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Chinese Journal of Polymer Science 2024年第5期42卷 570-578,I0005页

作者： Xiao-Fei Sun Xu Zhang Shu-Ping Song Ya-qun yao Yan Zhang Cheng-Liang wang Jing-Jiang Sun Qing-Fu wang Key Laboratory of Rubber-plastics Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao266042China Qingdao Research Academy of Environmental Science Qingdao266012China

L-glutamic acid(LA)is a bio-based,non-toxic,environmentally friendly material derived from *** present study reports the application of Passerini three-component polymerization(P-3CP)for the straightforward preparation of LA-based light-responsive polyesters(PLTDs)under mild *** with molar masses up to 8500 g/mol and high yields exceeding 90%are *** chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible(UV-Vis)spectroscopy,size exclusion chromatography(SEC),nuclear magnetic resonance(NMR)spectroscopy,and liquid chromatography mass spectrometry(LC-MS).Meanwhile,monodisperse PLTD-based doxorubicin-loaded nanoparticles(PLTD-DOX-NP)(size=193 nm,PDI=0.018)are formulated by nanoprecipitation *** light-induced depolymerization,the PLTD-DOX-NP undergoes rapid decomposition,resulting in a burst release of 80%cargo within 13 ***,according to biological toxicity tests,the PLTD-NP possesses adequate biosafety,both before and after ***,the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry,significantly simplifying the synthetic pathway of light-responsive polymers.

关键词： L-glutamic acid Passerini three-component polymerization Light-responsive Polyester Nanoparticles

Protective Effects of Phellodendron Species on Bone Health: A Novel Perspective on Their Potentials in Treating Osteoporosis and Osteoarthritis

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Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN Li TAN Guo-yao ZHANG Qiang ZHANG qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

Commissioning experiences with the spoke-based CW superconducting proton linac

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Nuclear Science and Techniques 2021年第10期32卷 12-29页

作者： Fang Yan Hui-Ping Geng Cai Meng Ya-Liang Zhao Hua Shi Hua-Fu Ouyang Tong-Min Huang Fei-Si He Jian-Li wang Rui Ge Yan-Feng Sui Qiang Ye Rong Liu qun-yao wang Sheng-Chang wang Jian-She Cao Wei-Min Pan Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy Physics(IHEP)Chinese Academy of ScienceBeijing 100049China Beijing Normal University Beijing 100875China

The 10-MeV Accelerator-Driven Subcritical(ADS)system Injector-I test stand at the Institute of High Energy Physics(IHEP)is a testing facility dedicated to demonstrating the feasibility of the spoke-based super-conducting(SC)linear accelerator(linac)for the ADS project in *** injector adopted a four-vane copper structure radio frequency quadrupole(RFQ)with an output energy of 3.2 MeV and an SC section accommodating 14 β_(g)=0.12 single spoke cavities,14 SC solenoids,and 14 cold beam position monitors(BPMs).A 10-MeV pulsed beam with a beam current of 10 mA and a 2-mA continuous wave(CW)beam were successfully shooting *** commissioning results confirmed the feasibility of using a 325-MHz spoke-type cavity for accelerating the proton beam in the low β and medium β *** paper describes the results achieved,the difficulties encountered,and the experiences obtained during commissioning.

关键词： Superconducting proton linac Spoke cavity High intensity CW commissioning

A Selective‑Response Hypersensitive Bio‑Inspired Strain Sensor Enabled by Hysteresis Effect and Parallel Through‑Slits Structures

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Nano-Micro Letters 2024年第2期16卷 139-153页

作者： qun wang Zhongwen yao Changchao Zhang Honglie Song Hanliang Ding Bo Li Shichao Niu Xinguan Huang Chuanhai Chen Zhiwu Han Luquan Ren Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China Liaoning Academy of Materials LiaoningShenyang 110167People’s Republic of China Key Laboratory of CNC Equipment Reliability(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China

Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced ***,the effective integration of hypersensitivity and highly selective response into one flexible strain sensor remains a huge ***,inspired by the hysteresis strategy of the scorpion slit receptor,a bio-inspired flexible strain sensor(BFSS)with parallel through-slit arrays is designed and ***,BFSS consists of conductive monolayer graphene and viscoelastic styrene–isoprene–styrene block *** the synergistic effect of the bio-inspired slit structures and flexible viscoelastic materials,BFSS can achieve both hypersensitivity and highly selective frequency ***,the BFSS exhibits a high gage factor of 657.36,and a precise identification of vibration frequencies at a resolution of 0.2 Hz through undergoing different morphological changes to high-frequency vibration and low-frequency ***,the BFSS possesses a wide frequency detection range(103 Hz)and stable durability(1000 cycles).It can sense and recognize vibration signals with different characteristics,including the frequency,amplitude,and *** work,which turns the hysteresis effect into a"treasure,"can provide new design ideas for sensors for potential applications including human–computer interaction and health monitoring of mechanical equipment.

关键词： Bio-inspired strain sensors Hysteresis effect Hypersensitivity Selective frequency response Health monitoring applications

Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2350-2361页

作者： Min yao Rong-Fei Fang qun Xie Min Xu Wen-Li Sai Deng-Fu yao Department of Immunology Medical School of Nantong University and Research Center of Clinical MedicineThe Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Gastroenterology The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Infectious Diseases Haian People’s HospitalHaian 226600Jiangsu ProvinceChina Research Center of Clinical Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

The prevention and early diagnosis of liver cancer remains a global medical *** the malignant transformation of hepatocytes,a variety of oncogenic cellular signalling molecules,such as novel high mobility group-Box 3,angiopoietin-2,Golgi protein 73,glypican-3,Wnt3a(a signalling molecule in the Wnt/β-catenin pathway),and secretory clusterin,can be expressed and secreted into the *** signalling molecules are derived from different signalling pathways and may not only participate in the malignant transformation of hepatocytes but also become early diagnostic indicators of hepatocarcinogenesis or specific targeted molecules for hepatocellular carcinoma *** article reviews recent progress in the study of several signalling molecules as sensitive biomarkers for monitoring hepatocarcinogenesis.

关键词： Hepatocarcinogenesis Cell signals Specific biomarkers Early diagnosis

The application of digital technology in BEPCII RF system

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Radiation Detection Technology and Methods 2018年第1期2卷 105-112页

作者： Mu-Yuan wang Yi Sun Guang-Wei wang Wei-Min Pan Hai-Ying Lin qun-yao wang Qiang Ma Zhong-Quan Li Jian-Ping Dai Peng Sha Zheng-Hui Mi Hong-Lei wang Dan-Yang Zhao University of Chinese Academy of Sciences Beijing 100049China Institute of High Energy Physics CASBeijing 100049China China National Electronics Import&Export Corporation(CEIEC) BeijingChina

Background The Beijing Electron Positron Collider(BEPCII)is a high-brightness collider and operates in compatible mode of synchronous light *** summer,BEPCII spare cavity,which was all made in China,had been put into BEPCII operation,and the LLRF system for the spare cavity was also upgraded at the *** The purpose is to stably control the amplitude and phase of the spare cavity and apply digital technology to achieve some intelligent *** The digital method is applied in the superconducting cavity feedback control of the accelerator and it introduces the digital technology of the RF low-level control system that has been stably applied to the BEPCII spare cavity *** addition,some functions such as quench detector and input protection as well as horizontal test have been realized in the RF system *** The amplitude and phase stabilities of cavity voltage with beam in the digital LLRF have reached±0.09%(RMS)and±0.055°(RMS),*** The BEPCII spare cavity with digital LLRF system has been stably operated for 2 *** DLLRF system has been reliable and stable,and the performance of the spare cavity with beam was very good.

关键词： Digital low-level Radio frequency Spare cavity

Role of hsa_circ_0007482 in pterygium development: insights into proliferation, apoptosis, and clinical correlations

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1387-1395页

作者： Li-Yun Zhang Xin Liu Shuo Zheng Wen-qun Xi Xue-Ping Wu Dan-yao Nie Hui-Ling Hu Jian-Tao wang Xin-Hua Liu Jing Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518000Guangdong ProvinceChina

AIM:To investigate the impact of hsa_circ_0007482 on the proliferation and apoptosis of human pterygium fibroblasts(HPFs)and its correlation with the severity grades of ***:Pterygium and normal conjunctival tissues were collected from the superior area of the same patient’s eye(n=33).The correlation between pterygium severity and hsa_circ_0007482 expression using quantitative reversetranscription polymerase chain reaction(RT-qPCR)were *** distinct siRNA sequences targeting hsa_circ_0007482,along with a negative control sequence,were transfected into *** proliferation was assessed using the cell counting *** levels of Ki67,proliferating cell nuclear antigen(PCNA),Cyclin D1,Bax,B-cell lymphoma-2(Bcl-2),and Caspase-3 were measured via *** staining was employed to detect Ki67 and vimentin *** was evaluated using flow ***:Hsa_circ_0007482 expression was significantly higher in pterygium tissues compared to normal conjunctival tissues(P<0.001).Positive correlations were observed between hsa_circ_0007482 expression and pterygium severity,thickness,and vascular *** of hsa_circ_0007482 inhibited cell proliferation,reducing the mRNA expression of Ki67,PCNA,and Cyclin D1 in ***_circ_0007482 knockdown induced apoptosis,increasing mRNA expression levels of Bax and Caspase-3,while decreasing Bcl-2 expression in ***,hsa_circ_0007482 knockdown attenuated vimentin expression in ***:The downregulation of hsa_circ_0007482 effectively hampers cell proliferation and triggers apoptosis in *** are discernible positive correlations detected between the expression of hsa_circ_0007482 and the severity of pterygium.

关键词： hsa_circ_0007482 circular RNA pterygium cell proliferation apoptosis

Structural transition,electric transport,and electronic structures in the compressed trilayer nickelate La_(4)Ni_(3)O_(10)

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 9-15页

作者： Jingyuan Li Cui-qun Chen Chaoxin Huang Yifeng Han Mengwu Huo Xing Huang Peiyue Ma Zhengyang Qiu Junfeng Chen Xunwu Hu Lan Chen Tao Xie Bing Shen Hualei Sun Dao-Xin yao Meng wang Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China Center for Materials of the Universe School of Molecular SciencesArizona State UniversityTempe 85287USA School of Sciences Sun Yat-sen UniversityShenzhen 518107China

Atomic structure and electronic band structure are fundamental properties for understanding the mechanism of superconductivity. Motivated by the discovery of pressure-induced high-temperature superconductivity at 80 K in the bilayer Ruddlesden-Popper nickelate La_(3)Ni_(2)O_(7), the atomic structure and electronic band structure of the trilayer nickelate La_(4)Ni_(3)O_(10) under pressure up to 44.3 GPa are investigated. A structural transition from the monoclinic P2_(1)/a space group to the tetragonal I4/mmm around 12.6-13.4 GPa is identified, accompanied by a drop of resistance below 7 K. Density functional theory calculations suggest that the bonding state of Ni 3d_(z^(2)) orbital rises and crosses the Fermi level at high pressures, which may give rise to possible superconductivity observed in resistance under pressure in La_(4)Ni_(3)O_(10). The trilayer nickelate La_(4)Ni_(3)O_(10) shows some similarities with the bilayer La_(3)Ni_(2)O_(7) and has unique properties, providing a new platform to investigate the underlying mechanism of superconductivity in nickelates.

关键词： La_(4)Ni_(3)O_(10) high pressure synchrotron X-ray diffraction structural transition DFT calculations

Phase structure evolution and its effect on magnetic and mechanical properties of B-doped Sm_(2)Co_(17)-type magnets with high Fe content

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Chinese Physics B 2024年第9期33卷 582-588页

作者： yao-Wen Li Zhuang Liu Hai-Chen Wu Fang wang Chao-qun Zhu Dong-Liang Tan Yu Liu Yang Yang Ming-Xiao Zhang Ren-Jie Chen A-Ru Yan Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry ofEducation&School of Chemistry and Materials Science Shanxi Normal UniversityTaiyuan 030032China CISRI&NIMTE Joint Innovation Center for Rare Earth Permanent Magnets Ningbo Institute ofMaterial Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China

The unique cellular microstructure of Fe-rich Sm_(2)Co_(17)-type permanent magnets is closely associated with the structure of the solid solution *** investigate the phase structure,magnetic properties,and mechanical behavior of B-doped Sm_(2)Co_(17)-type magnets with high Fe *** doped B atoms can diffuse into the interstitial vacancy,resulting in lattice expansion and promote the homogenization of the phase organizational structure during the solid solution treatment in ***,the resulting second phase plays a dominant role to result in more microtwin structures and highly ordered 2:17R phases in the solid solution stage,which inhibits the ordering transformation of 1:7H phase during aging and affects the generation of the cellular structure,and to result in a decrease in magnetic properties,yet the interface formed between it and the matrix phase hinders the movement of dislocations and enhances the mechanical ***,the precipitation of high flexural strain grain boundary phase induced by B element doping is also a new and effective way to improve the flexural strain of Sm_(2)Co_(17)-type *** study provides a new understanding of the phase structure evolution and its effect on the magnetic and mechanical properties of Sm_(2)Co_(17)-type magnets with high Fe content.

关键词： Sm_(2)Co_(17)-type magnets magnetic and mechanical properties

An air-stable single-crystal layered oxide cathode based on multifunctional structural modulation for high-energy-density sodium-ion batteries

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Science China Chemistry 2024年

作者： Yi-Feng Liu Hai-Yan Hu Jia-Yang Li Hongrui wang Yi Zhao Jingqiang wang Yuan-Bo Wu Yan-Jiang Li Guang-Yu Zhang Qing-qun Sun Yan-Fang Zhu Rui-Ren Tang Xiong-Wei Wu Jia-Zhao wang Shi-Xue Dou Shu-Lei Chou yao Xiao Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University School of Chemistry and Materials Science Hunan Agricultural University Institute of Energy Materials Science University of Shanghai for Science and Technology Wenzhou Key Laboratory of Sodium-Ion Batteries Wenzhou University Technology Innovation Institute for Carbon Neutralization Institute for Carbon Neutralization College of Chemistry and Materials Engineering Wenzhou University College of Chemistry and Chemical Engineering Central South University

P2-type layered oxide, Na2/3Ni1/3Mn2/3O2, has drawn particular interest as a promising cathode material for sodium-ion batteries(SIBs) due to its fast sodium-ion transport channels with low migration potential. However, some catastrophic flaws, such as air instability, complicated multiphase evolution, and irreversible anionic redox, limit its electrochemical performance and hinder its application. Here, an air-stable single-crystal P2-type Na2/3Ni1/3Mn1/3Ti1/3O2is proposed based on the multifunctional structural modulation of Ti substitution that could alleviate the issues for practical SIBs. As a result, the cathode with high energy density shows excellent air stability and highly reversible phase transitions(P2–OP4), and delivers faster kinetics and stable anion redox chemistry. Meanwhile, a thorough investigation of the relationship between structure, function, and properties is demonstrated,emphasizing formation processes, electrochemical behavior, structural evolution, and air stability. Overall, this study provides the direction of multifunctional structural modulation for the development of high-performance sodium-based layered cathode materials for practical applications.

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