检索结果-南通市图书馆

Butyltin compounds in vinegar collected in Beijing:Species distribution and source investigation

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2012年第2期55卷 323-328页

作者： CUI ZongYan ZHANG KeGang zhou qunfang LIU JiYan JIANG GuiBin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China

Forty-eight vinegar samples including white vinegar, rice vinegar and mature vinegar were collected from several markets in Beijing. Butyltin compounds were determined by headspace solid-phase microextraction coupled with gas chromatography and flame photometric detector after in situ ethylation with sodium tetraethylborate. Butyltin species were detected in sixteen vinegar samples and ranged from 0.012 to 14.10 lag Sn L 1. The detection rate of white vinegar is higher than that of rice vinegar and mature vinegar. Vinegar samples with relatively high butyltin concentration (〉1.5 μg Sn L-1) were those stored in plastic bags, indicating that the plastic bag was one of the possible sources of butyltin contamination. This was further confirmed by the leaching experiments of three selected plastic bags, and monobutyltin was detected in the leaching solvents. According to the estimation, the average daily intake of total butyltin compounds through vinegar consumption is about 0.04 ng Sn/kg b.w., much lower than the Tolerable Daily Intake (TDI) of 100 ng Sn/kg b.w. set by the European Food Safety Authority (EFSA).

关键词： butyltin compounds vinegar headspace solid-phase microextraction gas chromatography-flame photometric detection

Effects of cadmium,17 β-estradiol and their interaction in the male Chinese loach (Misgurnus anguillicaudatus)

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2012年第8期57卷 858-863页

作者： LÜ XueFei LIU FeiYuan zhou XiaoPing zhou qunfang DENG YuLin School of Life Science Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy ofSciencesBeijing 100085China Beijing Centre for Physical and Chemical Analysis Beijing 100094China

To assess the interaction effect between cadmium (Cd) and 17-estradiol (E2),male Chinese loaches (Misgurnus anguillicaudatus) were exposed to E2 (1 g/L) and Cd (50 or 500 g/L) alone and in combination using a semi-static waterborne exposure *** effects of E2 on the accumulation and distribution of Cd,as well as the effects of Cd on vitellogenin (Vtg) synthesis induced by E2,were *** mainly accumulated in the kidneys,liver,intestines,and gills,with little amounts in muscles,bones,and ***-exposure with E2 did not change the main targets for Cd.E2 could induce Vtg synthesis in male Chinese loaches,and co-exposure with 50 or 500 g/L Cd could inhibit the Vtg induced by 1 g/L *** with the results reported in the literature,it can be concluded that factors such as fish species,Cd dosage,and manner of exposure might make contributions to the interaction between Cd and *** results also suggested that male Chinese loaches are susceptible to Cd,and can be recommended as a potential sentinel species to study the ecotoxicology of heavy metals.

关键词：镉(Cd) 泥鳅中国雌二醇卵黄蛋白原生态毒理学互动效应曝光系统

Intranasal administration of tetrabromobisphenol A bis(2-hydroxyethyl ether) induces neurobehavioral changes in neonatal Sprague Dawley rats

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2018年第1期30卷 76-86页

作者： Qian S.Liu Na Liu Zhendong Sun qunfang zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences School of Life Science Shanxi University

Tetrabromobisphenol A（TBBPA） and its derivatives are now being highly concerned due to their emerging environmental occurrence and deleterious effects on non-target *** the potential neurotoxicity of TBBPA derivatives which has been demonstrated in vitro, what could happen in vivo is worthy of being studied. Tetrabromobisphenol A bis（2-hydroxyethyl ether）（TBBPA-BHEE）, a representative TBBPA derivative, was selected for a21-day exposure experiment on neonatal Sprague Dawley（SD） rats through intranasal administration. The neurobehavioral, histopathological changes, and differentially expressed genes based on RNA microarray were investigated to evaluate the neurological effects of this chemical. The results indicated that TBBPA-BHEE exposure significantly compromised the motor co-ordination performance and the locomotor activities（p 〈 0.05）. The neurobehavioral phenotype could be attributed to the obvious histopathological changes in both cerebrum and cerebellum, such as neural cell swelling, microglial activation and proliferation. A total of 911 genes were up-regulated, whereas 433 genes were down-regulated. Gene set enrichment analysis showed multiple signaling pathways, including ubiquitin-mediated proteolysis and wingless-int（Wnt） signaling pathway etc. were involved due to TBBPA-BHEE exposure. The gene ontology enrichment analysis showed the basic cellular function and the neurological processes like synaptic transmission were influenced. The toxicological effects of TBBPA-BHEE observed in this study suggested the potential neuronal threaten from unintended exposure,which would be of great value in the biosafety evaluation of TBBPA derivatives.

关键词： TBBPA derivatives Intranasal administration Neurobehavorial test Histopathological observation Microarray analysis

Vitellogenic responses of male Chinese loach (Misgurnus anguillicaudatus) exposed to the individual or binary mixtures of 17β-estradiol and nonylphenol

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2007年第24期52卷 3333-3338页

作者： LU XueFei zhou qunfang SONG MaoYong JIANG GuiBin SHAO Jing State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Beijing100085 China

Male Chinese loaches were exposed to 17β-estradiol (E2) and nonylphenol (NP) both singly and in combination for 42 days using semi-static waterborne exposure system. Plasma vitellogenin (Vtg) was chosen as determining endpoint. The results demonstrated that 0.5 μg/L E2 could induce the enhancement of Vtg contents in male Chinese loaches after exposure for 21 days, which showed a time-related increasing manner; NP was also estrogenic to male Chinese loach, and the vitellogenic responses showed in a time-and dose-related manner, which was less potent than that of E2. The bi- nary mixtures of E2 and NP can significantly elicit the production of Vtg in male Chinese loaches, which was more potent than that of individual compounds, and Vtg induced in the binary mixture groups was higher than the summation of Vtg induced in the corresponding single-compound groups at the same concentration.

关键词：化学相互作用内分泌 17β-雌二醇卵黄蛋白原

Alterations of endogenous metabolites in urine of rats exposed to decabromodiphenyl ether using metabonomic approaches

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2014年第4期26卷 900-908页

作者： Weijin Yang Jianjie Fu Thanh Wang Hanxia Liu Yawei Wang qunfang zhou Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

There is large usage of polybrominated diphenyl ethers （PBDEs） especially for decabromodiphenyl ether （BDE-209, Deca-BDE） in controlling the risks of fire. The toxicological effects of PBDEs are worth being concerned about. Female SD rats were daily gavaged with BDE-209 ether at the dose of 100 mg/kg for 20 days. Histological observation was performed for the screening of the target organs for BDE-209 exposure. The distribution and metabolism of PBDEs in the exposed main organs were evidenced by HRGC-HRMS. Alterations of the endogenous metabolite concentrations in urine were investigated using metabonomic approaches based on IH NMR spectrum. Histopathological changes including serious edema in kidney, hepatocellular spotty necrosis and perivasculitis in liver indicated that BDE-209 caused potential influences on endogenous metabolism in the exposed liver and the kidney. BDE-209 was found to be highly accumulated in lipid, ovary, kidney and liver after 20 days＇ exposure. Occurrence of other lower brominated PBDEs in the rats demonstrated that reductive debromination process happened in vivo. Hydroxylated and methoxylated-BDEs, as metabolism products, were also detected in the rat tissues. A total of 12 different endogenous metabolites showed obvious alterations in urine from the exposed rats, indicating the disturbance of the corresponding internal biochemical processes induced by BDE-209 exposure. These findings in vivo suggested the potential health risk might be of concern due to the toxicological effects of BDE-209 as a ubiquitous compound in the environment.

关键词： decabromodiphenyl ether metabonomic approaches endogenous metabolites

Rapid decolorization of water soluble azo-dyes by nanosized zero-valent iron immobilized on the exchange resin

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2008年第2期51卷 186-192页

作者： ZHAO ZongShan LIU JingFu TAI Chao zhou qunfang HU JingTian JIANG GuiBin Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Chemistry Shandong UniversityJinan 250100China

Nanosized zero-valent iron (NZVI) supported on the cation exchange resin was synthesized and applied to decompose some water soluble azo dyes. The decomposition efficiency for azo dyes was evaluated by using the aqueous suspensions and parked column of this material. Batch experiments indicated that this novel material exhibited excellent degradation ability for 0.05 g·L1 of Acid Orange 7, Acid Orange 8, Acid Orange 10, Sunset Yellow, and Methyl Orange, with decolorization ratio up to 95% in 4 min; pH value was the key factor for degradation and H+ was one of the reactants; adsorption of azo dyes onto the material existed at the beginning but reduced gradually until disappearing completely. For the packed column system, 58%~90% of azo dyes were decomposed in the 1st circle of solution passing through the column, and the adsorption onto the materials could accelerate the degradation azo dyes with the increasing reaction time. During the degradation process, Fe2+, the product of NZVI, was exchanged to the resin again and could be reduced to Fe0 by KBH4 for reusing. The 10th refreshed NZVI possessed reductive activity up to 90% of the newly systhesized NZVI. Decomposing pollutants in the aqueous solution with columns packed with NZVI immobilized on the cation exchange resin is a promising technology that can solve the reclaiming and refreshing problem of NZVI.

关键词： azo-dye nanosized-zero valent iron (NZVI) decomposition packing column

Mechanism of gold nanoparticle induced simultaneously increased PCR efficiency and specificity

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2013年第36期58卷 4593-4601页

作者： LIN Yan LI Jia YAO Jing LIANG Yong ZHANG Jie zhou qunfang JIANG GuiBin Key Laboratory of Subtropical Agriculture & Environment of the Ministry of Agriculture Huazhong Agricultural University School of Medicine Jianghan University Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education Jianghan University State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

Gold nanoparticles(AuNPs)have been reported to induce faster heat transfer of polymerase chain reaction(PCR)solution to enhance PCR *** can also increase the specificity of PCR by functioning analogously to single-stranded DNA binding protein(SSB).However,the simple structure of AuNPs makes it difficult to determine how AuNPs affect PCR efficiency and *** study aimed to elucidate the effect of AuNPs on PCR efficiency by altering the denaturation times and annealing *** addition,comparative study of the effect of AuNPs on PCR inhibition caused by two competitive primers allowed investigation of the mechanisms of AuNP-enhanced PCR ***,heat-treated salmon sperm DNA was used to evaluate whether AuNPs could eliminate the inhibitory PCR effect caused by DNA *** study demonstrated that enhanced thermal conductivity by AuNPs was the main mechanism for increased PCR efficiency and *** promoted efficient double-stranded DNA template unwinding and dissociation between mismatched primers,DNA fragments and template,and enhanced PCR efficiency and specificity ***,this significant finding suggests the future use of AuNP-assisted PCR in different fields,especially in rapid clinical diagnosis and screening by PCR.

关键词：金纳米粒子抑制PCR 诱导机制异性单链DNA DNA模板聚合酶链反应鱼精子DNA

Progress in the toxicological researches for quantum dots

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2008年第5期51卷 393-400页

作者： LI HongCheng zhou qunfang LIU Wei YAN Bing ZHAO Yibing JIANG GuiBin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Pharmaceutical Sciences Shandong UniversityJinan 250012China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China

Quantum dots (QDs) have received more and more attention as a novel example of nanomaterials. Due to their unique fluorescent characteristics,quantum dots have been successfully applied in biotech-nology and medicine applications. Recently,the toxicity and the potential environmental effects of QDs have become a research hotspot. In this paper,toxicological effects of QDs are reviewed,and the prospects and research directions are given based on the analysis of this research field.

关键词： quantum dot toxicology nanomaterial

Effects of nanoscale quantum dots in male Chinese loaches (Misgurnus anguillicaudatus):Estrogenic interference action,toxicokinetics and oxidative stress

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2009年第10期52卷 1683-1690页

作者： HongCheng Li WenRu Luo Yong Tao Yuan Wu XueFei Lv qunfang zhou GuiBin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Quantum dots (QDs) have more and more attention as a novel example of nanocrystals due to their unique fluorescent characteristics. Recently, the toxicity and the potential environmental effects of QDs have become a research hotspot. In this work, in vivo endocrine disrupting effect, toxicokinetics and oxidative stress of QDs were characterized following the intraperitoneal dosing in Chinese loaches. Vitellogenin (Vtg) levels induced by E2 decreased significantly when administrated with the mixture of QDs and E2, which was consistent with the observations of histopathology in testes. The release of free Cd2+ from QDs and the non-specific adsorption of E2 by QDs might be the joint factors contributing to the inhibition of Vtg expression induced by E2 in the male Chinese loaches. In the muscle, bone, intestines, blood and testis, CdSe QDs reached the maximal concentration (C max) in approximately 1-h postinjection and subsequently presented downtrend with the prolonged time. Whereas, there were even increasing tendencies of CdSe QDs’ concentrations in the liver and kidney. It is educible that CdSe QDs can be persistent at least for 7 days, indicating the overall half-life of CdSe QDs in the fish body is very long. The measurement of hepatic superoxide dismutase (SOD) activity and reduced glutathione (GSH) content indicate that QDs have smaller effects on the antioxidative system of the organisms compared with free Cd2+ due to the effective prevention of the release of Cd by PEG coating of QDs. The comprehensive evaluation of QDs’ toxicity in the present study provides an essential and general framework towards more focused research on the elucidation of the biological effects of QDs in vivo.

关键词： quantum dot estrogenic effect toxicokinetics oxidative stress