShandong UniversityQingdaoQingdao266237P.R.China National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution Wenzhou UniversityWenzhou325035P.R.China

The increasing production and extensive application of chemicals have led to their unintended release and contamination in the environment,posing a hazardous threat to wildlife and human health.Numerous studies have demonstrated that developmental toxicity could be induced by various emerging chemicals,causing abnormal embryonic and placental development,adverse pregnancy outcomes,obesity,and dysfunction of lipid metabolism in neonates.Given the currently-available experimental technology for developmental toxicological studies,an in vitro model based on stem cells showed promising performance in high-throughput screening of the early-stage developmental toxicity of emerging chemicals.In this review,the deleterious effects of environmental pollutants on stem cells were systemically assorted from the aspects of cytological dysfunction,self-renewal impairment,perturbation in embryoid body(EB)formation,and disruption of committed lineage differentiation.The toxicological data on the molecular level,including the altered expressions of gene and protein biomarkers,epigenomic regulation,and enhanced oxidative stress,were collected and summarized to provide the mechanism explanation for the link between environmental pollutant exposure and unfavorable phenotypes in stem cells.The advantage of the stem cell model in developmental toxicological studies was specifically emphasized.And the perspectives for stem cells were ultimately highlighted in the research field of environmental toxicology,especially developmental toxicology during the early stage of life.

关键词： Environmental pollutant Developmental toxicology Stem cell Early-stage life Health effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of human urine metabolites using SPE and NMR spectroscopy

引用

Science China Chemistry 2008年第3期51卷 218-225页

作者： YANG WeiJin WANG YaWei zhou qunfang TANG HuiRu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Centre for Magnetic ResonanceWuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China

Nuclear magnetic resonance (NMR) spectroscopic analysis of metabonome/metabolome has widespread applications in biomedical science researches. However, most of NMR resonances for urinary metabolites remain to be fully assigned. In the present study, human urine samples from two healthy volunteers were pre-treated with C18 solid-phase extraction and the resultant 5 sub-fractions were subjected to one- and two-dimensional NMR studies, including 1H J-Resolved, 1H-1H COSY, 1H-1H TOCSY, 1H-13C HSQC, and HMBC 2D NMR. More than 70 low molecular weight metabolites were identified, and complete assignments of 1H and 13C resonances including many complex coupled spin systems were obtained.

关键词： urine metabolites NMR spectroscopy solid phase extraction metabonomics/metabolomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：